--- Log opened Mon Feb 16 00:00:56 2015
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04:34 < archels> journal.frontiersin.org/Journal/10.3389/fnsys.2014.00213/full
04:34 < archels> .title http://journal.frontiersin.org/Journal/10.3389/fnsys.2014.00213/full
04:34 < yoleaux> Frontiers | Brain-machine interfaces as a challenge to the “moment of singularity” | Frontiers in Systems Neuroscience
04:35 < archels> frontiers publishes blogposts now?
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05:56 < pasky_> pretty pictures https://imgur.com/a/HjF2P
05:57 < kanzure> bloop
06:02 < kanzure> aaaah that's not a roadmap
06:03 < kanzure> really dumb how they think brain emulation wont work without having ai first. are they morons?
06:06 < kanzure> why are these images anyway >:(
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06:15 < justanotheruser> agreed. none of that is dependent on the previous step, it's just "this would be cool" "so would this"
06:17 < justanotheruser> I've got good news, this is fresh off of the Futurology subreddit (at least thats the most popular thing linking this)
06:18 < justanotheruser> with the title "What kind of immortality would you rather come true?"
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06:28 < kanzure> blah
06:28 < kanzure> thankfully that subreddit has not really filtered into here
06:28 < kanzure> except FourFire but he's awful anyway
06:28 < justanotheruser> /r/nootropics probably is though
06:28 < kanzure> :(
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06:39 < kanzure> Quashie_: welcome
06:39 < Quashie_> hey
06:39 < Quashie_> I am actually heading off to work in a bit
06:39 < kanzure> davidad used to show up in here :/
06:39 < kanzure> and then he didn't
06:39 < kanzure> but let's plot to get him out of twitter
06:40 < kanzure> and back to work on important things
06:40 < Quashie_> maybe I could talk to him about it
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06:41 < Quashie_> all right, be back tonight
07:23 < heath> paperbot: http://www.nature.com/nm/journal/v17/n8/abs/nm.2408.html
07:23 < paperbot> http://libgen.info/scimag/get.php?doi=10.1038%2Fnm.2408
07:23 < heath> http://bme.columbia.edu/samuel-k-sia
07:23 < heath> http://engineering.columbia.edu/smartphone-finger-prick-15-minutes-diagnosis%E2%80%94done-0
07:23 < heath> .title
07:23 < yoleaux> Smartphone, Finger Prick, 15 Minutes, Diagnosis—Done! | The Fu Foundation School of Engineering & Applied Science - Columbia University
07:25 < heath> .title https://www.youtube.com/watch?v=uGcqZCDvT_4
07:25 < yoleaux> MESH: Creative DIY Kit for the Connected Life - YouTube
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07:25 < heath> https://www.indiegogo.com/projects/mesh-creative-diy-kit-for-the-connected-life
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07:33 < heath> http://www.cell.com/pb/assets/raw/journals/research/cell-systems/do-not-delete/CELS1_FINAL.pdf
07:33 < heath> "Geospatial Resolution of Human and Bacterial Diversity with City-Scale Metagenomics"
07:33 < paperbot> http://libgen.info/scimag/get.php?doi=10.1016%2Fj.cels.2015.01.001
07:33 < heath> https://d2zahwnsqpmout.cloudfront.net/map/
07:34 < heath> ^ the actual map
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07:35 < heath> http://miroculus.com/ ::  miroculus "Imagine a simple blood test that can tell you, at the molecular level, the exact type of disease you have and its severity before presenting any symptoms. Imagine using the same test to monitor the success of the treatment"
07:37 < heath> .title https://technology.grc.nasa.gov/SS-rHealth.shtm
07:37 < yoleaux> The rHEALTH Sensor
07:37 < heath> https://www.youtube.com/watch?v=jB7Wy7Z_Vvw
07:37 < heath> .title
07:37 < yoleaux> NSXC Team DMI - YouTube
07:39 < heath> different way of tracking history with chrome http://www.trailblazer.io/
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08:09 < heath> this is nice
08:09 < heath> https://www.flickr.com/photos/104379556@N08/15758558858/in/photostream/
08:10 < heath> a new car from osvehicle: nika
08:10 < heath> it has windshield and is weatherproof
08:10 < heath> https://www.osvehicle.com/connected-car-nika/?utm_source=wysija
08:11 < heath> and by new, it's something i overlooked months ago it seems
08:12 < heath> wonder how much money there is to be had in bringing this to the US
08:15 < heath> .tell juri_ https://www.osvehicle.com/connected-car-nika/
08:15 < yoleaux> heath: I'll pass your message to juri_.
