--- Log opened Tue Feb 03 00:00:43 2015
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00:54 < archels> "Zero-G long-term is a death sentence for humans"
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01:09 < archels> Mammalian cells have an intrinsic program, the Hayflick limit, that limits their multiplication to about 60–70 doublings, at which point they reach a stage of senescence.
01:09 < archels> This limit can be overcome by disabling their pRB and p53 tumor suppressor proteins, which allows them to continue doubling until they reach a stage called crisis, with apoptosis, karyotypic disarray, and the occasional (10−7) emergence of an immortalized cell that can double without limit. Most tumor cells are immortalized.
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01:11 < archels> Hayflick limit being ascribed solely to telomere length
01:13 < archels> there's mention of an "immortality party" having been founded in The Netherlands in 2012, but I can't find anything on it
01:14 < gwillen> ~
01:14 < gwillen> oops
01:25 < archels> http://www.transcedo.org/ looks pretty dead
01:31 < archels> .wik Warburg hypothesis
01:31 < yoleaux> "The Warburg hypothesis (/ˈvɑrbʊərɡ/), sometimes known as the Warburg theory of cancer postulates that the driver of tumorigenesis is an insufficient cellular respiration caused by insult to mitochondria." — http://en.wikipedia.org/wiki/Warburg_hypothesis
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02:21 < archels> http://agi-conf.org/2010/wp-content/uploads/2009/06/agi10singmodels2.pdf
02:22 < archels> An overview of models of technological singularity
02:22 < archels> Anders Sandberg
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02:43 < archels> "if your baby-tickling machine involves black holes you have a good reason to be cautious." (Sandberg)
02:56 < archels> TransVision 2014 videos are online  https://www.youtube.com/watch?v=-GNLgrs2gg4&list=PLlB9Vm4imyfWwsWXDOvNuuwZvfj0nHAEZ
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05:25 < kanzure> ha transvision is still a thing? that's hilarious
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05:43 < kanzure> "You can donate blood, plasma, eggs, and sperm. Why not poop? Yes, your feces are perhaps your greatest untapped monetary resource. Thanks to a nonprofit organization called OpenBiome, you can cash in to the tune of $13,000 a year -- and save lives while you're at it."
05:44 < kanzure> http://www.openbiome.org/
05:44 < kanzure> "So far they've shipped about 2,000 treatments to 185 hospitals around the country."
05:44 < kanzure> "And yes, they pay for healthy poop: $40 a sample, with a $50 bonus if you come in five days a week. That's $250 for a week of donations, or $13,000 a year."
05:45 < kanzure> "The screening process can cost up to $5,000"
05:48 < chris_99> heh what the hell
05:53 < andytoshi> yashgaroth: fwiw if i explicitly asked i bet i could customize a bunch of things
06:04 < kanzure> "David Evans and I are organizing a symposium entitled “Retrosynthesis, Synthesis Planning, Reaction Prediction: When Will Computers Meet the Needs of the Synthetic Chemist?” in the Division of Chemical Information (CINF) program at the upcoming Fall ACS National Meeting in Boston, August 16-20, 2015. We are now accepting abstracts submitted via the ACS MAPS system. The deadline for submission of abstracts is March 13, 2015 when MAPS ...
06:04 < kanzure> ... will close."
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06:59 < archels> Natasha Vita-More worked on vitrifying and reviving trained C. elegans?
06:59 < archels> I guess I shouldn't be wholly surprised given her connection with Max
07:00 < kanzure> i haven't heard this before
07:00 < kanzure> can you give me evidence of this
07:03 < archels> 'my scientific paper is ready for publication, hasn't come out'  https://www.youtube.com/watch?v=BTe3Pc8aKzE&feature=youtu.be&t=34m30s
07:04 < kanzure> .title
07:04 < yoleaux> TransVision 2014 - Natasha Vita-More, "Informed Radical Life Extension, by Design" - YouTube
07:04 < archels> not much info in that talk
07:05 < archels> apparently Sandberg collaborated on it, 12 times 100 worms trained/frozen/revived/tested
07:05 < kanzure> hmmm. this is worrisome.
