--- Log opened Wed Aug 15 00:00:45 2012 00:06 < nmz787> "We're calculating for some of our larger designs that at 3000 mm/min 00:06 < nmz787> to take 15 minutes to fully finish. That math is: 00:06 < nmz787> 1,000,000 droplets 25 microns in diameter next to each other 00:06 < nmz787> single-file in a 'circular buffer'... * 1.25 for overheard and 00:06 < nmz787> reaction centers that use the droplets. That's 31,250,000 microns for 00:06 < nmz787> a single layer, the other layer or two would be much much less. We'd 00:06 < nmz787> like to keep this layer to about 15 minutes of cutting to allow for 00:06 < nmz787> rapid revision of digital to physical design. 31250 mm / 15 = 2083 00:06 < nmz787> mm/min" 00:08 < nmz787> so that's 33966.66 microns per second 00:08 < nmz787> brgl says it can handle 30 khz 00:10 < nmz787> with a 40 tpi screw, 25400 microns (1 inch) / 40 / 400 steps = 1.5875 microns per step 00:11 < nmz787> and we had talked about doing 1/8th or 1/16th microstepping 00:13 < nmz787> so at full-step that speed requires 21396.32 hz 00:13 < nmz787> at 1/8th it requires 171khz 00:13 -!- exiff [~ficl@unaffiliated/exiff] has quit [Ping timeout: 252 seconds] 00:13 < nmz787> at 1/1th it requires 342khz 00:14 < nmz787> s/1\/1/1\/16/ 00:14 < nmz787> (i mean 1/16th) 00:14 < nmz787> i was thinking of writing a simple g-code subset interpreter for a parallax propeller 00:17 -!- devrando1 [~devrandom@gateway/tor-sasl/niftyzero1] has joined ##hplusroadmap 00:21 < skorket> interesting, thank you. You might want to just port grbl over to the parallax 00:21 -!- devrandom [~devrandom@gateway/tor-sasl/niftyzero1] has quit [Ping timeout: 276 seconds] 00:31 < nmz787> skorket would you be interested/capable of helping? 00:31 < skorket> yes and probably 00:31 < skorket> though I don't own a parallax propeller 00:32 < skorket> oh, but they're cheap. Do they have a nice linux toolchain? 00:32 < skorket> oh, the other thing is the pic32, those are some pretty burly micros 00:34 < nmz787> grbl has a total of 3572 lines, not too bad 00:35 < nmz787> i don't remember about working in linux with the propeller 00:36 < nmz787> with windows it was a single zip/extracting-exe download, pretty small i think, and was as easy to start programming and debugging as an arduino is 00:37 < nmz787> this shows compiling through WINE, then uploading with pyserial http://propeller.wikispaces.com/Linux+Development 00:37 < skorket> yep, looking at it now 00:37 < skorket> looks like theres a native python loader 00:38 < skorket> anyway, looks like it's all possible 00:38 < nmz787> mac and linux native development http://propeller.wikispaces.com/Mac+and+Linux+native+development 00:40 < nmz787> the plan was to use these for drivers http://www.pololu.com/catalog/product/1182 00:41 < nmz787> or the same thing with voltage regulators http://www.pololu.com/catalog/product/1183 00:42 < nmz787> not sure if the voltage regulators on-board would help with isolation of power ripple, etc between motors 00:43 < skorket> yeah, I'm using the a4988. I've had trouble with them overheating, so if you do use them, I suggest getting some heatsinks and maybe a fan. http://www.newegg.com/Product/Product.aspx?Item=N82E16835708011&Tpk=mos-c1 00:47 < nmz787> yeah i was just wondering about heat 00:49 < skorket> I learned the hard way. I was trying to drive my motors with the a4988 and after about 10-30 seconds, the motors would start to 'pulse' 00:50 < skorket> I finally figured out it was the chip's automatic shutdown after it sensed the heat level getting to high 00:50 < skorket> so it would cyclically heat up, shut down, turn on and repeat 00:51 < skorket> putting a heatsink on it and having some fans alleviated the problem, but if I turn the current up to high, it still has the same problem. 00:51 < nmz787> hmm 00:51 < nmz787> peltier's needed maybe 00:51 < skorket> From talking to the others at #linuxcnc and #diycnc, they say that most people tune it by ear 00:51 < nmz787> what does turning up the current do, more torque?? 00:51 < skorket> yeah, maybe. Not sure how you physically align everything. I was thinking of just dunking them is vegetable oil or something 00:52 < skorket> yeah, more current = stronger magnetic field 00:52 < nmz787> physically line what up? 00:53 < nmz787> the axes of the CNC? 00:55 < skorket> no, the peltier device on top of the three a4988's with heatsinks 00:59 < gnusha_> laser_etcher.git: dad9b3f 01:01 < gnusha_> laser_etcher.git: b74d304 01:01 < nmz787> laser etcher cut speed calculations: http://diyhpl.us/laser_etcher/laser_etcher/?updated#index5h1 01:07 -!- sylph_mako [~mako@1.31.252.27.dyn.cust.vf.net.nz] has joined ##hplusroadmap 01:09 -!- sylph_mako [~mako@1.31.252.27.dyn.cust.vf.net.nz] has quit [Read error: Connection reset by peer] 01:11 -!- lichen [~lichen@c-24-21-206-64.hsd1.or.comcast.net] has joined ##hplusroadmap 01:20 -!- skorket [~skorket@cpe-24-58-232-122.twcny.res.rr.com] has quit [Ping timeout: 240 seconds] 01:21 -!- archels [~foo@sascha.esrac.ele.tue.nl] has quit [Ping timeout: 244 seconds] 01:22 -!- yashgaroth 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has joined ##hplusroadmap 07:57 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap 08:07 -!- nmz787 [~Nathan@ool-457e5cbd.dyn.optonline.net] has joined ##hplusroadmap 08:12 -!- nmz787 [~Nathan@ool-457e5cbd.dyn.optonline.net] has quit [Ping timeout: 260 seconds] 08:12 -!- ThomasEgi [~thomas@p5B13A89F.dip.t-dialin.net] has joined ##hplusroadmap 08:12 -!- ThomasEgi [~thomas@p5B13A89F.dip.t-dialin.net] has quit [Changing host] 08:12 -!- ThomasEgi [~thomas@panda3d/ThomasEgi] has joined ##hplusroadmap 08:28 <@kanzure> i am glad nobody on the list objected to the existence of diybio.mail.tar.gz 08:29 < foucist> i object! it should be named diybio_mail.tar.gz! 08:30 <@kanzure> i don' 08:30 <@kanzure> i don't know what the standard name for a maildir archive is supposed to be 08:31 <@kanzure> doh i wonder if that archive includes my outgoing emails 09:08 -!- EnLilaSko [~Nattzor@unaffiliated/enlilasko] has quit [Ping timeout: 248 seconds] 09:29 -!- nsh [~Smedley@wikipedia/nsh] has quit [Ping timeout: 248 seconds] 09:33 -!- devrando1 [~devrandom@gateway/tor-sasl/niftyzero1] has quit [Ping timeout: 276 seconds] 09:35 -!- devrandom [~devrandom@gateway/tor-sasl/niftyzero1] has joined ##hplusroadmap 09:36 -!- rmcl [~rmcl@rrcs-108-178-168-32.west.biz.rr.com] has joined ##hplusroadmap 09:37 < TheEmpath> these guys just gave out $5 million to UC Riverside in Pennsylvania to research immortality http://www.templeton.org/what-we-fund/funding-competitions/the-meanings-of-convergence 09:39 <@kanzure> no that was just some philosophy stuff iirc 09:40 <@kanzure> https://play.google.com/store/apps/details?id=org.fas.mobilebiothreat 09:43 -!- nsh [~Smedley@host86-165-113-100.range86-165.btcentralplus.com] has joined ##hplusroadmap 09:44 -!- nsh [~Smedley@host86-165-113-100.range86-165.btcentralplus.com] has quit [Changing host] 09:44 -!- nsh [~Smedley@wikipedia/nsh] has joined ##hplusroadmap 09:45 <@kanzure> if anyone wants the images from that app.. 09:45 <@kanzure> http://diyhpl.us/~bryan/irc/org.fas.mobilebiothreat.images/ 09:45 <@kanzure> http://diyhpl.us/~bryan/irc/org.fas.mobilebiothreat.images.zip 09:47 <@kanzure> and the app (if you don't want to download through that official channel): http://diyhpl.us/~bryan/irc/org.fas.mobilebiothreat.apk 09:49 -!- Jaakko96 [~Jaakko@94-194-89-130.zone8.bethere.co.uk] has joined ##hplusroadmap 09:51 -!- EnLilaSko [~Nattzor@unaffiliated/enlilasko] has joined ##hplusroadmap 09:56 < ParahSailin_> what app is that? 09:57 < ParahSailin_> also hi EnLilaSko 09:58 < EnLilaSko> Hey 09:59 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Ping timeout: 245 seconds] 10:01 <@kanzure> ParahSailin_: it's about those cards the fbi distributed.. 10:07 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap 10:30 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Ping timeout: 240 seconds] 10:41 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap 10:43 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Max SendQ exceeded] 10:45 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap 11:02 -!