--- Log opened Thu Oct 04 00:00:45 2012
00:10 < Urchin> freenode's policy is no public logging without asking
00:10 < Urchin> iirc
00:11 < Urchin> BioGuy: I simply keep my irc client running and it just loggs everything
00:11 < Urchin> it helps that I'm always on
00:11 < Urchin> I currently have 9 day uptime on my irc client
00:12 < Urchin> it used to go up to about 3 months
00:15 < BioGuy> I need a desktop again...then I could just keep that running all the time and it probably wouldn't be that difficult to write a script for my IRC client to write logs for each buffer I have open
00:16 < foucist> there are a bunch of loggers like clog for example (which is on a bunch of programming chans etc)
00:16 < foucist> 00:16 -!- clog [~nef@bespin.org]
00:16 < foucist> 00:16 -!-  ircname  : CLOG (Channel LOGger) http://tunes.org/~nef/logs/
00:16 < foucist> i log everything as well, for grepage purposes
00:19 < BioGuy> You ever wonder how some Linux/Unix commands got their names? Take grep... would it have killed them to name it 'filter'
00:21 < Urchin> actually, it was originally a command in a text editor, iirc
00:21 < Urchin> and I don't have a desktop computer
00:22 < Urchin> I just have an account on a shell server
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00:23 < Urchin> and, fortunately, I pay nothing for it
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00:41 < BioGuy> Vi?
00:43 < BioGuy> How would freenode be able to tell if the user logged in is an actual user or a logging program?
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00:46 < Urchin> I think it was vi
00:47 < Urchin> BioGuy: why don't you simply activate the logging option on your irc client
00:47 < Urchin> ?
00:50 < BioGuy> eherm... didn't even think about it. Didn't realize it might have that built in
00:51  * BioGuy feels a bit silly now.
00:52 < Urchin> lol
00:52 < Urchin> weechat is on the advanced side actually
00:52 < Urchin> even the most basic ones have it, AFAIK
00:53 < Urchin> (outside of web apps)
00:55 < BioGuy> Im pretty new to linux and terminal based IRC clients - I tried irssi and another one (forget which) before WEECHAT. I felt like weechat was the most newbie friendly
00:57 < BioGuy> It didn't take me too long to figure how to get a layout the way I wanted it and configure a list of servers to autoconnect as well as channels. In the other clients I had just a helluva time figuring how to do the most basic things.
00:59 < BioGuy> Now I just need to figure out where my logs are saved
01:01 < gedankenstuecke> BioGuy: grep indeed got it'S name through an ed-command: g/re/p as shorthand of the combination "global/regular expression/print" ;)
01:01 < Urchin> I'm running scrollz, it's a modified version of ircII
01:01 < Urchin> not very user friendly, apparently, but it does what I want it to do
01:02 < Urchin> I used to try bitchx for couple of times
01:02 < BioGuy> Figured weechat would be a good "training wheels" client for me. But, it seems to be able to do everything I would want it to and there are tons of scripts made for it
01:03 < BioGuy> I should just assume that anything unnecesarily cryptic or confusing came from vi
01:03 < Urchin> BioGuy: also, see the ice cream koan
01:03 < Urchin> http://en.wikipedia.org/wiki/Hacker_koan#Emacs_and_Bolio
01:04 < Urchin> weechat is solid, from what I understand
01:05 < Urchin> I don't get to be too picky over what I use
01:05 < Urchin> I'd have to submit any proposal for instalation of an irc client to the admins
01:05 < BioGuy> ROFL - His question answered, yet unanswered, the novice turned to go, but Stallman called to him, “Neither Emack nor Bolio had anything to do with the ice cream shop, either.” (The store is named after two homeless men.
01:06 < Urchin> and could expect a response next year
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06:54 < kanzure> well. i ninja kicked my glasses when i woke up and now i don't know where they went.
06:57 < archels> Time for laser surgery?
07:13 < skorket> http://imgur.com/Qlolw
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08:43 < kanzure> "What's the next step after openpcr to do a heredity test? Do I use the iconic Genome Compiler?"
08:43 < kanzure> blaah. i wish the "Genome Compiler" guy would go away.