07:06 < kanzure> so, conventionally i haven't seen natasha ever do anything related to biology really.
07:06 < kanzure> and also, anders hasn't been doing much but smoke philosophy papers with nick bostrom for a while now.
07:06 < archels> so this is a good thing then, no?
07:06 < kanzure> i might have to stop saying natasha never learned biology
07:06 < kanzure> no this is awful
07:08 < archels> explain?
07:08 < kanzure> my primary complaint has been that most transhumanists have not actually bothered with biology projects
07:11 < kanzure> more https://www.youtube.com/watch?v=HGoQnU6ySw4#t=1300
07:12 < kanzure> ah an alcor project
07:14 < archels> and now they are bothering, so wouldn't that allay your complaint?
07:17 < kanzure> yes but i have to weigh that against the bother of me making a better complaint now
07:18 < archels> hahaha
07:18 < kanzure> hopefully you can see why i am so troubled
07:18 < archels> yes, I see it now
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07:59 < fenn> http://www.washingtonpost.com/blogs/the-switch/wp/2015/01/06/elon-musk-gaming-supernerd/   weird to see an article about tech trees in the washington post
07:59 < yoleaux> 31 Jan 2015 17:42Z <kanzure> fenn: http://parts.io/
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08:03 < fenn> parts.io looks very useful for day to day electronics design and procurement
08:05 < kanzure> fenn: andytoshi will be in san francisco next week and you should meet him
08:05 < kanzure> maaku is also in the area i think
08:09 < fenn> hey it's daytime
08:09 < fenn> awesome. i'm going outside
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09:06 < archels> that's crazy talk
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11:00 < kanzure> gene_hacker: yo
11:19 < paperlooker> paperbot: http://onlinelibrary.wiley.com/doi/10.1002/ffj.3127/abstract
11:20 < paperbot> http://diyhpl.us/~bryan/papers2/paperbot/dd49347cfea962c7f4f0324becb95126.txt
11:26 < jrayhawk> archels: http://www.biomedcentral.com/content/pdf/1743-7075-7-7.pdf "metabolic theory of cancer" is the more up-to-date version of the warburg hypothesis if you want more stuff to read on the subject
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12:16 < nmz787> this instrumental analysis class is all really about analog electronics
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12:52 < archels> jrayhawk: cheers
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13:04 < archels> really fascinating that there *does* turn out to be this common factor behind the majority of all types of cancer
13:05 < kanzure> all cancer made up of cells, news at .. eh i can't do this
13:07 < archels> heh
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13:07 < archels> well, things are never going to be clear cut in biology--but they probably don't get more clear cut than this
13:07 < archels> (if we are to believe what this says, anyway)
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13:50 < jrayhawk> Unfortunately it's hit-or-miss as a treatment target since cancers can be pretty good at recruiting other cells to fill in for the metabolic role of mitochondria.
13:53 < gene_hacker> now this is neat:
13:53 < gene_hacker> https://www.youtube.com/watch?v=fMUemBZ0k5Q
13:53 < jrayhawk> .title https://www.youtube.com/watch?v=sBjnWfT8HbQ
13:53 < yoleaux> AHS12 Thomas Seyfried PhD —Targeting Energy Metabolism in Brain Cancer - YouTube
13:53 < gene_hacker> make hydrophobic pdms for microfluidics using a microwave oven
13:53 < gene_hacker> err hydrophilic
13:54 < kanzure> .title https://www.youtube.com/watch?v=fMUemBZ0k5Q
13:54 < yoleaux> Lab 6A: PDMS Microfluidics: O2 Plasma Treatment - YouTube
13:55 < gene_hacker> O2 plasma treatment using a microwave oven and a jar full of almost nothing!
