--- Log opened Fri Jan 27 00:00:16 2017
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05:17 < streety> juul: I was thinking about at minimum what might it mean. I think we are on safe ground in claiming that at minimum for something to be considered open source the sequence should be known. Everything beyond that seems a little fuzzy
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05:58 < kanzure> patent system needs to be dismantled first
05:58 < kanzure> open source is mostly about copyright law
05:58 < kanzure> you could do defensive patent pool things and claim it's open-source, i think, if you wanted to play around with patents... but it takes a long time to register a patent.
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06:40 < archels_> .title http://inscopix.com/
06:40 < yoleaux> Inscopix
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06:43 < archels_> "Cracking the neural code with Technology"
06:43 < archels_> actually, their tagline is "Cracking the neural code with Technology, Training, and Partnership", but the former sounds better
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09:08 < kanzure> http://www.anti-agingfirewalls.com/2016/09/23/aging-health-and-disease-view-from-the-dna-methylome/
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09:12 < kanzure> http://www.anti-agingfirewalls.com/2016/05/15/part-5-of-the-nad-world-the-conflicting-roles-of-nampt-inflammation-or-rescue-also-part-1-on-a-new-series-on-inflammation/
09:12 < kanzure> http://www.anti-agingfirewalls.com/2016/11/05/inflammation-part-2-the-tale-of-three-stress-sensors-and-their-interactions-1inflammation-2genomic-instability-p53-and-3oxidative-stress-nrf2/
09:12 < kanzure> http://www.anti-agingfirewalls.com/2016/12/14/inflammation-part-3-resolving-inflammation-resolvins-protectins-maresins-and-lipoxins/
09:13 < kanzure> cc jrayhawk
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09:21 < nmz787_w> sup all you aerobes
09:22 < kanzure> just oxiziding and shit
09:22 < kanzure> .. oxidizing.
09:24 < nmz787_w> mmm hmm
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09:41 < jrayhawk> this guy's references sections are fascinating
09:45 < kanzure> he gave some presentations here
09:45 < kanzure> http://www.anti-agingfirewalls.com/2016/06/09/meeting-and-live-webcast-notice-the-science-and-technology-of-longevity/
09:46 < kanzure> .title https://www.youtube.com/watch?v=kg1GbXk9yEk
09:46 < yoleaux> Science & Technology of Longevity Part 1 - Vincent Giuliano (June 2016) - YouTube
09:46 < kanzure> .title https://www.youtube.com/watch?v=4oe1rK6xZpA
09:46 < yoleaux> Science & Technology of Longevity Part 2 - Vincent Giuliano (June 2016) - YouTube
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10:03 < Erreur> 5
10:03 < Erreur> !request
10:03 < Erreur> !mit
10:03 < Erreur> !mut
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10:06 < kanzure> http://www.anti-agingfirewalls.com/2014/01/21/jim-watsons-top-12-list-of-things-i-learned-about-aging-in-2013/
10:10 < kanzure> http://www.vincegiuliano.name/Antiagingfirewalls.htm
10:10 < kanzure> http://www.anti-agingfirewalls.com/2013/11/14/prospectus-for-a-grand-unified-theory-of-biology-health-and-aging/
10:10 < kanzure> i like this guy.
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13:44 < docl> .title https://phys.org/news/2017-01-needle-pulse-pattern.html
13:44 < yoleaux> New 'needle-pulse' beam pattern packs a punch
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13:45 < docl> .title https://www.osapublishing.org/oe/abstract.cfm?uri=oe-24-25-28669
13:45 < yoleaux> OSA | Longitudinal iso-phase condition and needle pulses
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15:22 < kanzure> "Brain-region-specific organoids using mini-bioreactors for modeling ZIKV exposure" http://www.cell.com/cell/abstract/S0092-8674%2816%2930467-6
15:23 < kanzure> "... forebrain-specific organoids from human iPSCs. These organoids recapitulate key features of human cortical development, including progenitor zone organization, neurogenesis, gene expression, and, notably, a distinct human-specific outer radial glia cell layer. We also developed protocols for midbrain and hypothalamic organoids."
15:23 < kanzure> cool, a hypothalamus organoid
15:24 < kanzure> oh geeze this looks desperate "A screen of FDA-approved drugs for inhibitors of Zika virus infection" https://www.researchgate.net/profile/Reddisiva_Prasanth_Kambham/publication/305744707_A_Screen_of_FDA-Approved_Drugs_for_Inhibitors_of_Zika_Virus_Infection/links/579f6b7e08ae94f454e7bb75.pdf
15:26 < kanzure> "Towards neuronal organoids: a method for long-term culturing of high-density hippocampal neurons" http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0058996
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15:30 < kanzure> "Three-dimensional retinal organoids from mouse pluripotent stem cells mimic in vivo development with enhanced stratification and rod photoreceptor differentiation" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017542/
15:33 < kanzure> hrm i guess we don't have an auditory cortex organoid yet
15:33 < kanzure> or visual cortex organoid
15:35 < kanzure> '... Deletion of PTEN stimulates proliferation and generates significantly larger and substantially folded cerebral organoids' http://www.sciencedirect.com/science/article/pii/S1934590916304532
15:43 < kanzure> ". The author suggests two overarching frameworks for integrating and clarifying existing understandings from the diverse theories of aging. One framework is lifelong programmed changes in global gene expression due to DNA methylation, histone acetylation and other epigenomic modifications. For example, aging-related decline of efficacy of DNA repair machinery might possibly result from promot...
