--- Log opened Sun Nov 25 00:00:28 2012 00:20 -!- mgodinho [~user@pdpc/supporter/active/mgodinho] has joined ##hplusroadmap 00:51 -!- user123abc [~sally@c-67-171-79-251.hsd1.pa.comcast.net] has quit [Ping timeout: 265 seconds] 01:30 < fenn> hum well it's a start. http://fennetic.net/irc/tutorial_part.pdf 01:30 < fenn> just some random crap 02:01 < abetusk> what is that? 02:05 -!- sylph_mako [~mako@103-9-42-1.flip.co.nz] has quit [Ping timeout: 265 seconds] 02:26 -!- EnLilaSko [~Nattzor@unaffiliated/enlilasko] has joined ##hplusroadmap 02:55 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap 04:21 -!- ThomasEgi [~thomas@gw-ko-kostr2.inka-online.net] has joined ##hplusroadmap 04:21 -!- ThomasEgi [~thomas@gw-ko-kostr2.inka-online.net] has quit [Changing host] 04:21 -!- ThomasEgi [~thomas@panda3d/ThomasEgi] has joined ##hplusroadmap 05:01 -!- user123abc [~sally@c-67-171-79-251.hsd1.pa.comcast.net] has joined ##hplusroadmap 05:52 -!- srangewarp [~strangewa@c-67-173-247-251.hsd1.co.comcast.net] has joined ##hplusroadmap 05:53 -!- strangewarp [~strangewa@c-67-173-247-251.hsd1.co.comcast.net] has quit [Ping timeout: 252 seconds] 05:53 -!- srangewarp is now known as strangewarp 06:15 <@kanzure> maybe a thermocycler thing 06:30 -!- mgodinho [~user@pdpc/supporter/active/mgodinho] has quit [Quit: Ken sent me.] 06:51 -!- EnLilaSko- [~Nattzor@m77-219-226-49.cust.tele2.se] has joined ##hplusroadmap 06:52 -!- EnLilaSko [~Nattzor@unaffiliated/enlilasko] has quit [Ping timeout: 245 seconds] 07:24 < AdrianG> http://www.sciencedaily.com/releases/2011/10/111031215938.htm 07:25 <@kanzure> what is it? 07:31 < streety> that graph is great, two identical lines 07:32 < streety> apparently the enzyme is peroxiredoxin 07:33 -!- srangewarp [~strangewa@c-67-173-247-251.hsd1.co.comcast.net] has joined ##hplusroadmap 07:35 -!- strangewarp [~strangewa@c-67-173-247-251.hsd1.co.comcast.net] has quit [Ping timeout: 246 seconds] 07:35 -!- srangewarp is now known as strangewarp 08:02 -!- delinquentme [~asdfasdf@c-71-236-101-39.hsd1.pa.comcast.net] has joined ##hplusroadmap 08:30 -!- chevbird [~chevbird@66-87-85-42.pools.spcsdns.net] has joined ##hplusroadmap 08:31 -!- chevbird [~chevbird@66-87-85-42.pools.spcsdns.net] has quit [Read error: Connection reset by peer] 09:04 -!- synacktic [~synacktic@unaffiliated/jordyd] has quit [Ping timeout: 252 seconds] 09:10 -!- ElixirVitae [~Shehrazad@unaffiliated/shehrazad] has quit [Read error: Connection reset by peer] 09:17 -!- synacktic [~synacktic@99-177-65-98.lightspeed.wepbfl.sbcglobal.net] has joined ##hplusroadmap 09:17 -!- synacktic [~synacktic@99-177-65-98.lightspeed.wepbfl.sbcglobal.net] has quit [Changing host] 09:17 -!- synacktic [~synacktic@unaffiliated/jordyd] has joined ##hplusroadmap 09:20 -!- ElixirVitae [~Shehrazad@95.5.115.59] has joined ##hplusroadmap 09:20 -!- ElixirVitae [~Shehrazad@95.5.115.59] has quit [Changing host] 09:20 -!- ElixirVitae [~Shehrazad@unaffiliated/shehrazad] has joined ##hplusroadmap 09:21 -!- user123abc [~sally@c-67-171-79-251.hsd1.pa.comcast.net] has quit [Quit: Leaving] 10:07 -!- lichen [~lichen@c-24-21-206-64.hsd1.or.comcast.net] has joined ##hplusroadmap 11:32 -!- sylph_mako [~mako@103-9-42-1.flip.co.nz] has joined ##hplusroadmap 11:47 -!- sylph_mako [~mako@103-9-42-1.flip.co.nz] has quit [Read error: Connection reset by peer] 12:04 -!- sylph_mako [~mako@103-9-42-1.flip.co.nz] has joined ##hplusroadmap 12:08 -!- sylph_mako [~mako@103-9-42-1.flip.co.nz] has quit [Read error: Operation timed out] 12:09 -!- chevbird [~chevbird@209-6-62-26.c3-0.sbo-ubr1.sbo.ma.cable.rcn.com] has joined ##hplusroadmap 12:21 -!- sylph_mako [~mako@103-9-42-1.flip.co.nz] has joined ##hplusroadmap 12:23 < jrayhawk> i would be curious to read those papers to see if they actually controlled with a low-oxidative-stress diet 12:24 < jrayhawk> it would not surprise me in the least to find out that restricting garbage has some benefit 12:27 -!- sylph_mako [~mako@103-9-42-1.flip.co.nz] has quit [Ping timeout: 264 seconds] 12:33 < chevbird> i prefer kraft dinner 12:39 -!