--- Log opened Tue Sep 29 00:00:42 2015
00:19 -!- FourFire [~FourFire@185.7.192.138] has joined ##hplusroadmap
00:24 -!- FourFire [~FourFire@185.7.192.138] has left ##hplusroadmap []
00:58 -!- poppingtonic [~Thunderbi@unaffiliated/poppingtonic] has joined ##hplusroadmap
01:39 -!- nsh [~lol@wikipedia/nsh] has quit [Excess Flood]
01:39 -!- nsh [~lol@wikipedia/nsh] has joined ##hplusroadmap
01:45 -!- nsh [~lol@wikipedia/nsh] has quit [Excess Flood]
01:46 -!- nsh [~lol@wikipedia/nsh] has joined ##hplusroadmap
02:07 -!- juri_ [~juri@vpn166.sdf.org] has quit [Ping timeout: 240 seconds]
02:22 -!- poppingtonic [~Thunderbi@unaffiliated/poppingtonic] has quit [Remote host closed the connection]
02:22 -!- poppingtonic [~Thunderbi@unaffiliated/poppingtonic] has joined ##hplusroadmap
02:33 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-epoqhvkurvypvbaq] has joined ##hplusroadmap
02:42 -!- PatrickRobotham [uid18270@gateway/web/irccloud.com/x-ubvrefoxpwolunty] has joined ##hplusroadmap
02:44 -!- fleshtheworld- [~fleshthew@2602:306:cf0f:4c20:3cf5:ccc3:ad27:f328] has joined ##hplusroadmap
02:44 -!- fleshtheworld [~fleshthew@2602:306:cf0f:4c20:3cf5:ccc3:ad27:f328] has quit [Disconnected by services]
02:50 -!- midnightmagic [~midnightm@unaffiliated/midnightmagic] has quit [Ping timeout: 240 seconds]
02:52 -!- midnightmagic [~midnightm@unaffiliated/midnightmagic] has joined ##hplusroadmap
03:09 -!- poppingtonic1 [~Thunderbi@unaffiliated/poppingtonic] has joined ##hplusroadmap
03:10 -!- Houshalter [~Houshalte@oh-71-50-57-55.dhcp.embarqhsd.net] has quit [Read error: Connection reset by peer]
03:10 -!- poppingtonic [~Thunderbi@unaffiliated/poppingtonic] has quit [Ping timeout: 244 seconds]
03:10 -!- poppingtonic1 is now known as poppingtonic
03:11 -!- superkuh [~superkuh@unaffiliated/superkuh] has quit [Quit: the neuronal action potential is an electrical manipulation of reversible abrupt phase changes in the lipid bilayer]
03:34 -!- poppingtonic [~Thunderbi@unaffiliated/poppingtonic] has quit [Ping timeout: 264 seconds]
03:40 -!- poppingtonic [~Thunderbi@unaffiliated/poppingtonic] has joined ##hplusroadmap
04:21 < kanzure> beep
04:26 -!- nsh [~lol@wikipedia/nsh] has quit [Excess Flood]
04:28 < fenn> it's kind of embarrassing reading the backlog in #linuxcnc where justanotheruser doesn't have any clue what makes a good machine tool
04:29 -!- nsh [~lol@wikipedia/nsh] has joined ##hplusroadmap
04:32 < fenn> i've been holding the hand of someone who acquired a used shapeoko as he fixes it
04:33 < fenn> the ways are aluminum so you can't use anything harder than aluminum for the wheels, which means the wheels are made of plastic and wear quickly, thus losing even the semblance of accuracy it had from the original bolting-together
04:34 < fenn> the whole shapeoko design is bad, and i'm willing to break down exactly why it sucks, if anyone cares
04:38 < fenn> but please stop trying to make "a cnc" out of extruded aluminum
04:59 < fenn> this looks like about the right way to do it:
04:59 < fenn> .title http:youtu.be/ZhICrb0Tbn4
04:59 < yoleaux> fenn: Sorry, that command (.title) crashed.
04:59 < fenn> .title http://youtu.be/ZhICrb0Tbn4
04:59 < yoleaux> Hobbing (Gear cutting) on a Mini-Mill with EMC2 - YouTube
05:00 < fenn> you can also make an angled rotary axis to fit on a lathe toolpost, it doesn't even need a motor in many cases, just the action of the hob will spin the gear blank
05:12 < kanzure> i believe he was interested in reasons why it was bad, or obviously-better alternatives
05:13 < kanzure> (frankly i'm just proud he's even bothering)
05:13 < kanzure> peer pressure works!
05:14 < fenn> well machining is a specialized industrial craft and gear making is even more specialized subset of that
05:14 < fenn> just the gear cutting nomenclature takes a while to learn
05:15 < fenn> and at the end of the day, you can just buy gears
05:16 < fenn> i do think it's worth making your own timing pulleys, those things are way overpriced for what they are
05:18 < kanzure> http://finder.nhipulleys.com/
05:20 < fenn> those are not timing pulleys
05:21 < kanzure> agreed.