- Mokbortolan_ [~Nate@c-76-115-136-13.hsd1.or.comcast.net] has joined ##hplusroadmap 11:14 -!- HEx1 [~HEx@212.159.112.196] has quit [Ping timeout: 246 seconds] 11:27 -!- yashgaroth [~f@cpe-66-27-117-179.san.res.rr.com] has joined ##hplusroadmap 11:31 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Ping timeout: 240 seconds] 11:40 -!- gnusha [~gnusha@131.252.130.248] has joined ##hplusroadmap 11:40 -!- Topic for ##hplusroadmap: biohacking, nootropics, transhumanism, open hardware | sponsored by george church and the NRA | http://gnusha.org/logs http://diyhpl.us/wiki http://groups.google.com/group/diybio | friends don't let friends do super college 11:40 -!- Topic set by kanzure [~kanzure@131.252.130.248] [Fri Aug 10 08:01:18 2012] 11:40 [Users ##hplusroadmap] 11:40 [@kanzure ] [ coornail ] [ Guest56535 ] [ lichen ] [ pasky ] [ the_merlin ] 11:40 [ _sol_ ] [ cutbert ] [ Haruspex ] [ marainein ] [ phryk ] [ TheEmpath ] 11:40 [ AdrienG_ ] [ devrandom ] [ Helleshin ] [ Mokbortolan_ ] [ Proteus ] [ thesnark ] 11:40 [ AlonzoTG ] [ drazak ] [ ivan`_ ] [ nathaniel ] [ qnm ] [ ThomasEgi ] 11:40 [ archels ] [ EnLilaSko ] [ Jaakko96 ] [ nsh ] [ rmcl ] [ Thorbinator1] 11:40 [ augur ] [ epitron ] [ Jenda` ] [ nuba ] [ Sanky_ ] [ upgrayeddd ] 11:40 [ bkero ] [ exiff ] [ jennicde_ ] [ obscurite ] [ SDr ] [ Urchin ] 11:40 [ blumental_] [ fenn_ ] [ jmil ] [ octopine ] [ skorket ] [ Utopiah ] 11:40 [ brownies ] [ foucist ] [ jmil_ ] [ OldCoder_ ] [ smeaaagle ] [ Vicarious ] 11:40 [ Burninate ] [ gedankenstuecke] [ jrayhawk ] [ paperbot ] [ strages_home] [ yashgaroth ] 11:40 [ chido ] [ gnusha ] [ klafka ] [ ParahSailin_ ] [ strangewarp ] [ ybit ] 11:40 [ CIA-8 ] [ gnusha_ ] [ Lemminkainen_] [ ParahSailin__] [ superkuh ] [ yorick ] 11:40 -!- Irssi: ##hplusroadmap: Total of 72 nicks [1 ops, 0 halfops, 0 voices, 71 normal] 11:40 -!- Channel ##hplusroadmap created Thu Feb 25 23:40:30 2010 11:40 -!- Irssi: Join to ##hplusroadmap was synced in 6 secs 11:40 -!- nuba_ [~nuba@pauleira.com] has joined ##hplusroadmap 11:40 -!- pasky_ [pasky@nikam.ms.mff.cuni.cz] has joined ##hplusroadmap 11:40 -!- AdrienG_ is now known as AdrianG 11:45 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap 11:45 -!- Netsplit *.net <-> *.split quits: jmil, brownies, pasky, gnusha_, nuba 11:45 -!- jmil_ is now known as jmil 11:51 -!- nmz787 [~Nathan@ool-457e5cbd.dyn.optonline.net] has joined ##hplusroadmap 11:51 -!- Juul [~Juul@171.66.172.76] has joined ##hplusroadmap 12:05 -!- nsh [~Smedley@wikipedia/nsh] has quit [Ping timeout: 248 seconds] 12:19 -!- nsh [~Smedley@host86-137-162-91.range86-137.btcentralplus.com] has joined ##hplusroadmap 12:48 -!- nsh 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klafka [~textual@c-67-174-253-229.hsd1.ca.comcast.net] has quit [Quit: Computer has gone to sleep.] 14:43 -!- OldCoder_ [~OldCoder_@c-69-181-140-134.hsd1.ca.comcast.net] has quit [Ping timeout: 240 seconds] 14:44 -!- OldCoder_ [~OldCoder_@c-69-181-140-134.hsd1.ca.comcast.net] has joined ##hplusroadmap 14:47 -!- exiff [~ficl@unaffiliated/exiff] has quit [Ping timeout: 240 seconds] 14:51 -!- HEx1 [~HEx@212.159.112.196] has joined ##hplusroadmap 14:51 -!- brownies [u1042@gateway/web/irccloud.com/x-kygpadpbsfjzciqq] has joined ##hplusroadmap 14:57 -!- minimoose [~minimoose@74-95-191-59-Philadelphia.hfc.comcastbusiness.net] has joined ##hplusroadmap 14:57 <@kanzure> hi minimoose. 14:57 < minimoose> hi kanzure 14:57 <@kanzure> where are you in philadelphia? 14:57 < minimoose> Wayne 14:58 <@kanzure> hrmm 14:58 < minimoose> Where are you? 14:58 <@kanzure> texas. http://diyhpl.us/wiki/diybio/groups 14:59 < minimoose> Ahh… Austin. 15:02 <@kanzure> minimoose: what's your background? 15:03 < minimoose> 45M, fund manager - mostly midstream energy 15:03 < minimoose> Former computer hacker from the early 80s. 15:04 < minimoose> Built an OpenPCR unit with my 15 year old daughter on Sunday. 15:04 <@kanzure> why did you pick openpcr over the others? 15:04 <@kanzure> well, ok. cool. 15:05 < minimoose> We didn't know that there are others. 15:05 < minimoose> She thought it would be cool and loves biology... 15:05 <@kanzure> openpcr is sorta expensive (although cheaper than commercial models) 15:05 < minimoose> I saw the Arduino unit and read about it… seemed like a good Sunday project. 15:06 < minimoose> … which is was. We had a lot of fun. So now we have to decide what to do with it... 15:07 < minimoose> We kind of like reading about custom designed enzymes as replacements for people with nasty SNPs and possibly for industrial use. 15:07 <@kanzure> well the usual case is "buy lots of primers, and lots of pcr master mix" 15:08 < minimoose> I used to have an account at Sigma-Aldrich, but don't anymore... 15:08 < minimoose> So now I need to figure out where to order from. 15:08 <@kanzure> you can order primers online.. sigma's per-base pair prices seemed a little high last time i looked? 15:08 <@kanzure> although nmz787 claims he got $0.15/bp 15:08 <@kanzure> (from sgima) 15:08 <@kanzure> *sigma 15:09 <@kanzure> minimoose: i think idt is an ok go-to place to check first, then compare other prices to that 15:10 < minimoose> OK… I'll ask around… we were thinking of maybe trying to determine snake genders as a first project. 15:11 <@kanzure> no i meant just go look at their quotes http://idtdna.com/ 15:11 < minimoose> reading now 15:12 < yashgaroth> also you're at least gonna need a gel electrophoresis setup for that if you don't have one already 15:13 <@kanzure> also consider enrolling together in a community college class if you want to be shown the techniques hands-on, like for building gels (or you can figure it out given enough time..) 15:14 < yashgaroth> I wonder if biocurious got their gel issues resovled, since it had like multiple major problems 15:14 -!- jmil [~jmil@hive76/member/jmil] has quit [Quit: jmil] 15:15 <@kanzure> yashgaroth: i wasn't there that day.. what went wrong? 15:15 < yashgaroth> everything 15:15 <@kanzure> awesome 15:15 < yashgaroth> voltage was super-low I guess, the ladder was sort of running but like sideways, and of course none of the samples showed up 15:16 < ParahSailin_> there are lots of places that give free master mix as promotions 15:16 < ParahSailin_> idt is $.15/bp 15:20 <@kanzure> oh neat. i didn't know they were at that. 15:24 < minimoose> need to head home… back later. I'm going to start hanging in here kanzure (and bothering you with idiotic questions, no doubt). 15:25 -!- minimoose [~minimoose@74-95-191-59-Philadelphia.hfc.comcastbusiness.net] has quit [Quit: minimoose] 15:27 <@kanzure> score one fund manager.. 15:27 * kanzure checks it off his list 15:28 -!- strangewarp [~strangewa@c-76-25-200-47.hsd1.co.comcast.net] has quit [Quit: A cardboard cutout of Bill Murray, a tangerine with a face drawn on it, and a rough draft of a Harry Potter/Twilight crossover fanfic.] 15:33 -!- ThomasEgi [~thomas@panda3d/ThomasEgi] has quit [Remote host closed the connection] 15:34 -!- strangewarp [~strangewa@c-76-25-200-47.hsd1.co.comcast.net] has joined ##hplusroadmap 15:44 -!- Steel2 [ad42e490@gateway/web/freenode/ip.173.66.228.144] has joined ##hplusroadmap 16:12 -!- EnLilaSko- [~Nattzor@m77-219-191-140.cust.tele2.se] has quit [Quit: - nbs-irc 2.39 - www.nbs-irc.net -] 16:22 -!- jmil [~jmil@hive76/member/jmil] has joined ##hplusroadmap 16:35 -!- jmil [~jmil@hive76/member/jmil] has quit [Quit: jmil] 16:44 -!- minimoose [~minimoose@pool-98-114-46-42.phlapa.fios.verizon.net] has joined ##hplusroadmap 16:54 -!- delinquentme [~asdfasdf@c-71-236-101-39.hsd1.pa.comcast.net] has joined ##hplusroadmap 16:55 <@kanzure> minimoose: wb 16:55 < minimoose> Thanks, kanzure. 16:55 < minimoose> How do you like Austin? 16:55 <@kanzure> i prefer colder climates 16:56 <@kanzure> and more geek per capita 16:56 < minimoose> Me too, actually. On both. 16:56 < minimoose> Finland works. 16:56 -!- devrandom [~devrandom@gateway/tor-sasl/niftyzero1] has quit [Remote host closed the connection] 16:59 <@kanzure> minimoose: so what were you hacking in the 80s? 17:00 < minimoose> Originally a Sinclair Sinclair ZX-80 then a ZX-81 both with Zilog Z80s... 17:01 <@kanzure> oh cool. i've been doing some random z80 asm stuff lately. 