--- Log opened Sat Jan 16 00:00:06 2016
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04:38 < Diablo-D3> .title http://www.impactaging.com/papers/v6/n9/full/100690.html
04:38 < yoleaux> Reversal of cognitive decline: A novel therapeutic program - AGING Journal
04:39 < JayDugger> That's a rather long list of approaches in Table 1 of that paper.
04:40 < JayDugger> I'd call it a shotgun approach, but they seem to have chosen more carefully than that.
04:40 < Diablo-D3> No, I don't think it is
04:41 < Diablo-D3> In fact, thats actually rather similar to what I've been trying as an autism cure
04:41 < Diablo-D3> It enhances my brain function, it does not cure autism
04:44 < lkjhfr> it's basically: don't eat shit
04:44 < JayDugger> We seem to talking past each other here. Twenty-five rows appear in Table 1. I called that a long list, and I said nothing about its efficacy.
04:44 < Diablo-D3> JayDugger: several of them are parts of the same thing
04:45 < JayDugger> No, they have some non-dietary approaches in that list: dietary supplements and treating sleep apnea. Neither of those exclude items of diet.
04:45 < JayDugger> Yes, some of the 25 do seem to overlap.
04:45 < Diablo-D3> what I find weird is
04:45 < Diablo-D3> "CoQ or ubiquinol, α-lipoic acid, PQQ, NAC, ALCAR, Se, Zn, resveratrol, ascorbate, thiamine"
04:45 < JayDugger> I'll have to read the whole thing to understand that overlap better.
04:45 < Diablo-D3> is just one row
04:45 < JayDugger> By the way, thank you for posting a link to that paper.
04:46 < Diablo-D3> you know how many fucking vitamins I have to take to do that?
04:46 < Diablo-D3> just that fucking one row?
04:46 < JayDugger> Um...is that a trick question?
04:46 < Diablo-D3> and I dont even take that whole row
04:46 < JayDugger> It depends on where you shop and what you buy, obviously.
04:47 < JayDugger> Even more flippantly, if it prevents or treats A.D., do you really care?
04:47 < JayDugger> What's ALCAR in this context?
04:47 < Diablo-D3> Acetyl-L-carnitine
04:47 < JayDugger> If you want a number for the answer though,---oh, duh. Thanks.
04:47 < Diablo-D3> the thing is, almost all of that
04:48 < Diablo-D3> I take for mitocondrial improvement
04:48 < Diablo-D3> like, that entire list
04:48 < Diablo-D3> I know _exactly_ what they were doing
04:48 < JayDugger> The number would be three or four different supplements, without looking at the labels.
04:48 < Diablo-D3> JayDugger: well lets see here, Ill tell you what I take currently
04:48 < JayDugger> No, I think that's only part of it.
04:49 < Diablo-D3> "Optimize fT3, fT4, E2, T, progesterone, pregnenolone, cortisol"
04:49 < Diablo-D3> that part I find weird
04:49 < JayDugger> I don't know of any effects on mitochondria from MCT oil / cococnut oil, but I'd happily learn better.
04:49 < JayDugger> Yeah, that line goes over my head.
04:50 < Diablo-D3> MCT is extremely interesting
04:50 < JayDugger> Do you recognize fT3 fT4, and E2 in this context?
04:50 < JayDugger> I'll guess T means testosterone.
04:50 < JayDugger> Do fTN mean free Testosterone N?
04:50 < JayDugger> Estrogen 2 = E2?
04:51 < Diablo-D3> Not sure about those
04:51 < JayDugger> For all I know those might be common lab codes for blood analysis.
04:51 < lkjhfr> ft3 and ft4 is thyroid
04:52 < JayDugger> Optimize hygiene? What's that?
04:52 < JayDugger> Ah...thanks.
04:52 < Diablo-D3> well, taking a shower feels nice
04:52 < Diablo-D3> maybe feeling nice is the cure for this
04:52 < lkjhfr> e2 is estradiol
04:52 < JayDugger> Heh, heh. True enough, but I doubt it.
04:53 < JayDugger> fT3, free triiodothyronine; fT4, free thyroxine from under the table.
04:53 < JayDugger> I think I'll stop speculating until after I finish reading. Less embarrassing.
04:53 < lkjhfr> it's mostly: don't eat shit
04:53 < Diablo-D3> but yeah, MCT shuttles fats into your mitocondria
04:53 < JayDugger> Oh? I didn't know that.
04:54 < Diablo-D3> Im simplifying it, and I expect to be yelled at
04:54 < JayDugger> So they improve mitochondria function and encouraged autophagy.
04:54 < Diablo-D3> yes
04:54 < JayDugger> And ketogenesis.