08:16 < heath> .tell juri_ https://www.flickr.com/photos/104379556@N08/15758558858/in/photostream/
08:16 < yoleaux> heath: I'll pass your message to juri_.
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08:41 < archels> "Would you try to understand the universe by simulating every molecule? What would you have achieved? It’s going to be just as complicated as the real thing and you won’t understand it any better."
08:42 < archels> re the HBP, https://chronicle.com/article/Can-the-Human-Brain-Project-Be/190031/
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08:57 < kanzure> who cares?
08:57 < kanzure> like why would you care about understanding it better or worse?
08:57 < heath> .title https://www.youtube.com/watch?v=YQy0ZCx3UCY
08:58 < yoleaux> Cybertopia - Dreams of Silicon Valley (VPRO, Marije Meerman) - YouTube
08:58 < kanzure> do they even know how software works
08:58 < kanzure> that's infuriating
08:59 < kanzure> "yeah, you're absolutely right, there's zero value to working emulation software. better pack up and go home. also tell vmware to shove it."
08:59 < kanzure> also, i forget, but what is the competing project in the US called? there was some project with a very similar name but doing something quite different.
09:02 < heath> .title https://play.spotify.com/album/1j7rFAYUbJXDDAGwjnz1bd
09:02 < yoleaux> Spotify
09:02 < heath> Bach in Brazil: Rosauro
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09:05 < archels> kanzure: the BRAIN project?
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09:07 < kanzure> ah yes i think so
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09:30 < archels> initiative, sorry, not project
09:30 < archels> for obvious reasons
09:30 < archels> its scope can be summarised as "measure everything all the time"
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09:48 < kanzure> not a bda goal
09:48 < kanzure> *bad
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10:07 < kanzure> "I think the overall problem is that traditional neuro scientists and biologists bring virtually none of the required skills to the table. Moreover while neuroscience is able to show pretty pictures of brain activity, they have made insufficient progress in understanding it. On the other hand the physicists/mathematicians that have invaded the field have a background in computational methods, simulation and hardware development. So for ...
10:07 < kanzure> ... example a group at the University I studied had previous experience designing analog chips for feature detection in High Energy Physics, a number of years ago they re-branded themselves as a neurophysics group and recently landed a ~100 million euro+ grant in the context of the Human Brain Project. It is also much easier to learn the jargon and read some of the softer phenomenological articles than to develop a sound understanding of ...
10:08 < kanzure> ... the underlying mathematics and physics."
10:08 < kanzure> ouch :)
10:08 < kanzure> "Specifically neuroscience subproject funding was removed... This seems like angry academics that lost funding are trying to derail it through the media to my uneducated observance..."
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14:08 < superkuh> http://xkcd.com/793/
14:10 < kanzure> yeaaaaah but to be fair you don't see biologists building overwhelmingly large particle colliders
14:11 < kanzure> "Huh? No, I don't need to read your thesis. I can imagine roughly what it says."
