--- Log opened Fri Dec 09 00:00:19 2011
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07:53 < Lucas_> good morninging
07:53 < Lucas_> morning*
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09:53 < kanzure> "usceptibility to lung cancer due to smoking is at least partly genetic. If you have certain variants of a specific gene (don't have time for the lit search right now), smoking won't significantly increase your chances of lung cancer."
09:53 < kanzure> anyone know the allele or genes of interest?
09:58 < Lucas_> I have no clue
09:58 < Lucas_> where did you find the gene?
09:58 < kanzure> "Although cigarette smoking is the dominant risk factor for several epithelial cancers, only a small fraction of individuals with tobacco exposure develop cancer."
09:58 < kanzure> of course- cigs have much more than tobacco..
09:59 < kanzure> Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1 http://www.nature.com/ng/journal/v40/n5/abs/ng.109.html
09:59 < kanzure> "we analyzed 315,450 tagging SNPs in 1,154 current and former (ever) smoking cases of European ancestry and 1,137 frequency-matched, ever-smoking controls from Houston, Texas."
09:59 < kanzure> god damn it houston :(
09:59 < kanzure> "Two SNPs, rs1051730 and rs8034191, mapping to a region of strong linkage disequilibrium within 15q25.1 containing PSMA4 and the nicotinic acetylcholine receptor subunit genes CHRNA3 and CHRNA5, were significantly associated with risk in both replication sets"
10:00 < kanzure> "We conclude that variation in a region of 15q25.1 containing nicotinic acetylcholine receptors genes contributes to lung cancer risk."
10:02 < Lucas_> interesting stuff
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10:11 < Lucas_> too bad we can't leverage that to our advantage now042
10:12 < kanzure> it looks like it increases nicotine addiction, causing more smoking and causing more damage
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11:30 < archels> kanzure: rofl
11:40 < archels> kanzure: How far along are we in simulating protein-protein interactions?
11:41 < kanzure> there's lots of software released for that
11:52 < archels> How decent is it?
12:06 < archels> I'm asking for your personal opinion
12:07 < kanzure> yeah i know
12:07 < kanzure> it's been a long time so it's gonig to take me a while to remember anything good
12:07 < kanzure> ligand-ligand stuff tends to be good..
12:30 < kanzure> http://now.tufts.edu/news-releases/researchers-discover-changes-bioelectric-sign
12:43 < superkuh> Hm. Applying that in general to other organs and tissues probably will not work. Lots of animal eyes have a well known dipole, otherwise EOG wouldn't work. But not other tissues.
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22:24 < JayDugger> http://quantifiedself.com/2011/12/fenn-lipkowitzs-amazing-lifelog/
22:24 < JayDugger> Congratulations, Fenn!
22:24 < JayDugger> Now, if only QS would provide transcripts.
22:25 < JayDugger> Oh, and good evening, eveyone.
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23:54 < kanzure> huh, professional lab relocation service
23:54 < kanzure> http://www.perkinelmer.com/pages/010/onesource/lab_inst_relocation_services.xhtml?utm_source=LabrelocationRedirect&utm_medium=Redirect
--- Log closed Sat Dec 10 00:00:21 2011