--- Log opened Fri Nov 23 00:00:25 2012
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01:32 < kanzure> beep
01:40 < kanzure> internet archive live stream http://crawl432.us.archive.org/crawling/domain/liveupdates.html
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06:08 < kanzure> "当你把上面的条件逐一验证完之后，就会发现，关键词的科学设计，找优质客户就是那么简单"
06:08 < kanzure> spam is so weird
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06:32 < juri_> people are weirder. and thats *before* we start hacking them.
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06:52 < kanzure> juri_: what?
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06:58 < juri_> what did i say that was unclear?
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08:16 < eudoxia> i think he's saying people will get wierder when they start going full transhuman
08:17 < antifas> theres no reson not to go full transhuman
08:17 < antifas> ppl arnt going to get any better
08:17 < antifas> thats for sure
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08:23 < eudoxia> but i thought the whole point was to get better
08:24 < antifas> not getting better without science
08:28 < eudoxia> of course
08:30 < kanzure> okay?
08:30 < kanzure> i still don't get it. i was complaining about spam, and for some reason this leads to epic philosophical crap?
08:31 < antifas> nothing epic or philosophical, just the facts maam
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09:26 < kanzure> hah since when does andrew have a site http://andrewhessel.com/
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10:23 < kanzure> yashgaroth: hi
10:23 < yashgaroth> yo
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13:45 < archels> kanzure: what websites is Eugen talking about?
13:45 < kanzure> postbiota.org
13:45 < kanzure> really it's just a mailing ilst
13:45 < kanzure> i'm not sure why that would be any trouble to host
13:54 < archels> ~4000 euros in bandwidth?
13:55 < kanzure> wtf
13:55 < kanzure> "Still, when faced up to 4 kEUR/month additional costs overnight"
13:55 < kanzure> oh ok, so that's just +4000 not his usual payment
13:57 < jrayhawk> oh, it's a separate domain
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14:41 < kanzure> cakeboss: hi
14:46 < cakeboss> kanzure: h
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14:52 < kanzure> cakeboss: what brings you here?
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14:57 < cakeboss> kanzure: I am a hacker of sorts. Interested in biology, worked in a genetics lab. Thought this would be a fun hobby.
14:58 < cakeboss> I am minoring in biology.
15:15 < kanzure> http://mike-ibioloid.blogspot.com/2012/11/why-3dsystems-lawsuit-against-formlabs.html
15:15 < kanzure> "Why 3dsystems lawsuit against Formlabs for patent infringement has no merit"
15:16 < kanzure> oh the lawsuit is against kickstarter itself?
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16:47 < cakeboss> kanzure: Is there a website?
16:48 < kanzure> for kickstarter?
16:48 < cakeboss> kanzure: for hplusroadmap or diybio. An active group that participates in research, anything.
16:49 < kanzure> http://diyhpl.us/wiki/diybio/faq
16:49 < kanzure> http://diyhpl.us/wiki/diybio/groups
16:49 < cakeboss> kanzure: thanks
16:50 < cakeboss> Hm. There aren't any for my region, is there information on starting a group in the faq?
16:50 < kanzure> probably, but i forget where
16:50 < kanzure> basically just hang out with interesting people
16:51 < kanzure> where are you?
16:51 < cakeboss> Do any of them conduct legitimate research?
16:51 < kanzure> what do you consider legitimate
16:51 < cakeboss> I am in the deep south of the UA
16:51 < kanzure> united arab emirates?
16:51 < cakeboss> kanzure: scientific journals
16:51 < cakeboss> kanzure: sorry, multitasking. I am in the US.
16:52 < kanzure> some of the diygenomics people published some crap in a journal, if that matters
16:52 < kanzure> well, where in the US?
16:52 < cakeboss> Alabama.
16:52 < kanzure> you should talk with heath matlock (ybit)
16:52 < cakeboss> Ah.
16:52 < kanzure> he's our guy in alabama for this
16:53 < cakeboss> Is he a student or a professor?
16:53 < kanzure> neither
16:53 < cakeboss> Ah
16:53 < cakeboss> Hence the diybio part, I forget. heh.
16:54 < cakeboss> Well great. I will stick around to get into contact with him then.
16:54 < kanzure> eh just pester him at heathmatlock@gmail.com
16:54 < cakeboss> Thanks.
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17:03 < juri_> are there any people for this in the DC area?
17:03 < cakeboss> I am sure there are, kanzure?
