--- Log opened Fri Jun 17 00:00:32 2016
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05:30 < kanzure> yep....
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05:33 < eudoxia> lol kanz you were right about Ethereum being a bloodbath
05:34 < kanzure> big of you to admit it
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05:44 < kanzure> "I've got #29, and still one account which did not join. Give me your email and I'll send you the keys"
05:44 < kanzure> <3 utter madness out there
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09:03 < nmz787> eudoxia: kanzure: I asked a few days ago if ethereum ws good or bad, and now I see a comment about bloodbath??
09:04 < kanzure> nmz787: ethereum foundation central command has decided to force some changes in the system to rollback $60 million stolen earlier today
09:04 < kanzure> https://news.ycombinator.com/item?id=11921900
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09:11 < nmz787> hmm, I kinda feel like that founder guy might have also been at toorcamp
09:11 < nmz787> but I can't tell.
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09:14 < nmz787> wow, i bet that contract programmer is getting hell, from others or themselves :(
09:25 < nmz787> hmm, too bad this doesn't apparently have an IPS screen and backlit keyboard :(
09:25 < nmz787> .title https://www.sparkfun.com/products/13896
09:25 < yoleaux> Pi-Top (Green) - KIT-13896 - SparkFun Electronics
09:26 < nmz787> "The pi-top is a DIY laptop you build yourself that helps you start learning how to code, create awesome devices and take your knowledge to the next level. This Raspberry Pi powered laptop is an excellent resource to any budding hobbyist, student or intrigued user wanting to learn more about the capabilities of the credit card-sized development board. The only thing this kit doesn’t include is a speaker and its own Raspberry Pi;"
09:26 < chris_99> it's ridiculously expensive imo
09:28 < nmz787> yep
09:28 < nmz787> i guess it is reasonable since it is likely pretty small volume manufactiruing
09:28 < nmz787> but c'mon, give me a backlit kb
09:28 < chris_99> heh
09:30 < nmz787> aww, this has nothing to do with a bio-mouse: http://hackaday.com/2016/06/17/mouse-brains-plus-line-laser-equals-rangefinder/
09:35 < kanzure> .title http://bbci.de/supplementary/EEGconnectivity/BBCB.html
09:35 < yoleaux> Berlin Brain Connectivity Benchmark (BBCB)
09:36 < kanzure> "The Berlin Brain Connectivity Benchmark (BBCB) is a Matlab based simulation framework for generating electro- and magnetoencephalographic (EEG and MEG) data within a realistic electromagnetic volume conductor (head) model for the purpose of benchmarking EEG/MEG based brain connectivity estimation methodologies. Its development is motivated by our feeling that, while brain connectivity analyses using interaction measures such as Granger ...
09:36 < kanzure> ... Causality are frequently applied to EEG/MEG data, their validity to detect brain interactions rather than more trivial properties of the data is rarely validated in suitable simulations. Problems such as spurious connectivity affecting certain interaction measures are overlooked when essential features of real EEG/MEG data such as mixed brain signals or correlated noise are not reflected in a simulation (see e.g. [5-7]). Their impact ...
09:36 < kanzure> ... might therefore not be entirely clear to all researchers employing such measures. The goal of BCCB framework is therefore to facilitate the assessment of entire source connectivity estimation pipelines, which may be composed of separate pre-processing, inverse source reconstruction and connectivity estimation steps, as a whole, as opposed to benchmarking each analysis step separately under conditions that may be too simplistic."
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10:25 < maaku> if only there was a way to short ether
10:28 < xentrac> either Ⓑ or ether?
10:28 < xentrac> oh, just ether. not either
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10:46 < juri_> nmz787_i: any contact info for that other person in the aluminium levitation business?
10:50 < nmz787_i> juri_: hrmm, all I know if he was near Yakima WA
10:51 < nmz787_i> and I think he does computer security as consulting trade
10:51 < nmz787_i> he was very tall
10:52 < juri_> ok, so tall computer consultants in washington.
10:53 < juri_> oddly enough, i might be able to do something with that. thanks. ;)
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11:02 < nmz787_i> http://hackaday.com/2015/02/24/retrotechtacular-step-up-and-get-your-transformer-training/
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11:08 < thegtabot> Eyy lmao
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12:57 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=133e394d Bryan Bishop: remove some old headers >> http://diyhpl.us/diyhpluswiki/transcripts/coindesk-consensus-2016/why-bitcoin-still-matters/
12:58 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=8bcf8f73 Bryan Bishop: also document molecular lego stuff >> http://diyhpl.us/diyhpluswiki/dna/projects/
13:20 < nmz787_i> hmm, I wonder what the 'defects per million' for childbirth is
13:21 < nmz787_i> (to compare to semiconductor yield)
13:22 < nmz787_i> "Birth defects affect one in every 33 babies (about 3% of all babies) born in the United States each year"   (from http://www.cdc.gov/ncbddd/birthdefects/data.html)    so that'd be 30,000 DPM
13:23 < nmz787_i> higher than semiconductor mfg targets
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13:46 < kanzure> looks like we might have to add "sponsored by george church" back into the /topic
13:47 < nmz787_i> why?
