--- Log opened Sat Oct 03 00:00:46 2015
00:08 < JayDugger> Yeah, well, if kanzure's going to speak, best he knows the audience.
00:14 < kanzure> well htat's okay it's not like we needed two stars in our system anyway
00:14 < kanzure> doesn't look like they have room
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07:01 < kanzure> his presidential campaign is more amusing than i anticipated http://www.transhumanistparty.org/ZoltanIstvan.html
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07:04 < CaptHindsight> president Zoltan sounds great
07:04 < kanzure> right?
07:04 < CaptHindsight> was picturing him in a silver suit or similar
07:06 < kanzure> you mean like http://i2.wp.com/www.timemachinego.com/linkmachinego/wordpress/wp-content/uploads/2009/08/neil-before-zod.jpg?resize=338%2C270 ?
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07:08 < CaptHindsight> https://upload.wikimedia.org/wikipedia/commons/thumb/2/23/Day_the_Earth_Stood_Still,_1951_-_trailer.ogv/220px--Day_the_Earth_Stood_Still,_1951_-_trailer.ogv.jpg
07:08 < kanzure> ah, well that's the style these days, you know
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08:05 < justanotheruser> that page looks like its for a '96 election
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08:56 < kanzure> yes well he's also a time traveler
09:05 < kanzure> .title https://www.youtube.com/watch?v=NdSD07U5uBs
09:05 < yoleaux> Alan Kay, 2015: Power of Simplicity - YouTube
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11:25 < kanzure> .title http://arxiv.org/abs/1509.07175
11:25 < yoleaux> [1509.07175] Exploration and Exploitation of Victorian Science in Darwin's Reading Notebooks
11:25 < kanzure> "Darwin built his theory of natural selection in part by synthesizing disparate parts of Victorian science. When we analyze his extensively self-documented reading we find shifts, on multiple timescales, between choosing to remain with familiar topics and seeking cognitive surprise in novel fields. On the longest timescales, these shifts correlate with major intellectual epochs of his career, as detected by Bayesian epoch estimation. ...
11:25 < kanzure> ... When we compare Darwin's reading path with publication order of the same texts, we find Darwin more adventurous than the culture as a whole."
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12:59 < kanzure> "Multiplex CRISPR/Cas9-based genome engineering from a single lentiviral vector "
12:59 < kanzure> "... we developed a single lentiviral system to express a Cas9 variant, a reporter gene and up to four sgRNAs from independent RNA polymerase III promoters that are incorporated into the vector by a convenient Golden Gate cloning method. Each sgRNA is efficiently expressed and can mediate multiplex gene editing and sustained transcriptional activation in immortalized and primary human cells...
12:59 < kanzure> from http://nar.oxfordjournals.org/content/42/19/e147
13:00 < kanzure> "Efficient chromosomal gene modification with CRISPR/cas9 and PCR-based homologous recombination donors in cultured Drosophila cells" http://nar.oxfordjournals.org/content/42/11/e89
13:00 < kanzure> "Using cultured Drosophila melanogaster S2-cells and the phosphoglycerate kinase gene as a model, we reached targeted integration frequencies of up to 50% in drug-selected cell populations. Homology arms as short as 29 nt appended to the PCR primer resulted in detectable integration, slightly longer extensions are beneficial."
13:02 < kanzure> "A high-resolution network model for global gene regulation in Mycobacterium tuberculosis" http://nar.oxfordjournals.org/content/42/18/11291
13:03 < kanzure> i am still okay about meganucleases
13:05 < kanzure> "A platform for rapid prototyping of synthetic gene networks in mammalian cells" http://nar.oxfordjournals.org/content/42/21/13440
13:05 < kanzure> "We demonstrate the potential of this framework by assembling and integrating different functional mammalian regulatory networks including the largest gene circuit built and chromosomally integrated to date (6 transcription units, 27kb) encoding an inducible memory device. Using a library of 18 different circuits as a proof of concept, we also demonstrate that our method enables one-pot/single-flask chromosomal integration and screening ...
13:05 < kanzure> ... of circuit libraries"
13:06 < kanzure> review of discovery of endonucleases http://nar.oxfordjournals.org/content/42/1/3
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14:33 < kanzure> fenn: hexagons http://brtmr.de/index.html
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16:06 < justanotheruser> is anything from cppcon other than bjarne and herbs talks worth watching?
16:59 < kanzure> i haven't looked
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17:26 < kanzure> opencascade/oce/occt scheduled chat on monday october 5 at 9pm UTC at https://gitter.im/tpaviot/oce
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22:18 < JayDugger> [1509.07175] Exploration and Exploitation of Victorian Science in Darwin's Reading Notebooks[1509.07175] Exploration and Exploitation of Victorian Science in Darwin's Reading Notebooks
22:18 < JayDugger> Thank you for the link.
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22:25 < mgin> how do you stay motivated
22:29 < JayDugger> In general?
22:29 < JayDugger> In particular?
22:30 < mgin> are you confused by a simple fucking question
22:32 < JayDugger> Generally, no. I think that question might connote many different things.
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22:32 < JayDugger> No offense meant, but I don't even no if you meant it in any serious sense, or whether you made a sarcastic remark.
22:33 < JayDugger> Excuse me, s/no/know/
22:36 < JayDugger> Assuming the latter case, I find coffee helpful.
22:37 < mgin> rofl
22:40 < cpopell> mgin : greed as a terminal value?
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--- Log closed Sun Oct 04 00:00:47 2015