--- Log opened Sun May 17 00:00:14 2015
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10:55 < kanzure_> something anti-patent http://cultureandempire.com/html/cande.html
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11:06 < kanzure_> https://leastauthority.com/blog/a_bug_in_libsnark.html
11:21 < juri_> http://faikvm.com/20150403_191643.jpg
11:21 < juri_> one of my students has surpassed me.
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11:48 < kanzure> "A conditional knockout mouse line, called Prkcztm1a(EUCOMM)Wtsi[23][24] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[25][26][27]"
11:49 < kanzure> i wonder whether they have the same idea of "high-throughput" as i do, heh
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12:01 < kanzure> "As of 2008, Val66Met is probably the most investigated SNP of the BDNF gene, but, besides this variant, other SNPs in the gene are C270T, rs7103411, rs2030324, rs2203877, rs2049045 and rs7124442."
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12:40 < kanzure> http://diyhpl.us/~bryan/papers2/neuro/DNA%20methylation%20in%20memory%20formation%20-%20emerging%20insights%20-%202015.pdf
13:25 < kanzure> this is a pretty good review
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14:02 < kanzure> archels: yes/no on the memory methylation paper?
14:15 < kanzure> .wik calcineurin
14:15 < yoleaux> "Calcineurin (CN) is a protein phosphatase also known as protein phosphatase 3, and calcium-dependent serine-threonine phosphatase. It activates the T cells of the immune system and can be blocked by drugs. Calcineurin activates nuclear factor of activated T cell, cytoplasmic (NFATc), a transcription factor, by dephosphorylating it." — http://en.wikipedia.org/wiki/Calcineurin
14:17 < archels> no time right now, but have it open in a tab
14:34 < kanzure> those diagrams are awful
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15:04 < archels> okay, I'm trying out some new nootropics, so I just read most of the paper
15:04 < archels> memory suppressors vs. memory promoters, interesting
15:05 < archels> too bad they're only making experimental suggestions for tipping the balance towards suppression. Where's the hplus in that??
15:05 < archels> =)
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15:24 < kanzure> er, i think suppression in that context just means potentiation suppression, which is not the same thing as forgetting
15:25 < kanzure> i'm sure it's possible to imagine a system where data is remembered by suppression only
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15:28 < archels> indeed, like the seesaw in their diagrams, only the net outcome of (promotion - suppression) matters
15:30 < kanzure> https://z4ziggy.wordpress.com/2015/05/17/sniffing-gsm-traffic-with-hackrf/
15:32 < archels> the idea of accumulation of some factor due to hippocampal replay is also very interesting
15:32 < archels> apparently double-stranded methylation is very stable long-term, then
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15:34 < kanzure> sounds like there's some way to compare shor-term or working memory to long-term memory, and then adjust signals to attempt to kick methylation towards the correct direction for long-term retrieval reasons?
15:35 < kanzure> *short-term
15:36 < kanzure> oh maybe there are projection neurons that are used to direct or route to more efficient ways to store long-term data
15:36 < kanzure> to more specific neurons
15:36 < kanzure> rather than requiring lots of feedback to tweak a long-term memory based on methylation and gene expression shit
15:40 < kanzure> http://www.ivanyu.ca/blog/2014/2/2/wireless-das-keyboard-modification
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15:41 < archels> not sure, iterating something over and over again to get it into long-term storage is one thing, but mechanisms of forgetting are probably vastly different
15:44 < kanzure> i would be surprised if replay is the only mechanism
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15:51 < archels> indeed
15:51 < archels> a lot of learning seems to be based around repetition, but I'm not sure how unique the hippocampus is when it comes to one-shot learning, so to speak
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15:53 < kanzure> one-shot learning does not imply that replay/repetition isn't happening inside the head somewhere
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16:15 < archels> well yeah, as with the hippocampus-mediated system
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17:56 < fredox> that guy talking about cost gravity must not have bought a pc recently
17:57 < fredox> cost per benchmarked processing power has increaed ~30% over the last 5 years
18:12 -!- Taek is now known as Taek42
18:32 < andytoshi> thx for http://cultureandempire.com/html/cande.html it is very encouraging
18:32 < andytoshi> kanzure: ^
18:58 < cluckj> that seems like a bit of a rant-and-rave
18:58 < yoleaux> 11 May 2015 21:11Z <kanzure> cluckj: could you find me an anthropologist to organize #bitcoin-wizards logs?
18:58 < cluckj> lol
18:59 < cluckj> thanks yoleaux
18:59 < cluckj> kanzure, I don't know of anyone doing work with bitcoin stuff
19:05 < andytoshi> cluckj: shouldn't need too much bitcoin expertise, the stuff is generally either accessible or requires a ton of mathematical expertise to understand (in which case blindly categorizing it should be fine)
19:07 < cluckj> grinding logs might be a good use for some qualitative data crunching software
19:07 < andytoshi> cluckj: kanzure and i have tried this (him much much more than me i think) and it doesn't seem to work
19:08 < cluckj> in atlas ti or something?
19:08 < andytoshi> uh no i just strongarm stuff into spamassassin and call that "text analysis"
19:08 < cluckj> hahaha
19:13 < cluckj> I hadn't thought of that as doing some level of text analysis
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19:14 < cluckj> a specialized qualitative data analysis software might give you something interesting that you wouldn't see just by reading the logs
19:15 < andytoshi> i'd be very interested in the results of that
19:15 < andytoshi> i tried using some python package to do stuff but didn't get to the point of understanding the lingo used by text classification people
19:16 < cluckj> I have no idea how to use that software though, I can't help out there
19:16 < cluckj> all my software is in meatspace
19:18 < cluckj> I think everyone I know that has the need to use that kind of software uses atlas ti, or some crazy IBM package
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23:46 < archels> heh, DEFON tickets are cash at the door only?
23:47 < archels> no pre-registration
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--- Log closed Mon May 18 00:00:15 2015