--- Log opened Mon Jan 16 00:00:06 2017
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04:26 < kanzure> 18039fdaq
04:31 < bluebear_> kanzure: aaaaaand password is gone :-)
04:31 < kanzure> .title https://news.ycombinator.com/item?id=13406772
04:31 < yoleaux> Guide on how to design keyboard PCBs | Hacker News
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06:59 < kanzure> "We reject kings, presidents and voting. We believe in rough consensus and running code". - david clark, IETF
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07:15 < kanzure> "Neural mechanisms for lexical processing in dogs" http://science.sciencemag.org/content/353/6303/1030
07:16 < kanzure> "Voice-sensitive regions in the dog and human brain are revealed by comparative fMRI" http://www.cell.com/current-biology/abstract/S0960-9822(14)00123-7
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07:53 < archels> oh great, a video abstract
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11:40 < kanzure> .title https://news.ycombinator.com/item?id=13411838
11:40 < yoleaux> Balaji Srinivasan, who may run the FDA for Trump, hates the FDA | Hacker News
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11:51 < cluckj> not sure if that's a productive hate, though
11:53 < kanzure> *shrug* everyone hates their job, or something
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12:41 < jcluck> https://twitter.com/iamscicomm/status/821077435659780097
12:43 -!- jcluck is now known as cluckj
12:45 < cluckj> it's okay to not have a science degree and write about science, but maybe carl zimmer should not be an exemplar....
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12:48 < kanzure> .title
12:48 < yoleaux> I Am SciComm auf Twitter: "I had no idea @carlzimmer has no formal science ed. Oh man. Impostor syndrome just took a critical hit. https://t.co/IesdOtMYSp"
12:50 < kanzure> .title https://www.youtube.com/playlist?list=PLrAXtmErZgOeiKm4sgNOknGvNjby9efdf
12:50 < yoleaux> MIT 6.S094: Deep Learning for Self-Driving Cars - YouTube
12:57 < chris_99> Anyone played with electrowetting out of interest, i'm curious about the surface used,  i just found http://www.cytonix.com/FluoroPel-p/pfc-801uc.htm ($99), which sounds reasonably easy to apply i think
12:58 < kanzure> it's some kind of glass tape capacitor sandwhich ceramic thingy, for electrowetting
12:59 < chris_99> it seems to need a special hydrophobic surface though doesn't it? (or is glass enough?)
13:00 < chris_99> i was reading - https://en.wikipedia.org/wiki/Electrowetting#Materials
13:01 < kanzure> i was thinking of 'electrowetting on dielectrics'
13:03 < chris_99> ah i'll google that
13:29 < abetusk> chris_99, I haven't played with it but Gaudilabs has done some stuff at the DIY level: http://www.gaudi.ch/OpenDrop/?p=116
13:30 < abetusk> It looks like they're using http://www.cytonix.com/PFC1601V-p/2033e20_1_0.8.htm
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13:31 < chris_99> abetusk, cheers, i'm just looking at their pcb design
13:32 < chris_99> they're using quite high voltages apparently
13:34 < chris_99> i like the little game they made
13:37 < chris_99> http://meso.seas.harvard.edu/digitalmicrofluidics.html is cool too
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13:44 < ybit> http://www.wings3d.com/ https://www.cs.mtu.edu/~shene/COURSES/cs3621/NOTES/model/winged-e.html .title
13:44 < ybit> .title
13:44 < yoleaux> The Winged-Edge Data Structure
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13:49 < abetusk> chris_99, I don't think you can get away from HV.  I think they mention it on there but there's a high voltage driver that was originally used for nixie tubes.  See for example: http://www.ebay.com/itm/NCH6100HV-High-Voltage-DC-Power-Supply-Module-F-Nixie-Tube-Glow-Tube-Magic-Eye-/252535630225
13:49 < kanzure> yes, EWOD requires high voltage
13:50 < chris_99> http://www.gaudi.ch/GaudiLabs/?page_id=392 i was looking at the comment on there abetusk, the 11 volt one
13:50 < kanzure> .title
13:50 < yoleaux> Welcome to >> OpenDrop - Digital Microfludics Plattform
13:50 < kanzure> btw there is various EWOD things in the logs
13:51 < chris_99> cool
13:52 < abetusk> from http://www.gaudi.ch/OpenDrop/?p=57, http://desmith.net/NMdS/Electronics/NixiePSU.html
13:54 < chris_99> cheers, the driver they're using for outputting voltage to the matrix (HV507) look pretty nifty too
13:55 < abetusk> right, and the opendrop folks look to have had success with simple foil and Rain-X
13:56 < chris_99> heh neat, that looks cheap too
13:59 < chris_99> i can't seem to see, are they selling the opendrop v2?
