--- Log opened Wed May 16 00:00:11 2012
00:04 -!- sylph_mako [~mako@118-92-225-149.dsl.dyn.ihug.co.nz] has quit [Ping timeout: 245 seconds]
00:10 -!- skorket [~skorket@fltg1.blackboxcc.com] has quit [Quit: Leaving]
00:16 -!- sylph_mako [~mako@118-92-225-149.dsl.dyn.ihug.co.nz] has joined ##hplusroadmap
01:06 < fenn> hehe exercise mimetics http://www.fightaging.org/archives/2012/01/development-of-exercise-mimetics-will-recapitulate-the-development-of-calorie-restriction-mimetics.php
01:06 < fenn> take a pill that has the biochemical effect of a triathlon
01:09 < fenn> i'd like to see more mouse studies with multiple simultaneous treatments, with the goal of increasing mouse lifespan indefinitely
01:09 < fenn> seems like there should be an x-prize for the 10 year mouse, 20 year mouse, etc
01:11 < fenn> if you have 10 different treatments that all target the same pathways, there's no point in doing all of them at once
01:11 -!- _Sketch_ [~Sketch@71-91-221-175.dhcp.stls.mo.charter.com] has quit [Read error: Connection reset by peer]
01:11 -!- _Sketch_ [~Sketch@71-91-221-175.dhcp.stls.mo.charter.com] has joined ##hplusroadmap
01:14 -!- Mariu [Jimmy98@89.41.57.33] has joined ##hplusroadmap
01:16 -!- Thorbinator [~Thorbinat@c-67-166-146-169.hsd1.ca.comcast.net] has quit [Read error: Connection reset by peer]
01:17 -!- Cat4D [425b8c22@gateway/web/freenode/ip.66.91.140.34] has quit [Ping timeout: 245 seconds]
01:17 -!- Thorbinator [~Thorbinat@c-67-166-146-169.hsd1.ca.comcast.net] has joined ##hplusroadmap
01:40 < Utopiah_> is there a dedicated QuantifisedSelf IRC channel?
02:17 < fenn> no
02:17 < fenn> they exclusively communicate by blog comments :\
03:16 -!- sylph_mako [~mako@118-92-225-149.dsl.dyn.ihug.co.nz] has quit [Ping timeout: 250 seconds]
03:22 -!- chris_99 [~chris@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap
03:32 -!- ThomasEgi [~thomas@panda3d/ThomasEgi] has joined ##hplusroadmap
03:56 -!- augur [~augur@208.58.5.87] has quit [Remote host closed the connection]
03:58 -!- augur [~augur@208.58.5.87] has joined ##hplusroadmap
03:58 -!- augur [~augur@208.58.5.87] has quit [Remote host closed the connection]
04:13 -!- jennicide [jen@173-18-211-34.client.mchsi.com] has joined ##hplusroadmap
04:16 -!- jenniside [jen@173-18-211-34.client.mchsi.com] has quit [Ping timeout: 248 seconds]
04:18 -!- Mariu [Jimmy98@89.41.57.33] has quit [Ping timeout: 265 seconds]
04:31 -!- augur [~augur@206.196.185.197] has joined ##hplusroadmap
05:46 -!- delinquentme [~asdfasdf@c-24-3-85-154.hsd1.pa.comcast.net] has joined ##hplusroadmap
06:23 -!- azonenberg [~azonenber@2001:470:888b:2:206:70ff:fe01:46] has joined ##hplusroadmap
06:27 -!- nmz787 [~Nathan@129.21.145.169] has joined ##hplusroadmap
06:50 -!- jmil [~jmil@SEASNet-148-05.seas.upenn.edu] has joined ##hplusroadmap
06:57 -!- nmz787 [~Nathan@129.21.145.169] has quit [Quit: Leaving.]
07:06 <@kanzure> juul: lavaamp got run into the ground by rob
07:06 <@kanzure> and then they all went to startupchile for some reason
07:07 <@kanzure> "Weill Cornell Medical College scientists have discovered that single protein alpha 2 delta controls the volume of neurotransmitters and other chemicals that flow between the synapses of brain neurons."
07:08 -!- nmz787 [~Nathan@nathan-think.wireless.rit.edu] has joined ##hplusroadmap
07:24 < bkero> lmao, copeenhagen hackerspace is randomly 2 blocks away from where I'm staying
07:24 < bkero> win
07:24 <@kanzure> hijack the submarine!
07:30 < bkero> lul
07:31 < bkero> perhaps
07:31 < bkero> They haven't updated their site since last september, I want to know if it's still active.