17:01 < minimoose> Then an Apple ][+ with a MOS 6502 17:01 < minimoose> Then a DEC PDP-11 17:02 < minimoose> Then I turned 16 and discovered girls... 17:02 < minimoose> and took a break from computers for a couple years... 17:02 < minimoose> then when I got to college, an IBM PC-XT with a 10MB Hard Drive and a 1,200 bps modem. 17:03 < minimoose> I took the entry level computer course my freshman year, and then I TA-ed it for the next 6 semesters even though I ended up as a political philosophy major. 17:03 <@kanzure> that's not a very usual outcome 17:03 < minimoose> True. 17:03 < minimoose> Then worked in a famly biz for 10 years… quit... 17:04 < minimoose> started doing consulting developing monster sized financial models for the largest property owner in Europe in Excel and SQL Server… doing what MSFT said specifically NOT to do… runnng Excel as a service... 17:05 < minimoose> Started a commercial ISP in San Jose about the same time.... 17:05 <@kanzure> renting on some backbone? 17:06 < minimoose> http://www.robtex.com/as/as18779.html#graph 17:06 -!- devrandom [~devrandom@gateway/tor-sasl/niftyzero1] has joined ##hplusroadmap 17:06 < minimoose> We were all over the Bay area in half the data centers there... 17:07 < minimoose> but we've recently consolidated into 55 S. Market St aka the Gold Building aka MAE-West aka Coresites aka CRG West. 17:07 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Ping timeout: 260 seconds] 17:07 < minimoose> We still are in Hurricane's Fremont 1 and 2... 17:07 < minimoose> and SVTIX... 17:08 < minimoose> and I keep trying to buy something in Santa Clara… but CA is such a damn mess. 17:08 < minimoose> I'm thinking of buying in Houston instead. 17:08 <@kanzure> huh? why would you buy data centers for an isp? 17:08 <@kanzure> i'm misunderstanding which level you were operating at 17:09 < minimoose> We're not a residential ISP. We do server rentals, colocation, cabinet and cage leases, and servicing. 17:09 < minimoose> We push about 50 Gbps most afternoons for our customers. 17:09 <@kanzure> oh okay. so you don't own fiber in the ground :) 17:09 < minimoose> Hardly anybody owns fiber in the ground. 17:09 < minimoose> Most folks lease that. 17:09 <@kanzure> well, you might've, which is worth asking heh 17:10 < minimoose> Yeah.. I can't make the economics work on that no matter how hard I try when other companies lease it so cheap. 17:10 < minimoose> I might pull my own fiber between Zürich and Zug, though, since I need to be in Zug or another project. 17:10 <@kanzure> prolly need to get some cash friendly subsidy, which is another level of effort 17:11 < minimoose> Anyway… so that's not my day job. In 2005 I started a fund management business in midstream energy. That's what I really do 90% of the time. 17:11 < minimoose> So pipelines, storage, energy logistics..... 17:11 < jrayhawk> huh, nice colo prices 17:12 < minimoose> at EGI? 17:12 < minimoose> Thanks. 17:12 <@kanzure> i have seen a lot of recent software companies pumping out widgets for kwh/usage metering 17:12 < minimoose> We're pretty damn competitive, esp. for a service with REAL people who do tech support… all of whom are well trained and in CA. 17:13 <@kanzure> so you are doing venture capital? or trading on energy? 17:13 < minimoose> Support is 24x7x365… and if you call at 2:30am on a Sunday, whoever is on that shift will know what a /24 is, etc. 17:13 < minimoose> Kinda neither... 17:13 < minimoose> I have done some angel investing... 17:13 < Juul> i've never seen anyone use … and ... interchangably 17:14 <@kanzure> Juul: might be some crappy client 17:14 < Juul> ah 17:14 < minimoose> No… it's crappy me. 17:14 < minimoose> So I don't do VC at all, and I rarely do angel investing because I hate 99% of the stuff I look at. 17:14 <@kanzure> sure 17:15 <@kanzure> you should be warned that we're rabid about angel money, so you might get bugged by a few seekers in here 17:15 < minimoose> And I don't so much trade "on energy" as I buy midstream energy companies. 17:15 < brownies> rabid? how so? 17:15 < minimoose> I currently fund things like natural gas gathering and treatment and compression systems. 17:15 <@kanzure> brownies: well i can imagine delinquent-someone jumping up and down and spamming ;) 17:16 < minimoose> We are going to launch a PE fund shortly, but it will still be all energy related. 17:16 < brownies> bah 17:16 < brownies> once you spend enough time in startups, you grow a healthy disdain for investors 17:16 < minimoose> I love biology, but I am not in a position to invest my own or others money. Maybe one day. 17:17 < minimoose> If I were 20, I would be focusing on designing enzymes. 17:17 < minimoose> or maybe bioinformatics. 17:17 < minimoose> But alas, I am 45. 17:17 <@kanzure> http://diyhpl.us/~bryan/papers2/longevity/ start reading :P 17:17 < brownies> there's cool stuff happening with energy... there's a company whose name escapes me doing cool stuff at the intersection of utility companies and behavioral econ 17:17 < minimoose> So I'll stick with energy for another 5 years and then move to Switzerland. 17:18 < brownies> ah, no, this is the company http://opower.com/ 17:18 < brownies> minimoose: why switzerland? 17:18 <@kanzure> probably because it satisfies the requirement "Not the US" 17:18 < yashgaroth> that's a lot of places, many of which will even give you citizenship eventually 17:19 < minimoose> The US is on a fiscally dangerous path. I don't see that changing. 17:19 < minimoose> I would like to move to a 1st world country which is not going to go broke, which can produce its own energy and food, which is centrally located, and which is entirely defensible. 17:20 <@kanzure> brownies: is there something like that on the production side? 17:20 <@kanzure> i imagine most farms have their own custom software barf for monitoring that.. 17:20 < brownies> minimoose: i'd like to move to one of those too. are there other candidates than Switzerland? 17:20 < brownies> kanzure: many farms are run on MS Excel and manual labor. 17:20 <@kanzure> ah yes excel.. the achilles heel of western civilization? 17:20 < brownies> kanzure: there's a YC company just recently that started going farmware (?) as a service... doing quite well iirc. 17:21 <@kanzure> oh, i meant energy production farms 17:21 < minimoose> As much as I hate MSFT, Excel is an amazing product. 17:21 <@kanzure> like wind farms 17:21 < brownies> kanzure: more like... Excel, the reason western civilization continues. 17:21 <@kanzure> brownies: but yes i saw that company 17:21 < brownies> kanzure: oh? what would it be on the production side? 17:21 < TheEmpath> lol @ brownies @ excel @ lol 17:21 < brownies> the idea behind oPower is that, by engineering a good UX for energy consumers, you can motivate them to reduce their energy usage 17:21 < minimoose> brownies, maybe Chile, if you think of that as 1st world. 17:21 < brownies> minimoose: i don't. 17:21 < minimoose> which is not really. 17:22 < minimoose> Maybe New Zealand 17:22 < brownies> although StartupChile looks mildly interesting. 17:22 < minimoose> NZ is beautiful. 17:22 <@kanzure> brownies: i know a few people who have gone through StartupChile and it's really not. 17:22 < brownies> really? 17:22 < brownies> it is free money, in a country full of Chilean women 17:22 <@kanzure> there have been a few blog posts about the meta issues with StartupChile 17:22 <@kanzure> it's not quite free money 17:22 < brownies> so that's 2 in the "pros" column right there. 17:23 < brownies> isn't it? 17:23 <@kanzure> it's more like.. turn in your receipts and they might refund you eventually 17:23 < brownies> ah, yeah, reimbursable expsnese or something 17:23 < minimoose> counterparty risk 17:23 < brownies> kanzure: i saw the 1 article you're talking about 17:23 < minimoose> says I 17:23 <@kanzure> brownies: i think there was 2 :( 17:23 < brownies> the guy was whining about how they didn't reimburse his stuff 17:23 <@kanzure> not just that though 17:23 < brownies> and then a bunch of people came out and explained that he was an idiot 17:23 <@kanzure> there was also other issues like, they don't actually have that many advisors 17:23 < brownies> kanzure: i see 17:24 <@kanzure> jojack went through the program 17:24 <@kanzure> i should get him to do a writeup 17:24 < minimoose> Can I ask what StartupChile is? 17:24 <@kanzure> chilean government program trying to tap into the accelerator/startup scene 17:25 < brownies> minimoose: it's a government program where they give 40K grants to startups to come work and create jobs in Chile 17:25 <@kanzure> their goal is to bring companies from the US to chile for a few months and do biz dev work 17:25 < minimoose> That's really really really hard to make work. 17:25 <@kanzure> yes 17:25 < brownies> yeah, but they are shoveling money into it 17:25 < minimoose> Then it is our obligation to spend that money. 