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14:11 < abetusk> afaik they're not selling kits, but maybe that will change?
14:15 < chris_99> ah
14:15 < kanzure> jcline built one
14:16 < abetusk> fabbed their own boards or bought a kit from gaudilabs?
14:17 < kanzure> made his own boards
14:17 < abetusk> were did he have it fabbed?
14:18 < chris_99> any cheapo fab place should be able to do the matrix thing
14:19 < kanzure> was just a standard pcb
14:19 < kanzure> nothing magic
14:28 < kanzure> http://www.openwetware.org/wiki/User:Andor_J_Kiss " I am currently engaged in studies using the North American wood frog Rana sylvatica to determine the changes in protein expression permitting these frogs to be able to freeze solid, thaw and survive. This overwintering strategy is rare among higher vertebrates and demonstrates an extreme example of physiological, biochemical and molecular ada...
14:28 < kanzure> ...ptation. Future plans to employ cDNA arrays and genome technologies are underway that will further elucidate the mechanisms by which these animals are able to sense their environment thereby prompting a freeze competent state in the frogs."
14:28 < chris_99> i wrote a kicad python script that created most of https://www.anfractuosity.com/wp-content/uploads/2016/02/1.jpg automatically (a matrix style thing) i might adapt it for creating a bigger matrix for the electrowetting thing
14:31 < kanzure> https://experiment.com/projects/unlock-the-secrets-of-animals-that-survive-freezing
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15:07 < kanzure> rje0r9130rdq0wfq0w9
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15:10 < sachy> kanzure: nice password :)
15:10 < Forrest> derp
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15:11 < kanzure> hi
15:11 < Forrest> hi
15:12 < kanzure> which papers about blood have you been looking at?
15:13 < Forrest> I just found out about it, so the mouse study from 2014, and I was just looking over the awful experiment design Ambrosia was using
15:14 < Forrest> Basically, charge a bunch of rich pop-sci fans over 35 years old to get a liter of blood plasma injected, with a blood test before and a month after
15:14 < Forrest> oh, and charge them eight grand for the privledge
15:15 < Forrest> and since there's no control, everyone has to fill out a survey and 'be their own control'
15:15 < Forrest> because they can't very well charge eight grand for placebo
15:16 < kanzure> i doubt it's going to do anything
15:16 < Forrest> and the listing on clinicaltrials.gov didn't mention the fee, which makes me think it's something they tossed on after they got approval from the FDA
15:16 < Forrest> even if it did anything, their experiment design would hide it
15:17 < kanzure> did you find an experiment looking at injecting aged blood into young critters to see how bad that is?
15:17 < Forrest> I'd argue that placebo effect is pretty phenomenal among rich californians paying eight grand for an exclusive one-time medical treatment made famous by recent media attention and speculation.
15:18 < Forrest> Oh yeah, let me pull one up
15:18 < Forrest> Old blood in young things has some definite effects on a few organs
15:19 < kanzure> this should just be a task of centrifugation and chromatography to find which set of things in old blood is particularly nasty
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15:25 < Forrest> https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121415/
15:25 < kanzure> .title
15:25 < Forrest> Conboy is all over this stuff
15:25 < yoleaux> A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood
15:26 < Forrest> Er, Irina Conboy specifically
15:27 < Forrest> The researchers think that many benefits seen in old mice after receiving young blood might be due to the young blood diluting the concentration of inhibitors in the old blood.
