--- Log opened Mon Jul 11 00:00:54 2016
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05:57 < kanzure> .title http://journal.frontiersin.org/article/10.3389/fneng.2014.00043/full
05:57 < yoleaux> Frontiers | A low-cost programmable pulse generator for physiology and behavior | Frontiers in Neuroengineering
06:01 < kanzure> luke dyson has some questions about rTMS https://sourceforge.net/p/open-rtms/mailman/message/35213429/
06:04 < kanzure> http://www.coindesk.com/bitcoin-industry-seeking-bridge-scaling-divide-july-meeting/
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06:45 < JayDugger> Rational discussion, please ##hplusroadmap. You're our only hope.
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07:46 < archels> kanzure: I finished that neuroscience and deep learning paper — http://biorxiv.org/content/early/2016/06/13/058545
07:46 < archels> it's really quite good
07:46 < archels> an excellent overview of where computational neuroscience is as a field
07:48 < kanzure> .title
07:48 < yoleaux> Towards an integration of deep learning and neuroscience | bioRxiv
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09:27 < ybit_> has anyone used https://github.com/spotify/luigi ?
09:27 < ybit_> anyone here*
09:28 < ybit_> or airflow? https://github.com/apache/incubator-airflow
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14:10 < kanzure> i wonder if there's a way to make human brain development continue in an extended pregnancy and get back to how animals get born and then start running around immediately
14:10 < nmz787_i1> 'add cmake shortcut to the desktop?'   man, who is the person/people who that option targets?
14:10 < kanzure> e.g. ignoring the birthing problems
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14:11 < nmz787_i1> kanzure: I've thought of that, upgrading instincts/the-bootloader
14:11 < nmz787_i1> bootloader/firmware I guess
14:11 < kanzure> maybe keeping the shitheads cooking longer would be good enough
14:12 < nmz787_i1> undercooking doesn't seem to help
14:12 < nmz787_i1> but I know some undercooked folks who are pretty damn capable and very smart
14:12 < kanzure> "In 1945, for example, Beulah Hunter who was 25 at the time gave birth after a pregnancy lasting 375 days, which is slightly over a year and almost 100 days more than the average human gestational period"
14:12 < kanzure> but probably the kid was about average :|
14:12 < nmz787_i1> physically maybe they're weaker?
14:13 < kanzure> if there are no brain development benefits then why bother
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14:32 < kanzure> i guess the argument would be: in the past, brain development didn't happen in utero and then later increasingly happen after birth. instead, it was probably a combination of earlier birth followed by after-birth brain development. so there's unlikely to be "some set of small switches" to flip to get the brain development back in utero.
14:36 < TMA> too few data points in my opinion
14:37 < kanzure> okay so to fix this, we just have to look at all the gene transcripts that are active during childhood development, and then specifically activate them in utero
14:37 < kanzure> this will require taking a /lot/ of dead children
14:38 < TMA> yeah, that might be expensive
14:42 < TMA> to test whether longer gestation is beneficial for brain development I think the best approach is to have several sets of identical twins that are each implanted an embryo which is one half of identical twins and then somehow induce longer gestation in one of the mothers only
14:45 < TMA> I have no idea, how strong the effect should be and therefore how big N shall be used to reliably detect it
14:49 < kanzure> no, it's probably the case that it is not beneficial for brain development by default
14:49 < kanzure> but through some genetic changes it should be possible in principle and by example of other critters
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15:09 < chris_99> .title https://www.youtube.com/watch?v=jOyfZex7B3E
15:09 < yoleaux> Sega Saturn CD - Cracked after 20 years - YouTube
15:09 < chris_99> that's very impressive
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15:30 < kanzure> "personalized toothpaste"
15:31 < kanzure> gourneau: sup
15:32 < gourneau> Heya dude. I am really enjoying this web based IRC client https://thelounge.github.io/. Not as l33t as tmux and irssi, but it is nice :)
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15:36 < gourneau> Y'all see this? "Jennifer Doudna, inventor of gene editing technology CRISPR Cas9, is coming to Disrupt" https://techcrunch.com/2016/07/08/jennifer-doudna-inventor-of-gene-editing-technology-crispr-cas9-is-coming-to-disrupt/
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15:37 < kanzure> which side of the patent dispute is that
15:38 < kanzure> i sort of want to parade the synthetic virus stuff at their conference. is that sufficiently disruptive?
15:39 < gourneau> She is on the Berkeley side. I just think it is interesting she is going to be speaking at a startup event. I wonder if it is going to inspire VCs to invest in BioTech. Or if there will be a post Theranos VC funding winter for BioTech
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15:40 < kanzure> sos ventures is still going strong, i wouldn't worry about it
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17:13 < nmz787_i1> pretty cool: ...next, armed with your explanation of the order of files and REPL execution, I need to try writing files next.