14:11 < superkuh> http://abstrusegoose.com/156
14:12 < kanzure> the real magic trick there would be getting all of the cells to separate and stay in tact
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14:34 < kanzure> nmz787: cory says keep phosphoramidites at -20 celsius and they will be good for approximately 12 months
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14:49 < kanzure> paperbot: http://iopscience.iop.org/0960-1317/24/9/095004/article
14:49 < kanzure> .title
14:49 < yoleaux> On-chip enucleation of an oocyte by untethered microrobots - IOPscience
14:49 < paperbot> http://libgen.info/scimag/get.php?doi=10.1088%2F0960-1317%2F24%2F9%2F095004
14:50 < kanzure> "To confirm successful enucleation using this method, we investigated the viability of oocytes after enucleation. The results show that the production rate, i.e. the ratio between the number of oocytes that reach the blastocyst stage and the number of bovine oocytes after nucleus transfer, is 100%"
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15:07 < kanzure> http://arstechnica.com/security/2015/02/how-omnipotent-hackers-tied-to-the-nsa-hid-for-14-years-and-were-found-at-last/
15:07 < nmz787> kanzure: cool, so that's a normal freezer
15:08 < nmz787> http://diyhpl.us/~nmz787/pdf/A_high_resolution_MEMS_based_gas_chromatography_column_for_the_analysis_of_benzene_and_toluene_gaseous_mixtures.pdf
15:08 < nmz787> 3.6cm x 4.6cm
15:09 < nmz787> This 6.0 m long, 100ym wide, and 100um deep column
15:09 < nmz787> 100um*
15:11 < kanzure> 6 meters long?
15:11 < kanzure> oh it's compressed space
15:11 < kanzure> or er... geometry magic.. whatever you call that.
15:11 < kanzure> folded space?
15:13  * nmz787 is imagining a spin-coater with array interferometery to detect thickness in real-time, integrated direct-write exposure + development (baking) and making it fast enough to do 3d-printing style
15:13 < nmz787> but i guess that would then require the resin/substrate to be chemically compatible with the protocol you want to carry out
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15:14 < nmz787> i bet there is a way to do this with an e-beam and silicon oxide deposition or something
15:14 < nmz787> that seems like it would be compatible with lots of chemistry
15:14 < nmz787> and maybe optically clear too?
15:15 < nmz787> .title http://www.ncbi.nlm.nih.gov/pubmed/17129050
15:15 < yoleaux> Fabrication and functionalization of nanochannels by electron-beam-... - PubMed - NCBI
15:15 < nmz787> ' by electron-beam-induced silicon oxide deposition.'
15:15 < kanzure> is the government really saving that much money by not putting the entire title in the title? :/
15:17 < nmz787> paperbot: http://pubs.acs.org/doi/abs/10.1021/la061321c
15:17 < paperbot> http://diyhpl.us/~bryan/papers2/paperbot/Fabrication%20and%20Functionalization%20of%20Nanochannels%20by%20Electron-Beam-Induced%20Silicon%20Oxide%20Deposition.txt
15:19 < nmz787> http://diyhpl.us/~nmz787/pdf/Fabrication_and_Functionalization_of_Nanochannels_by_Electron-Beam-Induced_Silicon_Oxide_Deposition.pdf
15:20 < nmz787> "The electron beam decomposes the adsorbed precursor tetraethyl orthosilicate (Si(OC2H5)4, TEOS) within a small area around the pore to solid silicon oxide and volatile organic compounds."
15:27 < nmz787> bah, circular and parabolic channels seem like enough to think about for now
15:31 < kanzure> spirals.
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15:37 < nmz787> http://diyhpl.us/~nmz787/pdf/Electrodeposition_of_3D_microstructures_on_silicon.pdf
15:39 < nmz787> kanzure: i meant the cross-section of channels being circular or parabolic/similarly-curved
15:40 < kanzure> aren't sharp edges bad for pumping fluid through
15:40 < kanzure> were those square edges in the micro chromatograph?
15:40 < kanzure> or even pumping gas
15:40 < kanzure> or anything
15:42 < nmz787> http://diyhpl.us/~nmz787/pdf/Mixing_in_curved_tubes.pdf
15:42 < nmz787> I couldn't tell what their 'turn arounds' looked like in the GC column paper
15:43 < nmz787> i guess my best answer is that some channel shapes are better for certain applications
15:44 < nmz787> maybe sharp and square corners and channels matters less in gas-phase
15:52 < heath> suggestions on what to visit while in boston?