05:21 -!- Viper168 [~Viper@unaffiliated/viper168] has quit [Ping timeout: 246 seconds]
05:28 -!- Viper168 [~Viper@unaffiliated/viper168] has joined ##hplusroadmap
05:43 -!- Viper168 [~Viper@unaffiliated/viper168] has quit [Ping timeout: 246 seconds]
05:46 -!- Viper168 [~Viper@unaffiliated/viper168] has joined ##hplusroadmap
05:49 -!- fleshtheworld- [~fleshthew@2602:306:cf0f:4c20:3cf5:ccc3:ad27:f328] has quit [Read error: Connection reset by peer]
06:08 -!- zadock [~outsider@cthulhu.tuiasi.ro] has joined ##hplusroadmap
06:09 -!- zadock [~outsider@cthulhu.tuiasi.ro] has quit [Remote host closed the connection]
06:09 < kanzure> "SOX17 Is a Critical Specifier of Human Primordial Germ Cell Fate" http://www.cell.com/cell/abstract/S0092-8674(14)01583-9
06:17 < kanzure> for artificial uterus reproduction, should select for embryos that are able to survive the artificial uterus (and somewhat iterating on the device too), instead of only pandering to all of the requirements of currently-available embryos and their current genetic program.
06:20 < kanzure> 06:19 < Betawolf> no, wait, you could just freeze a load of them and introduce them to your tweaked uterus
06:20 < kanzure> 06:20 < kanzure> perhaps- but embryos themselves might have guards against "oops i am in a womb with 20 other embryos, none of us will survive, abort abort"
06:30 -!- eudoxia [~eudoxia@r167-57-74-100.dialup.adsl.anteldata.net.uy] has joined ##hplusroadmap
06:36 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-epoqhvkurvypvbaq] has quit [Quit: Connection closed for inactivity]
06:37 < kanzure> machinist bitcoiner we should stalk: https://www.reddit.com/user/SadieD
06:41 < kanzure> re: artificial womb plans above; nutrient problems will be catastrophic, so each stage of growth should be validated by comparing against typical in utero growth results. any deviations should be carefully tracked because otherwise you may end up with brain damage.
06:41 -!- Madplatypus [uid19957@gateway/web/irccloud.com/x-iklkfeyijbmfbmta] has quit [Quit: Connection closed for inactivity]
06:42 < kanzure> (and it's harder to do selection for embryos that don't end up with brain damage, because the brain damage is only noticeable near the later stages, so the timeline is extended and selection frequency has to go down)
06:43 < kanzure> not sure how to deal with placenta substitute
06:45 < Betawolf> is there a reason you're not just growing a uterus first?
06:45 < fenn> grow a pair
06:45 < kanzure> growing a uterus is hard
06:46 < kanzure> and afaik we can't currently do that
06:46 < Betawolf> engineering one might be harder, you have to manage all the hormone controls and the bits which assume there's a larger bloodstream to manipulate a host through
06:47 < kanzure> i believe we already have working embryo development up to some number of days (more than one day of development), so selection could continue from that point
06:47 < kanzure> but i see your point; would probably be easier to start with some non-human species too.
06:48 < Betawolf> legally, certainly
06:48 < Betawolf> also in terms of gestation length
06:49 < Betawolf> the fallback of mice would be fairly good there, and mice-human generalisability is probably well-studied
06:49 < kanzure> "A comparison of placental development and endocrine functions between the human and mouse model" http://humupd.oxfordjournals.org/content/9/6/531.full.pdf
06:50 < Betawolf> also, marketable -- an artificial mouse uterus could be valuable to other researchers by itself
06:50 < kanzure> that's not as useful
06:51 < Betawolf> I guess, mice are pretty cheap
06:51 < kanzure> better link http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.325.4526&rep=rep1&type=pdf
06:51 < Betawolf> but the ability to manipulate in-utero development with more precision would be good
06:52 < kanzure> ah so, in utero electroporation isn't enough for you?
06:56 < Betawolf> hadn't heard of that, looking it up, perhaps it negates the benefits here.
07:02 -!- poppingtonic [~Thunderbi@unaffiliated/poppingtonic] has quit [Remote host closed the connection]
07:03 -!- poppingtonic [~Thunderbi@unaffiliated/poppingtonic] has joined ##hplusroadmap
07:07 -!- drethelin [~drethelin@24-241-226-112.dhcp.mdsn.wi.charter.com] has quit [Ping timeout: 264 seconds]
07:20 < archels> "1st IEEE IROS Futurist Forum"
07:20 < archels> am I going to go to this tomorrow?
07:20 < archels> http://www.iros2015.org/index.php/program/futurist-forum
07:25 < maaku> why would you go to it?