17:13 < nmz787_i1> whoops
17:13 < nmz787_i1> http://mrob.com/pub/comp/xmorphia/ogl/index.html
17:13 < nmz787_i1> .title
17:13 < yoleaux> WebGL Gray-Scott Explorer at MROB
17:13 < nmz787_i1> from http://mrob.com/pub/comp/xmorphia/
17:13 < nmz787_i1> .title
17:13 < yoleaux> Reaction-Diffusion by the Gray-Scott Model: Pearson's Parameterization at MROB
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20:58 < fenn> https://www.i3detroit.org/wiki/Category:Equipment
20:58 < fenn> nice bit of kit there
21:07 < nmz787_i> haha, the VHS VCR has 3 owners
21:07 < yoleaux> 10 Jul 2016 18:24Z <chris_99> nmz787_i: Nope I haven't sorry
21:08 < nmz787_i> husqvarna makes sewing machines? for lumberjacks???
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21:12 < kanzure> "tireless and lightning fingers" https://www.w3.org/2016/04/blockchain-workshop/report.html
21:15 < nmz787_i> huh, an intel guy
21:15 < kanzure> yes, bowman does various hyperledger things
21:15 < nmz787_i> maybe I should go pester him, he appears to be in a building that is near a hot chocolate dispenser machine...
21:16 < kanzure> i'm glad that your priorities are correct
21:16 < nmz787_i> two birds with one stone...
21:16 < kanzure> casual bird murder? alright :)
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21:38 < kanzure> an old thread about dna synthesis https://groups.google.com/d/msg/diytranshumanist/SylIWrID-UY/FoL1ikPLhfQJ
21:41 < kanzure> "photographic memory in a pill" https://groups.google.com/d/msg/diytranshumanist/3kBK6WCUBgc/3yoP9Q7DIH0J
21:42 < kanzure> (speaking of which, we should do lucid dreaming in a pill)
21:48 < ebowden1> What protein did that?
21:49 < ebowden1> Oh.
21:49 < ebowden1> RGS-14
21:50 < ebowden1> Increasing the expression of the RGS14 protein in the V2 secondary visual cortex of mice promotes the conversion of short-term to long-term object-recognition memory.[2] Conversely RGS14 is enriched in CA2 pyramidal neurons and suppresses synaptic plasticity of these synapses and hippocampal-based learning and memory.
21:50 < ybit_> https://www.alchemistowl.org/pocorgtfo/pocorgtfo12.pdf
21:51 < kanzure> " Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.[1]"
21:51 < ybit_> turns out the 2600 community is still around
21:51 < kanzure> death is merely a temporary inconvenience, ybit
21:52 < ebowden1> It seems to suppress synaptic plasticity in hippocampal pyramidal neurons.
21:56 < ebowden1> I wonder what role GTPases play in cancer.
21:59 < ebowden1> "The importance of GAPs comes from its regulation of the crucial G proteins. Many of these G proteins are involved in cell cycling, and as such are known proto-oncogenes."
21:59 < ebowden1> Fuck!
22:00 < ebowden1> http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705331/
22:00 < ebowden1> I just wish we could have our cake and eat it too.
22:03 < ybit_> http://www.meetup.com/BitDevsNYC/events/231847507/
22:05 < ybit_> https://magoo.github.io/Blockchain-Graveyard/
22:06 < ybit_> https://gappleto97.github.io/visualizer/
22:06 < ybit_> "Visualization of unconfirmed bitcoin transactions as they are propagated."
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22:48 < CaptHindsight> where do they hide the databases for know human gene mutations considered genetic disorders?
22:48 < CaptHindsight> know/known
22:48 < CaptHindsight> http://omim.org/
22:49 < CaptHindsight> http://www.genenames.org/useful/genome-databases-and-browsers
22:49 < CaptHindsight> http://www.ncbi.nlm.nih.gov/gene
22:50 < CaptHindsight> http://www.ncbi.nlm.nih.gov/genome/guide/human/
22:50 < ebowden1> CaptHindsight, checked in ##chemistry, LM11A-31 would not be that expensive to synth.
22:50 < CaptHindsight> not really interested
22:51 < ebowden1> Yeah, I get it.
22:51 < ebowden1> You're worried you'll accidentally put cyanide in it.
22:51 < nmz787_i> kanzure: well there is dream herb (calea zachatechi?)
22:51 < CaptHindsight> working on other projects
22:52 < nmz787_i> .wik dream herb
22:52 < yoleaux> "Calea ternifolia (syn. Calea zacatechichi) is a species of flowering plant in the aster family, Asteraceae. It is native to Mexico and Central America. Its English language common names include Thepelakano (leaves of god), bitter-grass, Mexican calea, and dream herb." — https://en.wikipedia.org/wiki/Dream_herb
22:52 < ebowden1> CaptHindsight, I forget, resin, and some things do with additive manufacturing.