17:25 <@kanzure> minimoose: joseph jackson (a local in the biohacking scene) put his company LavaAmp through it 17:26 < TheEmpath> what's the local infrastructure? 17:26 < TheEmpath> are they trying to invest local to sell global>? 17:26 <@kanzure> minimoose: and lavaamp was originally something like openpcr except they spent $100k on a prototype 17:26 < minimoose> geez 17:26 <@kanzure> another one that went through was Backyard Brains 17:26 <@kanzure> http://backyardbrains.com/ 17:26 < brownies> i think i vaguely know some people going through it 17:26 <@kanzure> um, these are largely the exceptions though 17:26 <@kanzure> most of the companies going through are web/mobile software companies i think 17:26 < brownies> it would be much simpler if they just gave you the $40K and then left 17:27 <@kanzure> i agree 17:27 <@kanzure> having cash on-hand is significantly different to having to pony up your own money 17:28 < minimoose> In my experience… getting a lot of cash early tends to cause misallcoations of cash and expectations of endless more cash. 17:28 < minimoose> That's obviously not always the case. 17:28 <@kanzure> yes, well, the carrot has to eb big enough to move you to chile 17:29 < TheEmpath> minimoose: agree 17:29 < minimoose> And the VCs shovel a lot of cash into companies. But that tends to create really bad habits and corporate culture. 17:29 <@kanzure> minimoose: you might enjoy some of those backyardbrain.com kits 17:29 < minimoose> Aeron chairs. Launch parties. 17:29 < minimoose> looking at the kits now. 17:29 < brownies> well $40K is really not that much money 17:29 < minimoose> agree 17:29 <@kanzure> brownies: it is if you're broke (which i suspect is the status of most of the incoming companies) 17:29 < brownies> you pay some people, you buy some laptops, you stock up on ramen, and you get to work 17:30 < TheEmpath> ^ 17:30 < brownies> 6 months later, you write a ground-breaking blog post announcing your unique twist on sharing cat photos... 17:30 <@kanzure> brownies: you know this game so well 17:30 < TheEmpath> <_< 17:30 < brownies> heh 17:30 <@kanzure> branded startup robes: proper dress attire 17:30 < brownies> SF has made me bitter and cynical 17:30 < TheEmpath> are you reading my emails? 17:30 <@kanzure> that's it. i'll start a company making branded startup robes. 17:31 < jrayhawk> I want mine hooded. More culty that way. 17:31 <@kanzure> jrayhawk: siai branded? 17:31 <@kanzure> siai doesn't really have the "blowing millions of dollars" startup culture, sorry.. 17:31 < jrayhawk> hey man you give me a sweet robe and i will endorse anything 17:32 -!- nmz787 [~Nathan@ool-457e5cbd.dyn.optonline.net] has quit [Quit: Leaving.] 17:32 < jrayhawk> this is how i spent those unfortunate years in the KKK! 17:33 < TheEmpath> call those the "team building years" 17:35 < jrayhawk> i thought they were purveyors of fine occasionally combustive german turbochargers 17:36 < jrayhawk> boy was my face red, and not from third degree burns! 17:37 -!- Mokbortolan_ [~Nate@c-76-115-136-13.hsd1.or.comcast.net] has quit [Read error: Connection reset by peer] 17:37 <@kanzure> minimoose: so other projects we have going on around these parts.. 17:37 <@kanzure> http://diyhpl.us/~bryan/irc/diytranshuman_projects.v4.html 17:37 <@kanzure> http://github.com/kanzure/nanoengineer#readme 17:37 <@kanzure> dunno, what other things might be sufficiently amazing.. 17:37 < minimoose> I was thinking of getting my daughter a Makerbot for Xmas. 17:37 <@kanzure> hmm, why not a reprap? 17:38 < minimoose> maybe 17:38 <@kanzure> or, if you are interested in microstructures, consider a lemon curry 17:38 <@kanzure> i don't know if you can purchase an assembled lemon curry anywhere 17:39 < minimoose> lemon curry? 17:40 < minimoose> Yick = 14) Buy a lobbyist to get the National Fab Lab Network Act of 2010 to go through the House of Representatives, and other motions that are in direct support of open source hardware. The Fab Lab Network Act specifically calls for the creation of 1 fablab or hackerspace per 700,000 U.S. citizens, so approximately 407 community hackerspaces by 2015. $150,000?? 17:40 < minimoose> I would buy a lobbyist to lobby to STOP spending money. 17:41 < jrayhawk> Research best serves the market when its treated as a public good. 17:41 < minimoose> Sure, but that doesn't imply public funding. 17:41 < jrayhawk> What's the alternative? 17:41 <@kanzure> minimoose: that bill didn't really go through, and i didn't put a lot of thought into that one. but i wanted to at least mention something to satisfy people who claim you need to lobby to get things done. 17:42 < minimoose> look at the society of petroleum engineers…. 17:42 <@kanzure> but, i should point out that DARPA and o'reilly (via make magazine) ended up doing this makerspaces-for-schools initiative recently that got funding 17:42 < minimoose> their members are funded by private companies, but they all share research with each other... 17:42 <@kanzure> so that was sort of like a 'national fab lab network'.. although tied to schools, which probably negates all benefits. 17:42 -!- Mokbortolan_ [~Nate@c-76-115-136-13.hsd1.or.comcast.net] has joined ##hplusroadmap 17:43 <@kanzure> minimoose: what do you mean share research? does the Society of Petroluem Engineers pay for journal subscriptions? 17:43 < minimoose> I spent most of yesterday reading about northern white monocrystaline sand versus brown sand versus light weight ceramics versus curable resin coated sand. 17:43 <@kanzure> for curing patterns in things? 17:43 < minimoose> The members do their own research with private funding and then cooperatively share research and results.. 17:44 < minimoose> the sand studies I was reading were about proppants for fracturing shale in oil and gas wells... 17:44 < jrayhawk> huh i wonder what kind of incentives structures are needed to get other industries to join in 17:44 < minimoose> Spend $7 million on a well… use the wrong proppant… your well is worth zero. 17:44 < minimoose> That's a big incentive to share data. 17:44 < jrayhawk> Obviously there are things like IEEE, but they're relatively minor players. 17:44 <@kanzure> i don't know anything about how IEEE is managed 17:44 < minimoose> Maybe…. 17:45 < minimoose> publicly funded science is easily perverted...... 17:45 < minimoose> the state is the worst possible paymaster. 17:46 < jrayhawk> There's actual research into methodology and publication bias; I don't think your statement is quite true. 17:46 < minimoose> Your mileage may vary. 17:47 < minimoose> http://en.wikipedia.org/wiki/Lysenkoism 17:47 < minimoose> That's an extreme example, obviously….. but monolithic paymasters are a bitch. 17:48 < yashgaroth> perhaps petroleum companies are more willing to publish papers freely on sand dynamics because they have a shit-ton of money and it's not patentable information 17:48 < minimoose> It is patentable and the oil-services companies won't necessarily share everything... 17:49 < minimoose> but the reason they share is the opposite of them having shit-tons of money.... 17:49 < minimoose> it's that oil and gas production COSTS a shit ton of money... 17:49 < jrayhawk> Universities are pretty well set up to isolate researchers from political pressure. It's essentially what the concept of tenure was made for. 17:49 < minimoose> and actually their return on capital is no higher than any other industry. 