07:31 < Utopiah_> CFP http://agi-conf.org/2012/call-for-papers/
07:32 < Utopiah_> bkero: and the ML?
07:35 < bkero> Utopiah_: dunno f it has a ml
07:38 < Utopiah_> the wiki looks quite active https://labitat.dk/wiki/Special:RecentChanges
07:51 < bkero> not that one
07:51 < bkero> The other one
07:51 < bkero> Illutron
07:52 < bkero> Labitat is quite active and I need to make somet ime to go see them one of these weekends
07:59 -!- delinquentme [~asdfasdf@c-24-3-85-154.hsd1.pa.comcast.net] has quit [Ping timeout: 272 seconds]
08:27 -!- Cat4D [425b8c22@gateway/web/freenode/ip.66.91.140.34] has joined ##hplusroadmap
08:37 < bkero> Wrote Copenhagen Suborbitals an email asking to attend their rocket test this sunday
08:55 -!- nmz787 [~Nathan@nathan-think.wireless.rit.edu] has quit [Quit: Leaving.]
08:56 -!- Mariu [Jimmy98@89.41.57.33] has joined ##hplusroadmap
09:03 -!- Cat4D [425b8c22@gateway/web/freenode/ip.66.91.140.34] has quit [Ping timeout: 245 seconds]
09:17 -!- jmil [~jmil@SEASNet-148-05.seas.upenn.edu] has quit [Quit: jmil]
09:24 -!- ThomasEgi [~thomas@panda3d/ThomasEgi] has quit [Ping timeout: 244 seconds]
09:37 -!- ThomasEgi [~thomas@pppdyn-77.stud-ko.rz-online.net] has joined ##hplusroadmap
09:37 -!- ThomasEgi [~thomas@pppdyn-77.stud-ko.rz-online.net] has quit [Changing host]
09:37 -!- ThomasEgi [~thomas@panda3d/ThomasEgi] has joined ##hplusroadmap
09:45 -!- eudoxia [~eudoxia@r190-135-64-58.dialup.adsl.anteldata.net.uy] has joined ##hplusroadmap
09:47 <@kanzure> i found this old "neuropsychopharmacology" textbook of mine on a shelf
09:48 <@kanzure> filled with hand-written notes from 2007-2008
09:48 < jrayhawk> note 1: "EAT ALL THE DRUGS"
09:49 -!- chris_99 [~chris@unaffiliated/chris-99/x-3062929] has quit [Read error: Connection reset by peer]
09:50 < ThomasEgi> note 2: disregard note 1
09:50 <@kanzure> jrayhawk: that would be an appropriate comment if the book was pikhal
09:50 <@kanzure> *pihkal
09:52 -!- chris_99 [~chris@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap
09:56 -!- eudoxia [~eudoxia@r190-135-64-58.dialup.adsl.anteldata.net.uy] has quit [Quit: quit]
10:32 -!- SDr [SDr@unaffiliated/sdr] has joined ##hplusroadmap
11:02 -!- devrandom [~devrandom@gateway/tor-sasl/niftyzero1] has joined ##hplusroadmap
11:18 -!- Proteus [~Proteus@unaffiliated/proteus] has joined ##hplusroadmap
11:29 -!- Utopiah_ is now known as Utopiah
11:30 -!- Utopiah [~utopiah@rps7452.ovh.net] has quit [Changing host]
11:30 -!- Utopiah [~utopiah@unaffiliated/utopiah] has joined ##hplusroadmap
11:37 <@kanzure> Resolution doubling in live, multicellular organisms via multifocal structured illumination microscop
11:37 <@kanzure> http://www.nature.com/nmeth/journal/vaop/ncurrent/full/nmeth.2025.html
11:37 <@kanzure> *microscopy
11:37 <@kanzure> "We demonstrate three-dimensional (3D) super-resolution in live multicellular organisms using structured illumination microscopy (SIM). Sparse multifocal illumination patterns generated by a digital micromirror device (DMD) allowed us to physically reject out-of-focus light, enabling 3D subdiffractive imaging in samples eightfold thicker than had been previously imaged with SIM."
11:38 <@kanzure> "We imaged samples at one 2D image per second, at resolutions as low as 145 nm laterally and 400 nm axially. In addition to dual-labeled, whole fixed cells, we imaged GFP-labeled microtubules in live transgenic zebrafish embryos at depths >45 μm."
11:38 <@kanzure> "Our method uses commercially available parts and open-source software and is simpler than existing SIM implementations, allowing easy integration with wide-field microscopes."
