--- Log opened Sun Jun 26 00:00:40 2016
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07:05 < kanzure> can anyone get me a copy of "Towards automated design of mechanically functional molecules"?
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09:19 < kanzure> seti institute stuff https://www.youtube.com/user/setiinstitute/videos
09:19 < kanzure> .title https://www.youtube.com/watch?v=1G2GnRrMI5g
09:19 < yoleaux> 400 years of Planetary Cartography - mapping channels on Mars - Henrik Hargitai(SETI Talks) - YouTube
09:19 < kanzure> .title https://www.youtube.com/watch?v=XCXLdEI4B4M
09:19 < yoleaux> All Aboard The 100 Year Starship Panel Discussion (SETICon 2012) - YouTube
09:21 < kanzure> "Revised estimates for the number of human and bacteria cells in the body" http://biorxiv.org/content/early/2016/01/06/036103
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10:22 < kanzure> "An open-hardware platform for optogenetics and photobiology" http://biorxiv.org/content/early/2016/05/24/055053
10:23 < kanzure> "Light Plate Apparatus (LPA), a device that can deliver two independent 310 to 1550 nm light signals to each well of a 24-well plate with intensity control over three orders of magnitude and millisecond resolution. Signals are programmed using an intuitive web tool named Iris. All components can be purchased for under $400 and the device can be assembled and calibrated by a non-expert in one day. We use the LPA to precisely control gene ...
10:23 < kanzure> ... expression from blue, green, and red light responsive optogenetic tools in bacteria, yeast, and mammalian cells and simplify the entrainment of cyanobacterial circadian rhythm. The LPA dramatically reduces the entry barrier to optogenetics and photobiology experiments."
10:24 < kanzure> "Ex-STORM: Expansion Single Molecule Nanoscopy" http://biorxiv.org/content/early/2016/04/25/049403
10:25 < kanzure> "We present critical improvements to recently invented Expansion Microscopy (ExM), which resolve the incompatibility between ExM and single molecule super-resolution microscopy STORM. Specifically, the improved ExM circumvents the massive, 50-100%, bleaching of fluorophores during sample preparations, and preserve the efficiency of enzymatic oxygen scavenging systems in expanded samples. These improvements open up new avenues for ...
10:25 < kanzure> ... Ex-STORM - expanding a sample mechanically, and then visualizing the sample with STORM."
10:28 < kanzure> investigation of language impairment something something results point to microtubule transport, motor protein stuff, and cytoskeleton regulation http://biorxiv.org/content/early/2016/06/23/060301
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10:33 < kanzure> "Continuous genetic recording with self-targeting CRISPR-Cas in human cells" http://biorxiv.org/content/early/2016/05/20/053058
10:33 < kanzure> "The ability to longitudinally track and record molecular events in vivo would provide a unique opportunity to monitor signaling dynamics within cellular niches and to identify critical factors in orchestrating cellular behavior. We present a self-contained analog memory device that enables the recording of molecular stimuli in the form of DNA mutations in human cells. The memory unit consists of a self-targeting guide RNA (stgRNA) ...
10:33 < kanzure> ... cassette that repeatedly directs Streptococcus pyogenes Cas9 nuclease activity towards the DNA that encodes the stgRNA, thereby enabling localized, continuous DNA mutagenesis as a function of stgRNA expression"
10:33 < kanzure> "We analyze the temporal sequence evolution dynamics of stgRNAs containing 20, 30 and 40 nucleotide SDSes (Specificity Determining Sequences) and create a population-based recording metric that conveys information about the duration and/or intensity of stgRNA activity. By expressing stgRNAs from engineered, inducible RNA polymerase (RNAP) III promoters, we demonstrate programmable and multiplexed memory storage in human cells triggered ...
10:34 < kanzure> ... by doxycycline and isopropyl β-D-1-thiogalactopyranoside (IPTG). Finally, we show that memory units encoded in human cells implanted in mice are able to record lipopolysaccharide (LPS)-induced acute inflammation over time. This tool, which we call Mammalian Synthetic Cellular Recorder Integrating Biological Events (mSCRIBE), provides a unique strategy for investigating cell biology in vivo and in situ and may drive further ...
10:34 < kanzure> ... applications that leverage continuous evolution of targeted DNA sequences in mammalian cells."
10:34 < kanzure> huh. uh.
10:35 < kanzure> how much of the molecular ticker tape proposal is missing from that
10:36 < kanzure> other than the "record neural firing events" aspect
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16:30 < kanzure> http://foundersfund.com/2016/06/longevity-inc/
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17:44 < kanzure> "Without an AI that can live on the blockchain and replace human judgments, smart contracts are restricted to applications where such judgement are not required, and there doesn't seem to be many of these." http://lesswrong.com/lw/npy/are_smart_contracts_aicomplete/dcap
17:44 < kanzure> yes... ai will solve all your problems... what.
17:46 < UnderCoder> Of course, why has no one thought of using a blockchain for this
17:47 -!- UnderCoder is now known as justanotheruser
17:47 < kanzure> and how many zeroes did you want on that check, again?
17:48 < justanotheruser> Now that you ask, I do need some funding for my blockchain powered nanoAI startup
17:52 < kanzure> justanotheruser: yea i received your slides, looks interesting http://diyhpl.us/~bryan/deck4.pdf
17:55 < nmz787> 3D-printed piston and crankshaft was a hit with some kids
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18:32 < nmz787> hmm, fluidized beds with ultrasound seem like it could be a thing
18:33 < nmz787> .wik fluidized bed
18:33 < yoleaux> "A fluidized bed is formed when a quantity of a solid particulate substance (usually present in a holding vessel) is placed under appropriate conditions to cause a solid/fluid mixture to behave as a fluid. This is usually achieved by the introduction of pressurized fluid through the particulate medium." — https://en.wikipedia.org/wiki/Fluidized_bed
18:36 < nmz787> .g 3d printed Helikon vortex
18:36 < yoleaux> nmz787: Sorry, that command (.g) crashed.
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19:37 < kanzure> http://dilbert.com/strip/2016-06-26
20:01 < kanzure> "After the company Halycon Molecular folded over, I supervised Andrew Payne in the Church lab to write a publication reproducing, characterizing and documenting their DNA manipulation technology." http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0069058
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--- Log closed Mon Jun 27 00:00:41 2016