17:50 < yashgaroth> sure, but I'm just trying to imagine that dynamic in scientific fields 17:50 < minimoose> They have large absolute dollars because energy is such a large part of the economy… but return on assets or return on equity are the only measures that count. 17:50 < yashgaroth> but petroleum companies still do private, unshared research right? 17:50 < minimoose> Yes. 17:51 < minimoose> They will work cooperatively or solo, depending on the circumstances... 17:51 < minimoose> If you and I both own half the acreage in a new play... 17:51 < minimoose> you and I are very likely to work together... 17:51 < minimoose> If I own the whole play, you are not going to foot the bill for my gains. 17:51 < minimoose> In the real world... 17:52 <@kanzure> only on a per property basis? 17:52 < minimoose> geologicla plays are so large... 17:52 < minimoose> not per property... 17:52 < minimoose> per basin or per region.... 17:52 < minimoose> in the real world.... 17:52 < minimoose> a play like the Marcellus Shale or the Utica Shale… 17:52 < minimoose> they are so big… no one company can possibly develop the whole thing.... 17:52 < minimoose> even if they could, it would be extremely risky to do it on one's own... 17:53 < TheEmpath> risk spreading 17:53 <@kanzure> iirc rigs are usually built by single shipyards? 17:53 < minimoose> So the firms all sign data sharing…. 17:53 < minimoose> offshore is pretty different... 17:54 < minimoose> Offshore is typically so expensive that only the integratd majors and the national/state owned companies can do it. 17:54 < minimoose> Exxon (XOM) has like a $300b market cap... 17:54 -!- rmcl [~rmcl@rrcs-108-178-168-32.west.biz.rr.com] has quit [Quit: rmcl] 17:54 < minimoose> they can do giant deepwater projects.. 17:55 < minimoose> but I'm talking more about a company with a $10b or $20b market cap... 17:55 < minimoose> that might spend a couple billion in capex a year... 17:55 < minimoose> across a dozen regions in north america... 17:55 < TheEmpath> i understand that oil companies like that have a massive cost of operation 17:55 < minimoose> they might be 5% of the Niobrara and 7% of the Bakken and 2.5% of the Utica... 17:56 < minimoose> The big national oil companies are often like the US Post Office... 17:56 < minimoose> Pemex for example in Mexico... 17:56 < minimoose> There's a map on my wall of the Eagle Ford Shale... 17:56 < minimoose> wells there have 100% plus rates of return... 17:56 < TheEmpath> :O 17:56 < minimoose> there's an oil, a natural gas liquids, and a gas region.... 17:57 < minimoose> and on the map… all of a sudden the wells stop. 17:57 < minimoose> there are 3 lines…. then nada. 17:57 < minimoose> My junior analyst say "Is that some geological formation right there?" 17:57 < TheEmpath> heh 17:57 < minimoose> I said it's a politcal formation… across the Rio Grande is Mexico... 17:57 < TheEmpath> no, its a geopolitical fo 17:57 < TheEmpath> damn it you beat me to it 17:57 < minimoose> and there's plenty of hydrocarbons there with IRRs north of 100%... 17:58 < minimoose> but the Mexican government strips all the cash out of their national oil company to dole out... 17:58 < minimoose> so their oil production goes down year on year.. 17:58 < minimoose> not b/c there is no more oil… but b/c their company is like our post office. 17:58 < minimoose> Same is true in Venezuela... 17:58 < jrayhawk> Though it's not exactly losing value down there. 17:59 < minimoose> Pemex? 17:59 < jrayhawk> I mean, the oil. 18:00 < minimoose> Yeah true… but it's also not like we're running out of the stuff. 18:00 < TheEmpath> i suppose one could look at corruption as sort of a warehousing effect 18:00 < minimoose> howso? 18:01 < TheEmpath> well, if you have company A trying to produce product B, but they produce at 60% efficiency 18:01 < TheEmpath> thats 40% raw materials not being extracted. 18:02 < jrayhawk> Mexico's extreme instability (economic, social, political) makes it difficult to extract otherwise economical oil; this is probably good since most of the value created from oil extraction would probably be wasted anyway 18:02 < TheEmpath> the time value of the under consumed materials is effectively "warehoused" 18:03 < minimoose> Why would the value of oil extraction be wasted but not value created in other ways? 18:03 < TheEmpath> by efficiency, i mean the intake of raw materails 18:03 < minimoose> In the end, humans waste 100% of the value we create and accelerate the heat death of the universe. 18:04 < TheEmpath> speaking entropically, yes 18:04 < TheEmpath> but the fun is the inbetween :D 18:04 < minimoose> My epitaph will read: Entropy Wins Again (damnit) 18:04 < jrayhawk> Sometimes we spend it on neat toys like the LHC instead of in drug wars and land wars and culture wars though 18:04 < TheEmpath> if you have someone who can produce at 100% efficiency, then the resources that others aren't using becomes a factor as well 18:05 < minimoose> efficiency isn't a metric that's as useful as return on capital 18:05 < TheEmpath> agreed 18:05 < minimoose> humans make energy... 18:05 < TheEmpath> but the 40% of raw materials that company A isn't using has a potential time value that isn't being realized. 18:05 -!- Juul [~Juul@171.66.163.110] has quit [Ping timeout: 240 seconds] 18:05 < minimoose> we didn't run out of wood when we switched to coal and we didn't run out of coal when we switched to oil…and we won't be out of oil when we switch to whatever's next..... 18:06 < jrayhawk> (we hope) 18:06 < minimoose> I'm currently running my house of Rossi's e-Cats. 18:06 < minimoose> hah 18:06 < jrayhawk> (not that it matters, i suppose; it already happened to cuba without particularly heinous disaster) 18:07 < _sol_> natural gas and then ... 18:07 < minimoose> thorium nukes… then.... 18:07 < minimoose> who knows... 18:07 < minimoose> economics will decide. 18:07 < jrayhawk> how are you generating those unicode ellipses 18:07 < jrayhawk> do you have a unicode input method that you manually use 18:07 < jrayhawk> or is this some automatic client thing 18:08 < minimoose> [incompatable ending] 18:08 < minimoose> I think it's Colloquy 18:08 < jrayhawk> i am envious and wish to casually drop unicode characters in day-to-day communication 18:08 < jrayhawk> ah soh 18:09 < minimoose> We have so much natural gas in the US, it's ridiculous. 18:10 -!- tashoutang [~tata@pc131090206.ntunhs.edu.tw] has joined ##hplusroadmap 18:10 < minimoose> Someone in this room needs to engineer an enzyme that converts methane to a liquid syngas, since liquid fuels are worth WAY more than gaseous fuels. 18:10 < minimoose> You could put all the LNG guys out of business overnight. 18:11 <@kanzure> are you familiar with synthetic genomics and their exxon money? 18:11 < _sol_> crowdresearching biotech? 18:11 < _sol_> like crowdfunding 18:11 < _sol_> naa bad use of words 18:11 < _sol_> DIY group effort 18:11 <@kanzure> _sol_: stop saying random things 18:11 < minimoose> I'm not familiar with synthetic genomics nor their XOM money. 18:11 <@kanzure> minimoose: it's a company by craig venter 18:11 <@kanzure> craig is well known for his role in the human genome project 18:12 < minimoose> oh yes 18:12 < minimoose> I am. 18:12 <@kanzure> and more recently his role in paying for genome synthesis 18:12 < minimoose> He was sailing the ocean blue trolling for genes... 18:12 < minimoose> then started trying to create artificial genomes. 18:12 <@kanzure> so synthetic genomics inc. does bacteria genome modifications for oil stuff 18:12 < TheEmpath> craig ventner and the dude from family guy also funds an initiative to teach hollywood directors about the newer technologies that are coming out 18:12 <@kanzure> and exxon dumped something like $600 mil into that 18:12 < yashgaroth> and algal biofuels, I think that's where most of their money went 18:12 <@kanzure> oh right, algaes, not bacteria 18:13 < minimoose> oh that's a waste.. 18:13 <@kanzure> well, genome synthesis is not a waste 18:13 < minimoose> there's not enough energy in light here. 18:13 < minimoose> It would work really well on the planet Mercury. 