17:06 < kanzure> there's the baltimore stuff
17:07 < kanzure> http://www.bugssonline.org/
17:07 < kanzure> http://www.genoblasts.com/
17:09 < juri_> I have a LOT of reading to do, in order to accomplish what i want to do. its all impossible, at the moment.. but that doesn't mean i can't make it slightly-less-impossible.
17:14 < juri_> I'm thinking that first, we should build a 3d printer with a self leveling bed.
17:17 < juri_> then learn to move the extruder around (and hense the nozzle) at increasingly high precisions, using cdrom drive laser/optic mechanisms to determine position of extruder relative to x carriage...
17:19 < juri_> so, step 1 is new X carriage, that allows for a trinary optics system, so we can range-find the bed.
17:20 < juri_> I should be able to handle the image recognition output from three laptop-web-cams, to pull that off.
17:21 < juri_> oh, wait, i'm in the wrong channel. sorry about that. ;)
17:22 < cakeboss> juri_: what are you wanting to do exactly?
17:23 < juri_> cakeboss: i've got a friend who wants to design high quality neural probes. instead of using live animal testing, i'm trying to get good enough at building small structures to send him repeatedly back to the drawing board.
17:23 < cakeboss> juri_: ah
17:23 < juri_> basically, he can build, then i can build, then we test, and i send him back to the board.
17:24 < juri_> so, i need to build animals, specializing on neural tissue to pull that off.
17:25 < juri_> i figure the first thing to do is build the algae pick-and-place machine that's at http://diybio.org/2012/06/12/gaudilabalgaepicker/ , only on top of a prusa mendel 3d printer style.
17:25 < juri_> something between the two, with much better documentation.
17:26 < juri_> this way i can pick-and-place cells, while i learn about methods of generating appropriate extracelular matricies.
17:27 < juri_> it also gets me to the point of 'contributing back' very quickly, as the documentation on that picker is lacking, to say the least.
17:29 < cakeboss> juri_: I actually used to do my own research in something similiar
17:29 < cakeboss> juri_: specifically with p21 and neural regeneration
17:32 < juri_> Interesting.
17:32 < cakeboss> si
17:33 < juri_> I'm not so interested in changing cell behavior. more in just printing out the stuff we already have.
17:33 < kanzure> juri_: if you modify cell behavior, that becomes easier.
17:33  * juri_ nods.
17:33 < juri_> I can tell.
17:34 < juri_> still, the 'great unsolved' is still printing an ECM, and transporting live sells into the ECM.
17:34 < kanzure> by the way, you're evil for perpetuating inconsistent personal pronoun capitalization
17:35 < juri_> hah. ;)
17:35 < juri_> I try to remember. I just fail. ;)
17:36 < kanzure> printing cells isn't unsolved, you should read jmil's work
17:36 < kanzure> it seems jmil isn't logged in
17:36 < juri_> i don't figure its unsolved, just poorly documented. afte all, i've seen the TED talk. ;)
17:37 < juri_> just trying to reproduce work, and build better printers.
17:37 < kanzure> TED is not a useful medium for science
17:37 < cakeboss> ^
17:38 < cakeboss> For the record, cakeboss' cakes are just awful.
17:41 < juri_> my 3d printers look pretty terrible. i build out of mostly scrap. ;)
17:41 < kanzure> why are you always winking, shit
17:41  * juri_ shrugs.
17:41 < juri_> i've always been emoticon-heavy.
17:42 < cakeboss> protip: juri_ is flirting with kanzure
17:42 < kanzure> fuck
17:44 < AdrianG> TED is worthless and must be destroyed
17:44 < cakeboss> AdrianG: TED is so meaningful and really gives us lamers the most simplicitive explanations of what we just can't understand without them.
17:44 < AdrianG> orly
17:45 < cakeboss> no, not rly
17:45 < AdrianG> for a second I was woried you may be suffering from an occult mental illness
17:45 < cakeboss> Aside from my obsession of TED, none whatsoever
17:46 < cakeboss> with*
17:47 < juri_> I enjoy ted talks.
17:47 < juri_> they make good background, while doing useful stuff.
17:47 < cakeboss> juri_: useful stuff like reading about TED?
17:48 < juri_> no, like writing patches to softwares. ;)
17:48 -!- mode/##hplusroadmap [+o kanzure] by ChanServ
17:48 < cakeboss> juri_: what languages do you know?
17:49 < juri_> cake: primarily, i write in shell/XSLT/C.