11:50 -!- delinquentme [~asdfasdf@c-24-3-85-154.hsd1.pa.comcast.net] has joined ##hplusroadmap
12:02 < jrayhawk> bkero: if you like rockets you should hang out with http://psas.pdx.edu/
12:07 < bkero> jrayhawk: I've been invited to some of the meetings
12:12 -!- _0bitcount [~ulises11@81.61.35.16.dyn.user.ono.com] has joined ##hplusroadmap
12:15 -!- Mariu [Jimmy98@89.41.57.33] has quit []
12:23 -!- Mariu [Jimmy98@89.41.57.33] has joined ##hplusroadmap
12:32 -!- devrandom [~devrandom@gateway/tor-sasl/niftyzero1] has quit [Remote host closed the connection]
13:11 -!- Mokbortolan_ [~Nate@c-76-115-136-13.hsd1.or.comcast.net] has quit [Read error: No route to host]
13:11 -!- Mokbortolan_ [~Nate@c-76-115-136-13.hsd1.or.comcast.net] has joined ##hplusroadmap
13:24 -!- eudoxia [~eudoxia@r186-52-166-237.dialup.adsl.anteldata.net.uy] has joined ##hplusroadmap
13:24 < Utopiah> robot arm and BCI http://www.youtube.com/watch?v=ogBX18maUiM (braingate)
13:24 <@kanzure> braingate is still around? they took down their original tongue display page and i am sad
13:40 -!- augur [~augur@206.196.185.197] has quit [Remote host closed the connection]
13:47 -!- _0bitcount [~ulises11@81.61.35.16.dyn.user.ono.com] has quit [Quit: Leaving]
13:47 -!- sylph_mako [~mako@118-92-225-149.dsl.dyn.ihug.co.nz] has joined ##hplusroadmap
13:55 -!- yashgaroth [~f@cpe-66-27-117-179.san.res.rr.com] has joined ##hplusroadmap
13:55 -!- sylph_mako [~mako@118-92-225-149.dsl.dyn.ihug.co.nz] has quit [Ping timeout: 256 seconds]
14:10 -!- mensch [~mensch@c-67-189-240-148.hsd1.ma.comcast.net] has joined ##hplusroadmap
14:13 -!- sylph_mako [~mako@118-92-225-149.dsl.dyn.ihug.co.nz] has joined ##hplusroadmap
14:17 -!- chevbird [~chevbird@otis.broadinstitute.org] has joined ##hplusroadmap
14:18 < chevbird> long day in the lab.  save me with some stimulating conversation before i hit the bar
14:18  * jrayhawk farts
14:19 < chevbird> well played
14:21 < Mariu> lol
14:24 <@kanzure> chevbird: there's some stuff in the backlog about the google/oracle and the sage/press cases
14:24 <@kanzure> chevbird: http://gnusha.org/logs/2012-05-16.txt
14:25 < chevbird> saved again by kanzure
14:25 < chevbird> thanks buddy
14:25 <@kanzure> http://www.xconomy.com/seattle/2012/05/03/virtual-biotech-companies-built-on-solid-bedrock-or-unstable-landfill/
14:26 <@kanzure> "it's virtually a business!"
14:28 -!- sylph_mako [~mako@118-92-225-149.dsl.dyn.ihug.co.nz] has quit [Quit: Leaving]
14:59 <@kanzure> singularity comedy bit: http://www.youtube.com/watch?v=IFe9wiDfb0E
15:00 < mensch> haha
15:00 < mensch> just saw that
15:02 <@kanzure> hrm, well that's not very funny actually
15:05 < mensch> Depends on your mood, I guess.
15:06 <@kanzure> what's ironic about it?
15:06 < mensch> Sinister, nonetheless.
15:06 <@kanzure> i guess it might qualify to be "dry observational humor"
15:14 -!- eudoxia [~eudoxia@r186-52-166-237.dialup.adsl.anteldata.net.uy] has quit [Quit: quit]
15:23 -!- strages_shop [~strages@256.makerslocal.org] has joined ##hplusroadmap
15:35 < delinquentme> https://gist.github.com/2714505  << why
15:37 -!- eridu [~eridu@gateway/tor-sasl/eridu] has joined ##hplusroadmap
15:51 -!- eridu [~eridu@gateway/tor-sasl/eridu] has quit [Quit: Leaving]
15:57 -!- chris_99 [~chris@unaffiliated/chris-99/x-3062929] has quit [Quit: Leaving]
15:57 <@kanzure> delinquentme: because you are using gsub! instead of gsub
16:02 < delinquentme> kanzure, good call
16:26 < delinquentme> jrayhawk, intermittent fasting stimulated cell apoptosis right?