14:04 < kanzure> gene_hacker: show me cool recent microfluidics things
14:07 < kanzure> gene_hacker: http://diyhpl.us/~bryan/papers2/mems/
14:09 < kanzure> "Animal microsurgery using microfluidics" http://crane-lab.com/content/uploads/2013/12/Crane-2014-Current-Opin-Biotech.pdf
14:14 < gene_hacker> gotta work on cool nanotech things
14:14 < gene_hacker> you familiar with drexler's pressure threshold actuators?
14:14 < kanzure> nope
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14:24 < kanzure> $0.003 per base pair http://www.sciencedirect.com/science/article/pii/S0168165613005324
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14:48 < archels> CircuiTikz might be a pain in the neck, but it sure typesets circuits beautifully
14:49 < kanzure> .title http://link.springer.com/article/10.1134/S1068162014050124
14:49 < yoleaux> Photogenerator of trichloroacetic acid as a promising detritylation agent for oligonucleotide microarray synthesis - Springer
14:49 < kanzure> typesetting is swhack
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14:50 < gene_hacker> http://www.molecularassembler.com/KSRM/Figures/4.39.JPG
14:50 < gene_hacker> this thing
14:50 < gene_hacker> pressure threshold actuators are pistons that close at a specified pressure
14:51 < gene_hacker> by oscillating the pressure one can use them to actuate ratchets
14:52 < archels> kanzure: publishing papers is doing science :S
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15:11 < eudoxia> i'd forgotten how small the figs on the KSRM were
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17:52 < kanzure> hmm
17:58 < heath> what's all the hmming about?
18:21 < kanzure> heath: you should switch to rails
18:28 < nsh> *railguns
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20:22 < nmz787> http://diyhpl.us/~nmz787/pdf/Next_generation_1536-well_oligonucleotide_synthesizer_with_on-the-fly_dispense.pdf
20:24 < kanzure> did you see the paper i showed yashgaroth
20:24 < kanzure> 19:40 < yoleaux> 2 Feb 2015 19:06Z <kanzure> yashgaroth: "A highly convenient procedure for oligodeoxynucleotide purification" http://benthamopen.com/contents/pdf/TOOCJ/TOOCJ-8-15.pdf
20:24 < kanzure> 19:40 < yashgaroth> kanzure: wrt the paper you linked me, the polymerization of the deletion mutants is the interesting bit; claiming that a centrifuge is "high-throughput" compared to HPLC is stretching it
20:28 < nmz787> yeah, I think I commented on the centrifuge
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20:30 < nmz787> so anodic stripping voltammetry == variable/programmable constant voltage source electrode, a low-impedance current sense electrode, and an electrode for voltage feedback
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21:09 < nmz787> .title
21:09 < nmz787> http://blog.mbl.edu/?p=3285
21:09 < yoleaux> nmz787: Sorry, that doesn't appear to be an HTML page.
21:09 < nmz787> .title
21:09 < yoleaux> Sea Slug has Taken Genes from the Algae it Eats, Allowing it to Photosynthesize Like a Plant, Study Reports « @mbl
21:10 < nmz787> .title http://www.biolbull.org/content/227/3/300.full.pdf+html
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21:11 < nmz787> "It has been known since the 1970s that E. chloritica “steals” chloroplasts from V. litorea (called “kleptoplasty”) and embeds them into its own digestive cells. Once inside the slug cells, the chloroplasts continue to photosynthesize for up to nine months—much longer than they would perform in the alga. The photosynthesis process produces carbohydrates and lipids, which nourish the slug. How the slug manages to maintain these ...
21:11 < nmz787> ... photosynthesizing organelles for so long has been the topic of intensive study and a good deal of controversy. “This paper confirms that one of several algal genes needed to repair damage to chloroplasts, and keep them functioning, is present on the slug chromosome,” Pierce says. “The gene is incorporated into the slug chromosome and transmitted to the next generation of slugs.” While the next generation must take up ...
21:11 < nmz787> ... chloroplasts anew from algae, the genes to maintain the chloroplasts are already present in the slug genome, Pierce says."
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