--- Log opened Sat Dec 03 00:00:01 2016 --- Day changed Sat Dec 03 2016 00:00 -!- ebowden [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap 00:03 -!- ebowden [~ebowden@unaffiliated/ebowden] has quit [Remote host closed the connection] 00:04 -!- ebowden [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap 00:12 -!- ebowden_ [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap 00:14 -!- ebowden [~ebowden@unaffiliated/ebowden] has quit [Ping timeout: 240 seconds] 00:22 -!- Orpheon [~Orpheon@213.200.193.129] has quit [Read error: Connection reset by peer] 01:23 -!- cluckj [~cluckj@pool-173-49-237-221.phlapa.fios.verizon.net] has quit [Ping timeout: 265 seconds] 01:38 -!- sandeepkr [~sandeepkr@103.49.155.114] has quit [Ping timeout: 256 seconds] 01:44 -!- fleshtheworld [~fleshthew@108-240-244-194.lightspeed.frsnca.sbcglobal.net] has quit [Quit: Leaving] 01:54 -!- sandeepkr [~sandeepkr@103.49.155.114] has joined ##hplusroadmap 02:15 -!- M4l3z [~M4l3z@LFbn-1-4220-37.w92-169.abo.wanadoo.fr] has joined ##hplusroadmap 02:25 -!- wrldpc1 [~ben@p352135-ipngn200606kyoto.kyoto.ocn.ne.jp] has joined ##hplusroadmap 02:49 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-gvngllguqbfxdumu] has joined ##hplusroadmap 03:01 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap 03:54 -!- PatrickRobotham [uid18270@gateway/web/irccloud.com/x-bzvfavubqengmpyd] has joined ##hplusroadmap 04:05 -!- darsie [~darsie@84-113-55-42.cable.dynamic.surfer.at] has joined ##hplusroadmap 04:06 -!- Gurkenglas [~Gurkengla@dslb-178-000-094-167.178.000.pools.vodafone-ip.de] has joined ##hplusroadmap 04:19 -!- Urchin[emacs] [~user@unaffiliated/urchin] has joined ##hplusroadmap 04:32 -!- urchin_ [~urchin@89.17.11.52] has joined ##hplusroadmap 04:33 -!- Urchin[emacs] [~user@unaffiliated/urchin] has quit [Disconnected by services] 04:34 -!- Urchin[emacs] [~user@unaffiliated/urchin] has joined ##hplusroadmap 04:35 -!- Urchin [~urchin@unaffiliated/urchin] has quit [Ping timeout: 250 seconds] 04:36 -!- FriendComputer [~urchin@unaffiliated/urchin] has quit [Ping timeout: 260 seconds] 04:48 -!- M4l3z [~M4l3z@LFbn-1-4220-37.w92-169.abo.wanadoo.fr] has quit [Remote host closed the connection] 04:55 -!- cluckj [~cluckj@pool-173-49-237-221.phlapa.fios.verizon.net] has joined ##hplusroadmap 04:55 -!- M4l3z [~M4l3z@LFbn-1-4220-37.w92-169.abo.wanadoo.fr] has joined ##hplusroadmap 05:13 -!- juri_ [~juri@192.94.73.193] has quit [Ping timeout: 250 seconds] 05:21 -!- juri_ [~juri@192.94.73.193] has joined ##hplusroadmap 05:23 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-gvngllguqbfxdumu] has quit [Quit: Connection closed for inactivity] 05:28 -!- Gurkenglas [~Gurkengla@dslb-178-000-094-167.178.000.pools.vodafone-ip.de] has quit [Ping timeout: 256 seconds] 05:28 -!- Gurkenglas [~Gurkengla@dslb-178-000-094-167.178.000.pools.vodafone-ip.de] has joined ##hplusroadmap 05:50 -!- urchin_ [~urchin@89.17.11.52] has quit [Changing host] 05:50 -!- urchin_ [~urchin@unaffiliated/urchin] has joined ##hplusroadmap 05:50 -!- urchin_ is now known as Urchin 06:09 -!- wrldpc1 [~ben@p352135-ipngn200606kyoto.kyoto.ocn.ne.jp] has quit [Quit: wrldpc1] 06:25 < kanzure> bloop 06:26 -!- jtimon [~quassel@186.31.134.37.dynamic.jazztel.es] has quit [Ping timeout: 260 seconds] 06:27 < cluckj> beep 06:27 < kanzure> ah.. 06:27 < cluckj> do you know of any good resources that talk about the FDA's biosimilar drug regulations and policies? 