17:49 -!- juri_ was kicked from ##hplusroadmap by kanzure [;)]
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17:49 < cakeboss> nice
17:50 < juri_> for a full list, i'd scroll the channel into oblivion. ;)
17:50 < cakeboss> I am currently writing software that will automate catching intruders in a network by various means, including watermarking data streams
17:50 <@kanzure> cakeboss: what a coincidence, i find new ways to obfuscate my footprint
17:50 <@kanzure> and ripping out watermarks from pdfs
17:51 < cakeboss> kanzure: aha. Also I am building software that will track hackers by nothing more than their handle. I have around a 90%+ success rate.
17:52 <@kanzure> huh?
17:52 < cakeboss> For instance, I take your name 'kanzure'. I can use that to find out your full name where you live.
17:52 <@kanzure> welcome to whois
17:52 < juri_> ah. another person who uses 'hacker' to mean 'network intruider'.
17:52 <@kanzure> are you an idiot, or are you trolling me
17:52  * juri_ throws rocks at cakeboss.
17:52 < cakeboss> juri_: nope.avi
17:53 < cakeboss> hacker != network intruder
17:53 < cakeboss> read above
17:54 < cakeboss> kanzure: I am not talking about with just your /whois....
17:54 <@kanzure> you'd have to be an idiot to not be able to get my address from the web
17:54 <@kanzure> i paste it all over the fucking place
17:54 <@kanzure> what do you mean 90% success rate.. it should be 100% success rate.
17:54 < cakeboss> kanzure: You aren't a hacker, this is designed for people who aren't spreading their information across the web...
17:55 <@kanzure> hear that everyone, i'm officially not a hacker
17:55 <@kanzure> YOu HEARD IT HERE FIRST
17:55 < juri_> you'd have to be pretty smart to get my address (i do not know what it is), but information about me is everywhere.
17:55 < cakeboss> meh, w.e
17:55 <@kanzure> NO TAKESIES-BACKSIES
17:55 < juri_> kanzure: congratulations!
17:56 <@kanzure> what?
17:56 < cakeboss> kanzure: from what I know about you, you aren't a hacker. You are just someone in an IRC channel. This software has been used on people like Sabu, for instance.
17:56 < juri_> ah. so again, someone who intrudes on networks.
17:56 <@kanzure> cakeboss: i know you mean well
17:56 < cakeboss> juri_: That is not the only thing he ever did.
17:56  * juri_ continues pelting cakeboss with bigger rocks.
17:56 <@kanzure> juri_: i think english isn't your native language
17:57 < juri_> kanzure: astute.
17:57 < juri_> its close to my native language, does that count?
17:57 <@kanzure> no
17:57 < cakeboss> juri_: Tu hablo espanol?
17:57 < juri_> nein.
17:57 < juri_> ;)
17:57 < cakeboss> Ah.
17:57 < cakeboss> My brothers speak german. I have been wanting to learn.
17:57 -!- juri_ was kicked from ##hplusroadmap by kanzure [;)]
17:57 < cakeboss> aha.
17:58 <@kanzure> i hate this guy
17:58 < cakeboss> haha.
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17:58 < juri_> supengo wa iie wakarimashita.
17:58 < juri_> stop that. :P
17:58 < strangewarp> oh my god what am I even reading
17:59 < juri_> three hackers, one irc channel?
18:00 < juri_> my german skills are so old as to be near-useless. i learned english afterward, forgot german, and am still studying japanese.
18:00 < juri_> so, my linguistic slant is all kinds of sideways.
18:11 < nmz787> haxx0rs
18:11 < nmz787> oO
18:11 -!- cakeboss is now known as onethreethreesev
18:11 -!- onethreethreesev is now known as cakeboss
18:17 < nmz787> ai ai ai, que paso y'all, es grasa albert
18:21 < cakeboss> jajaja
18:21 < cakeboss> Damn albert grasa que necesita para bajar de peso
18:21 < nmz787> que?
18:21 < cakeboss> "Damn fat albert you need to lose some weight"
18:22 < nmz787> :)
18:22 < nmz787> traductor Google es bueno
18:22 < cakeboss> Nope.avi
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18:22 < cakeboss> I learned spanish in colombia
18:22 < cakeboss> y ecuador
18:23 < nmz787> how would you detect a virus in linux
18:23 < nmz787> or rather, a linux virus
18:23 < nmz787> all i know is clamav
18:24 < cakeboss> nmz787: in terminal type, "rm -f /"
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18:24 < nmz787> ahh, yeah that worked!