15:29 < kanzure> great, let's find some inhibitor inhibitors
15:30 < kanzure> oh this one was recent
15:32 < kanzure> .wik CDK inhibitor
15:32 < yoleaux> "A CDK (cyclin-dependent kinase) inhibitor is any chemical that inhibits the function of CDKs. They are used to treat cancers by preventing overproliferation of cancer cells." -- https://en.wikipedia.org/wiki/CDK_inhibitor
15:36 < kanzure> "Notch-mediated restoration of regenerative potential to aged muscle" http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.690.1713&rep=rep1&type=pdf
15:42 < kanzure> "The emerging role of Notch pathway in ageing: focus on the related mechanisms in age-related diseases" https://www.researchgate.net/profile/Carmela_Balistreri/publication/304250067_The_emerging_role_of_Notch_pathway_in_ageing_Focus_on_the_related_mechanisms_in_age-related_diseases/links/577cc58708ae355e74f2ab65.pdf
15:43 < kanzure> also carboninc anhydrase
15:43 < kanzure> and ellagic acid as an inhibitor of.. er.
15:48 < Forrest> The effect of old blood on brain development is particularly bad, I'm digging through conboys more recent stuff
15:54 < Forrest> https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121415/figure/f2/
15:56 < Forrest> nasty. the readings on the top bar graph are neurogenisis in a particular region for a young mouse with young blood, followed by a young mouse with old blood, and then and old mouse with young blood and an old mouse with old blood
15:57 < Forrest> Pretty much no difference on the old mice, but old blood just trashes the young mouse's brain
15:58 < Forrest> er, maybe that's getting ahead of myself
15:59 < Forrest> it causes new brain cell development to drop to less than half
16:00 < kanzure> i wonder if we do aged-matching for blood transfusions
16:01 < Forrest> I don't know, but Ambrosia just bought the plasma from a blood bank, so that info was on file
16:01 < Forrest> if you ever need a transfusion, you could probably request really young blood
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16:04 < Forrest> India has those blood farms, and they're mostly full of young people
16:06 < Forrest> I recall reading some horror stories about people that escaped having prematurely grey hair and hemoglobin counts that were a third of normal
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16:30 < fenn> wood frog genome "Funded
16:31 < fenn> on 11/08/14"
16:31 < fenn> so where's the genome?
16:32 < kanzure> that's my question
16:44 < fenn> "Apr 26, 2016 We're going to get started this summer. There was an intentional delay in the start of the project as Illumina introduced their new high capacity HiSeq3000 and HiSeq4000 instruments. There was also time needed to let these instruments find their way to university core-labs. Now that this has happened, we're going to start the process."
16:45 < fenn> that's a pretty lame reason to delay
16:50 < fenn> someone tells him on a sequencing forum, "you may be drastically overestimating the cost-savings of the HiSeq3000/4000. It will probably be a less than 1.5x lower cost per base. I mean, that is still a substantial drop in price, but not 10x"
16:50 < fenn> "you were comparing the number of reads in a lane (HiSeq2500) to number of reads in a flowcell==8lanes(HiSeq3000).
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17:14 < kanzure> aren't we supposed to have a $1k genome by now?
17:17 < cluckj> like ten years ago
17:18 < kanzure> hmm https://github.com/bitcoin/bitcoin/pull/9263
17:57 < kanzure> "A review and synthesis of the first 20 years of PET and fMRI studies of heard speech, spoken language and reading" http://ling.umd.edu/~ellenlau/courses/ling646/Price_2012.pdf
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18:25 < kanzure> firefox can't handle 163 tabs?
18:31 < kanzure> .wik insular cortex
18:31 < yoleaux> "In each hemisphere of the mammalian brain the insular cortex (often called insula, or insular lobe) is a portion of the cerebral cortex folded deep within the lateral sulcus (the fissure separating the temporal lobe from the parietal and frontal lobes)." -- https://en.wikipedia.org/wiki/Insular_cortex
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19:55 < superobserver> .wik reticular activation system
19:55 < yoleaux> "The reticular activating system (RAS), or extrathalamic control modulatory system, is a set of connected nuclei in the brains of vertebrates that is responsible for regulating wakefulness and sleep-wake transitions. As its name implies, its most influential component is the reticular formation." -- https://en.wikipedia.org/wiki/Reticular_activation_system
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--- Log closed Tue Jan 17 00:00:07 2017