06:28 < cluckj> I'm churning through my research databases already 06:30 < cluckj> I figured I could ask the kanzure database too :) 06:30 < streety> have you asked the FDA? 06:30 < streety> although a response is unlikely during the weekend 06:33 < cluckj> :/ 06:37 < kanzure> no 06:38 < cluckj> k, thanks 06:38 < cluckj> the fda would just point me at their publicly available whitepapers and policy documents, which I am already looking through 06:42 < cluckj> I'm talking with a senator's office on wednesday about insulin and am trying to prepare arguments :P 06:56 < streety> actually I wouldn't assume that is all they will be willing/able to do. Try to set up a phone call with someone and they can probably address any questions you have that aren't covered in their public material 06:57 < streety> depends on getting the right someone but when I've been at meetings with FDA attendance they've always encouraged people making contact 07:14 < cluckj> ah okay 07:14 < cluckj> I can throw credentials around and get a callback, for sure 07:17 -!- maaku [~quassel@173-228-107-141.dsl.static.fusionbroadband.com] has quit [Quit: No Ping reply in 180 seconds.] 07:19 -!- maaku [~quassel@173-228-107-141.dsl.static.fusionbroadband.com] has joined ##hplusroadmap 07:26 -!- maaku [~quassel@173-228-107-141.dsl.static.fusionbroadband.com] has quit [Quit: No Ping reply in 180 seconds.] 07:27 -!- maaku [~quassel@173-228-107-141.dsl.static.fusionbroadband.com] has joined ##hplusroadmap 07:30 < kanzure> cluckj: i'm sure you follow all the diy insulin stuff much more closely than i do 07:34 < cluckj> yes, as little as they report on publicly...I'm going to have a chat with them soon 07:35 < kanzure> i'm not sure about ideal reforms for fda to propose, it's a hard thing to figure out 07:35 < cluckj> I see their work as a "this is how important it is to diabetics" and not as a solution to systemic problems with pharmaceuticals 07:35 < cluckj> yeah, I think that's what I'm being sourced for 07:36 < kanzure> apparently it's illegal to build diy wheelchairs or something. fda is severe. 07:36 < kanzure> http://diyhpl.us/wiki/fda/ 07:36 < cluckj> haha they were having a weird reaction to the DIY artificial pancreas stuff too afaik 07:37 < cluckj> like "we aren't going to stop you..................................yet" 07:37 < kanzure> our "walking dead" members of society should be allowed to do more insane/risky medical tech stuff, and there should be businesses selling to them prolly 07:38 < kanzure> i dunno if it has to be totally unregulated, maybe a small light amount of regulation at least, but certainly not anything to prevent one-shot one-off attempts at improving quality of life and function 07:39 < cluckj> as one of the walking dead, I kind of want the ability to safely experiment and push companies to experiment more with their tech 07:40 < kanzure> alternatively, if the fda is so worried about unregulated tech screwing people up, then they should allocate a budget for pursuing quality-of-life "points" and the "walking dead" should get to collectively spend hypothetical quality years on pursuing different innovations and research or practical short-term solutions, so e.g. if something is "too risky" then the regulators should be required ... 