--- Log opened Sun Jan 08 00:00:59 2017
00:31 -!- augur [~augur@2601:640:8001:4222:2df6:1bed:fc7d:8e14] has joined ##hplusroadmap
00:52 < fenn> "The most interesting issue is how these Palaeo-Eskimos survived the winter. This is very relevant to Neanderthals as well. Since these people lived in an area with no trees, and hadn't invented sea mammal fuels, it's unconceivable they could keep themselves warm without some genetic adaptations. In fact, torpor, hibernation or at least months of inactivity must have been their way of surviving.
00:52 < fenn> Considering outside temperatures could easily drop to -30 degrees Celsius, with frequent blizzards, and months of total darkness, they would simply die of cold and starvation very fast if they didn't have special adaptations."
00:53 < fenn> (the Dorset people)
00:54 < fenn> "According to legend, the First Inhabitants were "giants", people who were taller and stronger than the Inuit, but who were easily scared off. Scholars now believe the Dorset and the later Thule people were the peoples encountered by the Norse who visited the area. The Norse called these indigenous peoples skraeling."
00:57 -!- Guest56868 [~abe@68.175.143.22] has quit [Ping timeout: 258 seconds]
01:10 -!- Guest56868 [~abe@68.175.143.22] has joined ##hplusroadmap
01:32 -!- juri_ [~juri@205.166.94.194] has quit [Ping timeout: 258 seconds]
02:24 -!- jtimon [~quassel@197.red-88-0-200.dynamicip.rima-tde.net] has joined ##hplusroadmap
02:29 -!- kghosh [~kelu124@mon75-h10-89-81-14-210.dsl.sta.abo.bbox.fr] has joined ##hplusroadmap
02:49 -!- kghosh [~kelu124@mon75-h10-89-81-14-210.dsl.sta.abo.bbox.fr] has quit [Remote host closed the connection]
02:51 -!- kghosh [~kelu124@mon75-h10-89-81-14-210.dsl.sta.abo.bbox.fr] has joined ##hplusroadmap
02:53 -!- darsie [~darsie@84-113-55-42.cable.dynamic.surfer.at] has joined ##hplusroadmap
03:02 -!- sfwqersdfa [50f080dd@gateway/web/freenode/ip.80.240.128.221] has joined ##hplusroadmap
03:02 -!- m4l3z [~m4l3z@2a01cb040226f200b47c015d7e1fe601.ipv6.abo.wanadoo.fr] has joined ##hplusroadmap
03:03 -!- sfwqersdfa [50f080dd@gateway/web/freenode/ip.80.240.128.221] has quit [Client Quit]
03:14 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap
03:28 -!- m4l3z [~m4l3z@2a01cb040226f200b47c015d7e1fe601.ipv6.abo.wanadoo.fr] has quit [Quit: Leaving]
03:41 -!- augur [~augur@2601:640:8001:4222:2df6:1bed:fc7d:8e14] has quit [Remote host closed the connection]
03:50 -!- jtimon [~quassel@197.red-88-0-200.dynamicip.rima-tde.net] has quit [Remote host closed the connection]
04:02 -!- augur [~augur@2601:640:8001:4222:2df6:1bed:fc7d:8e14] has joined ##hplusroadmap
04:03 -!- Mariu [~Jimmy98@89.41.57.33] has joined ##hplusroadmap
04:07 -!- augur [~augur@2601:640:8001:4222:2df6:1bed:fc7d:8e14] has quit [Ping timeout: 255 seconds]
04:20 -!- q4 [~q4@user-94-254-164-27.play-internet.pl] has joined ##hplusroadmap
04:56 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Remote host closed the connection]
04:56 -!- chris_999 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap
05:09 -!- chris_999 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Quit: Leaving]
05:21 < kanzure> hrmph
05:35 -!- Mariu [~Jimmy98@89.41.57.33] has quit [Quit: leaving]
06:03 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap
06:12 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-jyfholgkfadznomi] has joined ##hplusroadmap
06:46 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Quit: Leaving]
06:58 -!- Guest56868 [~abe@68.175.143.22] has quit [Ping timeout: 240 seconds]
07:01 -!- Gurkenglas_ [~Gurkengla@dslb-178-012-150-130.178.012.pools.vodafone-ip.de] has joined ##hplusroadmap
07:37 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap
07:49 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has quit [Ping timeout: 248 seconds]
08:00 -!- abetusk [~abe@68.175.143.22] has joined ##hplusroadmap
08:01 -!- abetusk is now known as Guest96376
08:04 < gnusha_> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=2c1f0a3e Bryan Bishop: describe WWC1/KIBRA memory benefits (19-24% better free recall performance) >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
08:06 < kanzure> https://www.snpedia.com/index.php/Rs17070145
08:13 -!- jtimon [~quassel@245.30.134.37.dynamic.jazztel.es] has joined ##hplusroadmap
08:17 < gnusha_> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=1b824b84 Bryan Bishop: some more sleep duration SNPs >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
08:35 -!- Guest96376 is now known as abetusk
09:41 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Quit: WeeChat 1.5]
09:47 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap
09:54 -!- Gurkenglas_ is now known as Gurkenglas
10:38 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Quit: Leaving]
10:45 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap
10:48 < gnusha_> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=88aa40f5 Bryan Bishop: some SNPs related to hippocampus size >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
10:48 < gnusha_> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=5b782afc Bryan Bishop: more hippocampus and memory SNPs >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
10:48 < gnusha_> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=d14c4550 Bryan Bishop: also hearing loss SNPs >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
10:57 < kanzure> "Homologs of the WWC1 gene: The WWC1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog."