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09:08 < kanzure> "Kasianowicz estimates that the technique could identify a DNA building block with extremely high accuracy at an error rate of less than 1 in 500 million"
09:08 < kanzure> oh another nanopore method
09:08 < kanzure> PEG-labeled nucleotides and nanopore detection for single molecule DNA sequencing by synthesis
09:08 < kanzure> http://www.nature.com/srep/2012/120921/srep00684/full/srep00684.html
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09:26 < kanzure> oh neat apparently i know those guys (via money/who's paying me)
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09:53 < kanzure> jrayhawk: i need some hints on cleaning up memory on gnusha
09:53 < kanzure> http://diyhpl.us/~bryan/humanityplus-at-caltech/ seems to be 37 GB.. is this worth keeping around? or what do i do with it?
09:54 < bkero> encode that shit down to a reasonable size
09:54 < bkero> and then it'll be 1gb
09:54 < bkero> kanzure: I see your name on there along with other hplus nerds
09:55 < bkero> gg
09:56 < kanzure> huh?
09:56 < kanzure> gg for what?
09:56 < bkero> presumably you gave a talk at caltech, along with them
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09:58 < kanzure> bkero: yeah. also i did a harvard talk.
09:58 < bkero> right on
09:58 < kanzure> oh hrm. i seem to have 17 GB of opencascade stuff.
09:59  * bkero isn't hosting openfarmtech anymore :/
09:59 < kanzure> wait, you were hosting them?
10:00 < bkero> yes
10:01 < bkero> elifarley I think his name was
10:01 < kanzure> 3.4 GB TP-v261.exe
10:01 < kanzure> seems to be a traceparts.com thing
10:02 < bkero> gzip that shit
10:02 < kanzure> and it looks like "http://dl2.traceparts.com/dl/traceparts/tpdvd/updates/TP-v261.exe" doesn't exist anymore. so i'm not so sure about deleting it.
10:02 < kanzure> it's already a compressed archive
10:02 < bkero> hope so
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10:02 < eudoxia> openfarmtech was the old OSE, right?
10:03 < kanzure> i think it's the same site.
10:03 < bkero> I think it was called openecology at some point
10:03 < bkero> yup
10:03 < bkero> Although he upgraded mediawikis
10:04 < kanzure> so, i always disliked marcin for keeping everything in a wiki. i mean, a wiki is better than nothing, but it's not the best format to encourage people to collaborate on his machines..
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10:04 < kanzure> "gzip: No space left on device" doh
10:04 < delinquentme> metal is gud mkay.
10:04 < delinquentme> http://www.youtube.com/watch?v=JWjg-_7xtpo  pedal point .. im so obsessed w this right now
10:06 < eudoxia> kanzure: i guess they need something more than a wiki since everything in there seems to depend on these external google docs thing
10:06 < kanzure> jmil: are you still using the reprap git backups in /home/jsmiller on gnusha.org?
10:06 < kanzure> eudoxia: using google docs is even worse for this!
10:07 < jmil> kanzure: naw i think i turned htat off when Adrian pu-pu'ed the idea for the last time
10:08 < kanzure> yeah it looks like /home/jsmiller/reprap is just a copy of /srv/git/reprap.git, so i'm just going to remove the dupe
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11:13 < kanzure> http://www.kickstarter.com/projects/10263143/labstrip-now-your-iphone-4-is-your-personal-mobile
11:13 < kanzure> eh. proprietary chemical strip tester.
11:15 < jrayhawk> du -m / | sort -n is usually a fun operation
11:16 < kanzure> i cleaned up some dupes and stuff. the extra reprap/nanoengineer repos, for example.
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12:30 < kanzure> Juul: hi
12:30 < Juul> kanzure, hi
12:30 < kanzure> Juul: so it turns out that only 2 biobricks are open source.
12:30 < Juul> kanzure, oh? you mean the BPL ?
12:31 < kanzure> BPA/BPL thing.. yes
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12:49 < kanzure> nmz787: hi
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13:02 < nmz787> kanzure: sup
13:03 < nmz787> kanzure: so apparently 9 year old Barr dexedrine is OK
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13:23 < kanzure> nmz787: having fun?