18:13 <@kanzure> metabolic engineering is basically "making enzymes work how we want them" 18:13 <@kanzure> so once you design a hypothetical enzyme or network of enzymes you still have to get the damn buggers to synthesize them 18:14 <@kanzure> which involves significant amounts of dna synthesis 18:14 < minimoose> But on Earth, sunlight is way too diffuse an energy source, even assuming 100% of photons could be converted into autogas with zero loss. 18:14 < TheEmpath> well, that's the sun 18:14 < TheEmpath> we have other sources of light 18:14 < minimoose> yes, but they take energy to run. 18:14 <@kanzure> the point isn't that it's primarily algae 18:14 < minimoose> ALTHOUGH.... 18:14 < minimoose> the solar subsidies in Germany were so high... 18:15 < minimoose> that there was a company using arclights in a warehouse to power solar panels in that warehouse to create power to put back on the grid for which their subsidies were worth way more than their power costs. 18:15 < minimoose> You humans are doomed. 18:15 < TheEmpath> wow rofl 18:16 <@kanzure> link to this arclight story? 18:17 < minimoose> lemme find it….. 18:17 < TheEmpath> http://bishophill.squarespace.com/blog/2010/4/13/its-true.html 18:18 <@kanzure> oh i see, they were scamming 18:18 < TheEmpath> whats wrong with arbitrage and gresham's law? 18:18 <@kanzure> neat 18:18 < minimoose> bingo 18:18 < TheEmpath> :D 18:19 <@kanzure> that's rather clever 18:19 < minimoose> The feed in tariffs in the UK are insane too. 18:19 < minimoose> They might work in Ecuador. 18:20 < minimoose> http://www.klimaskeptiker.info/einzelmeldung.php?nachrichtid=988 18:20 < minimoose> That one is a German article about a Spanish company. 18:21 < minimoose> Then 2 years later, such economic incentives lead to this: 18:21 < minimoose> http://www.zerohedge.com/news/spain-discussed-%E2%82%AC300-billion-full-bailout-germany-uncomfortable 18:22 <@kanzure> i find their html 4.01 validation amusing 18:22 < minimoose> klimaskeptiker or zerohedge? 18:23 < strangewarp> Man... economic incentives really have to be foolproofed against greed-based loopholes, that's ridiculous 18:24 <@kanzure> minimoose: klimaskeptiker. i think those html 4.01 validation buttons were originally meant to help spread the adoption of html 4.01-compliancy.. i guess i can't complain since 5 isn't entirely released yet. 18:24 < brownies> what sort of backwards browser doesn't have HTML5? 18:24 < minimoose> We already have economic incentives to allocate capital properly. It's what I do all day every day. Subsidies are created specifically to create distortions. 18:24 < minimoose> I'm using Lynx. 18:25 <@kanzure> have you considered upgrading to w3m 18:25 < minimoose> hmm… maybe 18:25 <@kanzure> wait, that's not the right one 18:25 <@kanzure> there's an earlier browser that rendered one line at a time 18:25 < minimoose> WebbIE 18:25 < minimoose> oh.. 18:26 < minimoose> Line Mode Browser 18:26 < minimoose> http://en.wikipedia.org/wiki/Line_Mode_Browser 18:26 <@kanzure> ah yes. :) 18:26 * strangewarp nods, about subsidies.. 18:27 < jrayhawk> links2, elinks, and links-hacked are also all substantially better than lynx 18:28 < minimoose> http://www.w3.org/INSTALL.html 18:28 <@kanzure> what is links-hacked? 18:28 < minimoose> I don't really use lynx… I was yust yoking. 18:28 <@kanzure> oh. jrayhawk seriously only uses elinks. 18:28 < jrayhawk> I think it's elinks forked to provide graphics a la links2 and some other feature merges 18:28 <@kanzure> except when he's poking at uzbl or chromium.. ahem 18:28 < jrayhawk> No, I mostly use links2. elinks tries to support javascript. 18:29 <@kanzure> oh i see 18:29 < minimoose> I'm going to port Java to Line Mode Browser. 18:29 <@kanzure> well, i'm sure we could compile Line Mode Browser to javascript with emscripten, and then run it in a modern browser with websockets 18:30 <@kanzure> however, i might kill myself 18:30 < jrayhawk> I guess if links-hacked does x font rendering then I am sortof tempted. links2's custom font rendering is dumb. 18:34 < minimoose> Anybody know about Protalix ? 18:35 <@kanzure> "ELELYSO is a plant cell-expressed form of the glucocerebrosidase (GCD) enzyme" 18:35 <@kanzure> hmm 18:35 <@kanzure> "the U.S. Food and Drug Administration granted approval for ELELYSO as a hydrolytic lysosomal glucocerebroside-specific enzyme indicated for long-term enzyme replacement therapy (ERT) for adults with a confirmed diagnosis of Type 1 Gaucher disease" 18:35 < minimoose> Right 18:35 < yashgaroth> yeah it's a competitor to genzyme's option 18:36 < minimoose> They also intend to use a novel delivery system for their designed enzymes… we call this delivery system: a carot. 18:36 < yashgaroth> err cerezyme 18:36 <@kanzure> oh they are expressing it in carrot, and then asking customers to eat carrots? 18:36 < minimoose> Yes... 18:36 <@kanzure> are you sure they aren't just purifying it from carrot extract? 18:36 < minimoose> yes 18:37 < minimoose> http://protalix.com/objects/img/Protalix_Oral_Illustrations_021511.pdf 18:37 <@kanzure> if i click this and it's illustrations of some guy eating a carrot, my day will be complete 18:37 < yashgaroth> " intend to plan a phase I clinical trial " uh huh 18:38 <@kanzure> well, if you know the amino acid sequence, and have an urgent use for this, there's no particular reason to wait for them 18:38 < minimoose> It's some chick drinking carrot juice. 18:38 < minimoose> So that's what I was thinking... 18:38 < minimoose> there are all sorts of orphan diseases that could be fixed ... 18:38 <@kanzure> yes, and some of them have very expensive treatments that don't really need to be so expensive 18:39 < minimoose> but I read about ELELYSO... 18:39 <@kanzure> many rare blood diseases (even those that aren't orphaned) have treatments that cost $10,000/dose.. which is more than enough to fund diy solutions 18:39 < minimoose> and it seems that engineered enzymes have a nasty tendency to generate immune responses. 18:39 < yashgaroth> you don't need an engineered enzyme for gaucher's, just recombinant 18:39 < minimoose> I was thinking about Trimethylaminuria. 18:40 < minimoose> It's an FMO3 defect. 18:40 < minimoose> nonsense and missense mutations 18:41 < minimoose> It's a single missing digestive enzyme. 18:41 < yashgaroth> then I'd be looking into generating immune tolerance, because magically delivering anything with carrot cells can still generate an immune response 18:41 <@kanzure> well that could even be done in yogurt 18:41 <@kanzure> and then delivery some gut bacteria 18:42 <@kanzure> *deliver some gut bacteria 18:42 < minimoose> Wouldn't gut bacteria that produces some novel enzyme for a human with defective FMO3 code still produce an immune response? 18:43 < minimoose> Are gut bacteria somehow protected from immune response? I'll bet not. 18:43 <@kanzure> i don't know where the digestion takes place- is this a digestion tract issue, or a metabolic issue elsewhere 18:44 < yashgaroth> they have to be doing something else to the enzyme than just putting it in carrots, lemme go check their patents 18:44 < minimoose> why so, yash? 18:44 < yashgaroth> because otherwise every protein in carrot cells would be flooding our body everytime we ate carrots 18:45 < yashgaroth> or any other plant for that matter; and they seem to be playing up their bioreactors rather than their method for enzyme delivery 18:45 < minimoose> I see. 18:46 < Steel2> sup y'all 18:46 < Steel2> going over docs for the LLC filing this weekend :D 18:46 < yashgaroth> I should also throw in here that diy enzyme production for such diseases would cost about 1000x less than cerezyme etc are charging if you ignore their patents 18:47 < minimoose> yup 18:47 < minimoose> I know. 18:47 < yashgaroth> ok good 18:47 <@kanzure> now all we have to do is find some desperate, wealthy parents 18:47 < minimoose> Plus I would ignore their patent and deliver free carrots to people. 18:47 <@kanzure> .. with sufficiently easy diseases 18:47 < yashgaroth> I think it' still some sort of plant cell culture suspension, but yeah 18:47 <@kanzure> patient advocacy groups are sometimes helpful, but they don't always have any money 18:49 < minimoose> The poor TMAU people have no cash. 18:49 < minimoose> They are all recluses because they absolutely stink. They smell like rotting fish. 18:52 < minimoose> Also.. I know a kid with a broken medium chain fatty acid oxidation enzyme… there are a lot of such kids. 18:52 < yashgaroth> ok I found a relevant patent; it figures the guys working on gaucher's would be israeli 18:52 < minimoose> what does the patent show, yash? 18:52 < yashgaroth> let me work through the whereins and therebys 18:54 <@kanzure> minimoose: did you read this one? http://matt.might.net/articles/my-sons-killer/ 18:54 -!