--- Log opened Sun Dec 04 00:00:29 2016
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02:28 < Reventlov> 9@
02:28 < Reventlov> miss
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06:18 < kanzure> seems to be updated:
06:18 < kanzure> "Rapidly evolving homing CRISPR barcodes" http://biorxiv.org/content/early/2016/12/01/055863
06:19 < kanzure> "We present here an approach for engineering evolving DNA barcodes in living cells. The methodology entails using a homing guide RNA (hgRNA) scaffold that directs the Cas9-hgRNA complex to target the DNA locus of the hgRNA itself. We show that this homing CRISPR-Cas9 system acts as an expressed genetic barcode that diversifies its sequence and that the rate of diversification can be controlled...
06:19 < kanzure> ... in cultured cells. We further evaluate these barcodes in cultured cell populations and show that they can record lineage history and and that their RNA can be assayed as single molecules in situ. This integrated approach will have wide ranging applications, such as in deep lineage tracing, cellular barcoding, molecular recording, dissecting cancer biology, and connectome mapping."
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07:32 < kanzure> ah, i was thinking of https://tlsnotary.org/ not https://github.com/bjornedstrom/timmy
07:34 < kanzure> https://github.com/tlsnotary/pagesigner-browserless
07:43 < kanzure> oh. the model is a little weird. what? it's using some kind of 'oracle' living on amazon aws. https://tlsnotary.org/pagesigner.html
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08:51 < kanzure> 08:45 <@SketchCow> Internet Archive has several, many times in the past where it has done "something" to every item on the Archive in the name of integrity, improvement, or management. So no, not burdonsome.
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13:42 < Fausta> .
13:43 < darsie> .
13:44 < Fausta> are you mr. darsie
13:44 < nsh> Algorithm design manual: http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.471.4772&rep=rep1&type=pdf
13:44 < darsie> Fausta: I'm an adult male.
13:44 < darsie> I'm not Mr. Darcy from Pride and Perjudice.
13:45 < Fausta> bummer
13:45 < Fausta> actually I never got through the book, it wasn't my cup of tea
13:46 < darsie> Darsie is my boy scout nick. It is derived from Hindi for tailor and Darsie (english spelling darzee) is a male tailor bird in the Rikki Tikki Tavi tale of the "Jungle Book" by Rudyard Kipling. http://www.cs.cmu.edu/~mongoose/rtt.html
13:46 < darsie> I'm from a shorter story.
13:49 < Fausta> are there any other fictional characters here
13:49 < Fausta> well, I guess me
13:49 < darsie> Are you still with Gretchen?
13:49 < Fausta> no, we broke up because I'm not into women
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13:57 < kanzure> what is happening here
13:57 < kanzure> do i need to ban everyone again?
13:57 < darsie> kanzure: Would that include yourself?
13:58 < kanzure> absolutely
13:59 < adlai> i vote Reventlov gets to stay because of the cool name
14:00 < darsie> I'm fine with it if I get Gretchen.
14:00  * Fausta senses that this is a channel with a relatively high average IQ
14:00 < adlai> have whatever you want as long as you simulate it yourself
14:01 < darsie> I'll try to dream of her.
14:01 < adlai> Fausta: average iq is by definition 100. anybody not in this channel doesn't count.
14:01 < kanzure> we have a below average IQ; we actually schedule dissections for everyone with high IQ so that we can investigate their brain anatomy.
14:01 < adlai> dissections are led by next week's subject
14:01 < Fausta> lol
14:02 < darsie> My IQ once was determined to be 124 and another time as 120-130.
14:02  * kanzure moves darsie to the discard pile
14:02 < kanzure> don't need more IQ testtakers in here
14:03 < darsie> Actually I want to be "dissected" and transferred to an artificial (e.g. electronic) brain.
14:03 < Fausta> idk what mine is
14:04 < Fausta> actually they did investigate Einstein's brain and found that he had four times the average glial cell density
14:06 < darsie> Glial cells are non-neuronal cells that maintain homeostasis, form myelin, and provide support and protection for neurons in the central and peripheral nervous systems.
14:08 < Fausta> so I bought an REM dreamer device for lucid dreaming and I think customs is holding it up
14:08 < Fausta> it was sent from Poland a month ago and I still haven't gotten it
14:09 < kanzure> .title https://www.youtube.com/watch?v=N_8Po022S-E
14:09 < yoleaux> Brain Dissection (Big John) - YouTube
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14:28 < adlai> ugh. i'm pretty sure this was mentioned here within the past few weeks, but i'm failing at grep. isn't there some site with a bunch of Ted Chiang stories, including Story of Your Life? no pdf, just text on the site
14:30 < Fausta> http://www.freesfonline.de/authors/Ted_Chiang.html
14:30 < Fausta> just google
14:31 < adlai> i've been ddging/googling for the past 15 minutes, found that site a while ago and it doesn't have the one i'm looking for
14:31 < adlai> iirc this site had all of Story of Your Life And Others
14:34 < kanzure> adlai: infinityplus
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14:36 < adlai> this is just a site selling dead trees
14:37 < adlai> so i found http://archive.is/FtVYn but apparently i forgot to archive Story of Your Life when i read it a couple weeks ago, and the site is dead now. fuck.
14:38 < adlai> ... archive.org to the rescue :D
14:39 < adlai> looks like archive.is does not like getting told to archive archive.org
14:39 < adlai> here we go: http://archive.is/v9xMy http://web.archive.org/web/20160422165053/http://www.ibooksonline.com/88/Text/story.html
14:42 < adlai> enough intellectual property arson for one night, time to let the lizard neurons roam free of primate guidance
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15:33 < harold> hi
15:33 < harold>  i'm trying to get the elecrostatic surface area of codeine -- I think I could by loading the pdb file http://nbcr-222.ucsd.edu/pdb2pqr_2.1.1/ and running apbs ... but somewhere im' fucking up and i don't know where)
15:33 < harold> if anyone has any expereicne with this, any help would be appreciated
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15:59 < jcorgan> http://i.imgur.com/HSA0HUA.png
16:14 < adlai> lol everything other than hydrogen is 'heavy atom'
16:15 < adlai> reminds me of the joke about astrophysicists who remember the periodic table as two elements: hydrogen and 'metals'
16:29 < kanzure> sounds right to me
16:30 < jcorgan> even hydrogen might have a metallic phase under the right pressure conditions
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17:25 < superkuh> There was a paper on arxiv recently showing the formation of metallic phase hydrogen on earth in a diamond anvil.
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17:38 < nmz787> harold: interesting problem
17:40 < nmz787> harold: idk but maybe the software 'fenics' could present some interesting links if you use that in your searches instead of apbs (which I hadn't heard of and looks very cool)
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19:08 < fenn> .wik the inevitable (book)
19:08 < yoleaux> "The Inevitable is a 2016 nonfiction book by Kevin Kelly that forecasts the twelve technological forces that will shape the next thirty years." -- https://en.wikipedia.org/wiki/The_Inevitable_(book)
19:09 < fenn> the prediction seems to be, "we put a phone on it"
19:12 < fenn> "this book will have some dialling furiously for Morpheus to deliver a fresh batch of red pills"
19:13 < kanzure> is this really the best use of his time
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19:46 < Fausta> what would be a better use of his time
19:58 < cluckj> herding cats
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22:59 < ybit> https://news.ycombinator.com/item?id=13098868
22:59 < ybit> "Brain Computation Is Organized via Power-of-Two-Based Permutation Logic"
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--- Log closed Mon Dec 05 00:00:29 2016