07:26 < archels> well, I'm trying to pick the least boring talks to go to
07:27 < kanzure> epistemology stuff is sometimes fun, but "future of society and cognition" does not sound like an epistemology thing
07:28 < kanzure> "Reconstructed Brain Models for Virtual Bodies and Robots" talks about human brain project robotics platform thingy
07:28 < maaku> futurist events are places for peoplele hwo don't do anything to feel better about someone else doing the work :(
07:29 < maaku> the real question is who is going and whether it is worth going to corner them in the hallways
07:29 < kanzure> also the stuff under "2nd International Workshop on Aerial Open Source Robotics" looks interesting
07:29 < kanzure> https://ras.papercept.net/conferences/conferences/IROS15/program/IROS15_ProgramAtAGlanceWeb.html#mowsafternoon-22
07:30 < kanzure> maybe "Real-Time Cognitive Computing for Service Robots"
07:31 < fenn> isn't "cognitive computing" an ibm trademark
07:32 < archels> that one's already in the past, I went for the Bremen University lab tours instead
07:32 < archels> definitely going to Gewaltig's plenary, but the other talks so far have kindof disappointed
07:32 < kanzure> "Unmanned Aerial Systems 1/2" or "Surgical Robots 1/2" or "Manipulation Planning and Control 1/2" or "Biologically-Inspired Robots 1/2" or "Joint/Mechanism Design" all look somewhat tolerable
07:33 < archels> there's lots of robot hardware here (pics later), but the control of it all is pretty shit
07:33 < archels> I think my expectations are too high
07:34 < kanzure> "wearable robots"
07:34 < kanzure> "Space Robotics and Automation"
07:34 < kanzure> "Actuation and Mechanism"
07:34 < kanzure> "Robotics in Construction"
07:34 < kanzure> "New Actuators"
07:35 < kanzure> "Bioinspired Underwater Robotics"
07:35 < kanzure> alright that's all i see
07:36 < archels> yeah had no idea underwater robotics was so big. But there's lots of money in it, obviously.
07:37 < fenn> it's a huge growth area
07:37 < archels> did you know there's a fibre-based underwater 100 Mbps network off the West coast of the states, hundreds of kilometres into the pacific?
07:37 < fenn> only 100Mbit?
07:38 < kanzure> new ed boyden stuff: http://syntheticneurobiology.org/publications
07:39 < cpopell4> kanzure : biologically inspired unmanned aerial surgical robots
07:39 < archels> there are junction boxes at set intervals that the ROVs, tethered to the ship, plug the robots into that they're releasing
07:40 < kanzure> "Processes for design, construction and utilisation of arrays of light-emitting diodes and light-emitting diode-coupled optical fibres for multi-site brain light delivery" http://syntheticneurobiology.org/publications/publicationdetail/238/25
07:40 < kanzure> oops bad link, i mean http://syntheticneurobiology.org/PDFs/15.05.bernstein.FULL.pdf
07:40 < kanzure> "Transgenic Mice for Intersectional Targeting of Neural Sensors and Effectors with High Specificity and Performance" http://syntheticneurobiology.org/PDFs/15.03.madisen.FULL.pdf
07:40 < kanzure> "Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory" http://syntheticneurobiology.org/PDFs/15.07.li.pdf
07:40 < fenn> cpopell4: now you know what the harvard bee is for
07:41 < kanzure> "Close-Packed Silicon Microelectrodes for Scalable Spatially Oversampled Neural Recording" http://syntheticneurobiology.org/publications/publicationdetail/234/25
07:41 < kanzure> gah i keep doing that
07:41 < kanzure> wanted http://syntheticneurobiology.org/PDFs/15.02.scholvin.pdf
07:41 < kanzure> "A direct-to-drive neural data acquisition system" http://syntheticneurobiology.org/PDFs/15.09.kinney.pdf
07:42 < kanzure> man.. what. how is that novel? that's so sad. we literally haven't had people dumping data from an ADC straight to storage?
07:44 < archels> bandwidth becomes a bit restrictive with the new ~10^3 contact site probes
07:44 < kanzure> http://syntheticneurobiology.org/PDFs/15.05.guo.FULL.pdf "Cell-type specific expression is trivial to realize in laboratory animals, where Cre-loxP transgenic recombination systems used in conjunction with Cre-dependent viruses ensure that transcription of viral constructs are limited to the cell
07:44 < kanzure> type of interest[52]"
07:45 < kanzure> [52] Madisen, L. et al. A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing, Nature  Neuroscience 15, 793–802 (2012)
07:45 < archels> people messing around with PCI cards and so
07:45 < archels> after they come to the realisation that USB is too slow
07:45 < kanzure> [53] Dittgen, T. et al. Lentivirus-based genetic manipulations of cortical neurons and their optical and electrophysiological monitoring in vivo. Proc. Natl. Acad. Sci. USA 101, 18206–18211 (2004).