07:40 < kanzure> ...to make up for the difference in pursuing some other short-term direction for their benefit 07:40 < cluckj> I think it needs to be regulated enough so that it's not insanely risky 07:40 < cluckj> precisely 07:40 -!- PatrickRobotham [uid18270@gateway/web/irccloud.com/x-bzvfavubqengmpyd] has quit [Quit: Connection closed for inactivity] 07:41 < kanzure> as it is, regulators can just say "lol nope, or we sue the fuck out of you and/or raid you with military strike force" but really it should be about delivering and pursuing quality of life and enhancement overall, rather than simply attacking the diseased 07:41 < kanzure> i get it -- a *lot* of snake oil out there. but preventing snake oil is not quite what everyone is interested in.... people are more interested in pursuing solutions. 07:41 < cluckj> the whole "we are not waiting" group/movement is trying to do incremental change stuff by experimenting together by hacking COTS tech 07:42 < cluckj> but the security in that tech that the FDA regulation requires makes hacking it a little dangerous and not super fruitful 07:42 < kanzure> best way to repurpose the FDA would be to give them a mandate to participate and help the proactive stuff, like e.g. making engineering talent more available, or otherwise spending money on DIY stuff, etc. 07:43 < cluckj> yes, that's how they've been treating #wearenotwaiting so far 07:43 < kanzure> is that a twitter hashtag 07:43 < cluckj> yeah, my bad 07:43 < kanzure> they ain't waiting but they're tweeting..? 07:44 < cluckj> lol, that's just the community building stuff, they're really making artificial pancreas tech 07:44 < cluckj> stuff that works 07:45 < cluckj> interfacing certain insulin pumps with continuous glucose monitors, and running algorithms for closed-loop dosing 07:45 < cluckj> and semi-closed loop dosing 07:47 < cluckj> https://openaps.org/ 07:49 < kanzure> .title 07:49 < yoleaux> OpenAPS.org - #WeAreNotWaiting to reduce the burden of Type 1 diabetes 07:50 < kanzure> are they doing insulin production too? 07:52 < cluckj> not the openaps folks, but open insulin talks about and identifies with #wearenotwaiting 07:54 < cluckj> also holy shit novo nordisk is fucking evil, like old testament evil 07:55 < cluckj> pulling their insulin products out of both greece and germany when they tried to institute price controls, and bribing regulatory officials in china 09:22 -!- ebowden_ [~ebowden@unaffiliated/ebowden] has quit [Remote host closed the connection] 09:50 < drethelisk> cluckj how long until someone's pump gets hacked and they get assassinated over wifi 09:57 < kanzure> precautions: don't go to defcon 10:16 -!- ebowden [~ebowden@1.152.97.65] has joined ##hplusroadmap 10:16 -!- ebowden [~ebowden@1.152.97.65] has quit [Changing host] 10:16 -!- ebowden [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap 10:20 -!- ebowden [~ebowden@unaffiliated/ebowden] has quit [Ping timeout: 240 seconds] 10:53 < souljack> blue team goes blue 11:05 < cluckj> drethelisk, who knows 11:05 < cluckj> there's already been vulnerabilities found in wireless-enabled medical devices 11:13 -!- helleshin [~talinck@66-161-138-110.ubr1.dyn.lebanon-oh.fuse.net] has quit [Read error: Connection reset by peer] 11:30 -!- helleshin [~talinck@66-161-138-110.ubr1.dyn.lebanon-oh.fuse.net] has joined ##hplusroadmap 11:48 -!