--- Log opened Sat Nov 14 00:00:25 2015 00:01 -!- Aurelius_Laptop [~cpopell@c-73-129-20-70.hsd1.md.comcast.net] has quit [Ping timeout: 265 seconds] 00:26 -!- Viper168 [~Viper@unaffiliated/viper168] has joined ##hplusroadmap 00:30 -!- Hercules [Hercules@unaffiliated/genkei] has quit [Read error: Connection reset by peer] 00:30 -!- Hercules [Hercules@unaffiliated/genkei] has joined ##hplusroadmap 00:30 -!- drethelin [~drethelin@24-241-226-112.dhcp.mdsn.wi.charter.com] has quit [Ping timeout: 240 seconds] 01:37 -!- Hercules [Hercules@unaffiliated/genkei] has quit [Read error: Connection reset by peer] 01:37 -!- Hercules [Hercules@117.229.134.111] has joined ##hplusroadmap 01:37 -!- Hercules [Hercules@117.229.134.111] has quit [Changing host] 01:37 -!- Hercules [Hercules@unaffiliated/genkei] has joined ##hplusroadmap 01:39 -!- Hercules [Hercules@unaffiliated/genkei] has quit [Read error: Connection reset by peer] 01:39 -!- Hercules [Hercules@unaffiliated/genkei] has joined ##hplusroadmap 01:54 -!- Hercules [Hercules@unaffiliated/genkei] has quit [Quit: Powered off :-)] 02:00 -!- strangewarp [~strangewa@50.141.116.135] has joined ##hplusroadmap 02:17 -!- btcdrak_ [uid115429@gateway/web/irccloud.com/x-feqmqxzmdxuavzvt] has joined ##hplusroadmap 02:17 -!- strages_ [sid11297@gateway/web/irccloud.com/x-yzodomfpsmqjmgdc] has joined ##hplusroadmap 02:20 -!- sivoais_ [~zaki@199.19.225.239] has joined ##hplusroadmap 02:20 -!- midnightmagic_ [~midnightm@unaffiliated/midnightmagic] has joined ##hplusroadmap 02:20 -!- Pompolic_ [~A@unaffiliated/pompolic] has joined ##hplusroadmap 02:20 -!- btcdrak [uid115429@gateway/web/irccloud.com/x-imyuodkxuzcjbsnp] has quit [Ping timeout: 252 seconds] 02:20 -!- strages [sid11297@gateway/web/irccloud.com/x-gfbzdmtqkyhnaxsb] has quit [Ping timeout: 252 seconds] 02:20 -!- midnightmagic [~midnightm@unaffiliated/midnightmagic] has quit [Ping timeout: 252 seconds] 02:20 -!- proofoflogic [uid65184@gateway/web/irccloud.com/x-bkbqbgdbncohspoy] has quit [Ping timeout: 252 seconds] 02:20 -!- sivoais [~zaki@unaffiliated/sivoais] has quit [Ping timeout: 252 seconds] 02:20 -!- redlegion [~x@unaffiliated/redlegion] has quit [Ping timeout: 252 seconds] 02:20 -!- pompolic [~A@unaffiliated/pompolic] has quit [Ping timeout: 252 seconds] 02:20 -!- strages_ is now known as strages 02:20 -!- btcdrak_ is now known as btcdrak 02:21 -!- Houshalter [~Houshalte@oh-71-50-56-224.dhcp.embarqhsd.net] has quit [Quit: Quit] 02:22 -!- redlegion [~x@unaffiliated/redlegion] has joined ##hplusroadmap 02:22 -!- Act [uid89656@gateway/web/irccloud.com/x-pxknzmbmhteyyomf] has joined ##hplusroadmap 02:26 -!- sivoais_ [~zaki@199.19.225.239] has quit [Ping timeout: 260 seconds] 02:27 -!- proofoflogic [uid65184@gateway/web/irccloud.com/x-fycavaqtotrywfrq] has joined ##hplusroadmap 02:29 -!- sivoais [~zaki@unaffiliated/sivoais] has joined ##hplusroadmap 02:43 -!- midnightmagic_ is now known as midnightmagic 02:50 -!- PatrickRobotham [uid18270@gateway/web/irccloud.com/x-gajzaozvgzcqsgmi] has joined ##hplusroadmap 03:08 -!- Madplatypus [uid19957@gateway/web/irccloud.com/x-xvofrhmvobbvjuhk] has quit [Quit: Connection closed for inactivity] 03:16 -!- strangewarp_ [~strangewa@c-76-25-206-3.hsd1.co.comcast.net] has joined ##hplusroadmap 03:19 -!- QuadIngi [FourFire@cm-84.215.195.59.getinternet.no] has joined ##hplusroadmap 03:20 -!- strangewarp [~strangewa@50.141.116.135] has quit [Ping timeout: 240 seconds] 03:22 -!- AetherServer [~FourFire@178.162.211.211] has quit [Ping timeout: 240 seconds] 03:26 -!- jtimon [~quassel@74.29.134.37.dynamic.jazztel.es] has joined ##hplusroadmap 04:28 -!