13:33 < nmz787> lol, nah, i drove for 7 hours earlier
13:33 < nmz787> gonna prep a bit for my genspace DNA talk
13:33 < nmz787> :P
13:33 < nmz787> but I was /very/ concentrated on driving
13:34 < nmz787> I dunno if it was fake or not, but I thought I felt my heart fluttering a bit
13:35 < paragone> fake heart fluttering
13:36 < nmz787> i can only hope
13:36 < paragone> does hoping make it less likely that more fake heart flutterings might take place?
13:38 < nmz787> :/
13:38 < nmz787> i felt my jugular for a while and didn't detect anything, but I think the real test is an EKG
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13:48 < archels> Don't worry, it was your digestive system.
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13:48 < archels> (oh, and your hypochondria, but that was implied)
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14:31 < delinquentme> nmz787, wait you has focus??
14:32 < delinquentme> tell me aboot dis. is this this  barr dexedrine
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14:37 < brownies> english, man. english.
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14:54 < delinquentme> brownies, i ate you this morning.
14:54 < delinquentme> you're not allowed to IRC from my stomach.
14:56 < brownies> and yet, here we are.
15:02 < delinquentme> brownies, i liked you better going down.
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16:12 < Mokstar> augur: http://med.stanford.edu/ism/2012/october/hypnotize.html
16:25 < bkero> kanzure: those videos are terribly encoded.  I just mencoder $input -ovc x264 -oac mp3lame -o $input.m4v and it went from 1.1GB -> 129MB.
16:35 < augur> Mokstar: what
16:52 < Mokstar> just wanted to pass that alon
16:52 < Mokstar> g
16:53 < Mokstar> we had a discussion many months ago regarding the validity of hypnosis as an observed phenomenon
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18:39 < BioGuy> Hrmm... wondering if anyone could help me acquire or has a plasmid and single cutting restriction enzyme for that plasmid?
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20:10 < kanzure>  /win 4
20:10 < kanzure> blah? oh.
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20:23 < skorket> yeah!
20:31 -!- IDWMaster [~brian@aug-student-141-224-202-196.augsburg.edu] has joined ##hplusroadmap
20:31 < IDWMaster> Hi
20:31 < IDWMaster> Topic is biohacking, does disabling the HGS14 gene count?
20:32 < IDWMaster> *RGS14
20:32 < yashgaroth> sure, why not
20:33 < kanzure> sounds like a weird thing to target
20:33 < kanzure> g-protein signaling can fuck a lot of stuff up
20:33 < yashgaroth> good luck injecting viruses into your brain, but it does fit the definition
20:34 < IDWMaster> That's why I'm here. I've been wondering if anybody was looking for a human test subject, or if it would be possible to somehow test what they've been doing on mice on myself.
20:34 < IDWMaster> I have the active RGS14 gene and would like it disabled.
20:34 < IDWMaster> Where would I start and who should I contact?
20:34 < yashgaroth> jesus bro just do some fucking nootropics or something, no one has anything remotely effective to do that in humans
20:35 < yashgaroth> they do it in mice with germline genetic engineering, and you're a couple decades too late to do that to yourself
20:35 < kanzure> rgs14 seems to control all protein signaling in cells. of course you have the "active" version.
20:36 < IDWMaster> Hmm. So you'd need something else which could counter-act it to disable it when it's active and somehow distrbute it to all the cells....
20:36 < kanzure> here.. read some books http://diyhpl.us/wiki/diybio/faq/books
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20:39 < yashgaroth> that was bizarre
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21:10 < brownies> wtf was that O.O
21:10 < brownies> and what is RGS14?
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21:12 < yashgaroth> there was some study on mice where they knocked it out in a very specific part of the hippocampus and the mice did better on some test
21:12 < yashgaroth> it's like a minor, brain version of the telomerase idiocy
21:13 < yashgaroth> and of course since mice are identical to humans, many dipshits will read some terrible pop-sci article and apparently think you can get it done in a black clinic
21:15 < yashgaroth> and I die a little more on the inside
21:16 < brownies> jesus.