10:58 < kanzure> we should put human WWC1 into chimpanzee and dog
10:59 < poppingtonic> So they can forget non-semantic information more easily?
10:59 < poppingtonic> https://dx.doi.org/10.1016%2Fj.neulet.2009.04.050
11:00 < kanzure> it is also implicated in short-term memory retention in general
11:04 < poppingtonic> Would it still have an effect on the chimp (for example) phenotype?
11:04 < kanzure> good question. worth checking.
11:09 < kanzure> https://www.ncbi.nlm.nih.gov/homologene/69180
11:10 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap
11:15 < kanzure> seems to be 99.5% similarity between chimp and human WWC1
11:16 < kanzure> http://www.informatics.jax.org/homology/marker/MGI:2388637
11:16 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has joined ##hplusroadmap
11:17 < kanzure> wow the default FASTA comparison tools are really lame, they don't even highlight the actual differences
11:24 < poppingtonic> How different is it from searching for pairwise alignment using BLAST?
11:25 -!- yashgaroth [~yashgarot@2602:306:35fa:d500:f5e0:f867:a11d:8d52] has joined ##hplusroadmap
11:29 -!- cpc26 [~cpc26@2602:306:8b94:d1f0:3874:9e7d:5668:41b4] has joined ##hplusroadmap
11:29 -!- cpc26 [~cpc26@2602:306:8b94:d1f0:3874:9e7d:5668:41b4] has quit [Changing host]
11:29 -!- cpc26 [~cpc26@fsf/member/cpc26] has joined ##hplusroadmap
11:39 -!- cpc26 [~cpc26@fsf/member/cpc26] has quit []
12:00 < kanzure> yashgaroth: i have added various things http://diyhpl.us/wiki/genetic-modifications/
12:01 < yashgaroth> ah good
12:02 -!- Jen_ [~Jen@cpc76806-brmb10-2-0-cust240.1-3.cable.virginm.net] has joined ##hplusroadmap
12:02 < kanzure> yashgaroth: a surprising amount of interesting stuff is controlled by single nucleotide polymorphisms. what gives?
12:03 < yashgaroth> you sure they're directly controlled, not just correlated with SNPs? usually unless it's a SNP that alters a protein it's not going to do much on its own
12:04 < kanzure> yes many of these look like SNPs inside genes that encode proteins
12:05 -!- JenElizabeth [~Jen@cpc76806-brmb10-2-0-cust240.1-3.cable.virginm.net] has quit [Ping timeout: 245 seconds]
12:06 < yashgaroth> well in that case yeah one point mutation is all you need, and with the monumentally slow timescales of evolution, one change is all you're gonna get, so we notice those that have an effect
12:07 < kanzure> what would you say about finding some target of neural metabolism and optimizing the crap out of something,
12:07 < kanzure> it looks like there might be some neurotransmitter metabolisms that we could optimize?
12:09 < yashgaroth> you have an example one? depends whether the metabolism is the limiting factor for function
12:10 < kanzure> uhh umm
12:10 < kanzure> AMPA receptor trafficking?
12:10 < kanzure> yeah nevermind. hard to pick a target.
12:12 < kanzure> people have done work on better receptors, i guess
12:21 < yashgaroth> I mean ultimately we do need to work on brain mods, but it's a lot easier to translate "oh this mouse runs 10x further than normal" into humans, vs. "gee this mouse sure remembered where that platform was", and you put that mod into humans who get a seizure when they think about gambling
12:25 < kanzure> well, the sleep stuff seems to work, that's brain.