07:58 < justanotheruser> fenn: sorry to disappoint
08:01 < fenn> it's always surprising to find that people don't think the way you do
08:02 < fenn> we don't have enough spare brain matter to simulate an entirely alien way of thought so it just loops back onto your normal mental process with some footnotes attached
08:05 < justanotheruser> I have zero experience with machining
08:05 < justanotheruser> let me take that back, I watched someone cut some metal for me once
08:05 < justanotheruser> horizontally, no fancy shapes
08:06 < fenn> if you are interested in learning, the standard advice is to take a course at a night school or vocational college
08:06 < kanzure> bring candy to the resident machinists employed by your university
08:06 < kanzure> or pizza
08:06 < kanzure> pizza is less weird
08:07 < fenn> show up in a white van with lots of blankets in the back? (so the scrap metal doesn't scratch up the interior you pervs)
08:07 < maaku> yeah actually taking a basic machine shop class is pretty enlightening
08:08 < maaku> and relatively cheap at a community college, vocational school, or tech shop
08:08 < fenn> tech shop won't teach you the theory and practice
08:08 < justanotheruser> Does a standard class teach hobbing, milling, routing, and all the other important stuff?
08:08 < kanzure> university's machine shop probably does free training
08:08 < fenn> probably not hobbing or routing
08:08 < justanotheruser> mhm
08:08 < kanzure> will be found below the mechanical engineering building
08:08 < fenn> there is a whole crapton of knowledge beyond basic safety training
08:09 < fenn> it's not something you master in a weekend (or a lifetime)
08:09 < justanotheruser> no machining or milling related club
08:09 < justanotheruser> we have a 3d printing club
08:09 < justanotheruser> perhaps night school is the best option
08:09 < maaku> justanotheruser: wouldn't expect there to be a club
08:10 < maaku> as kanzure says, looks to the mechanical engineering dept
08:10 < fenn> physics building sometimes has a shop but you probably need to be a grad student to use it
08:10 < justanotheruser> We have one in our research park, looking into training
08:10 < justanotheruser> nah, it looks like they just do work
08:11 < justanotheruser> I'll see if the mechanical engineering dept has one
08:11 < fenn> anyway just poking your nose in and looking around will give you an idea of what works and what doesn't work
08:11 < justanotheruser> check out this retro page https://engineering.purdue.edu/MECL/pshop/
08:11 < fenn> you won't see any 80/20 extrusions doing metal removal
08:11 < kanzure> looks about right
08:12 < fenn> i have those black dial calipers on my desk 4 inches from the keyboard
08:17 < justanotheruser> I'll talk to some vocational school instead
08:20 < fenn> https://engineering.purdue.edu/MECL/pshop/tour/shop4.jpg
08:21 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap
08:24 < fenn> looks like a pretty well equipped teaching shop, you'd be spoiled after that
08:40 -!- eudoxia_ [~eudoxia@r167-56-136-245.dialup.adsl.anteldata.net.uy] has joined ##hplusroadmap
08:40 -!- eudoxia_ [~eudoxia@r167-56-136-245.dialup.adsl.anteldata.net.uy] has quit [Remote host closed the connection]
08:40 -!- eudoxia [~eudoxia@r167-57-74-100.dialup.adsl.anteldata.net.uy] has quit [Read error: Connection reset by peer]
08:42 < kanzure> 08:41 <@gwern> Burninate: I looked at it but the whole area of willpower is very confusing right now
08:42 < kanzure> 08:41 <@gwern> ever since kurzban's big review pretty much demolishing it
08:42 < kanzure> good
08:42 < fenn> link?
08:43 < kanzure> maybe this one: http://slatestarcodex.com/2015/03/12/book-review-willpower/
08:43 < kanzure> or maybe http://epjournal.net/blog/2011/08/glucose-is-not-willpower-fuel/
08:43 < fenn> no
08:43 < fenn> maybe
08:43 < kanzure> maybe http://lesswrong.com/lw/jan/kurzban_et_al_on_opportunity_cost_models_of/
08:45 < fenn> "the fact that the brain is an information-processing system" uh huh
08:45 < fenn> sure it is
08:45 < fenn> and so is my pet rock
08:45 < kanzure> even a rock has information processing capacity, but it might be only one bit or something
08:46 < fenn> it computes being a rock
08:46 < Burninate> That was from https://www.reddit.com/r/science/comments/3mtp80/selfcontrol_saps_memory_resources_new_research/
08:46 < kanzure> "it computes being a rock" i think this is why you're not a scientist
08:47 < archels> .wik Kidnapped robot problem
08:47 < yoleaux> "In robotics, the kidnapped robot problem commonly refers to a situation where an autonomous robot in operation is carried to an arbitrary location." — https://en.wikipedia.org/wiki/Kidnapped_robot_problem
08:48 < fenn> kanzure: it's somewhat tongue in cheeck, the MIT CBA people look at the world that way
08:48 < fenn> i get pissy when people think the brain is a {watch, computer, $machine_of_the_day}
08:49 < archels> $metaphorOfTheDay
08:49 < kanzure> yes yes, i know. it was funny.