18:25 < nmz787> i guess that's not your field of intrusion detection, eh?
18:26 < cakeboss> No, I am actually very skilled in detecting/removing viruses. I don't use software, none that I don't make anyways.
18:31 < juri_> I've trained clamAV to remove a virus before. pretty simple.
18:58 < yashgaroth> haha what the hell is going on in this channel
19:00 < cakeboss> yashgaroth: propane and propane accessories
19:12 < cakeboss> nmz787: fyi, you wont get a virus in linux unless you are logged in a root...not usually.
19:13 <@kanzure> ...
19:14 < cakeboss> kanzure: unless its something cross platform...
19:14 < cakeboss> kanzure: I assume you use linux, how many viruses have you gotten?
19:15 <@kanzure> i have a couple of GB of collected samples
19:15 < cakeboss> Then you are a moron
19:15 <@kanzure> or a security researcher
19:15 < cakeboss> or that
19:15 <@kanzure> you're full of shit
19:15 < cakeboss> no, you
19:16 < cakeboss> kanzure: for the average linux user I highly doubt there are many infections at all.
19:17 <@kanzure> "as long as you're not root, you're safe" is bad
19:18 <@kanzure> for instance, root exploits
19:18 < cakeboss> Well, no shit. Here is my thing though, unless they are torrenting, connected to networks that have infected computers, or going to sketch sites, they are fine.
19:18 < cakeboss> There is no reason they would get a virus otherwise.
19:19 < cakeboss> I am not saying its impossible, I am saying that in order to get infected someone has to give it to you. If you don't put yourself in that situation you are normally fine.
19:21 < cakeboss> kanzure: http://www.unixmen.com/meet-linux-viruses/
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19:36 < nmz787> cakeboss: i never said what i was or wasn't doing, as root or otherwise
19:36 < nmz787> but yes i was thinking of torrent related stuff
19:36 < nmz787> like what kind of exploits might already exist out there
19:39 < cakeboss> nmz787: most of them are kernel related
19:39 < cakeboss> nmz787: If it is a distro that is a splinter of any ubuntu version it will most likely be a DDoS vulnerability for the kernel
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19:43 < nmz787> i didn't know people based distros on ubuntu no
19:43 < nmz787> now
19:43 < cakeboss> nmz787: blackbuntu, backtrack are the two splinters I am most familiar with. There are an array of others.
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21:46 < xlhl> hello mgodinho
21:46 < xlhl> what are your interests here?
21:47 <@kanzure> yashgaroth: this one has questions about synthetic proteins or something
21:48 < yashgaroth> who does
21:48 <@kanzure> patrickgrunkle
21:48 < yashgaroth> hokay then
21:48 <@kanzure> grinaway, i mean
21:48 <@kanzure> damn.
21:48  * kanzure goes back to sleep
21:49 < xlhl> yeah i am interested in synthetic protein interaction networks
21:49 < yashgaroth> as in, interactions between synthetic proteins, or calling interaction networks 'synthetic'
21:50 < xlhl> calling interaction networks synthetic, i presume. i'm not sure what synthetic proteins would really accomplish (unless we are talking about protein engineering)
21:50 < xlhl> i am interested in altering/creating protein signaling pathways
21:50 < yashgaroth> well that's gonna be protein engineering
21:50 < xlhl> yeah
21:51 < xlhl> i think protein kinase networks are very interesting, i suppose engineering them would involve an understanding of how the kinases recognize their targets
21:53 < yashgaroth> we have an idea of how they recognize targets...like with most protein interactions, you've got mostly electrostatic attraction, and then a phosphate donation to a hydroxyl
21:54 < yashgaroth> but that doesn't really tell you how to make one
21:54 < xlhl> yeah it strikes me as a sort of molecular docking problem?