15:52 < heath> i have a few people scouted from the wyss institute
15:52 < heath> and i've never been to the mit fablab
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16:11 < kanzure> paperbot: http://jap.physiology.org/content/112/10/1625
16:11 < kanzure> .title
16:11 < paperbot> http://libgen.info/scimag/get.php?doi=10.1152%2Fjapplphysiol.00435.2011
16:11 < yoleaux> Transcriptome signature of resistance exercise adaptations: mixed muscle and fiber type specific profiles in young and old adults | Journal of Applied Physiology
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16:22 < kanzure> paperbot: http://physreports.physiology.org/content/2/11/e12212.abstract
16:22 < kanzure> .title
16:22 < yoleaux> Resistance exercise increases active MMP and β1‐integrin protein expression in skeletal muscle | Physiological Reports
16:22 < paperbot> http://libgen.info/scimag/get.php?doi=10.14814%2Fphy2.12212
16:22 < kanzure> "Recent studies indicate that matrix metalloproteinases (MMPs) and critical linkage proteins in the extracellular matrix (ECM) regulate skeletal muscle mass, although the effects of resistance training (RT) on protein expression and activity are unclear. Thus, the purpose of the present study was to investigate the effects of RT on MMP activity and expression of ECM‐related proteins. Ten male Sprague–Dawley rats were randomly ...
16:22 < kanzure> ... assigned to 1 bout (1B) or 18 bouts (18B) of electrical stimulation. The right gastrocnemius muscle was isometrically contracted via percutaneous electrical stimulation (five sets of 5 sec stimulation × five contractions/set with 5 sec interval between contractions and 3 min rest between sets) once (1B) or every other day for 5 weeks (18B). The left leg served as a control."
16:22 < kanzure> isn't science great?
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17:17 < heath> http://panorender.com/magic-leap-is-surely-making-the-best-out-of-those-ui-concepts/
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17:30 < kanzure> paperbot: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0111521
17:30 < kanzure> .title
17:30 < yoleaux> PLOS ONE: Hormonal and Neuromuscular Responses to Mechanical Vibration Applied to Upper Extremity Muscles
17:30 < paperbot> http://diyhpl.us/~bryan/papers2/paperbot/9cf9458ee436b51eaa01114807065843.txt
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18:00 < kanzure> homebrew testosterone http://imgur.com/a/1Kie8
18:01 < kanzure> .title https://www.youtube.com/watch?v=0LL7bL4F9G4
18:01 < yoleaux> Anabolic Steroids: an evolving black market - YouTube
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18:23 < kanzure> http://www.reddit.com/r/steroids/comments/1j4pu4/homebrew_wpics/
18:25 < heath> ~"value results over activity"
18:25 < kanzure> hahaha http://www.reddit.com/r/steroids/comments/2dtrnl/effects_of_taking_aas_without_lifting/
18:26 < kanzure> "I read a study somewhere of where they tested the effects of taking steroids without working out (WO) There were 4 groups: No WO/No AAS, WO/No AAS, No WO/AAS, and WO/AAS. They all did the same workouts (except the first group) and had the same diet, adjusted to bodyweight of course. No WO/No AAS stayed roughly the same. WO/No AAS gained ~4lbs of muscle. No WO/AAS gained ~7lbs of muscle. WO/AAS gained ~13lbs of muscle."
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18:27 < kanzure> paperbot: http://www.nejm.org/doi/full/10.1056/NEJM199607043350101
18:27 < kanzure> .title
18:27 < yoleaux> MMS: Error
18:27 < kanzure> "The Effects of Supraphysiologic Doses of Testosterone on Muscle Size and Strength in Normal Men"
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18:28 < paperbot> http://libgen.info/scimag/get.php?doi=10.1056%2FNEJM199607043350101
18:32 < maaku> so taking steroids and sitting on my ass is 75% better than working out?
18:33 < kanzure> you're welcome
18:36 < nmz787> fenn: I don't understand why you chose to use 8mm thrust bearings for the laser etcher when the threaded rod chosen is 3/8" (~9.5mm)
18:36 < maaku> kanzure: is taking steroids dangerous?
18:36 < kanzure> maaku: i strongly recommend steroids
18:36 < kanzure> there are many concerns to be aware of, however
18:37 < maaku> kanzure: do you have or can point in the direction of a good writeup?
18:37 < kanzure> none of which i feel like outlining... it's all fairly obvious stuff... like test your supplies, buy safely, learn good technique, don't be a moron.
18:37 < kanzure> ehh no i don't think i do at the moment. i'll think some on it. i might have seen a thing once..