- QuadIngi is now known as FourFire 05:38 -!- ArturShaik [~ArturShai@31.29.7.72] has joined ##hplusroadmap 05:40 -!- QuadIngi [~FourFire@cm-84.215.195.59.getinternet.no] has joined ##hplusroadmap 05:40 -!- FourFire is now known as ButaTine 05:40 -!- QuadIngi is now known as FourFire 05:45 -!- justanotheruser [~Justan@unaffiliated/justanotheruser] has quit [Ping timeout: 240 seconds] 05:46 -!- sandeepkr [~sandeepkr@111.235.64.4] has joined ##hplusroadmap 05:56 < kanzure_> .title https://www.youtube.com/watch?v=RXJKdh1KZ0w 05:56 < yoleaux> Rockwell Retro Encabulator - YouTube 06:00 < kanzure_> .title https://www.youtube.com/watch?v=MXW0bx_Ooq4 06:00 < yoleaux> Chrysler Turbo Encabulator - YouTube 06:14 -!- justanotheruser [~Justan@unaffiliated/justanotheruser] has joined ##hplusroadmap 06:15 -!- Hercules [Hercules@unaffiliated/genkei] has joined ##hplusroadmap 06:16 -!- FourFire [~FourFire@cm-84.215.195.59.getinternet.no] has quit [Ping timeout: 265 seconds] 06:21 < kanzure_> maaku: re: droplet array stuff, it occurs to me that it may not have been clear to you that there was a hydrophobic flat surface involved. that might help. 06:22 -!- sandeepkr [~sandeepkr@111.235.64.4] has quit [Remote host closed the connection] 06:34 -!- zadock [~outsider@81.180.210.212] has joined ##hplusroadmap 06:36 -!- jdqx [~jdqx@2602:306:cc94:1950:840e:f576:f3ef:f8e6] has quit [Ping timeout: 240 seconds] 06:40 -!- zadock [~outsider@81.180.210.212] has quit [Quit: Leaving] 06:54 -!- atomical [~atomical@209.153.22.182] has joined ##hplusroadmap 06:55 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-cfaaxsqxolhkcgko] has joined ##hplusroadmap 07:04 -!- AmbulatoryCortex [~Ambulator@173-31-155-69.client.mchsi.com] has joined ##hplusroadmap 07:11 -!- c0rw|zZz is now known as c0rw1n 07:26 -!- kanzure_ is now known as kanzure 07:28 -!- AmbulatoryC0rtex [~Ambulator@173-31-155-69.client.mchsi.com] has joined ##hplusroadmap 07:31 -!- AmbulatoryCortex [~Ambulator@173-31-155-69.client.mchsi.com] has quit [Ping timeout: 265 seconds] 07:49 < kanzure> https://www.fightaging.org/archives/2015/11/progress-towards-engineered-extracellular-matrix.php 07:49 < kanzure> https://www.fightaging.org/archives/2015/11/the-prospects-for-pig-to-human-xenotransplantation.php 07:49 < kanzure> "United Therapeutics has spent $100 million in the past year to speed up the process of making transgenic pigs for lung transplants" 07:50 < kanzure> http://cryonics-research.org.uk/ 07:51 < kanzure> "A team led by Hal Sternberg of Biotime claimed to bring back to life baboons that were previously cooled to one degree Celsius. They injected a substance called Hextend to replace the blood and protect the cells from deterioration." 07:51 < kanzure> "At a more basic level, Gregory Fahy and colleagues at 21st Century Medicine vitrified (i.e., stored at < -130°C without ice formation, see about page for details) a rabbit kidney and then transplanted it into a live animal with the kidney maintaining some degree of function. The same team showed that rat and rabbit brain slices can be vitrified and rewarmed and still maintain neural responses." 07:58 < AmbulatoryC0rtex> growing spare organs on donor extracellular matrix and storing them cryogenically would be something 07:58 < AmbulatoryC0rtex> keep a backup or two of all my organs 08:04 -!- jcluck [~cluckj@pool-108-16-231-242.phlapa.fios.verizon.net] has joined ##hplusroadmap 08:06 < AmbulatoryC0rtex> end up with a full set of organs grown when the guy was a month old or whatever 08:07 < AmbulatoryC0rtex> to avoid age-related issues 08:07 < kanzure> at the moment besides not knowing how to grow organs in that manner, the cryonics portion of your plan is also not going to work. 08:08 -!