04:55 < Diablo-D3> now what Ive done
04:55 < Diablo-D3> in my research
04:55 < Diablo-D3> which apparently does fucking work
04:55 < Diablo-D3> just not for me
04:55 < Diablo-D3> Ive gone strict paleo
04:55 < Diablo-D3> no grains, no refined sugars, no shit
04:55 < lkjhfr> Diablo-D3, what do you mean by taking vitamins?
04:56 < Diablo-D3> Ive increased protein and fat intake
04:57 < JayDugger> What effect did you seek but not get?
04:57 < Diablo-D3> oh, cure for autism
04:59 < Diablo-D3> I was suspecting it was either a mitocondrial disorder or a problem with something in the dopamine system somewhere
04:59 < lkjhfr> also: what do you mean by increasing fat intake?
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05:00 < Diablo-D3> literally, eating fat
05:00 < Diablo-D3> anyhow, the list of shit I take
05:00 < lkjhfr> but, SFAs, or PUFA?
05:00 < Diablo-D3> no, I mean fat
05:00 < Diablo-D3> on meat
05:00 < Diablo-D3> fatty cuts of meat
05:00 < lkjhfr> SFA
05:00 < Diablo-D3> the skin and fat on chicken
05:00 < Diablo-D3> none of this low fat FDA nonsense
05:01 < lkjhfr> that's saturated fatty acids, and noone said that those chicken are fed well
05:02 < JayDugger> Ah... that provides some context.
05:02 < Diablo-D3> anyhow, vitamin D, ubiquinol, biopqq, beta carotine, alpha carotine, luetein, zeaxanthin, lycopene, astaxanthin, dmae...
05:03 < Diablo-D3> vitamin E in the forms of alpha, beta, gamma, and delta tocopherols, and the same for tocotrienols
05:04 < Diablo-D3> vitamin C, mixed bioflavonoids
05:04 < Diablo-D3> alcar, arginine, alpha lipolic acid
05:06 < Diablo-D3> vitamin b1, 2, 3, 5, 6, 7, 9, 12,
05:06 < JayDugger> optimize "oral" hygiene--what's an electric flosser?
05:07 < Diablo-D3> 6 as pyridoxal 5-phosphate, folate as methyl-tetrahydrofolate
05:07 < Diablo-D3> choline, paba
05:08 < Diablo-D3> k1, k2, calcium, iodine, magnesium, zinc, selenium, copper, maganese, chromium, molybdenum, potassium
05:08 < lkjhfr> but... you were taking pills with those?
05:08 < Diablo-D3> and north of 2000mg of EPA, and north of 1000mg DHA.
05:08 < Diablo-D3> lkjhfr: yup.
05:09 < lkjhfr> but, you know that all those are basically components or food
05:09 < lkjhfr> of food
05:09 < Diablo-D3> was interested in the amounts.
05:10 < JayDugger> Pills are easier to count and handle than food.
05:11 < lkjhfr> but just then, he could replace the chicken with a bottle of oil and soy protein isolate
05:11 < JayDugger> Yes. Not for everyone, I admit, even if one has the luxury of ignoring the social aspects of eating.
05:12 < lkjhfr> no, i mean: he didn't. he controled everything besides that chicken.
05:12 < JayDugger> Oh. Sorry, my misunderstanding.
05:13 < Diablo-D3> I dont eat a lot of chicken =P
05:13 < Diablo-D3> I eat mostly beef and pork
05:14 < Diablo-D3> and until they fucked beef pricing it was mostly beef
05:24 < lkjhfr> Diablo-D3, didn't you forget about sodium though?
05:24 < lkjhfr> the less processed the food, and the more fat in it, the more salt you need to add
05:25 < Diablo-D3> lkjhfr: yes, I eat unrestricted sodium
05:26 < lkjhfr> so, you thought you'd feel better if you ate all the vitamins and changed the macronutrient proportions, and it didn't work?
05:29 < Diablo-D3> lkjhfr: vaguely
05:33 < Diablo-D3> lkjhfr: I take almost everything the body uses to make almost every neurotransmitter
05:33 < lkjhfr> haha
05:33 < Diablo-D3> whatever autism is, its not a shortage of the ingredients.
05:36 < lkjhfr> i am undernourished, and i did try doing this stuff with vitamins, but i chose natural sources, and it did make me feel a bit better, it even changed my perception a bit
05:36 < Diablo-D3> sufficient amounts of some things, large amounts of others, doesnt fix it
05:37 < Diablo-D3> taking everything I could think of to boost mitochondria performance
05:37 < Diablo-D3> didnt fix it
05:38 < lkjhfr> i have like, narrow vision usually, but at those times that i tried eating better, my perception was wider
05:39 < lkjhfr> and i ate, like, 200% of the vitamins
05:39 < lkjhfr> of the rda or whatever is it called
05:40 < Diablo-D3> I can stay alert longer, I can think harder, my exercise performance has increased way more than I imagined, and Im building muscle faster than I ever have
05:41 < lkjhfr> then what didn't work
05:42 < Diablo-D3> Still autistic.