16:26 < delinquentme> stimulates **
16:26 < delinquentme> also.. what do you normally consume post fast?
16:27 < jrayhawk> Protein fasting for more than 18 hours does that.
16:29 < jrayhawk> Usually I'm fasting by circumstance; if I'm sated enough to not eat for that long, it's because I'm eating a high-fat diet, so fat is what'll bring me out of it.
16:32 -!- devrandom [~devrandom@gateway/tor-sasl/niftyzero1] has joined ##hplusroadmap
16:37 -!- augur [~augur@c-69-250-19-178.hsd1.md.comcast.net] has joined ##hplusroadmap
16:38 < jrayhawk> fwiw i am not a big believer in the power of intermittent fasting. keto-adaptation and apoptosis are handy, but thyroid downregulation sucks and longevity studies all use garbage calorie sources dubious animal models.
16:38 < jrayhawk> garbage calroie sources and dubious animal models
16:40 < jrayhawk> and i can get those upsides by other means
16:40 < delinquentme> wait I thought you said you're into fasting?
16:40 < delinquentme> and what other ways are there to stimulate apoptosis?
16:43 < jrayhawk> I do occasional carbohydrate and protein fasting versus, like, general caloric restriction
16:44 < jrayhawk> Cold is another way of causing all sorts of interesting apoptotic effects
16:44 < delinquentme> yeahh cold showers
16:44 < delinquentme> they're rough to get through but i feel awesome once I get out
16:45 < jrayhawk> Baths are a bit less awful, and you can get some of the same effects just by dunking your face as long as you can.
16:45 < jrayhawk> mind you a cold shower is better at hammering you metabolicly. it's a good workout.
16:47 < jrayhawk> i just ordered a five gallon bucket of saturated fat this morning :)
16:47 < delinquentme> jrayhawk, you did what?
16:48 < delinquentme> lol wait how why ?
16:48 < jrayhawk> 150,000 largely innocuous calories for $135 seems like a good deal to me
16:48 < jrayhawk> http://www.tropicaltraditions.com/expeller-pressed_coconut_oil.htm
16:49 < delinquentme> lolol
16:49 < delinquentme> jrayhawk, do you not like food? or cooking?
16:50 < jrayhawk> I'm not really motivated by taste reward like some people are; I assume some of that's genetic and some of it's based on leptin/insulin resistance.
16:51 < jrayhawk> And yes, I find cooking irritating. I tend to just shove most of my shopping list in a 3-gallon pot and cook it for 24 hours to provide meals I can pad out with raw greens and fat for the rest of the week.
16:51 < jrayhawk> This cuts my cooking time down substantially.
16:52 < jrayhawk> When you cook a chicken for 24 hours, you don't need to bother disarticulating it!
16:52 < jrayhawk> aum nyaum bones
16:54 < jrayhawk> for a while i could get beef fat for a dollar per pound; that was pretty cool
16:55 < jrayhawk> it was grain-fed, though, which kinda sucked
16:55 < jrayhawk> Not, like, scary CAFO grainfed, though.
17:03 < delinquentme> jrayhawk, you've got backing for liking grass fed beef?
17:04 < jrayhawk> micronutrient density, lipid profile
17:05 < delinquentme> grass fed = lower fat im guessing?
17:05 < delinquentme> Ohh and whats the butter in the coffee thing again
17:05 < delinquentme> i need to youtube this
17:07 <@kanzure> jrayhawk: you are my favorite chef
17:07 < delinquentme> http://quantifiedself.com/2011/01/results-of-the-buttermind-experiment/
17:07 < jrayhawk> It usually is lower fat, but that's not all that important to me. Human-safe omega-3-to-omega-6 ratio, and not-insignificant levels of conjugated linoleic acid.
17:09 < delinquentme> so if I eat cupcakes with that much butter
17:09 < jrayhawk> And I suppose there's the issue of bacterial overgrowth and attendent health risks to grain-fed beef, but those are pretty marginal risks.
17:09 < delinquentme> will I get the same effects even though im digesting it along w carbs?
17:09 -!- augur [~augur@c-69-250-19-178.hsd1.md.comcast.net] has quit [Remote host closed the connection]
17:10 < delinquentme> bc I've ate some delicious cupcakes
17:10 < delinquentme> and I'd love to be able to do that for brain health
17:10 < jrayhawk> Cupcakes, huh? Have neither the Taubesians or the paleoites gotten to you yet?