21:16 < brownies> that's a new, special level of stupid.
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21:19 < Adifex> ha
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21:23 < BioGuy> Telomerase idiocy?
21:24 < yashgaroth> you know, the "let's add telomerase to every cell somehow and I'll never die"
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21:27 < brownies> extend ALL the telomeres
21:29 < yashgaroth> upregulating telomerase by itself will make you die of cancer faster, so all the studies are either with special cancer-resistant mice, or 'we engineered mice to not have telomerase and they were all shitty, then we gave them back telomerase and they were okay, what a fucking surprise'
21:33 < brownies> hahah
21:33 < brownies> you crazy biologists and your experimental setup
21:34 < brownies> "with several million dollars of grant money, we have discovered that if we remove this critical piece of cellular machinery from mice, they will die faster"
21:36 < yashgaroth> that, combined with the fact that biology is the only scientific field where laypeople feel entitled - nay, obligated - to voice their own opinion on the topic, e.g. GMOs, evolution, vaccines, and the 'second definition' of biohacking
21:41 < brownies> trust me, it is not the only scientific field where idiots trumpet their own opinions as fact.
21:44 < brownies> i suppose they are especially dangerous with biology though
21:44 < yashgaroth> you don't see ballot measures demanding that cold fusion be taught in schools, or that SN2 reactions are only a theory; but you're right, if I weren't in biology it wouldn't seem quite so one-sided, I'd imagine
21:44 < brownies> the whole vaccine... meme... was (is?) especially mind-boggling
21:45 < brownies> oh, right, creationism. that's still going on. -_-
21:46 < yashgaroth> wait climatologists have it worse, at least when no one believes in evolution the world doesn't become uninhabitable
22:02 < BioGuy> Though I think one could argue that creationsim isn't so much an argument of biology as it is a belief of how we came to be that happens to clash with biology
22:02 < BioGuy> ...kind of like Galileo and the Church
22:04  * BioGuy thinks climatologists would be much more stressed out about the missinformation on global warming that biologists are about creationism
22:05 < BioGuy> Though I'm curious why do you think re-activating telomerase wouldn't lead to greater longevity?
22:06 < yashgaroth> because it's used by the body to limit the prevalence of cancer; stem cells have telomerase, and I have my private theory that most cancers derive from stem cells rather than somatic cells
22:07 < yashgaroth> without telomerase a cancer will crap out and die pretty quick
22:08 < yashgaroth> and every method to induce telomerase post-natally, usually some sort of viral vector with the telomerase gene, will only affect superficial cells that die off naturally with no negative consequence
22:08 < yashgaroth> if you're doing germline genetic engineering, and you throw it in with a bunch of extra tumor suppressor genes, and that manages not to fuck up normal cellular activities, it might be viable
22:09 < yashgaroth> but no one wants to discuss germline gengineering, and so you get skin creams infused with recombinant telomerase and sell it to morons
22:12 < BioGuy> Oh... so your not suggesting that telomerase wouldn't be a major factor in increasesd longevity, but that the problem is just more complicated than just re-activate telomerase in every single cell?
22:13 < yashgaroth> yes
22:14 < BioGuy> Oh ya I totally agree. I love the Oscar Wilde quote, "The pure and simple truth is rarely pure and never simple."
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22:21 < BioGuy> It would be interesting to see a mouse model study where one set of mice somehow had telomerase reactivated in as many cell types as possible and another set of 'normal' mice, feed them both food or water with some carcinogenicity and then look at which sets have higher prevelance of cancer.
22:22 < yashgaroth> I think it's been done and they get more cancer, but I haven't been keeping up on the literature since putting 'telomerase' in the article automatically discourages me from reading
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22:27 < BioGuy> Personally I think longevity is an interesting subject, but in the end how interested should we really be in it. I think for far too long (even outside of biotech) we have been far too concerned with living longer than living healthier and happier. Before I could ever be really interested increasing longevity I think we need to first tackle chronic disease, psychiatric and braind disorders, the
22:27 < BioGuy> ecological consequences of humans living longer, etc, etc.
22:28 < BioGuy> oops "...but in the end how intersted should we really be in it?"...