18:38 < nmz787> all the good stuff is reserved for sex changes
18:38 < nmz787> i wonder if you could go complain you aren't feeling 'masculine enough'
18:38 < maaku> well, if there were serious health concerns I'd avoid it. a dead body is not aethetically pleasing
18:39 < kanzure> nmz787: you can definitely get your doctor to prescribe you testosterone
18:39 < kanzure> nmz787: this is currently a fad actually
18:39 < nmz787> it's more like supply chain management concerns IMO
18:39 < maaku> nmz787: makes you a jerk though
18:39 < kanzure> "under 80 nanograms per gigaliter?"
18:39 < nmz787> all the other info is available online
18:39 < kanzure> maaku: eh i think that's overstated
18:39 < kanzure> maaku: like maybe steroid users just fucking hate you
18:39 < kanzure> etc
18:39 < kanzure> oh wait, sorry
18:40 < kanzure> yes i do think there's possible increased aggression, but i am highly suspicious of the roid rage stuff
18:40 < maaku> but i hear contrary information about steroids -- some say it actually is health beneficial in small dosages, other say it isn't studied, etc.
18:40 < JayDugger> I'm not.
18:40 < kanzure> many people are prescribed steroids for all sorts of reasons
18:41 < maaku> i'm willing to try anything that will make me healthier, or allow me to leverage the small amount of time I have into improving my well-being (I do not work out enough)
18:41 < JayDugger> Ah...my mistake. Should've read the log farther back.
18:41 < kanzure> maaku: there's also lots of historical reasons why steroid use has been advocated against.. and the reasons are all lousy (like "those pesky soviets invented them, so you shouldn't use them")
18:42 < maaku> also, baseball. but i'm not a pro athelete, so I care fuck all about that
18:42 < nmz787> JayDugger: you're not what?
18:42 < maaku> kanzure: the "makes you a jerk" statement was about testosterone
18:42 < JayDugger> Skeptical of "roid rage."
18:42 < kanzure> well surely not all steroid users are throwing chairs at kittens or whatever
18:43 < maaku> T can make you a confident asshole
18:43 < maaku> or so i'm told by my transgender family members who are on it
18:43 < kanzure> i would be very interested in a drug that can make me more of an ass
18:44 < kanzure> my only requirement is that it must make me a good and righteous ass
18:44 < JayDugger> Right. There exists a big difference between taking prescription steroids under medical supervision and buying them "at the gym."
18:45 < JayDugger> Heh...your options on that one are pretty broad. Best ask your doctor what's right for you. :)
18:46 < maaku> well i mostly haven't ventured into nootropics, steroids, etc. because i haven't the time to investigate, I don't want to be a guinnea pig myself, and I didn't know asking a doctor could be an option
18:46 < kanzure> older men can easily ask for testosterone and get it
18:46 < kanzure> it's being marketed under the name "low T"
18:46 < kanzure> or rather, the condition that your doc has been incentivized to treat
18:47 < maaku> what do you say? "I'm too busy to work out more than once a week. Can you prescribe me some 'roids please?"
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18:47 < kanzure> for testosterone specifically? nah just go in with typical manly problems. "doc, i don't have the same youthful energy i once had, is there anything you can give me that will put hair back on my chest?"
18:47 < JayDugger> No, complain of depression, low energy, apathy, and then in the follow-up questions admit to low sex drive as if embarrassed.
18:47 < kanzure> yep
18:48 < JayDugger> kanzure's suggestion might work better, depending on your doctor.
18:48 < kanzure> nah, JayDugger's is more accurate
18:48 < JayDugger> My luck has been to have doctors who get suspicious when you recite ad keywords at them.
18:48 < kanzure> also they will measure your blood level
18:48 < JayDugger> Which is why I can't get a scrip for NuVigil from my PCP.
18:48 < JayDugger> Yeah, that too.
18:48 < kanzure> which you can manipulate since ytou know ahead of time when the blood test will be
18:49 < JayDugger> Really? How would you manipulate the blood test?