21:55 < yashgaroth> and retaining that binding during the phosphorylation, while modifying the surrounding amino acids so it actually binds your intended target
21:57 < yashgaroth> idk I'm sure a good review of GPCRs would cover the topic pretty well
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21:58 < yashgaroth> if they can bind to thousands of ligands and signaling proteins, anything can
21:59 < xlhl> yeah GPCRs are pretty versatile
21:59 < xlhl> as are immunoglobulins
21:59 < xlhl> though i guess downstream GPCRs have many more targets
22:00 < yashgaroth> sure but IGs get the benefit of nearly infinite mutation
22:00 < xlhl> well GPCRs are very varied as well, I haven't tried a sequence alignment but I assume there is considerable diversity
22:01 < xlhl> so over evolutionary time scales they get to accumulate mutations as well
22:01 < yashgaroth> oh totally, but not like IGs do
22:01 < xlhl> gotcha. I'm an EE by training, just started with systems biology
22:02 < xlhl> so bear with my potential errors in biology
22:02 < yashgaroth> IGs get recombined in every immune cell after you're born
22:03 < yashgaroth> GPCRs have a lot of diversity but it's all heritable, unlike IGs
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22:05 < yashgaroth> but yes they are both cool and unique
22:05 < mgodinho> xlhl: hello, you meant my interests here?
22:06 < xlhl> yeah, i just figured i'd start something :P
22:06 < xlhl> they are. actually, on the topic of GPCRs, it would be cool to use them as biosensors
22:06 < xlhl> though I imagine expressing them in another organism might be difficult
22:07 < mgodinho> xlhl: right ;) i bit bioinfo, tools for synthetic bio, more on the DIY side
22:07 < yashgaroth> well you'd have to use eukaryotes to express gpcrs, but that doesn't limit you terribly
22:08 < xlhl> right, so maybe yeast
22:08 < xlhl> since that seems to be the easiest eukaryote to work with
22:08 < yashgaroth> yeah yeast are great
22:08 < xlhl> i was recently working with 293T and yeast seem much easier :P
22:09 < xlhl> mgodinho: cool, the diy stuff interests me as well
22:09 < yashgaroth> oh man 293s are like the easiest mammalian cells
22:09 < xlhl> this should be fun then
22:09 < xlhl> :P
22:10 < juri_> document, document, document! ;)
22:10 < xlhl> have you worked with K562? I have to deal with those at some point
22:10 < xlhl> :P
22:10 < yashgaroth> not that I know of but it might have been in some multi-cancer screen plate
22:11 < xlhl> ah understood. i suppose the only thing about 293T that annoyed me is their quasi-attachment
22:11 < xlhl> at least the transfection was easy
22:12 < yashgaroth> indeed, you'll be happy to work with yeast then; and the media costs about 100 times less
22:12 < xlhl> yeah, and no need for the 5% CO2 incubator, right?
22:13 < yashgaroth> that too
22:13 < yashgaroth> what types of molecules are you interested in biosensing?
22:14 < xlhl> small organic molecules, common pollutants
22:14 < xlhl> i guess one might be able to use bacteria for that as well, using one of their transcriptional regulators that responds to the compound of interest
22:15 < yashgaroth> would be the far easier method
22:15 < xlhl> yeah
22:15 < xlhl> bacteria have those cell surface receptors too (receptor histidine kinases?) but idk how much is known about them
22:16 < yashgaroth> depending on how small the molecules are, they may just float into the cell at a sufficient level
22:16 < xlhl> thats true
22:18 < yashgaroth> unless you've got a pollutant that's already known to bind to some GPCR or whatever, though, you'll have a long road ahead of you
22:19 < xlhl> i don't have a very good sense of the timescale of directed evolution with GPCRs, i guess it would be very tedious
22:19 < yashgaroth> ten years in a well-equipped lab
22:20 < xlhl> well, that's pretty intense
22:21 < yashgaroth> the timescales are coming down, slowly
22:21 < yashgaroth> but yes generally it's not feasible unless you're going after them sweet sweet cancer moniez
22:21 < xlhl> yeah i've realized that
22:22 < xlhl> cancer is interesting but there is so much more to biology
22:22 < xlhl> :P
22:23 < xlhl> though my recent limited experience with cell culture comes from working in a cancer lab, so there's that
22:23 < yashgaroth> it definitely keeps biologists employed
22:23 < xlhl> yeah
22:25 < xlhl> well im going to head off to bed. it was nice talking to you, thanks
22:26 < yashgaroth> sure thing, come back soon
22:26 < xlhl> will do
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23:57 < nmz787> i want to design a GPCR-based biosensor using a serotonin receptor
23:58 < nmz787> then i could do TLC on random stuff and easily see if it might be interesting
23:58 < yashgaroth> well that should be relatively easy
23:59 < nmz787> i hadn't seen any good examples of taking human GPCR and linking it to GFP production, etc
23:59 < nmz787> GPCR reporter
--- Log closed Sat Nov 24 00:00:25 2012