15:43 < kanzure> ...er methylation of the Mms22 gene, resulting in increasing susceptibility to oxidative damage with age. Promoter methylation of the P21 and P53 apoptosis genes can result in increased susceptibility to cancers. The second framework sees aging as decline in functioning of the stem cell supply chain, the chain where adult stem and progenitor cells progressively differentiate as-needed into other ...
15:43 < kanzure> ...cells of increased specificity and decreased pluripotency, resulting in lifelong renewal of somatic cell types. As the supplies of multipotent mesenchymal and haemopoietic stem cells available in their niches for differentiation decline because of their replicative senescence, for example, fewer progenitor and somatic cells are available to replace ones that have died or become senescent."
15:47 < kanzure> i wonder if anyone has tried a low-efficacy dna methyltransferase mutation in mice
15:53 < kanzure> "Mouse models with both copies of DNMT1 deleted are embryonic lethal at approximately day 9, due to the requirement of DNMT1 activity for development in mammalian cells.[57]"
15:55 < kanzure> [57] "DNA methylation dynamics in plants and mammals: overview of regulation and dysregulation" http://onlinelibrary.wiley.com/doi/10.1002/cbf.3183/abstract
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17:39 < kanzure> .wik FNDC5
17:39 < yoleaux> "Fibronectin type III domain-containing protein 5, the precursor of irisin, is a protein that is encoded by the FNDC5 gene. Irisin is a cleaved version of FNDC5, named after the Greek messenger goddess Iris." -- https://en.wikipedia.org/wiki/FNDC5
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18:46 < nmz787> kanzure: I recently heard from a friend that The Broad Institute (Cambridge, MA) has had a good amount of traction with that brute-force try a bunch of already-approved stuff method
18:47 < nmz787> and it's supposed to be easier to take to trials I think, or get further approval, since it's already been approved once and now it's an alternate use, etc
18:51 < kanzure> yashgaroth: i don't see the irisin updates to the doc, is it a new doc?
18:52 < yashgaroth> ah I haven't done a rundown on it yet, just the teaser
18:52 < yashgaroth> this weekend, I promise
18:53 < yashgaroth> and we're gonna hold off on the electroporator until john puts a shell around it, since it'd be up in the carlsbad lab and someone will inevitably stick their finger inside otherwise
18:54 < kanzure> okay, maybe nmz787 or juul will take it
18:56 < nmz787> hmm "Many of the stem cells became a type of cell that matures into bone. The tissue treated with irisin produced about 40 percent fewer mature fat cells."
18:57 < nmz787> i think john's giving me one already
18:57 < nmz787> I was going to try to convince kanzure to push it to Josiah now rather than John's plan of waiting for V0.2 for that
18:58 < nmz787> idk if he'd have issues with zapping himself
18:59 < nmz787> so the whole fat stem cells to bone... how many of those stem cells float around my stomach fat?
19:00 < yashgaroth> I'd have to check the paper that article is referring to, but "a type of cell that matures into bone" doesn't necessarily mean you grow a femur
19:00 < nmz787> if I huff some quickly-cleared irisin virus (or bare mRNA/cDNA or something), would my stomach fat calcify?
19:00 < yashgaroth> one group did find an increase in cortical bone mass from irisin administration
19:00  * nmz787 likes my new stomach plate
19:01 < yashgaroth> actually wait that'd be awesome
19:01 < nmz787> and thigh plates, and cheek plates
19:01 < nmz787> brain is fat too, so maybe I'd become a bonehead
19:02 < nmz787> actually a stomach plate would probably hamper things like picking up things from the floor
19:03 < yashgaroth> yes that may be a problem for our bone-encrusted supersoldiers
19:39 < kanzure> no that's why you have specialization
19:39 < kanzure> some soldiers are bendy others not so much
19:39 < kanzure> nmz787: i don't talk with josiah that much btw
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20:59 < fenn> this is the ideal male form. you may not like it, but this is what peak performance looks like: http://flyingdebris.deviantart.com/art/The-Fiddler-188382821
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21:23 < kanzure> the ideal male form is a howitzer?
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22:55 < nmz787> kanzure: shall I ask?
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--- Log closed Sat Jan 28 00:00:17 2017