18:49 < kanzure> i've heard a few tricks regarding not eating or not sleeping, i forget which
18:49 < kanzure> something trivial like that
18:50 < JayDugger> Probably not sleeping. My intermittent fasting hasn't affected my blood test, I don't think...
18:50 < maaku> hrm those symptoms aren't a stretch anyway, although in my case i think it's just the stress of balancing work & family
18:50 < JayDugger> I'd have to look through a bunch of old test results to make certain of that.
18:51 < maaku> well if anyone has some published research they recommend looking at, i'd appreciate it
18:51 < kanzure> maaku: on a related note, have you seen the muscle montage video that joseph jackson uploaded years ago?
18:51 < maaku> no...
18:52 < nmz787> so apparently fancy mass-specs don't ensure great results for seemingly simple experiments (nicotine detection in tobacco extract)
18:52 < kanzure> he's a transhumanist friendly of ours who used to do bodybuilding (and some powerlifting?)
18:52 < kanzure> maaku: https://www.youtube.com/watch?v=kmTNtSs1UQY
18:52 < nmz787> and the chemists blame it on 'the matrix'
18:52 < kanzure> he posted that to facebook once and i gnabbed it :p
18:52 < kanzure> and now he will be reminded for eternity how ridiculous it was
18:53 < maaku> heh i'll check it out in a few minutes
18:54 < kanzure> maaku: jojack was the one that started the biocurious lab and the one in la jolla
18:54 < kanzure> biotechnbeyond i mean
19:12 < kanzure> anyway.... given a choice between very little muscle mass and.. lots.. go with lots.
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19:36 < kanzure> "The development of muscle-building properties of testosterone was pursued in the 1940s, in the Soviet Union and in Eastern Bloc countries such as East Germany, where steroid programs were used to enhance the performance of Olympic and other amateur weight lifters. In response to the success of Russian weightlifters, the U.S. Olympic Team physician John Ziegler worked with synthetic chemists to develop an anabolic steroid with reduced ...
19:36 < kanzure> ... androgenic effects.[167] Ziegler's work resulted in the production of methandrostenolone, which Ciba Pharmaceuticals marketed as Dianabol. The new steroid was approved for use in the U.S. by the Food and Drug Administration (FDA) in 1958. It was most commonly administered to burn victims and the elderly. The drug's off-label users were mostly bodybuilders and weight lifters. "
19:36 < kanzure> hmm i need a reference for the "eastern bloc countries" testosterone programs
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20:06 < fenn> nmz787: the leadscrew would have been turned down to 8mm to fit the 8mm radial bearings
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20:30 < maaku> kanzure: The Millennial Project? wow that brings back memories
20:31 < kanzure> he just sits at home writing constantly
20:31 < kanzure> that's like his superpower
20:31 < maaku> i am not ashamed to admit that book is what introduced me (indirectly) to futurism and transhumanism
20:32 < maaku> totally, absolutely incorrect on every count (Savage had no engineering background at all and it shows in retrospect), but I was 12 and impressionable and it was quite a vision
20:32 < kanzure> well, look at his revisions
20:32 < kanzure> or uh v2
20:32 < kanzure> http://tmp2.wikia.com/wiki/Main_Page
20:33 < maaku> i'm looking at it now.
20:33 < maaku> i've always wanted someone to go back and redo TMP
20:33 < kanzure> well, there you go haha
20:35 < maaku> it was a beautiful vision, one which still shapes my goals. it's why i'm here and doing what I do. solving death? that's just so I and everyone I know can have a chance to experience the vision underlying TMP.
20:35 < maaku> the vision, because the implementation described in the book was bonkers :P
20:36 < maaku> i'll definately reach out to him in any case
20:36 < kanzure> you're sitting in the only eric hunting fan club
20:36 < kanzure> although i think fenn's our resident eric hunting stalker more than i am
20:39 < maaku> think he cares about bitcoin?
20:41 < kanzure> yeah i've been emailing him about bitcoin for a while now
20:41 < kanzure> he is very much an email person
20:42 < maaku> cool
20:42 < kanzure> he is excellent at getting high-level themes right and being historically accurate or plausible, and recently i have been helping him get started on basic programming
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--- Log closed Tue Feb 17 00:00:56 2015