- devrandom [~devrandom@gateway/tor-sasl/niftyzero1] has quit [Remote host closed the connection] 18:54 < yashgaroth> http://www.faqs.org/patents/app/20110070201 is the patent for anyone following along at home; I'm looking for some sort of cell-penetrating peptide fusion they'd be using 18:55 -!- devrandom [~devrandom@gateway/tor-sasl/niftyzero1] has joined ##hplusroadmap 18:55 -!- Juul [~Juul@171.66.163.110] has joined ##hplusroadmap 18:56 < minimoose> reading that, kanz 18:56 < jrayhawk> i always wondered why he took the kid off of the ketogenic diet 18:59 < minimoose> gezz... 18:59 < minimoose> it's bad enought your kid has a horrible disease... 18:59 < jrayhawk> it seems like if you have problems with advanced glycation end products damaging proteins you should stop eating goddamned carbohydrates already 18:59 < minimoose> then to have every doctor ask you if you are fucking your brother… ugh. 18:59 < minimoose> "Are your sure you are not banging your brother… really sure?" 18:59 <@kanzure> i'm pretty sure genetics doesn't deteriorate that quickly 19:00 <@kanzure> so it should be more like, "has your family been inbreeding for a while now?" 19:00 < yashgaroth> well it looks like they can get the enzyme into the liver, but not actually the spleen, and can't prove it has activity, just that it's there (e.g. getting digested in a lysosome) 19:02 < minimoose> A for effort. F for delivering functional engineered enzymes to the wrong place. 19:02 < yashgaroth> also nothing about membrane-penetrating anything that would explain why only the therapeutic enzyme gets into the bloodstream, and not CarOT4 19:03 < minimoose> What… MALE Rett syndrome? I thought Rett was 100% female. 19:05 < minimoose> How much does whole exome sequencing cost? 19:05 < yashgaroth> makes it easy to get laid at the support grou-- oh wait :/ 19:05 < minimoose> ouch…. Rett syndrome humor. 19:06 < yashgaroth> like 5-10 grand? kanzure didn't you have a link to some company doing exomes 19:06 < yashgaroth> oh snap 1000 without analysis, not bad 19:09 < minimoose> dang that was a great article, kanz 19:09 -!- OldCoder_ [~OldCoder_@c-69-181-140-134.hsd1.ca.comcast.net] has quit [Remote host closed the connection] 19:10 < yashgaroth> throw in another g to pay some company or a grad student to analyze for potential causative mutations 19:10 <@kanzure> whole exome sequencing is dropping pretty fast 19:10 <@kanzure> i knew someone a few years ago who paid >$100k 19:10 <@kanzure> but i have seen some recent <$5000 quotes 19:10 <@kanzure> where did you see $1000? 23andme was saying $1000ish but that was "coming soon" 19:11 < yashgaroth> yeah it was them, but shouldn't take them more than a year to open it up 19:11 <@kanzure> minimoose: yep, i thought it was a good story.. we need more of that. 19:11 <@kanzure> a year? that's like forever 19:11 -!- OldCoder_ [~OldCoder_@c-69-181-140-134.hsd1.ca.comcast.net] has joined ##hplusroadmap 19:12 < yashgaroth> okay but still <5 grand is pretty good considering, especially if they throw in analysis 19:12 <@kanzure> i think knome might throw in analysis these days 19:12 < minimoose> There are a lot of Amish a few counties west of here.. they have all sorts of novel mutations. 19:12 < yashgaroth> alopecia of the upper lip 19:13 < yashgaroth> :V 19:13 <@kanzure> minimoose: http://www.kk.org/thetechnium/archives/2009/02/amish_hackers_a.php 19:13 -!- Juul [~Juul@171.66.163.110] has quit [Ping timeout: 245 seconds] 19:13 <@kanzure> only read that if you're into amish stuff (or if you're an amish hater, it might change your mind) 19:13 < minimoose> A rare mutation that makes them speak German with a 17th century accent. 19:13 < minimoose> I'm into Amish pr0n. 19:13 < minimoose> KIDDING 19:14 < minimoose> The Amish are the cheapest carpenters and run the farmers' markets… otherwise I don't interact with them at all. 19:14 <@kanzure> amish porn might exist, but it's definitely not recorded on modern sd cards.. maybe there's some for edison's old school video stuff 19:14 < minimoose> Also, they have a huge advantage over the rest of us.... 19:14 < minimoose> they don't have to pay social security tax. 19:15 <@kanzure> consider that kk.org link then 19:15 < minimoose> and for Amish pr0n, they have to use old 8" floppies. 19:15 < yashgaroth> too far 19:15 < minimoose> newer magnetic media is to showy 19:16 < yashgaroth> oh that's a real floppy disk format, I thought you were making a penis joke 19:16 < minimoose> http://amishporn.tumblr.com/ 19:17 < minimoose> I just missed the 8" floppies, but used the 5.25" ones. 19:19 <@kanzure> that tumblr blog is insufficiently hipster.. needs more instagram filters 19:23 < minimoose> My wife keeps talking about instagram, and then my daughters start giggling. 19:23 < Steel2> hah 19:23 <@kanzure> you could put instagram together in a weekend if you're up for that :p 19:24 <@kanzure> i suspect openpcr has more practical value though 19:24 < Steel2> I need someone to gimme a retrovirus that doubles my metabolism 19:24 * Steel2 is wishful. 19:24 < yashgaroth> an oncovirus would do that, but you won't like the side effects 19:27 < minimoose> Hmm… these Amazon customer reviews are very helpful: http://www.amazon.com/On-Art-Cinema-Kim-Jong/dp/0898756138/ref=pd_sim_sbs_b_6 19:32 < minimoose> I already saw the new Bourne movie, yash, and the guy with the virus gets Rachel Weisz. 19:32 < yashgaroth> huzzah! 19:40 -!- skorket [~skorket@cpe-24-58-232-122.twcny.res.rr.com] has quit [Quit: Leaving] 20:00 -!- minimoose [~minimoose@pool-98-114-46-42.phlapa.fios.verizon.net] has quit [Quit: minimoose] 20:11 -!- Jaakko96 [~Jaakko@94-194-89-130.zone8.bethere.co.uk] has quit [Quit: Nettalk6 - www.ntalk.de] 20:16 -!- blumental_ [~Kvltist@p5B33F0D9.dip.t-dialin.net] has quit [Quit: Computer has gone to sleep.] 20:16 -!- He||eshin [~talinck@cpe-174-101-208-182.cinci.res.rr.com] has joined ##hplusroadmap 20:20 -!- Helleshin [~talinck@cpe-174-101-208-182.cinci.res.rr.com] has quit [Ping timeout: 245 seconds] 20:25 <@kanzure> yashgaroth: know anywhere this guy can buy agrobacterium? i told him to go hunting 20:25 < yashgaroth> agrobacterium that's useful for transforming plants, I'm guessing? 20:26 < ParahSailin__> n_bentha here has agrobacterium 20:26 < ParahSailin__> t plasmids too 20:26 < yashgaroth> I seem to remember somewhere possibly doling it out to amateurs, but that's a better bet ^ 20:27 <@kanzure> i dunno if bugging n_bentha is a sustainable strategy 20:27 < yashgaroth> http://www.sciencestuff.com/prod/5Ls-LiveBac/BLB1002 Shipped to Schools only 20:28 < yashgaroth> not the one I was thinking of, but 20:29 -!- Netsplit *.net <-> *.split quits: alusion, marainein, CIA-8, smeaaagle 20:31 < ParahSailin__> if you got something to trade, n_bentha'd give up the goods 20:31 < Steel2> woo, just spent another 100 bucks on protein powder >_> 20:34 -!- Netsplit over, joins: alusion, marainein, CIA-8, smeaaagle 20:42 < ParahSailin__> kanzure, who's looking for agro 20:44 <@kanzure> some person on the diybio list with bad grammar 20:47 < ParahSailin__> sounds unlikely he has much to give in exchange 20:47 <@kanzure> well, that's why i suggested a company instead of n_bentha 20:47 < ParahSailin__> heh yah 20:48 -!- n_bentha [~lolicon@75.110.212.117] has joined ##hplusroadmap 20:49 < n_bentha> grammar nazi, reporting for duty 20:49 <@kanzure> heil! 20:49 < ParahSailin__> i need to rescue all my old useful genetic material out of my old lab's minus 70 20:50 < ParahSailin__> cathal didnt want any, said he wants to stay "legal" and shit 20:50 < n_bentha> heh. 20:50 -!- nmz787 [~Nathan@ool-457e5cbd.dyn.optonline.net] has joined ##hplusroadmap 20:51 <@kanzure> ParahSailin__: just send him a bunch of empty, marked petri dishes 20:51 < n_bentha> lol 20:51 <@kanzure> be sure to make up some crazy fake strain names 20:51 -!