- sylph_mako [~mako@103-9-42-1.flip.co.nz] has joined ##hplusroadmap 12:55 -!- ParahSailin [~parah@unaffiliated/parahsailin] has quit [Read error: Connection reset by peer] 12:56 -!- ParahSailin [~parah@unaffiliated/parahsailin] has joined ##hplusroadmap 13:15 -!- augur_ [~augur@c-75-74-129-116.hsd1.fl.comcast.net] has quit [Ping timeout: 244 seconds] 13:16 < curt1s> last i heard about those caloric restriction diets, they were turning out to be bullshit 13:17 < curt1s> this stuff is new though 13:23 < chevbird> anyone read the CDPPB/MGluR5 paper from earlier this month? 13:24 < chevbird> i just came across it...very interesting 13:24 < chevbird> (fowler et al.) 13:27 -!- yashgaroth [~f@cpe-66-27-117-179.san.res.rr.com] has joined ##hplusroadmap 13:44 < brownies> jrayhawk: eh? i thought that latest news on caloric restriction on primates showed it had no effect 13:45 < jrayhawk> diet's really complicated; a single study isn't going to cover the problemspace 13:57 < jrayhawk> the primate one at least showed that the rodent models are not applicable slam-dunks for longevity in humans, but there's a lot more work yet to be done in characterizing what sort of restriction is beneficial 13:58 < jrayhawk> like we already know that periodic protein fasting and carb fasting each produce some pretty useful metabolic adaptations 13:59 < jrayhawk> but these diet studies don't really get more sophisticated than macros and calories, which is a damned shame 14:01 < brownies> what other dimensions are worth studying ? 14:03 < jrayhawk> Oxidative/inflammatory stressors is the biggest one. 14:03 < jrayhawk> http://www.sciencedaily.com/releases/2011/10/111031215938.htm which this looks like it was admirably interested in, but not to the point of identifying specific stressors in the diet. 14:08 < brownies> intriguing. 14:08 < brownies> have those stressors been identified? 14:08 <@kanzure> yes, all the foods 14:08 < brownies> i.e. before exploring diets that reduce those, we should find out what the causes are 14:08 < brownies> kanzure: damn, i like to eat those. 14:20 < jrayhawk> Yeah, we know severe inflammation/oxidative stress pathways for linoleic acid, fructose, and gliadin (and, by anecdote and inference, other prolamines) 14:22 -!- chevbird [~chevbird@209-6-62-26.c3-0.sbo-ubr1.sbo.ma.cable.rcn.com] has quit [Quit: Leaving] 14:23 < jrayhawk> like, just searching scholar.google.com for each of those things plus keywords like oxidative or cytokine generates lots of interesting hits 14:23 < jrayhawk> http://scholar.google.com/scholar?q=linoleic+acid+cytokines+-conjugated+-alpha 14:24 -!- ParahSailin [~parah@unaffiliated/parahsailin] has quit [Read error: Connection reset by peer] 14:25 -!- EnLilaSko- is now known as EnLilaSko 14:25 -!- EnLilaSko [~Nattzor@m77-219-226-49.cust.tele2.se] has quit [Changing host] 14:25 -!- EnLilaSko [~Nattzor@unaffiliated/enlilasko] has joined ##hplusroadmap 14:25 <@kanzure> there's also nice diagrams on reactome and KEGG 14:25 <@kanzure> although that's only for known metabolic/catabolic pathway stuff 14:28 -!- ParahSailin [~parah@adsl-69-151-150-200.dsl.hstntx.swbell.net] has joined ##hplusroadmap 14:28 -!- ParahSailin [~parah@adsl-69-151-150-200.dsl.hstntx.swbell.net] has quit [Changing host] 14:28 -!- ParahSailin [~parah@unaffiliated/parahsailin] has joined ##hplusroadmap 14:28 < jrayhawk> Joey added linkmap support to the graphviz plugin for Ikiwiki. I occasionally get tempted to start doing heavily hyperlinked biochemistry diagrams. 14:28 < jrayhawk> imagemap 14:28 < jrayhawk> whatever the term is for that 14:30 -!- EnLilaSko [~Nattzor@unaffiliated/enlilasko] has quit [Quit: - nbs-irc 2.39 - www.nbs-irc.net -] 14:31 -!- EnLilaSko [~Nattzor@unaffiliated/enlilasko] has joined ##hplusroadmap 14:32 <@kanzure> jrayhawk: i'm not sure if auto-summarization is the answer, but definitely some of the stuff in longevity/ should be consolidated somehow 14:40 -!