13:47 < nmz787_i> what has he done for us lately?
13:47 < kanzure> this channel has become appropriated by the human genome project
13:47 < nmz787_i> ?
13:47 < kanzure> just got off a long phone call with them
13:47 < nmz787_i> i thought that is old news
13:48 < nmz787_i> as in like done 10 years ago
13:48 < nmz787_i> ( i guess I remember you mentioning something about this recently)
13:48 < nmz787_i> (but don't remember details)
13:48 < kanzure> nmz787: they have decided to make a human genome project focused on human genome synthesis using enzymatic approaches
13:48 < nmz787_i> ah
13:49 < kanzure> nmz787: http://science.sciencemag.org/content/early/2016/06/03/science.aaf6850
13:49 < kanzure> err,
13:49 < kanzure> http://diyhpl.us/~bryan/papers2/bio/The%20human%20genome%20project%20-%20write,%20hgp-write%20-%202016.pdf
13:50 < juri_> i was reading about that. reminds me a lot of what we were trying to accomplish last summer.
13:50 < nmz787_i> isn't church still sport the boring Gen9 outfit though?
13:51 < kanzure> he supports many things
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14:08 < eudoxia> hey congrats kanzure
14:11 < kanzure> george says that one of the main problems continues to be assembly even if we do figure out highly parallelized oligo synthesis
14:12 < kanzure> so therefore andrew wants to focus on enzymatic approaches and such
14:12 < kanzure> i would call that the major bottleneck. but there's also lots of software that doesn't entirely exist for these things.
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14:30 < nmz787_i> kanzure: did you ask what those assembly problems were?
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14:44 < maaku> use dna origami on the tips or between genes to provide work grips
14:44 < maaku> but i'm a newb in biology don't listen to me
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14:48 < nmz787_i1> "A primary consideration- if I can't get 1 page or less ikea style instructions that 90% of the researchers can understand then it is too complicated!"
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14:57 < drethelin> nmz781_i1 even with that lots of people fuck up the protocol
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15:03 < kanzure> nmz787: just the traditional problems.... pick n place of 100 million spots is not quick.
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15:04 < nmz787_i1> kanzure: they're really still talking about macro/meso handling solutions?
15:05 < nmz787_i1> that is both sad and relieving at the same time
15:05 < kanzure> there aren't other options at the moment.
15:05 < nmz787_i1> right, not when you have $100 million
15:06 < kanzure> enzymatic synthesis might be an option but it's highly theoretical and nobody has any workable ways of doing that
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15:06 < kanzure> my ribosome manufacturing stuff is cool but it only works for protein synthesis
15:06 < nmz787_i1> i'm talking about not using pick'n'place overall
15:07 < kanzure> well their only idea for not using pipettes is hacking polymerase but again, that's an unsolved problem
15:07 < kanzure> and my "flooding levels" stuff is sort of boring
15:07 < kanzure> yashgaroth's nicking enzyme assembly stuff might work
15:08 < nmz787_i1> huh, I guess Madoo Varma was right, I have 20 years or so to innovate
15:08 < nmz787_i1> kanzure: so no micro/nano fluidics huh?
15:09 < kanzure> microfluidic designs would not be substantially better than pick-and-place
15:09 < nmz787_i1> lol
15:09 < nmz787_i1> sweet
15:09 < kanzure> yes i know you get off on having secrets you don't share...
15:10 < nmz787_i1> yeah I am lonely
15:10 < kanzure> in the microfluidic designs the problem was that even with photolithography you end up with routing problems because high valve count designs don't work yet
15:10 < kanzure> er i mean photolithography for the dna synthesis stage
15:10 < nmz787_i1> sounds like a mfg yield issue
15:11 < kanzure> i doubt it
15:11 < nmz787_i1> oh diff issue then
15:11 < nmz787_i1> still too macro
15:12 < kanzure> picoliter water droplets were also inappropriate for assembly reactions because you still have the same routing problems getting to the stage where you use picoliter encapsulation before the picoliter drop-drop reaction chamber intersection
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15:12 < kanzure> or was it femtoliter... whatever.
15:13 < nmz787_i1> i was just reading a few days ago neuron cells etch silicon dioxide
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15:13 < kanzure> did you have a proposal ?
15:13 < nmz787_i1> which is a problem for sensing/neural growth sernsor array chips
15:14 < nmz787_i1> kanzure: I do, discussing some things on Monday with some folks
15:17 < kanzure> you and your valves..