- yashgaroth [~yashgarot@2602:306:35fa:d500:f5e0:f867:a11d:8d52] has joined ##hplusroadmap 12:15 -!- M4l3z [~M4l3z@LFbn-1-4220-37.w92-169.abo.wanadoo.fr] has quit [Read error: Connection reset by peer] 12:17 < kanzure> hrm. 12:24 -!- drewbot [~cinch@ec2-54-92-177-249.compute-1.amazonaws.com] has quit [Remote host closed the connection] 12:24 -!- drewbot [~cinch@ec2-54-205-252-23.compute-1.amazonaws.com] has joined ##hplusroadmap 12:27 < cluckj> ? 13:15 -!- sandeepkr [~sandeepkr@103.49.155.114] has quit [Ping timeout: 265 seconds] 13:27 -!- Solvaring [~Solvaring@162.219.178.146] has joined ##hplusroadmap 13:32 -!- ebowden [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap 13:36 -!- ebowden [~ebowden@unaffiliated/ebowden] has quit [Ping timeout: 240 seconds] 13:41 < kanzure> http://rajlaboratory.blogspot.com/2016/12/some-reluctant-thoughts-on-postdoc-pay.html?spref=tw 14:16 -!- fleshtheworld [~fleshthew@2602:306:cf0f:4c20:811:c644:3a17:a0f6] has joined ##hplusroadmap 14:26 -!- ebowden [~ebowden@2001:8003:103c:ee00:edbd:b87e:47b:a147] has joined ##hplusroadmap 14:26 -!- ebowden [~ebowden@2001:8003:103c:ee00:edbd:b87e:47b:a147] has quit [Changing host] 14:26 -!- ebowden [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap 14:30 -!- ebowden [~ebowden@unaffiliated/ebowden] has quit [Ping timeout: 240 seconds] 15:02 < kanzure> a39e3a8d37793792f62b85cbd7b74cafe482b5b2014203ca28b8555822ce74f3 public-file-size-md_20150304205357.json.gz 15:02 < kanzure> from https://archive.org/details/ia-bak-census_20150304 15:03 < kanzure> unfortunately that one had all md5-only hashes 15:12 < kanzure> 8daa7a635d77eddb9fecb000abbe10b19611b623a1242b4a7b4b7881b92ddae6 file_hashes_sha1_20160411221100_public.tsv.gz.ots 15:12 < kanzure> from https://archive.org/details/ia_census_201604 15:27 -!- maaku [~quassel@173-228-107-141.dsl.static.fusionbroadband.com] has quit [Quit: No Ping reply in 180 seconds.] 15:29 -!- maaku [~quassel@173-228-107-141.dsl.static.fusionbroadband.com] has joined ##hplusroadmap 15:30 < kanzure> e2bc2f240490e91d52a1eaeb5636664f75795da9bfcbbe7692c07b90ae18244b file_hashes_sha1_20160411221100_private.tsv.gz 15:41 < kanzure> and from https://archive.org/download/archiveteam_census_2016 15:42 < kanzure> 2840f4e64f4c2bf562e97294714371cfe7beb4122e73c3437d535175d93e53df 2016.10.23-ia_identifiers.txt.gz 15:47 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Quit: Leaving] 15:50 < kanzure> er, i don't mean ".ots" above obviously. sorry. 16:11 -!- fleshtheworld [~fleshthew@2602:306:cf0f:4c20:811:c644:3a17:a0f6] has quit [Quit: Leaving] 16:21 -!- gbara22 [be169e16@gateway/web/freenode/ip.190.22.158.22] has joined ##hplusroadmap 16:38 < kanzure> .wik PTPRS 16:38 < yoleaux> "Receptor-type tyrosine-protein phosphatase S, also known as R-PTP-S, R-PTP-sigma, or PTP?, is an enzyme that in humans is encoded by the PTPRS gene." -- https://en.wikipedia.org/wiki/PTPRS 16:38 < kanzure> "Alzheimer's disease pathogenesis is dependent on neuronal receptor PTPsigma" http://biorxiv.org/content/early/2016/12/01/079806 17:04 -!- ebowden [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap 17:13 -!- jtimon [~quassel@186.31.134.37.dynamic.jazztel.es] has joined ##hplusroadmap 17:20 -!- drethelisk [~drethelin@24-241-226-112.dhcp.mdsn.wi.charter.com] has quit [Ping timeout: 245 seconds] 17:21 -!