05:43 < lkjhfr> did you tried to pretend to not be autistic?
05:43 < Diablo-D3> Heh, doesn't work that way.
05:44 < lkjhfr> so you haven't tried?
05:44 < Diablo-D3> You mean lying out my ass?
05:44 < lkjhfr> no, like, acting out
05:44 < Diablo-D3> I am not a gifted liar, something that comes natural to most people
05:45 < lkjhfr> but that's what kids do
05:45 < lkjhfr> at early age, kids socialize by acting
05:46 < Diablo-D3> Yes, but it requires their mirror neurons to functio
05:46 < Diablo-D3> They need to use their innate ability to read other people
05:49 < lkjhfr> so, science basically says that you can't stop being autistic?
05:49 < Diablo-D3> Yes, and I believe science just isn't there yet
05:50 < Diablo-D3> But hey, its great to know that the research I was performing on myself (as shoddy as it is)
05:50 < Diablo-D3> Fixes _something_
05:50 < Diablo-D3> And I know exactly why they're doing a lot of whats on that list
05:51 < Diablo-D3> Not all of it, but a good chunk of it
05:55 < Diablo-D3> The thing is
05:55 < Diablo-D3> For awhile I've thought cognitive decline, in general
05:56 < Diablo-D3> was caused by mitochondrial disfunction then death
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05:59 < Diablo-D3> Keeping them functioning, even by force, reverses this
05:59 < Diablo-D3> Everything they've done on that list presumably contributes to it
05:59 < Diablo-D3> with no upper limit, ie, all of them together all add to the effect
07:50 < lkjhfr> 13:49 < JayDugger> Optimize hygiene? What's that?
07:50 < lkjhfr> 05:06 < JayDugger> optimize "oral" hygiene--what's an electric flosser?
07:51 < lkjhfr> it's meant to reduce the stress on the immune system, to let it take care of more useful things
07:54 < lkjhfr> i have this thing that makes me paralyzed with options when i get to interact with other people, which in result leads to either no interaction or very useless ones, it's like my mind becomes empty, and i'm slow to answer and can't find words i want to use
07:54 < lkjhfr> is this some kind of disorder?
07:56 < TMA> it sounds a bit like generalized social phobia
07:56 < Diablo-D3> its social anxiety basically
07:57 < TMA> lkjhfr: it could be a DSM acknowledged disorder
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08:20 < streety> one issue with unburdening the immune system so it is free to "take care of more useful things" is the hypothesis that this is a primary cause of the increasing incidence of allergies and auto-immune diseases
08:24 < lkjhfr> isn't that when people take antibiotics, leaving the immune system with nothing to do at all?
08:25 -!- hehelleshin is now known as helleshin
08:27 < TMA> lkjhfr: immune system has to deal with more than killing the infection vectors
08:29 < TMA> lkjhfr: ATB is somewhat like a rat poison - it kills the rats but you are left with the rat carcasses
08:32 < lkjhfr> with the poison in them
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08:43 < kanzure> "Reversal of hair greying following autologous adipose mesenchymal stem cell transplantations: a coincidental finding" http://www.hoajonline.com/stemcells/2054-717X/2/3
08:44 < kanzure> "Adipose derived autologous mesenchymal stem cells have been transplanted and tested for their ability to regenerate tissues for several indications. While treating various age related neurodegenerative disorders with autologous mesenchymal stem cells for their regenerative and rejuvenating properties, we accidentally observed a transition of hair colorations from mostly grey to black in all the 4 elderly patients. We have given ...
08:44 < kanzure> ... 20million cells intravenous and also 20 million cells intrathecal, in multiple sessions to each patient. Though low dose the effects were very obvious and may indicate an anti aging effect. We also found that the effect was transient and changed with time through a follow up period of 20 months. This may be through positive activation and regeneration of melanocyte stem cells in the hair follicular niche. In this paper we intend to ...
08:44 < kanzure> ... report this unique observation which may lead to further research and solutions to problems like premature greying of hair or indicate new anti aging solutions."
08:44 < AdrianG> kanzure: have you ever seen any papers on stemcells and risks of tumor
08:44 < AdrianG> tumors developing?
08:45 < AdrianG> theoretically, thats the major downside of any new growth.
08:45 < streety> antibiotics have other effects, but I doubt they help
08:45 < streety> except in the acute phase
08:57 < streety> Is there anything not in the regimen from that article that you have been doing Diablo-D3?