15:17 < thegtabot> Hey guys
15:18 < nmz787_i1> sup thegtabot
15:19 < thegtabot> I'm from hacdc
15:20 < thegtabot> You guys ever think of establishing a biohacking space for DIY biohackers?
15:20 < kanzure> no, community lab spaces are morally wrong
15:20 < nmz787_i1> thegtabot: lots of them exist already
15:20 < kanzure> calling them DIY is especially morally wrong
15:20 < nmz787_i1> DIT (do it together)
15:20 < kanzure> just call it corporate
15:20 < kanzure> or group
15:20 < nmz787_i1> (pronounced DEET, like the famous chemical)
15:21 < thegtabot> Any in Washington d.c?
15:22 < nmz787_i1> thegtabot: https://diybio.org/local/
15:23 < nmz787_i1> thegtabot: https://diyhpl.us/wiki/diybio/groups/
15:26 < thegtabot> First I find that there are spaces for computer and electrical engineers to collaborate....
15:26 < thegtabot> Now I know there are biotechnology spaces that are the same way...? I am a very happy man now.
15:28 < nmz787_i1> :)
15:40 < kanzure> zilch content http://neochromosome.com/
15:40 < kanzure> http://www.recombinetics.com/ "These animals will possess a wide variety of genetically preferable traits that enhance productivity"
15:41 < kanzure> "develop unique and improved genetic lines of pigs bred to duplicate human diseases such as heart disease, diabetes, and cancer. The result: generations of highly effective drugs and medical devices developed more quickly and at lower costs as Recombinetics models enable testing of both safety and efficacy."
15:41 < kanzure> "using CRISPR and TALENs, the proprietary gene editing technology for which we have global exclusive rights in livestock"
15:42 < kanzure> http://www.editasmedicine.com/ http://enevolv.com/ "engineers microorganisms to produce valuable bio-based products from renewable feedstocks"  "enEvolv builds and screens genomic designs in massive parallel – directly in a single culture – on the order of billions of strains per month"
15:43 < chris_99> Random question, say you have paper, with print on, which is then covered with opaque material, can anyone suggest any way to see through opaque material, to see the print on the paper, i've tried IR with a powerful IR beam, but that didn't work alas
15:43 < kanzure> http://www.egenesisbio.com/ "mission is to transform xenotransplantation into an everyday, lifesaving ​medical procedure"
15:47 < nmz787_i1> chris_99: I know a guy used a highpower green laser pointer to see through scratch-off plastic covering single-use phone-card codes
15:47 < drethelin> why phone-cards and not lottery
15:47 < nmz787_i1> phone cards were a monopoly in his country... i bet lottery is illegal
15:48 < chris_99> nmz787_i1, interesting, and used a standard camera to pick up the result?
15:48 < nmz787_i1> chris_99: I want to say he used his eyes
15:48 < chris_99> heh, that sounds dangerous
15:51 < nmz787_i1> hmm, I wonder if there are MP3/wav to MIDI converters out there.
15:51 < nmz787_i1> I've got a song that is already supposedly '8 bit'... so seems it should convert well
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15:51 < chris_99> i _think_ ages ago, i've seen something that could do that
15:52 < nmz787_i1> it also seems like it would sound pretty good on a tesla coil speaker thing
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15:53 < nmz787_i1> hmm http://www.pluto.dti.ne.jp/~araki/amazingmidi/
15:53 < nmz787_i1> .title
15:53 < yoleaux> WAV to MIDI, wav to mid converter, music transcribe software, freeware, AmazingMIDI
15:53 < chris_99> cool
15:55 < nmz787_i1> hmm, so I am guessing the general technique would be, load audio, do FFT on small chunks at a time, then for each FFT peak, find the closest MIDI note?
15:56 < chris_99> when you press a note on a piano, like A, or whatnot, im assuming it's not a single sine wave though, are there lots of harmonics?
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16:01 < nmz787_i1> hmm, good question
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16:54 < xentrac> nmz787: there are a bunch of algorithms for music transcription, but in the polyphonic case, it's still a substantially unsolved problem
16:55 < xentrac> I suspect probabilistic programming languages will conquer it shortly
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16:56 < xentrac> chris_99: there are a lot of kinds of radiation you can use and a lot of things you can detect about the radiation
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21:53 < kanzure> hmph
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23:06 < nmz787> xentrac: polyphonic meaning multiple frequencies at once?
23:11 < nmz787> .tell chris_99 3d-printer with magnetometer to map magentics http://hackaday.com/2016/06/17/hackaday-prize-entry-visualizing-magnetic-fields/
23:11 < yoleaux> nmz787: I'll pass your message to chris_99.
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--- Log closed Sat Jun 18 00:00:33 2016