17:10 < delinquentme> lol i know carbs
17:11 < delinquentme> but like butter in coffee doesnt sound awesome
17:11 < delinquentme> cupcakes do
17:14 < jrayhawk> well, i don't think inflammation from fructose metabolism, insulin spiking, or gliadin will be good for your brain, no
17:14 < delinquentme> so the sugar is the issue
17:16 < jrayhawk> technically i suppose the wheat is more disastrous, but probably not on a marginal basis
17:18  * delinquentme sad kid raised on cupcakes
17:22 -!- Mariu [Jimmy98@89.41.57.33] has quit []
17:39 -!- augur [~augur@c-69-250-19-178.hsd1.md.comcast.net] has joined ##hplusroadmap
17:56 -!- augur [~augur@c-69-250-19-178.hsd1.md.comcast.net] has quit [Read error: Connection reset by peer]
17:58 -!- augur [~augur@c-69-250-19-178.hsd1.md.comcast.net] has joined ##hplusroadmap
18:08 -!- augur [~augur@c-69-250-19-178.hsd1.md.comcast.net] has quit [Remote host closed the connection]
18:10 -!- augur [~augur@c-69-250-19-178.hsd1.md.comcast.net] has joined ##hplusroadmap
18:19 -!- delinquentme_ [~asdfasdf@c-24-3-85-154.hsd1.pa.comcast.net] has joined ##hplusroadmap
18:23 -!- delinquentme [~asdfasdf@c-24-3-85-154.hsd1.pa.comcast.net] has quit [Ping timeout: 272 seconds]
18:34 -!- HEx1 [~HEx@212.159.112.196] has quit [Ping timeout: 260 seconds]
18:35 -!- HEx1 [~HEx@212.159.112.196] has joined ##hplusroadmap
18:40 -!- devrandom [~devrandom@gateway/tor-sasl/niftyzero1] has quit [Quit: leaving]
18:53 -!- augur [~augur@c-69-250-19-178.hsd1.md.comcast.net] has quit [Read error: Connection reset by peer]
18:54 -!- ThomasEgi [~thomas@panda3d/ThomasEgi] has quit [Remote host closed the connection]
18:54 -!- augur [~augur@c-69-250-19-178.hsd1.md.comcast.net] has joined ##hplusroadmap
19:26 -!- klafka [~klafka@c-67-174-253-229.hsd1.ca.comcast.net] has joined ##hplusroadmap
19:29 -!- Thorbinator [~Thorbinat@c-67-166-146-169.hsd1.ca.comcast.net] has quit [Quit: Leaving.]
19:30 -!- Thorbinator [~Thorbinat@c-67-166-146-169.hsd1.ca.comcast.net] has joined ##hplusroadmap
19:35 -!- joshcryer [~g@unaffiliated/joshcryer] has joined ##hplusroadmap
19:51 -!- mensch [~mensch@c-67-189-240-148.hsd1.ma.comcast.net] has quit [Quit: leaving]
20:31 -!- azonenberg [~azonenber@2001:470:888b:2:206:70ff:fe01:46] has quit [Ping timeout: 245 seconds]
20:38 -!- delinquentme_ [~asdfasdf@c-24-3-85-154.hsd1.pa.comcast.net] has quit [Quit: Leaving]
20:39 -!- azonenberg [~azonenber@2001:470:888b:2:206:70ff:fe01:46] has joined ##hplusroadmap
21:18 -!- strages_shop [~strages@256.makerslocal.org] has quit [Ping timeout: 244 seconds]
21:55 -!- augur [~augur@c-69-250-19-178.hsd1.md.comcast.net] has quit [Remote host closed the connection]
22:03 -!- azonenberg [~azonenber@2001:470:888b:2:206:70ff:fe01:46] has quit [Ping timeout: 245 seconds]
22:16 -!- strages_home [~strages@adsl-98-81-19-3.hsv.bellsouth.net] has quit [Ping timeout: 272 seconds]
22:24 < jrayhawk> err, everywhere i said apoptosis, i meant autophagy
22:25 <@kanzure> this is why you could never pass your chef certification test
22:25 < jrayhawk> there's a lot of overlap
22:53 -!- augur [~augur@208.58.5.87] has joined ##hplusroadmap
23:09 -!- srangewarp [~strangewa@c-76-25-200-47.hsd1.co.comcast.net] has joined ##hplusroadmap
23:10 -!- strangewarp [~strangewa@c-76-25-200-47.hsd1.co.comcast.net] has quit [Disconnected by services]
23:11 -!- srangewarp is now known as strangewarp
23:38 -!- SDr [SDr@unaffiliated/sdr] has quit [Ping timeout: 245 seconds]
--- Log closed Thu May 17 00:00:12 2012