- cluckj [~cluckj@pool-108-16-231-242.phlapa.fios.verizon.net] has quit [Ping timeout: 265 seconds] 08:08 < AmbulatoryC0rtex> kanzure, I thought they did it with a heart? 08:08 < AmbulatoryC0rtex> am I mistaken? 08:08 < kanzure> did what? 08:09 < AmbulatoryC0rtex> decellularized a pig heart, then regrew human tissue over the underlying extracellular matrix 08:10 < kanzure> what does that have to do with your "grow organs and cryonically store them" plan? 08:11 < AmbulatoryC0rtex> take cells from young person, and grow backup organs on decellularized pig organs 08:11 < AmbulatoryC0rtex> then store for later, but you say that won't work 08:11 < kanzure> growing tissue is not the same thing as growing organs 08:11 < kanzure> yes, it's true that we don't have cryonics working for organs yet 08:12 < AmbulatoryC0rtex> so you're saying the heart is actually easier than other organs, like the pancreas, for example 08:13 -!- FourFire [~FourFire@cm-84.215.195.59.getinternet.no] has joined ##hplusroadmap 08:14 -!- atomical_ [~atomical@172.56.13.9] has joined ##hplusroadmap 08:15 -!- atomical [~atomical@209.153.22.182] has quit [Ping timeout: 255 seconds] 08:15 < kanzure> i have no idea how you think or what you're trying to communicate to me 08:16 < kanzure> is this your attempt at making a sensationalized statement like "organs aren't real, only tissue" ? 08:16 < AmbulatoryC0rtex> no, no 08:17 < kanzure> if you can recreate the organs on demand, why would you need to cryonically store them? 08:18 < AmbulatoryC0rtex> I'm suggesting stripping the cells out of a pig heart and growing human cells on the ECM using this process: http://www.nature.com/news/tissue-engineering-how-to-build-a-heart-1.13327 08:18 -!- atomical_ [~atomical@172.56.13.9] has quit [Ping timeout: 255 seconds] 08:18 < AmbulatoryC0rtex> the cryonics part is irrelevant if we can crogenically store organs 08:18 < AmbulatoryC0rtex> can't* 08:18 < kanzure> artificial organs swapped into another animal body would be useful if you wanted to control for ability to cryonically store the host, but that doesn't seem to be what you were saying 08:19 < AmbulatoryC0rtex> and if we can't cryogenically store organs, the whole idea is moot 08:19 < AmbulatoryC0rtex> the idea was to store young organs as a person ages 08:19 < AmbulatoryC0rtex> by growing backups 08:20 < AmbulatoryC0rtex> but it's moot, as we can't store them 08:20 < kanzure> we could theoretically store them by freezing the cell lines or storing the cell lines in cryonic storage prior to organ construction iff (1) you know the exact cell lines required, (2) you have a working method of creating an organ with those cell lines once thawed. 08:22 < kanzure> however, most of the cell lines can probably be constructed through direct differentiation of pluripotent stem cells, which can be constructed by dosing certain other cell lines (i'm not entirely convinced that older human cells are ungood for this, because ultimately eggs seem to survive for a few decades without debilitating mutation or aging). 08:24 -!- drethelin [drethelin@24-241-226-112.dhcp.mdsn.wi.charter.com] has joined ##hplusroadmap 08:25 < kanzure> when surgeons move a hand into the abdomen or something, does that require immunosuppression of any kind? 08:25 < AmbulatoryC0rtex> no, as long as it's the patient's own tissue 08:26 < AmbulatoryC0rtex> I'm trying to find a better articale than this nature one: http://www.nature.com/news/tissue-engineering-how-to-build-a-heart-1.13327 08:28 -!