08:49 < archels> the brain is a switchboard!
08:50 < fenn> a tank of water!
08:50 < fenn> oh wait that was a battery
08:50 < archels> thet brain is a battery! It generates potentials!
08:51 < fenn> hey let's hook up the human race to pods and use them to generate electricity
08:51 < fenn> it'll be the least efficient lulz generator ever
08:51 < archels> dude, there are lots of robots around me now staring back at me. stop freaking me out
08:52 < kanzure> don't worry, they are busy being preoccupied with the existential horror of their existence
08:52 < archels> ah, that must be why they invariably seem so stricken with ennui
08:59 < fenn> i wonder if anyone has looked at waste-accumulation as the "resource" that is being "depleted"
08:59 < kanzure> there was someone that looked at waste removal/cleanup and sleep
08:59 < fenn> yes
09:01 < archels> sounds Aubrey de Grey-ish
09:01 < archels> or did you mean on the shorter term
09:01 < kanzure> nope wasn't him
09:01 < archels> there was the whole CSF and intracellular spacing thing
09:02 < kanzure> .title http://www.sciencemag.org/content/342/6156/373
09:02 < yoleaux> Sleep Drives Metabolite Clearance from the Adult Brain
09:02 < kanzure> there was also another one that was about waste-specific physical pathways for draining or something. not sure.
09:03 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-kjezprzmqdmizflg] has joined ##hplusroadmap
09:03 < archels> yeah that's the one
09:33 -!- PatrickRobotham [uid18270@gateway/web/irccloud.com/x-ubvrefoxpwolunty] has quit [Quit: Connection closed for inactivity]
09:33 < fenn> i'm mildly disappointed that kurzban wasn't the handle of someone who hated kurzweil
09:34 -!- QuadIngi [~FourFire@185.7.192.138] has joined ##hplusroadmap
09:38 < kanzure> kurzwreked
09:40 < fenn> "Remarkably, given that fatigue has been studied formally for well over 100 years, there is still no scientifically mature theory of its origins and functions."
09:41  * fenn remarks
09:43 -!- poppingtonic1 [~Thunderbi@unaffiliated/poppingtonic] has joined ##hplusroadmap
09:44 -!- poppingtonic [~Thunderbi@unaffiliated/poppingtonic] has quit [Ping timeout: 272 seconds]
09:44 -!- poppingtonic1 is now known as poppingtonic
09:53 < maaku> fenn: meaning mental fatigue?
09:54 < fenn> yes
09:56 < kanzure> mental whatnow? :-)
09:58 < fenn> that thing that happens when you stop taking adderall
09:59 -!- Daeken [~daeken@demoseen.com] has quit [Quit: Lost terminal]
09:59 < fenn> one day i realized that the reason it seemed like i never got anything done was because everyone else was cheating and drinking coffee
09:59 -!- Daeken [~daeken@demoseen.com] has joined ##hplusroadmap
10:00 < kanzure> or because they are lying; try tracking what they claim to have accomplished versus actual results.
10:04  * fenn clears some brain metabolites
10:05 < kanzure> .title http://www.nature.com/ncomms/2015/150915/ncomms9264/full/ncomms9264.html
10:05 < yoleaux> Sonogenetics is a non-invasive approach to activating neurons in Caenorhabditis elegans : Nature Communications : Nature Publishing Group
10:05 -!- drethelin [~drethelin@24-241-226-112.dhcp.mdsn.wi.charter.com] has joined ##hplusroadmap
10:24 -!- vivi2 [~vivi@inhu.me] has quit [Read error: Connection reset by peer]
10:24 -!- vivi2 [~vivi@inhu.me] has joined ##hplusroadmap
10:43 -!- omanomanooer [~omanomano@unaffiliated/omanomanooer] has joined ##hplusroadmap
11:02 -!- poppingtonic1 [~Thunderbi@unaffiliated/poppingtonic] has joined ##hplusroadmap
11:03 -!- poppingtonic [~Thunderbi@unaffiliated/poppingtonic] has quit [Ping timeout: 264 seconds]
11:03 -!- poppingtonic1 is now known as poppingtonic
11:15 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Remote host closed the connection]
11:16 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap
11:47 -!- marchtemp [~bitnami@ec2-54-69-125-142.us-west-2.compute.amazonaws.com] has left ##hplusroadmap ["WeeChat 0.4.2"]
11:49 -!- Viper168 [~Viper@unaffiliated/viper168] has quit [Ping timeout: 246 seconds]
11:57 -!- Viper168 [~Viper@unaffiliated/viper168] has joined ##hplusroadmap
12:06 -!- poppingtonic1 [~Thunderbi@unaffiliated/poppingtonic] has joined ##hplusroadmap
12:08 -!- poppingtonic [~Thunderbi@unaffiliated/poppingtonic] has quit [Ping timeout: 250 seconds]
12:10 -!- poppingtonic1 [~Thunderbi@unaffiliated/poppingtonic] has quit [Ping timeout: 240 seconds]
12:28 -!- QuadIngi [~FourFire@185.7.192.138] has quit [Ping timeout: 255 seconds]
12:28 < kanzure> cathal posting about libgen stuff https://www.reddit.com/r/Scholar/comments/3bs1rm/meta_the_libgenscihub_thread_howtos_updates_and/cu5oebb
12:32 < kanzure> maaku: quite sneaky of you https://www.reddit.com/r/Transhuman/comments/3l59ou/opportunities_to_further_the_goals_of/
12:37 < cpopell4> maaku if you're ex-nasa, are you MD based?