22:28 < Adifex> ^^^ very good point.
22:29 < Adifex> especially the happier part.
22:29 < yashgaroth> that's not typically a popular position in communities like this channel, but still valid
22:31 < Adifex> But to that end, how much can we do? There will always be depression, and it's hard to solve things like existential problems one has like one would use science to produce longevity.
22:35 < BioGuy> I think there will always be sadness (...or at least I don't think its something we should strive to get rid of), but depression is something I think we should actively work toward eliminating from the human population and it is possible - we just need to understand all the biochemical pathways involved, figure out the causes, and eliminate them potentially by reducing toxic burdens, epigenetic
22:35 < BioGuy> mechanisms, and or regenerative medicine.
22:39 < BioGuy> Right now, for example, chronic long term depression can be caused by a mutation in the MTHFR gene. They may or may not have some relief by taking SSRIs but these individuals have complete relief when they supplement with methyl-tetra-hydrofolate (the MTHFR gene methylates folic acid) without methylated folic acid the body has a realy hard time synthesizing seretonin as well as many other biochemical
22:39 < BioGuy> activities (for example recycling homocysteine back to SAM-E)
22:40 < nmz787> hmm, cool
22:41 < nmz787> i think teaching kids faster and better is probably key too just dealing with death
22:41 < nmz787> seems pretty far off that we'll be able to repair every cell, and only once
22:41 < nmz787> well, maybe it could use a quorum sensing system or something
22:43 < nmz787> uploading 3.8gb video from the talk i gave tonight to youtube, slow upload speed though... 195 mins remaining
22:44 < yashgaroth> do we really need to see you in glorious 1080p?
22:45 < nmz787> nah, its only 720p
22:45 < nmz787> but it's mainly focused on the white board
22:45 < Adifex> what's your youtube channel?
22:46 < nmz787> ntm787
22:46 < yashgaroth> http://www.youtube.com/watch?v=FsKKuF8VIaE :D
22:46 < nmz787> i also have nmz787 but i can't merge the two accounts
22:46 < nmz787> :D
22:48 < BioGuy> ROFL I need to quote this somehow - Do we really need to see you in glorious 1080p? --nah, its only 720p
22:49 < BioGuy> nmz787 your talk was at genspace?
22:49 < nmz787> yes
22:49 < BioGuy> What did you give a talk on?
22:51 < nmz787> http://www.youtube.com/watch?v=empgExApnaU
22:51 < nmz787> but it won't be up for another 3 hours
22:51 < nmz787> uploaded
22:51 < nmz787> then it will actually have to process
22:53 < BioGuy> Hey very cool, cant wait to watch it
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23:00 < BioGuy> I've often wondered if people's fear of death is innate or cultural. I'm leaning towards cultural. Some buddhists for example embrace death in such away (I think its called mindful dying/death, something like that) where they actively feel and observerve everything that occurs as they are dying. Though regardless of whether fear of death is cultural or innate one thing I am 99% sure of at this point is
23:00 < BioGuy> that when a person's body is ready to die they are no longer afraid of death. They might be afraid up to a certain point, but past that point it becomes a non-issue for some reason.
23:03 < nmz787> I think you all need to watch this 15 seconds http://www.youtube.com/watch?v=ejvbhKErm6c&feature=player_detailpage#t=282s
23:12 < brownies> was that relly necessary -_-
23:17 < brownies> hm, now i want a solid gold toilet
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23:23 < BioGuy> nmz787 was that you?
23:24 < BioGuy> If so your hillarious! We definitely need to meet when you get into Portland.
23:25 < BioGuy> I love how the chick in the background is just going about her business with not a single look of, "What the hell is he talking about?"
23:26 < BioGuy> I think I'm actually genuinely interested in queen Victoria's and the pooping habits of peasants now
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23:28 < bkero> wat did I miss
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23:30 < nmz787> yes
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23:44 < lichen> gold toilets. okay then.
23:45 < bkero> gold toirets?
23:45 < lichen> idk. it was linked a bit ago
23:53 < lichen> more portlanders in here i see
--- Log closed Fri Oct 05 00:00:46 2012