- Viper168 [~Viper@unaffiliated/viper168] has quit [Ping timeout: 246 seconds] 08:31 < kanzure> hmm looks like decompressive craniectomy patients experience bone infection while their skull is stored in their abdomen 08:32 < kanzure> "Replantation of Amputated Distal Phalangeal Parts of Fingers Without Vascular Anastomoses, Using Subcutaneous Pockets" http://journals.lww.com/plasreconsurg/Citation/1979/01000/Replantation_of_Amputated_Distal_Phalangeal_Parts.1.aspx 08:34 -!- jcluck [~cluckj@pool-108-16-231-242.phlapa.fios.verizon.net] has quit [Quit: Leaving] 08:34 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap 08:34 < kanzure> .title http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3115275/ 08:34 < yoleaux> Cranioplasty with subcutaneously preserved autologous bone grafts in abdominal wall—Experience with 75 cases in a post-war country Kosova 08:37 -!- Viper168 [~Viper@unaffiliated/viper168] has joined ##hplusroadmap 08:38 < kanzure> some images from a surgery to reconstruct forearm by storing it in the abdomen https://www.youtube.com/watch?v=bFBGuOxy5l0 08:50 -!- _hanhart [~hanhart@static.101.25.4.46.clients.your-server.de] has joined ##hplusroadmap 09:03 -!- Act [uid89656@gateway/web/irccloud.com/x-pxknzmbmhteyyomf] has quit [Quit: Connection closed for inactivity] 09:03 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-cfaaxsqxolhkcgko] has quit [Quit: Connection closed for inactivity] 09:06 -!- atomical [~atomical@209.153.22.182] has joined ##hplusroadmap 09:12 -!- _hanhart [~hanhart@static.101.25.4.46.clients.your-server.de] has quit [Killed (Sigyn (Spam is off topic on freenode.))] 09:15 -!- Hercules [Hercules@unaffiliated/genkei] has quit [Quit: Powered off :-)] 09:32 -!- Act [uid89656@gateway/web/irccloud.com/x-tjxtygvpizlaxgzl] has joined ##hplusroadmap 10:09 -!- AmbulatoryCortex [~Ambulator@173-31-155-69.client.mchsi.com] has joined ##hplusroadmap 10:13 -!- AmbulatoryC0rtex [~Ambulator@173-31-155-69.client.mchsi.com] has quit [Ping timeout: 264 seconds] 10:19 -!- Guest9101 is now known as helleshin 10:25 -!- Pompolic_ is now known as pompolic 10:31 < pasky> https://en.wikipedia.org/wiki/Megaphragma_mymaripenne 10:32 < chris_99> intriguing 10:32 < chris_99> wonder if they sting 10:32 < kanzure> .wik 10:32 < yoleaux> Search for an article on Wikipedia 10:32 < kanzure> .wik megaphragma mymaripenne 10:32 < yoleaux> "Megaphragma mymaripenne is a microscopically sized wasp. At 200 μm in length, it is the third smallest extant insect, comparable in size to single celled organisms. It has a highly reduced nervous system, containing only 7400 neurons, several orders of magnitude fewer than in larger insects." — https://en.wikipedia.org/wiki/Megaphragma_mymaripenne 10:43 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-vturcmcdycqmdanz] has joined ##hplusroadmap 10:54 -!- fleshtheworld [~fleshthew@2602:306:cf0f:4c20:3031:fccd:f4fc:337c] has joined ##hplusroadmap 10:54 -!- ArturShaik [~ArturShai@31.29.7.72] has quit [Ping timeout: 260 seconds] 11:03 -!- PatrickRobotham [uid18270@gateway/web/irccloud.com/x-gajzaozvgzcqsgmi] has quit [Quit: Connection closed for inactivity] 11:15 -!- jdqx [~jdqx@2602:306:cc94:1950:3ca7:5740:95ab:1d46] has joined ##hplusroadmap 11:26 < chris_99> .title http://www.sciencedaily.com/releases/2015/11/151109143616.htm 11:26 < yoleaux> chris_99: Sorry, that doesn't appear to be an HTML page. 11:26 < chris_99> odd 11:26 < chris_99> 'Implantable wireless devices trigger, and may block, pain signals' 11:52 -!