12:38 -!- math3 [uid54897@gateway/web/irccloud.com/x-nbmlxhhwphjjhzcr] has joined ##hplusroadmap
12:38 -!- justanotheruser [~Justan@unaffiliated/justanotheruser] has quit [Read error: Connection reset by peer]
12:40 -!- justanotheruser [~Justan@unaffiliated/justanotheruser] has joined ##hplusroadmap
12:40 < kanzure> can't find this in the logs, not sure if i've mentioned this, but kent kemmish had an idea about doing one-pot large batch selection of dna polymerase for responsiveness to electrical conduction somehow. i don't remember the exact details of the technique, but it didn't require emulsions for some reason.
12:42 -!- archels_ [charl@toad.stack.nl] has joined ##hplusroadmap
12:44 -!- archels [charl@toad.stack.nl] has quit [Ping timeout: 264 seconds]
12:46 < kanzure> crispr-cpf1 http://www.cell.com/cell/abstract/S0092-8674(15)01200-3
12:46 < kanzure> .title
12:46 < yoleaux> kanzure: Sorry, that doesn't appear to be an HTML page.
12:47 < kanzure> "Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System"
12:47 < kanzure> "Cpf1 is a CRISPR-associated two-component RNA-programmable DNA nuclease; Targeted DNA is cleaved as a 5-nt staggered cut distal to a 5′ T-rich PAM; Two Cpf1 orthologs exhibit robust nuclease activity in human cells"
13:04 -!- FourFire [~FourFire@19-68-11.connect.netcom.no] has joined ##hplusroadmap
13:09 -!- HEx1 [~HEx@hexwab.plus.com] has quit [Ping timeout: 240 seconds]
13:11 -!- c0rw|zZz [~c0rw1n@91.176.79.56] has quit [Ping timeout: 246 seconds]
13:18 -!- Madplatypus [uid19957@gateway/web/irccloud.com/x-bvqardjnftwvvdgr] has joined ##hplusroadmap
13:22 -!- HEx [~HEx@hexwab.plus.com] has joined ##hplusroadmap
13:23 -!- HEx is now known as Guest45818
13:28 -!- FourFire [~FourFire@19-68-11.connect.netcom.no] has left ##hplusroadmap ["Leaving"]
13:44 -!- sandeepkr [~sandeepkr@111.235.64.135] has quit [Ping timeout: 250 seconds]
13:46 -!- fleshtheworld [~fleshthew@2602:306:cf0f:4c20:f9c7:d289:1342:6f32] has joined ##hplusroadmap
14:19 < maaku> cpopell4: california. nasa ames
14:19 < maaku> kanzure: it just happened to be the convenient truth
14:19 < cpopell4> maaku : ahh, k. My GF is at JHUAPL
14:25 < maaku> cpopell4: ah that's a cool place to work
14:25 < maaku> i interfaced with a bunch of people over ther
14:27 < cpopell4> maaku : yeah, though she's moving to private enterprise next year
14:35 < kanzure> "If/since some/most experiments show no benefit from youthful plasma/blood exchange, then I hypothesize that in heterochronic parabiosis, what is happening is that the young mouse's entire organism/systems (Not its unmodified young blood) are responding to the old mouse's biomarkers carried into the young mouse via the aged mouse blood. These Old markers are interpreted as (for instance) injury and anomalous characteristics by the young ...
14:36 < kanzure> ... mouse's systems that are no longer considered anomalous by the old mouse's systems. If this hypothesis has merit, it predicts that simple plasma or whole blood exchanges will NOT induce reversal of aging. I believe this experiment has already happened and has been falsified via chronic blood transfusions in (for instance) early dialysis patients and others who have had to have multiple transfusuons. Statistically, many of such ...
14:36 -!- erasmus [~esb@unaffiliated/erasmus] has joined ##hplusroadmap
14:36 < kanzure> ... individuals should have benefitted from a lucky coin flipping outcome, and thus experienced significant benefits. If true, this implies that Aging to a significant degree appears to be based on a countdown clocking system that may be very widely distributed in an organism. In other words, aging is a program."