22:52 < ebowden1> UV curing resin?
22:53 < nmz787_i> CaptHindsight: if you are doing UV cure resin... do you have any knowledge of toxicity? I have desired a UV-curable bandage for wounds like severe bleeding or blisters
22:54 < nmz787_i> I almost bought some solarEZ to try out for that sort of thing, along with 3D printing/microfab stuff
22:54 < CaptHindsight> I have a company that makes, resins, coatings, paints, inks etc
22:54 < ebowden1> Oh, interested in non-toxic fire retardants that don't leech out?
22:54 < CaptHindsight> radcure, isocyanates, acrylics etc
22:55 < ebowden1> (And that are actually better than the toxic ones.)
22:56 < nmz787_i> CaptHindsight: are you a polymer chemist by training, or materials scientist?
22:56 < nmz787_i> or just regular chemist?
22:56 < nmz787_i> or chem E?
22:56 < nmz787_i> ebowden1 are you talking to me about fire retardants?
22:56 < ebowden1> :D
22:56 < ebowden1> Oh? :D
22:57 < nmz787_i> I only really considered them when I was bed shopping a few years ago
22:57 < CaptHindsight> I pretty much avoid chemistry until all the great chemists I worked with started dying off
22:57 < nmz787_i> something about them killing you softly during sleep
22:57 < ebowden1> Yup.
22:58 < CaptHindsight> I never knew that babies were so combustible
22:58 < ebowden1> But there's now one that is not at all toxic and performs better.
22:58 < ebowden1> Polydopamine.
22:58 < CaptHindsight> mine never even smoked or got much above 104F
22:58 < ebowden1> lol
22:59 < ebowden1> So, what was your field CaptHindsight?
22:59 < CaptHindsight> mostly cornfields, but this year it is soy
23:00 < ebowden1> lol
23:00 < ebowden1> Materials Scientist?
23:00 < CaptHindsight> I do whatever
23:00 < ebowden1> Production Engineer?
23:00 < ebowden1> Ok.
23:00 < ebowden1> What was your training then?
23:01 < CaptHindsight> potty and bible as a child
23:01 < ebowden1> lol
23:01 < ebowden1> How about university?
23:02 < CaptHindsight> more potty
23:02 < CaptHindsight> oh and some arts
23:03 < ebowden1> No technical training whatever?
23:03 < CaptHindsight> I never let my schooling interfere with my education
23:04 < ebowden1> How did you learn to set up factories then?
23:05 < ebowden1> Just learned by doing?
23:07 < CaptHindsight> by the time you hit 30 or so this all becomes very unimportant
23:07 < CaptHindsight> I forget about all the pissing contests 20 something tech people go through
23:09 < ebowden1> I know a tech man in his late 20s, pushing 30 real hard, him not having a degree has meant that the only way he can get decent pay is by being a contractor Iraq.
23:09 < CaptHindsight> some of the best chemists and geneticists I worked with only had degrees in math
23:09 < ebowden1> I know a tech man in his late 20s, pushing 30 real hard, him not having a degree has meant that the only way he can get decent pay is by being a contractor in Iraq.
23:10 < CaptHindsight> any relation to the bowden extruder?
23:10 < nmz787_i> 'only'???
23:10 < nmz787_i> math is like, the hottest degree
23:11 < CaptHindsight> got me all the girls
23:11 < ebowden1> No, my Grandfather was a surface physicist, my father a landscape impressionist.
23:11 < nmz787_i> I mean, math is the cutting edge of society (or at the base of cutting edge science/engineering research and development)
23:12 < nmz787_i> CaptHindsight: I might guess you grew up in the USA... based on some supposed research article about how other countries are supposed to have less dichotomy between nerds and jocks, or something fairy-tale like
23:13 < CaptHindsight> zzzzz
23:13 < CaptHindsight> just relax and find something to do
23:14 < nmz787_i> /me is working on math for pay for electronics
23:14 < nmz787_i> well, applied math programming
23:14 < nmz787_i> or something
23:15 < CaptHindsight> you guys might actually accomplish something if you'd cooperate with each other vs the constant manipulation
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23:15 < ebowden1> What guys?
23:15 < nmz787_i> manipulating variables or bits
23:15 < nmz787_i> ?
23:15 < nmz787_i> or electrons
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23:16 < nmz787_i> co-operation seems like it would require co-manipulation, as far as electron clouds go
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23:22 < ebowden1> CaptHindsight, any thermosets?
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--- Log closed Tue Jul 12 00:00:54 2016