- PatrickRobotham [uid18270@gateway/web/irccloud.com/x-xbozrcgbtoolkwah] has joined ##hplusroadmap 17:28 < kanzure> http://bioviva-science.com/blog/dual-gene-therapy-has-beneficial-effects-on-blood-biomarkers-and-muscle-composition 17:30 < kanzure> 17:30 -!- Madars [~null@unaffiliated/madars] has quit [Ping timeout: 260 seconds] 17:32 -!- Madars [~null@unaffiliated/madars] has joined ##hplusroadmap 17:38 -!- duper [~super@ca4.blackcatz.org] has quit [Ping timeout: 240 seconds] 17:40 -!- Orpheon [~Orpheon@213.200.193.129] has joined ##hplusroadmap 17:49 -!- duper [~super@ca4.blackcatz.org] has joined ##hplusroadmap 17:57 -!- yashgaroth [~yashgarot@2602:306:35fa:d500:f5e0:f867:a11d:8d52] has quit [Ping timeout: 240 seconds] 18:21 -!- duper [~super@ca4.blackcatz.org] has quit [Ping timeout: 268 seconds] 18:29 < kanzure> c01ab15c61ad21adb0f690579204ac4287f65d3efde068b7c3c108df38bc6dbc http://gnusha.org/logs/hashes/loghashes.005.txt 18:33 < kanzure> https://hash-archive.org/history/http://gnusha.org/logs/hashes/loghashes.005.txt 18:34 -!- Orpheon [~Orpheon@213.200.193.129] has quit [Remote host closed the connection] 18:38 < kanzure> http://web.archive.org/web/20161204023006/http://gnusha.org/logs/hashes/loghashes.005.txt 18:39 < kanzure> https://archive.org/details/hplusroadmap-logs-2016-09-18 18:44 < kanzure> af43f33d154cfc2bb4ca467ac6e360411f4178e3faf3f28202d7199988ce216a http://gnusha.org/logs/archives/hplusroadmap-logs-2016-12-03.tar.gz 18:44 < kanzure> https://hash-archive.org/history/http://gnusha.org/logs/archives/hplusroadmap-logs-2016-12-03.tar.gz 18:59 -!- duper [~super@104.167.98.38] has joined ##hplusroadmap 19:04 -!- maaku [~quassel@173-228-107-141.dsl.static.fusionbroadband.com] has quit [Quit: No Ping reply in 180 seconds.] 19:05 -!- maaku [~quassel@173-228-107-141.dsl.static.fusionbroadband.com] has joined ##hplusroadmap 19:30 -!- Gurkenglas [~Gurkengla@dslb-178-000-094-167.178.000.pools.vodafone-ip.de] has quit [Ping timeout: 256 seconds] 19:42 < kanzure> qidq091341aid 19:43 -!- maaku [~quassel@173-228-107-141.dsl.static.fusionbroadband.com] has quit [Quit: No Ping reply in 180 seconds.] 19:45 -!- maaku [~quassel@173-228-107-141.dsl.static.fusionbroadband.com] has joined ##hplusroadmap 19:55 < kanzure> https://github.com/bjornedstrom/timmy ""Trusted timestamping" is using a trusted party to sign a timestamp together with a piece of data (normally a hash of a document). This can for example be used to prove that a document was authored at, or before, a certain date. timmy is a command line tool that uses a peculiarity in the TLS protocol to let many TLS servers act as a trusted timestamping s... 19:55 < kanzure> ...erver. That is, you can let a TLS server, such as www.google.com, sign your hash with a timestamp provided by the server." 19:59 < kanzure> there was another tool like this, but it wasn't explicitly for timestamping. does anyone remember what it was? 20:23 < streety> reminds me somewhat of the NIST randomness beacon, well the complement of it 20:30 -!- maaku [~quassel@173-228-107-141.dsl.static.fusionbroadband.com] has quit [Quit: No Ping reply in 180 seconds.] 20:32 -!- maaku [~quassel@173-228-107-141.dsl.static.fusionbroadband.com] has joined ##hplusroadmap 20:35 -!- maaku [~quassel@173-228-107-141.dsl.static.fusionbroadband.com] has quit [Client Quit] 20:36 -!