14:36 -!- erasmus [~esb@unaffiliated/erasmus] has quit [Max SendQ exceeded]
14:37 < maaku> kanzure: unfortunately StealerofSuns needs a bouncer. he showed up here a few days ago and then disappeared
14:38 -!- erasmus [~esb@unaffiliated/erasmus] has joined ##hplusroadmap
14:39 -!- erasmus [~esb@unaffiliated/erasmus] has quit [Read error: Connection reset by peer]
14:44 -!- erasmus [~esb@unaffiliated/erasmus] has joined ##hplusroadmap
14:44 -!- erasmus [~esb@unaffiliated/erasmus] has quit [Max SendQ exceeded]
14:44 -!- c0rw|zZz [~c0rw1n@91.176.79.56] has joined ##hplusroadmap
14:44 -!- erasmus [~esb@unaffiliated/erasmus] has joined ##hplusroadmap
15:22 -!- Viper168 [~Viper@unaffiliated/viper168] has quit [Ping timeout: 246 seconds]
15:32 -!- Houshalter [~Houshalte@oh-71-50-57-55.dhcp.embarqhsd.net] has joined ##hplusroadmap
15:40 -!- c0rw|zZz is now known as c0rw1n
15:43 -!- omanomanooer [~omanomano@unaffiliated/omanomanooer] has quit [Remote host closed the connection]
15:45 < maaku> kanzure: you got something against clifford wolf?
15:46 < kanzure> openscad
15:48 < maaku> ah
15:48 < kanzure> triangles everywhere
15:48 < kanzure> reinventing languages just for cad? weak
15:49 < kanzure> he has since moved on though
15:53 < maaku> I once looked down on complicated geometrical representations, since any 3d polymesh can be represented with triangles
15:53 < maaku> then i tried writing finite element analysis and getting consistent results
15:53 < kanzure> hard to express curves with just triangles
15:54 < maaku> oh well yeah you need some curve structure too. although just one will do
15:54 < kanzure> boolean operations on surface-surface intersections is ugh, and triangle representation leads to loss of quality
15:54 < kanzure> plus, as the size of your model increases, memory consumption balloons
15:54 < kanzure> (with triangle bag approach)
15:55 < kanzure> but anyway; none of this necessitates a custom new language integrated into an IDE or whatever.
15:56 < kanzure> maaku: have i complained about opencascade to you before? http://diyhpl.us/wiki/cad/opencascade/
15:56 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Ping timeout: 255 seconds]
16:00 < maaku> no not yet
16:01 < kanzure> opencascade is one of the few canonical example of open-source cad kernels (other than brlcad, which is written by the military)
16:03 -!- yashgaroth [~ffffff@2602:306:35fa:d500:f5e0:f867:a11d:8d52] has joined ##hplusroadmap
16:06 < kanzure> yashgaroth: how goes summer of freedom?
16:06 < yashgaroth> awaiting exit interview thursday morn
16:07 < yashgaroth> the urge to burn bridges is strong, but if I've learned anything about biotech, it's an very incestuous community
16:10 -!- Guest45818 is now known as HEx1
16:19 -!- AmbulatoryCortex [~Ambulator@173-31-155-69.client.mchsi.com] has joined ##hplusroadmap
16:23 -!- Betawolf [~matthew@xn--bta-yla.net] has quit [Ping timeout: 256 seconds]
16:33 -!- abetusk [~abe@c-66-31-30-204.hsd1.ma.comcast.net] has quit [Ping timeout: 246 seconds]
16:33 -!- thundara_ [~thundara@jean.markov.codes] has quit [Ping timeout: 246 seconds]
16:34 -!- thundara [~thundara@jean.markov.codes] has joined ##hplusroadmap
16:34 -!- abetusk [~abe@c-66-31-30-204.hsd1.ma.comcast.net] has joined ##hplusroadmap
16:34 -!- abetusk is now known as Guest3589
17:28 -!- Guest3589 is now known as abetusk
17:37 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=28eda632 Bryan Bishop: transcript of mike walfish talk on snarks >> http://diyhpl.us/diyhpluswiki/transcripts/simons-institute/a-wishlist-for-verifiable-computation/
17:48 -!- drewbot [~cinch@ec2-54-196-16-177.compute-1.amazonaws.com] has quit [Remote host closed the connection]
17:48 -!- drewbot [~cinch@ec2-54-81-165-74.compute-1.amazonaws.com] has joined ##hplusroadmap
18:04 -!- erasmus [~esb@unaffiliated/erasmus] has quit [Quit: Namaste	]
18:10 -!- erasmus [~esb@unaffiliated/erasmus] has joined ##hplusroadmap
18:23 -!- erasmus [~esb@unaffiliated/erasmus] has quit [Quit: Namaste	]
18:24 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=ac254d8e Bryan Bishop: transcript: eran tromer, snarks >> http://diyhpl.us/diyhpluswiki/transcripts/simons-institute/snarks-and-their-practical-applications/