12:25 < kanzure> and there's some memory improvements with single mutations
12:26 < kanzure> and hippocampus size improvements
12:30 -!- augur [~augur@c-67-160-198-240.hsd1.ca.comcast.net] has joined ##hplusroadmap
12:31 < yashgaroth> true, the sleep stuff is interesting though I'd like a more thorough examination of the natural carrier population to make sure they're not otherwise affected mentally
12:32 -!- augur [~augur@c-67-160-198-240.hsd1.ca.comcast.net] has quit [Read error: Connection reset by peer]
12:40 -!- augur [~augur@2601:640:8001:4222:4a1:bf2:ad6a:3eaa] has joined ##hplusroadmap
13:09 -!- drewbot [~cinch@ec2-54-159-161-220.compute-1.amazonaws.com] has quit [Remote host closed the connection]
13:09 -!- drewbot [~cinch@ec2-54-82-113-66.compute-1.amazonaws.com] has joined ##hplusroadmap
13:50 -!- esmerelda [~andares@unaffiliated/jacco] has joined ##hplusroadmap
14:11 -!- kghosh [~kelu124@mon75-h10-89-81-14-210.dsl.sta.abo.bbox.fr] has quit [Ping timeout: 258 seconds]
14:46 -!- esmerelda [~andares@unaffiliated/jacco] has quit [Ping timeout: 255 seconds]
14:48 -!- maaku [~quassel@173-228-107-141.dsl.static.fusionbroadband.com] has joined ##hplusroadmap
14:48 < kanzure> welcome back maaku
15:03 -!- augur [~augur@2601:640:8001:4222:4a1:bf2:ad6a:3eaa] has quit [Remote host closed the connection]
15:05 -!- augur [~augur@2601:640:8001:4222:4a1:bf2:ad6a:3eaa] has joined ##hplusroadmap
15:09 -!- augur [~augur@2601:640:8001:4222:4a1:bf2:ad6a:3eaa] has quit [Ping timeout: 255 seconds]
15:58 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has joined ##hplusroadmap
16:10 -!- jtimon [~quassel@245.30.134.37.dynamic.jazztel.es] has quit [Ping timeout: 245 seconds]
16:38 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Quit: Leaving]
17:02 -!- q4 [~q4@user-94-254-164-27.play-internet.pl] has quit [Ping timeout: 245 seconds]
17:07 -!- Gurkenglas [~Gurkengla@dslb-178-012-150-130.178.012.pools.vodafone-ip.de] has quit [Ping timeout: 240 seconds]
17:12 -!- Netsplit *.net <-> *.split quits: kanzure, indiebio_, strages, Madars, nnnn20430, WizJin, rancyd_, pasky, Dumuzi, vikraman,  (+2 more, use /NETSPLIT to show all of them)
17:12 -!- pasky_ [~pasky@nikam.ms.mff.cuni.cz] has joined ##hplusroadmap
17:12 -!- indiebio [~quassel@quassel.tumbleweed.org.za] has joined ##hplusroadmap
17:12 -!- Netsplit over, joins: kanzure
17:12 -!- y0no [~y0no@2001:bc8:212d:201:ff01::a] has joined ##hplusroadmap
17:12 -!- vikraman [~vh4x0r@2605:2700:0:5::4713:952b] has joined ##hplusroadmap
17:12 -!- vikraman [~vh4x0r@2605:2700:0:5::4713:952b] has quit [Changing host]
17:12 -!- vikraman [~vh4x0r@gentoo/developer/vikraman] has joined ##hplusroadmap
17:12 -!- Netsplit over, joins: nnnn20430
17:13 -!- Netsplit over, joins: Dumuzi
17:13 -!- Netsplit over, joins: Madars
17:13 -!- ensign_ [~ensign@2001:41d0:8:d711::1] has joined ##hplusroadmap
17:15 -!- strages [sid11297@gateway/web/irccloud.com/x-hjxmagmxondtlveu] has joined ##hplusroadmap
17:19 -!- y0no [~y0no@2001:bc8:212d:201:ff01::a] has quit [Ping timeout: 245 seconds]
17:22 -!- y0no [~y0no@2001:bc8:212d:201:ff01::a] has joined ##hplusroadmap
17:23 -!- Netsplit *.net <-> *.split quits: Cory, jcorgan, Qfwfq, espes_, lexik, nickjohnson, catern
17:23 -!- Netsplit over, joins: catern, lexik
17:24 -!- espes [~espes@205.185.120.132] has joined ##hplusroadmap
17:24 -!- Netsplit over, joins: jcorgan
17:27 -!- Cory [~Cory@unaffiliated/cory] has joined ##hplusroadmap
17:28 -!- WizJin [WizJin@gateway/shell/fnordserver.eu/x-uqzkqwfudocsaxdb] has joined ##hplusroadmap
17:29 -!- darsie [~darsie@84-113-55-42.cable.dynamic.surfer.at] has quit [Ping timeout: 260 seconds]
17:30 -!- nickjohnson [sid789@gateway/web/irccloud.com/x-ypjygijcjyvaewku] has joined ##hplusroadmap
17:33 -!- juri_ [~juri@205.166.94.194] has joined ##hplusroadmap
17:38 -!- Qfwfq [Qfwfq@gateway/shell/fnordserver.eu/x-azcxvkekeakmiuxu] has joined ##hplusroadmap
17:41 -!- y0no [~y0no@2001:bc8:212d:201:ff01::a] has quit [Ping timeout: 245 seconds]
17:44 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has quit [Remote host closed the connection]
17:46 -!- y0no [~y0no@2001:bc8:212d:201:ff01::a] has joined ##hplusroadmap
17:53 -!- c0rw1n is now known as GreenBat
17:54 -!- GreenBat is now known as c0rw1n
18:01 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has joined ##hplusroadmap
18:03 -!- indiebio [~quassel@quassel.tumbleweed.org.za] has quit [Quit: No Ping reply in 180 seconds.]