- n_bentha [~lolicon@75.110.212.117] has left ##hplusroadmap [] 20:52 < ParahSailin__> Bacillus AIDS 20:52 <@kanzure> that's the spirit! 20:54 < ParahSailin__> i have a couple igem distributions 20:54 < strangewarp> "Anthrax Leprosy Mu" 20:55 < strangewarp> "Monsteritis" 20:55 <@kanzure> strangewarp: needs to be more latinized 20:55 < strangewarp> hmmm 20:55 < ParahSailin__> Iomonad arrowginosa 20:55 < yashgaroth> pichia omniconsumens 20:56 < ParahSailin__> i have some pichia strains that lorenzo was trying to make but failed horribly 20:57 <@kanzure> you have his failed strains? 20:57 < ParahSailin__> he was trying to put stuff like peroxidases, ligninases, etc in 20:58 < ParahSailin__> i dont think any dna stuff he did really worked 21:29 -!- klafka [~textual@c-67-174-253-229.hsd1.ca.comcast.net] has joined ##hplusroadmap 21:31 <@kanzure> hi klafka 21:32 -!- rmcl [~rmcl@99-71-136-35.lightspeed.sndgca.sbcglobal.net] has joined ##hplusroadmap 21:33 -!- klafka1 [~textual@c-24-6-18-31.hsd1.ca.comcast.net] has joined ##hplusroadmap 21:35 <@kanzure> geeze so i just got an email recruiting for some doctor to appear in a commercial 21:35 <@kanzure> "Pay is up to approximately $13,740 +20% (depending upon usage)" 21:36 <@kanzure> "$6, 000 + 20% buyout for ONE YEAR, Internet only, for UP TO 15 different 21:36 <@kanzure> scripts" 21:36 <@kanzure> "$500 + 20% per 8 hour shoot day (most likely 2 days)" 21:36 -!- klafka [~textual@c-67-174-253-229.hsd1.ca.comcast.net] has quit [Ping timeout: 244 seconds] 21:36 <@kanzure> this seems like a low price to buy out a medical opinion 21:37 < yashgaroth> 20% of what 21:37 <@kanzure> it seems to be 20% of the base rate, and then it increases per hour compounding? 21:38 <@kanzure> maybe not 21:39 < yashgaroth> unless that's 20% of drug profits it is kinda lowball, but that third maserati won't pay for itself 21:44 -!- klafka [~textual@c-67-174-253-229.hsd1.ca.comcast.net] has joined ##hplusroadmap 21:46 -!- klafka1 [~textual@c-24-6-18-31.hsd1.ca.comcast.net] has quit [Ping timeout: 240 seconds] 21:47 -!- klafka1 [~textual@c-24-6-18-31.hsd1.ca.comcast.net] has joined ##hplusroadmap 21:48 -!- klafka [~textual@c-67-174-253-229.hsd1.ca.comcast.net] has quit [Ping timeout: 244 seconds] 21:52 -!- klafka [~textual@c-67-174-253-229.hsd1.ca.comcast.net] has joined ##hplusroadmap 21:53 -!- klafka1 [~textual@c-24-6-18-31.hsd1.ca.comcast.net] has quit [Ping timeout: 252 seconds] 21:58 <@kanzure> klafka: having difficulty? :/ 21:59 < nmz787> kanzure: how are those plugins? 22:00 -!- Cat4D [182bc9d2@gateway/web/freenode/ip.24.43.201.210] has joined ##hplusroadmap 22:01 <@kanzure> nmz787: going strong, i'm fucking around with subprocess/popen at the moment 22:03 < nmz787> kanzure: so i was thinking that the microfluidic design should be as curvy as possible 22:04 < nmz787> that way the CNC mill won't have quick shifts of inertia that we have to program for 22:09 <@kanzure> wtf github is down 22:09 < nmz787> hahah 22:10 <@kanzure> "scheduled database maintenance" 22:10 <@kanzure> why is their service outage for that? 22:10 -!- Cat4D [182bc9d2@gateway/web/freenode/ip.24.43.201.210] has quit [Ping timeout: 245 seconds] 22:13 <@kanzure> http://www.grindhousewetware.com/bottlenose-v0-1 22:13 <@kanzure> ehh. "The Bottlenose takes in a large range of data such as sonar, UV, wi-fi and thermal information and translates it to a magnetic field via induction where it interacts with an implanted magnet (usually in the finger)." 22:14 <@kanzure> "The haptic model vibrates with varying intensity in the presence of sensory information." 22:14 < nmz787> sounds pretty cool, until your cells get all pissed that you keep shaking them back and forth 22:14 <@kanzure> oh this is just lucas 22:14 < nmz787> seems like it would get inflamed 22:15 <@kanzure> why is lucas using google sites 22:15 <@kanzure> damn i thought i taught him better than that 22:17 -!- klafka [~textual@c-67-174-253-229.hsd1.ca.comcast.net] has quit [Ping timeout: 245 seconds] 22:18 <@kanzure> even with videos :/ http://www.youtube.com/watch?v=q__Sps3WwmQ&feature=plcp&list=PLF3C27313C06E25E3 22:18 <@kanzure> so, why not just show wifi data on a laptop screen 22:19 <@kanzure> http://www.aircrack-ng.org/ it even makes your console look cool. 22:25 -!- Mokbortolan_1 [~Nate@c-76-115-136-13.hsd1.or.comcast.net] has joined ##hplusroadmap 22:26 -!- Mokbortolan_ [~Nate@c-76-115-136-13.hsd1.or.comcast.net] has quit [Ping timeout: 256 seconds] 22:32 -!- klafka [~textual@c-67-174-253-229.hsd1.ca.comcast.net] has joined ##hplusroadmap 22:34 < nmz787> kanzure: do you know what city startup chile happens in? 22:40 <@kanzure> no 22:40 < nmz787> and their FAQ doesn't say either 22:41 < yashgaroth> bet you money it's santiago 22:45 < brownies> yeah it's santiago 22:46 <@kanzure> hplusroadmap bets are lame.. we're always right and nobody pays up 22:47 < yashgaroth> bet you they're not lame 22:47 <@kanzure> yes but would you bet me money 22:47 < yashgaroth> ...no 22:52 -!- yashgaroth [~f@cpe-66-27-117-179.san.res.rr.com] has quit [Quit: Leaving] 23:05 -!- delinquentme [~asdfasdf@c-71-236-101-39.hsd1.pa.comcast.net] has quit [Ping timeout: 272 seconds] 23:11 -!- lichen [~lichen@c-24-21-206-64.hsd1.or.comcast.net] has quit [Quit: Lost terminal] 23:19 -!- skorket [~skorket@cpe-24-58-232-122.twcny.res.rr.com] has joined ##hplusroadmap 23:20 < skorket> anyone still awake? 23:20 < nmz787> i am 23:20 < brownies> hm 23:20 < skorket> hey, nmz, how's it going? 23:20 < nmz787> kanzure: have you heard of Rhino 3D? 23:21 < nmz787> alright, thinking of taking a walk 23:25 < tashoutang> I am 23:26 < tashoutang> in fact it is noon here in Taipei 23:27 < nmz787> so you work at a biolab tashoutang 23:27 < nmz787> ? 23:27 < tashoutang> yeah, a lab for teaching the nursing school students 23:28 < nmz787> kanzure: http://en.wikipedia.org/wiki/Rhinoceros_3D#File_format 23:28 < nmz787> kanzure: is this the answer to CAD for you? 23:29 < nmz787> tashoutang: cool 23:29 < nmz787> tashoutang: are you a teacher? 23:31 <@kanzure> nmz787: rhino is proprietary 23:31 <@kanzure> i mean, their nurbs stuff is proprietary 23:31 < tashoutang> well, i quit my phd program and found a teaching assistant here 23:31 <@kanzure> opennurbs has all the fun stuff removed 23:31 <@kanzure> skorket: yes 23:33 < nmz787> kanzure: fun stuff removed as in? 23:33 < nmz787> kanzure: i thought you were complaining that you couldn't find a good open NURBS format 23:33 < brownies> why'd you quit your phd? 23:37 < tashoutang> good question 23:38 < tashoutang> cannot afford the pressure I guess 23:38 <@kanzure> nmz787: they have all their nurbs intersection algorithms removed in opennurbs 23:38 < tashoutang> and a phd degree will make me more difficult to find a job 23:43 < tashoutang> here I had mentioned before, we have good equipment in this school 23:44 < tashoutang> but no budget for chemicals 23:45 < tashoutang> I am trying to get some cheap materials 23:46 < tashoutang> and some other solutions 23:48 < tashoutang> to get some consumable items. 23:53 < tashoutang> and to find some interesting subjects to do some small projects.... 23:54 < nmz787> skorket: do you know how to determine max RPM of a stepper? 23:54 < nmz787> it seems the polulo controller tops out in the 10s of khz 23:55 < nmz787> so with it achieving cut speeds with microstepping might not be possible, with that at least 23:55 < tashoutang> that is why I am in this forum 23:55 < nmz787> some people are saying the max freq for steppers depends on the torque avail and the max RPM of the motor 23:55 < skorket> yeah, sorry, don't know 23:56 < skorket> it's of course a function of what kind of load you have on the stepper, but I imagine you should be able to figure it out from the given torque and some other parameters 23:57 < skorket> where are you getting the 10s of khz figure? 23:58 < nmz787> some pololu forum post 23:58 < nmz787> i think that was the controllers limit, maybe? 23:58 < tashoutang> is this channel about biology or electronics? 23:59 <@kanzure> tashoutang: both 23:59 < tashoutang> yeah so does it have other fields? --- Log closed Thu Aug 16 00:00:22 2012