18:25 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=9fd6306e Bryan Bishop: typofix: greg -> craig >> http://diyhpl.us/diyhpluswiki/transcripts/simons-institute/a-wishlist-for-verifiable-computation/
18:26 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-kjezprzmqdmizflg] has quit [Quit: Connection closed for inactivity]
18:38 < kanzure> http://selenianboondocks.com/2015/09/mars-surface-shielding-from-radiation/
18:46 -!- yoleaux [~yoleaux@xn--ht-1ia18f.nonceword.org] has quit [Remote host closed the connection]
18:46 -!- yoleaux [~yoleaux@xn--ht-1ia18f.nonceword.org] has joined ##hplusroadmap
18:47 -!- yoleaux [~yoleaux@xn--ht-1ia18f.nonceword.org] has quit [Client Quit]
18:47 -!- yoleaux [~yoleaux@xn--ht-1ia18f.nonceword.org] has joined ##hplusroadmap
18:47 -!- yoleaux [~yoleaux@xn--ht-1ia18f.nonceword.org] has quit [Client Quit]
18:47 -!- yoleaux [~yoleaux@xn--ht-1ia18f.nonceword.org] has joined ##hplusroadmap
19:10 < kanzure> http://garzikrants.blogspot.com/2015/09/decoupling-financial-indices-with.html
19:20 < kanzure> " Simple injections of young 'blood' were sufficient to increase neurogenesis in the brain of older animals - and that is impossible given your thesis as there's no involvement of the entire young animal in that.  Also Saul Villeda showed that simple injections of eotaxin, a chemokine that accumulates with age, were enough to decreases neurogenesis in the brain. Now it would seem, if nothing else, that the injection experiments ...
19:20 < kanzure> ... necessarily show some 'positive' factors in young blood plasma (able to incite old neural precursors to become neurons) - as no dilution was involved, while the original Villeda experiments show that negative factors exist in the blood of old animals able to repress neurogenesis. And of course all the old tissue and organ transplantation experiments show that it's the old tissues that become rejuvenated by purely humoral factors, ...
19:20 < kanzure> ... there are no cellular inputs from the hosts."
19:24 < catern> brb injecting baby blood
19:25 < catern> will it work if i just drink it?
19:25 < kanzure> ask the priests
19:30 < yashgaroth> gotta mainline that shit
19:32 < JayDugger> I hear anointing, if done properly, also works.
20:05 -!- Viper168 [~Viper@unaffiliated/viper168] has joined ##hplusroadmap
20:21 -!- erasmus [~esb@unaffiliated/erasmus] has joined ##hplusroadmap
20:34 < erasmus> justanotheruser is a convicted pedophile and has a record.
20:34 < justanotheruser> I thought you said you were going to use your botnet to harass me? this is too easy :(
20:34 < erasmus> it's known he likes little boys.
20:34 < erasmus> pedophile
20:35 < erasmus> you make me sick
20:35 < erasmus> you are as bad as bluelobster
20:37 -!- AmbulatoryCortex [~Ambulator@173-31-155-69.client.mchsi.com] has quit [Read error: Connection reset by peer]
20:37 < erasmus> justanotherchild_offender.
21:32 < fenn> offend all the children!
21:32 < fenn> inject their young "blood"!
21:34 < fenn> heil kkkrist http://2.bp.blogspot.com/-6arA2h1sOSs/UdBHs3DC-II/AAAAAAAAGrs/1EN5LDA0mcY/s1600/IMG_0267.JPG
21:40 -!- sandeepkr [~sandeepkr@111.235.64.135] has joined ##hplusroadmap
21:46 < cpopell> hurrah, I understand the most basics of church numerals!
21:50 < mgin> what the fuck?
21:58 -!- Houshalter [~Houshalte@oh-71-50-57-55.dhcp.embarqhsd.net] has quit [Ping timeout: 244 seconds]
22:11 -!- Houshalter [~Houshalte@oh-71-50-57-55.dhcp.embarqhsd.net] has joined ##hplusroadmap
22:13 < fenn> "The inventor has been invited to the white house, got a job offer at facebook and twitter, will be admitted at stanford and is probably going to pass 2 million followers" <- any guesses as to what the invention was?
22:16 < Stskeeps> fenn: the exocortex says an electro-mechanical clock with liquid display :P
22:30 -!- math3 [uid54897@gateway/web/irccloud.com/x-nbmlxhhwphjjhzcr] has quit [Quit: Connection closed for inactivity]
22:33 -!- yashgaroth [~ffffff@2602:306:35fa:d500:f5e0:f867:a11d:8d52] has quit [Quit: Leaving]
22:44 -!- nsh [~lol@wikipedia/nsh] has quit [Excess Flood]
22:51 -!- nsh [~lol@wikipedia/nsh] has joined ##hplusroadmap
23:49 -!- PatrickRobotham [uid18270@gateway/web/irccloud.com/x-yhgakdcsjzfqhgfj] has joined ##hplusroadmap
--- Log closed Wed Sep 30 00:00:43 2015