- Aurelius_Laptop 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quit [Changing host] 13:42 -!- andytoshi [~andytoshi@unaffiliated/andytoshi] has joined ##hplusroadmap 13:43 < kanzure> hmm. 13:51 < kanzure> libpng buffer overflows https://news.ycombinator.com/item?id=10566664 13:54 < kanzure> comex commenting on libpng https://news.ycombinator.com/item?id=10567353 14:00 < chris_99> nmz787, do you know what the actual lower end in nm of the CCD you used was out of interest, the graph just stops at 400nm on the datasheet iirc 14:04 < chris_99> ah http://oceanoptics.com/product/usb2000uv-vis/ since it seems to similar to the sony sensor in terms of sensitivity, i'll guess maybe it's also 200nm 14:30 -!- eudoxia_ [~eudoxia@r179-24-255-212.dialup.adsl.anteldata.net.uy] has joined ##hplusroadmap 14:30 -!- eudoxia [~eudoxia@r179-25-128-116.dialup.adsl.anteldata.net.uy] has quit [Read error: Connection reset by peer] 14:33 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-vturcmcdycqmdanz] has quit [Quit: Connection closed for inactivity] 15:00 -!- Aurelius_Laptop [~cpopell@c-73-129-20-70.hsd1.md.comcast.net] has quit [Ping timeout: 244 seconds] 15:22 < kanzure> "Meta-analysis of heritability of human traits based on 50 years of twin studies" http://www.gwern.net/docs/2015-polderman.pdf 15:44 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Quit: Leaving] 15:47 -!- eudoxia_ [~eudoxia@r179-24-255-212.dialup.adsl.anteldata.net.uy] has quit [Quit: Leaving] 15:49 < QuadIngi> kanzure, thoughts on this: https://www.indiegogo.com/projects/dracos-may-be-effective-against-all-viruses#/story 15:50 -!- QuadIngi is now known as FourFire 15:51 < FourFire> I'm mildly concerned that it will cause problems for a potential. future whole organism DNA editing vector, but then that's just a design problems 15:51 < FourFire> DO DNA (as opposed to RNA) viruses exist (in nature?) 15:56 < kanzure> DRACOS stuff in the logs would be good start 16:10 < yashgaroth> there's plenty of dna viruses, but most viruses have an intermediate dsRNA 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ZZZzzz…] 20:09 -!- atomical [~atomical@209.153.22.182] has joined ##hplusroadmap 20:38 -!- Hercules [Hercules@unaffiliated/genkei] has joined ##hplusroadmap 20:43 -!- docl_ [~docl@104.131.200.203] has joined ##hplusroadmap 20:43 -!- Hercules` [Hercules@117.237.18.28] has joined ##hplusroadmap 20:45 -!- Hercules [Hercules@unaffiliated/genkei] has quit [Ping timeout: 264 seconds] 20:45 -!- docl [~docl@104.131.200.203] has quit [Ping timeout: 264 seconds] 20:56 < kanzure> http://www.nycsubway.org/wiki/NXSYS,_Signalling_and_Interlocking_Simulator 21:00 -!- Viper168 [~Viper@unaffiliated/viper168] has quit [Ping timeout: 246 seconds] 21:27 -!- Hercules` [Hercules@117.237.18.28] has quit [Quit: Powered off :-)] 21:59 -!- Viper168 [~Viper@unaffiliated/viper168] has joined ##hplusroadmap 22:05 -!- Viper168 [~Viper@unaffiliated/viper168] has quit [Ping timeout: 246 seconds] 22:08 -!- lastfuture [~Peter@HSI-KBW-46-223-1-54.hsi.kabel-badenwuerttemberg.de] has quit [Quit: Bye bye baby] 22:08 -!- drethelin [drethelin@24-241-226-112.dhcp.mdsn.wi.charter.com] has quit [Ping timeout: 272 seconds] 22:14 -!- Viper168 [~Viper@unaffiliated/viper168] has joined ##hplusroadmap 22:35 -!- sandeepkr [~sandeepkr@111.235.64.4] has joined ##hplusroadmap 22:58 -!- Aurelius_Laptop [~cpopell@c-73-129-20-70.hsd1.md.comcast.net] has quit [Ping timeout: 260 seconds] 23:22 -!- ArturShaik [~ArturShai@31.29.7.72] has joined ##hplusroadmap --- Log closed Sun Nov 15 00:00:25 2015