18:05 -!- indiebio [~quassel@quassel.tumbleweed.org.za] has joined ##hplusroadmap
18:12 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has quit [Remote host closed the connection]
18:25 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has joined ##hplusroadmap
18:40 -!- yashgaroth [~yashgarot@2602:306:35fa:d500:f5e0:f867:a11d:8d52] has quit [Read error: Network is unreachable]
18:41 -!- yashgaroth [~yashgarot@2602:306:35fa:d500:f5e0:f867:a11d:8d52] has joined ##hplusroadmap
18:42 -!- Dumuzi [Dumuzi@Dont.Blink.PanicBNC.org] has quit [Ping timeout: 258 seconds]
18:43 -!- streety [streety@2a01:7e00::f03c:91ff:feae:ded6] has quit [Ping timeout: 258 seconds]
18:44 -!- Reventlov [~reventlov@unaffiliated/reventlov] has quit [Ping timeout: 258 seconds]
18:45 -!- nnnn20430 [nnnn@lightning.bouncer.ml] has quit [Ping timeout: 258 seconds]
18:45 -!- nnnn20430 [nnnn@lightning.bouncer.ml] has joined ##hplusroadmap
18:46 -!- streety [streety@2a01:7e00::f03c:91ff:feae:ded6] has joined ##hplusroadmap
18:46 -!- Reventlov [~reventlov@unaffiliated/reventlov] has joined ##hplusroadmap
18:52 -!- Dumuzi [Dumuzi@Dont.Blink.PanicBNC.org] has joined ##hplusroadmap
18:55 -!- y0no [~y0no@2001:bc8:212d:201:ff01::a] has quit [Ping timeout: 245 seconds]
19:01 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has quit [Remote host closed the connection]
19:02 -!- y0no [~y0no@2001:bc8:212d:201:ff01::a] has joined ##hplusroadmap
19:20 -!- strages [sid11297@gateway/web/irccloud.com/x-hjxmagmxondtlveu] has quit [Ping timeout: 240 seconds]
19:22 -!- strages [sid11297@gateway/web/irccloud.com/x-zhasynxqvdxbmhby] has joined ##hplusroadmap
19:27 < kanzure> .title http://www.orionsarm.com/eg-article/472136a42f3e9
19:27 < yoleaux> Orion's Arm - Encyclopedia Galactica - Utility Fog
19:49 -!- Jen_ [~Jen@cpc76806-brmb10-2-0-cust240.1-3.cable.virginm.net] has quit [Read error: Connection reset by peer]
19:53 < poppingtonic> Orion's Arm is the most ambitious world-building I've ever seen
19:56 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Quit: Leaving.]
19:57 < kanzure> famous last words
20:21 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has joined ##hplusroadmap
21:05 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has quit [Ping timeout: 255 seconds]
21:16 -!- yash [~yashgarot@2602:306:35fa:d500:f5e0:f867:a11d:8d52] has joined ##hplusroadmap
21:16 -!- yash is now known as Guest6159
21:18 -!- yashgaroth [~yashgarot@2602:306:35fa:d500:f5e0:f867:a11d:8d52] has quit [Ping timeout: 240 seconds]
21:26 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has joined ##hplusroadmap
21:58 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap
22:14 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Ping timeout: 240 seconds]
22:24 -!- Guest6159 [~yashgarot@2602:306:35fa:d500:f5e0:f867:a11d:8d52] has quit [Quit: Leaving]
22:27 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap
22:54 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Ping timeout: 248 seconds]
23:12 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-jyfholgkfadznomi] has quit [Quit: Connection closed for inactivity]
23:59 -!- Gurkenglas [~Gurkengla@dslb-178-012-150-130.178.012.pools.vodafone-ip.de] has joined ##hplusroadmap
--- Log closed Mon Jan 09 00:00:00 2017