- maaku [~quassel@173-228-107-141.dsl.static.fusionbroadband.com] has joined ##hplusroadmap 20:42 -!- gbara22 [be169e16@gateway/web/freenode/ip.190.22.158.22] has quit [Ping timeout: 260 seconds] 20:46 -!- darsie [~darsie@84-113-55-42.cable.dynamic.surfer.at] has quit [Ping timeout: 244 seconds] 20:50 -!- maaku_ [~quassel@173-228-107-141.dsl.static.fusionbroadband.com] has joined ##hplusroadmap 20:50 -!- maaku [~quassel@173-228-107-141.dsl.static.fusionbroadband.com] has quit [Ping timeout: 260 seconds] 20:53 -!- maaku_ [~quassel@173-228-107-141.dsl.static.fusionbroadband.com] has quit [Excess Flood] 20:55 -!- maaku [~quassel@173-228-107-141.dsl.static.fusionbroadband.com] has joined ##hplusroadmap 21:06 -!- maaku [~quassel@173-228-107-141.dsl.static.fusionbroadband.com] has quit [Ping timeout: 260 seconds] 21:08 -!- maaku [~quassel@173-228-107-141.dsl.static.fusionbroadband.com] has joined ##hplusroadmap 21:26 -!- maaku_ [~quassel@173-228-107-141.dsl.static.fusionbroadband.com] has joined ##hplusroadmap 21:27 -!- maaku [~quassel@173-228-107-141.dsl.static.fusionbroadband.com] has quit [Ping timeout: 260 seconds] 21:36 -!- augur [~augur@c-73-46-94-9.hsd1.fl.comcast.net] has quit [Ping timeout: 260 seconds] 21:41 -!- maaku_ [~quassel@173-228-107-141.dsl.static.fusionbroadband.com] has quit [Quit: No Ping reply in 180 seconds.] 21:44 -!- augur [~augur@c-73-46-94-9.hsd1.fl.comcast.net] has joined ##hplusroadmap 21:45 -!- maaku [~quassel@173-228-107-141.dsl.static.fusionbroadband.com] has joined ##hplusroadmap 21:51 -!- maaku [~quassel@173-228-107-141.dsl.static.fusionbroadband.com] has quit [Quit: No Ping reply in 180 seconds.] 21:52 -!- maaku [~quassel@173-228-107-141.dsl.static.fusionbroadband.com] has joined ##hplusroadmap 21:57 -!- ebowden [~ebowden@unaffiliated/ebowden] has quit [] 21:57 -!- ebowden [~ebowden@2001:8003:103c:ee00:e98e:6d6a:298d:fbc4] has joined ##hplusroadmap 21:57 -!- ebowden [~ebowden@2001:8003:103c:ee00:e98e:6d6a:298d:fbc4] has quit [Changing host] 21:57 -!- ebowden [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap 22:18 -!- maaku [~quassel@173-228-107-141.dsl.static.fusionbroadband.com] has quit [Remote host closed the connection] 22:19 -!- maaku [~quassel@173-228-107-141.dsl.static.fusionbroadband.com] has joined ##hplusroadmap 22:31 -!- maaku [~quassel@173-228-107-141.dsl.static.fusionbroadband.com] has quit [Ping timeout: 260 seconds] 22:35 -!- maaku [~quassel@173-228-107-141.dsl.static.fusionbroadband.com] has joined ##hplusroadmap 22:37 -!- juri_ [~juri@192.94.73.193] has quit [Ping timeout: 260 seconds] 22:43 -!- wrldpc1 [~ben@p352135-ipngn200606kyoto.kyoto.ocn.ne.jp] has joined ##hplusroadmap 22:43 -!- juri_ [~juri@192.94.73.193] has joined ##hplusroadmap 22:46 -!- maaku [~quassel@173-228-107-141.dsl.static.fusionbroadband.com] has quit [Ping timeout: 260 seconds] 22:46 -!- maaku [~quassel@173-228-107-141.dsl.static.fusionbroadband.com] has joined ##hplusroadmap 22:50 -!- PatrickRobotham [uid18270@gateway/web/irccloud.com/x-xbozrcgbtoolkwah] has quit [Quit: Connection closed for inactivity] 22:54 -!- sandeepkr [~sandeepkr@103.49.155.114] has joined ##hplusroadmap 22:56 -!- maaku [~quassel@173-228-107-141.dsl.static.fusionbroadband.com] has quit [Ping timeout: 260 seconds] 22:58 -!- maaku [~quassel@173-228-107-141.dsl.static.fusionbroadband.com] has joined ##hplusroadmap --- Log closed Sun Dec 04 00:00:29 2016