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14:05 < Diablo-D3> streety: yah
14:06 < Diablo-D3> "8 hr sleep per night; melatonin 0.5mg po qhs; Trp 500mg po 3x/wk if awakening. Exclude sleep apnea.
14:06 < Diablo-D3> I dont do th melatonin or the triptophan
14:08 < Diablo-D3> not doing Citicoline
14:09 < Diablo-D3> not doing N-Acetyl-L-Cysteine (NAC)
14:12 < Diablo-D3> and not doing curcumin
14:12 < Diablo-D3> or TMG
14:13 < Diablo-D3> Im also not oxiginating myself
14:13 < Diablo-D3> and as for exercise, high impact weight lifting for roughly an hour every other day
14:14 < Diablo-D3> so I think that meets their requirements
14:15 < Diablo-D3> oh and not doing resveratrol
14:22 < Diablo-D3> .title http://news.mit.edu/2016/nanophotonic-incandescent-light-bulbs-0111
14:22 < yoleaux> A nanophotonic comeback for incandescent bulbs? | MIT News
14:33 < fenn> Diablo-D3: you should probably cycle on/off the antioxidants
14:34 < fenn> i don't think there's a "cure" for autism
14:53 < streety> thanks Diablo-D3, is there anything you think they have missed? Optimizing iron might be one, drawing a blank on others at the moment.
14:55 < Diablo-D3> fenn: I think Im just going to drop it
14:55 < Diablo-D3> all of it
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17:40 < Diablo-D3> .title http://www.fasebj.org/content/20/9/1567.abstract
17:40 < yoleaux> Towards a “free radical theory of graying”: melanocyte apoptosis in the aging human hair follicle is an indicator of oxidative stress induced tissue damage
17:40 < Diablo-D3> .title http://www.ncbi.nlm.nih.gov/pubmed/18573711
17:40 < yoleaux> Changing expression of the genes related to human hair graying. - PubMed - NCBI
17:40 < Diablo-D3> .title http://www.eurekalert.org/pub_releases/2013-05/foas-gha050313.php
17:40 < yoleaux> Gray hair and vitiligo reversed at the root | EurekAlert! Science News
18:07 -!- Quashie_ is now known as Quashie
18:42 < xentrac> yay undoing vitiligo!
18:43 < xentrac> pasky: if you said things to me they've been pushed out of my scrollback buffer by lots of 01:43 < Diablo-D3> I don't believe in stuff like alcor
18:43 < xentrac> 01:43 < Diablo-D3> it just seems like too much of a scam
18:43 < xentrac> 01:44 < Diablo-D3> the human race is just too fucking disorganized to be useful
18:44 < Diablo-D3> heh.
18:44 < xentrac> 01:52 < Diablo-D3> Humanity is just a bunch of self serving dicks, none of them interested in the greater good
18:44 < xentrac> 01:57 < Diablo-D3> you want shitty?
18:44 < xentrac> 01:57 < Diablo-D3> the entire silicon valley
18:44 < xentrac> 01:57 < Diablo-D3> that entire fucking place should be burned to the ground
18:44 < cluckj> lol
18:44 < xentrac> 01:58 < Diablo-D3> ruby coders: should all be shot
18:44 < Diablo-D3> yes, we get it, Im awesome
18:47 < xentrac> although I guess I've been guilty of the same kind of thing in the past.  maybe including right now
18:47 < cluckj> minor misanthropy isn't so bad
18:51 < cluckj> as long as you remember you are part of it...
19:02 < xentrac> what I'm complaining about is more the large amount of text with no information content.  I mean, you could go through and read the entire rant and I doubt you'd know anything more about humanity or Alcor or Silicon Valley or Ruby programmers than you did before
19:03 < cluckj> :)
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19:11 < Quashie> you know, I've been thinking a lot lately about how to go about pursuing the goals I want without doing it recklessly
19:11 < Quashie> my threshold for recklessness is probably too low
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20:49 < kanzure> https://github.com/LightningNetwork/lnd
20:49 < kanzure> https://github.com/LightningNetwork/lightning-onion
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23:10 < lkjhfr> xentrac: take a look at the topic, those logs are updated in realtime
23:11 < lkjhfr> bash-4.3$ wget -q -O - http://gnusha.org/logs/2016-01-16.log | tail -n 1
23:11 < lkjhfr> 23:10 < lkjhfr> xentrac: take a look at the topic, those logs are updated in realtime
23:29 < xentrac> lkjhfr: of course you are right
23:30 < lkjhfr> but... i'm not helpful...
23:31 < xentrac> I think it was helpful
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--- Log closed Sun Jan 17 00:00:07 2016