- EnLilaSko [~Nattzor@unaffiliated/enlilasko] has quit [Quit: - nbs-irc 2.39 - www.nbs-irc.net -] 14:50 < nmz787> IYbio has been slow lately 14:50 < nmz787> DIYbio* 14:50 < nmz787> stupid turkey day screwing up people's internet lives 14:52 < nmz787> how do i close a channel in irssi? 14:53 <@kanzure> /wc 15:00 < nmz787> how do i change which server i want when joining a channel? 15:00 -!- synacktic [~synacktic@unaffiliated/jordyd] has quit [Ping timeout: 265 seconds] 15:03 <@kanzure> nmz787: ctrl-x i think 15:03 <@kanzure> look in window 0 to see which server you are currently running commands on 15:03 <@kanzure> i think you can also use /server but that might only be for connecting 15:22 < nmz787> yeah if i issue the cmd from a channel that is the server i get 15:22 < nmz787> it's that channel's server* 15:24 <@kanzure> yes, so i just issue it from window 0 15:32 -!- audy- is now known as audy 15:32 -!- audy [~audy@heyaudy.com] has quit [Changing host] 15:32 -!- audy [~audy@unaffiliated/audy] has joined ##hplusroadmap 16:00 -!- delinquentme [~asdfasdf@c-71-236-101-39.hsd1.pa.comcast.net] has quit [Ping timeout: 264 seconds] 16:01 < fenn> jrayhawk: do you take NAC? or antioxidant supplements? just curious 16:06 < fenn> neat idea of the day: photo-enhanced diffusion of hydrogen from hollow glass microspheres, to maximize gravimetric energy density by eliminating valves 16:08 < fenn> http://ceer.alfred.edu/Research/glassspheres.html 16:09 < jrayhawk> The only antioxidant thing I take is glutathione precursor in the form of Vitamin D 16:14 < jrayhawk> And I eat a shitton of bone broth for glutamate and various other things for sulfer. I don't actually know what's used to maintain endogenous NAC levels, come to think of it. 16:14 < jrayhawk> glutamate and glycine in bone broth 16:15 < jrayhawk> ah, methionine 16:16 < jrayhawk> 'Methionine, an essential amino acid, is found mainly in egg whites and fish' I suspect I'm good, then! 16:18 < jrayhawk> i guess vitamin d isn't really a precursor, but it does tend to determine production rates regardless 16:27 -!- devrandom [~devrandom@gateway/tor-sasl/niftyzero1] has quit [Ping timeout: 276 seconds] 16:32 -!- torwag` [~user@130.34.206.97] has left ##hplusroadmap ["ERC Version 5.3 (IRC client for Emacs)"] 17:22 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Quit: Leaving] 18:13 -!- devrandom [~devrandom@gateway/tor-sasl/niftyzero1] has joined ##hplusroadmap 18:22 -!- ThomasEgi [~thomas@panda3d/ThomasEgi] has quit [Read error: Connection reset by peer] 19:22 -!- wizrobe is now known as Leia-SpaceHo 20:00 -!- sylph_mako [~mako@103-9-42-1.flip.co.nz] has quit [Ping timeout: 248 seconds] 20:17 -!- sylph_mako [~mako@103-9-42-1.flip.co.nz] has joined ##hplusroadmap 20:44 -!- superkuh [~superkuh@unaffiliated/superkuh] has quit [Remote host closed the connection] 20:46 -!- superkuh [~superkuh@unaffiliated/superkuh] has joined ##hplusroadmap 21:24 < nmz787> kanzure: have you seen any PDMS safe DNA synthesis papers? 21:36 -!- RebelBunny [~RebelBunn@108-250-133-41.lightspeed.irvnca.sbcglobal.net] has joined ##hplusroadmap 21:50 <@kanzure> hm, apparently not 22:16 -!- augur [~augur@208.58.5.87] has joined ##hplusroadmap 22:21 <@kanzure> commit c4b92829d8203ec988be10d433fe0150065cba4f 22:21 <@kanzure> Author: Bryan Bishop 22:21 <@kanzure> Date: Sun Nov 25 16:03:24 2012 -0600 22:21 <@kanzure> i have no memory of this 22:26 < fenn> so it seems fish oil is not just fish oil anymore: http://www.ascentahealth.com/health-science/science-articles/fish-oil-triglycerides-vs-ethyl-esters-as-nature-intended 22:33 < fenn> oh ethyl ester purification was invented in 1980's 23:09 -!- augur [~augur@208.58.5.87] has quit [Remote host closed the connection] 23:12 -!- augur [~augur@208.58.5.87] has joined ##hplusroadmap 23:34 -!- yashgaroth [~f@cpe-66-27-117-179.san.res.rr.com] has quit [Quit: Leaving] 23:43 -!- archels [~foo@sascha.esrac.ele.tue.nl] has quit [Ping timeout: 256 seconds] 23:45 -!- archels [~foo@sascha.esrac.ele.tue.nl] has joined ##hplusroadmap --- Log closed Mon Nov 26 00:00:30 2012