--- Log opened Sun Jan 29 00:00:18 2017
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05:29 < archels_> "Like death and taxes, it is inevitable that we will have to drive some form of capacitance. Unlike death and taxes, techniques exist to deal with capacitive loads to some degree."
05:43 < kanzure> whowhat
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07:04 < Jenda`> nmz787: FYI for dumping serial communication (and anything other below 8 bits and 24 MHz), I'd go for a "saleae logic" clone -- it sells for $7 on ebay and works with sigrok/pulseview on Linux.
07:04 < Jenda`> you just need to put in MAX2323 if it'? true RS-232 levels
07:05 < JayDugger> Heh, thanks, jenda`.
07:07 < JayDugger> That will come in handy later this week at work.
07:08 < Jenda`> And regarding the SEM, we are discussing it in our hackerspace now. We already have some vacuum stuff (https://brmlab.cz/project/heliovy_hledac_netesnosti/start).
07:09 < Jenda`> and a 500 GBP SEM seems to be a good deal. Of course depends how much the price will rise and how to transport it to CZ from UK :)
07:10 < kanzure> does brmlab have one?
07:10 < Jenda`> no
07:10 < kanzure> well.....
07:11 < Jenda`> we have only a cool optical microscope, neophot 30
07:11 < kanzure> freight is gonna cost a bunch
07:22 < pasky> probably a multiple of the GBP500, and it could be likely they'd ask the buyer to come on site to dismantle it and prepare for shipping, as it seems they expect the buyer to ship it out themselves
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09:02 < kanzure> "Gene therapy using bacterial vectors" https://www.ncbi.nlm.nih.gov/pubmed/27814603
09:03 < kanzure> "gene therapy [...] by transfection of eukaryotic host cells using bacteria (bactofection)"
09:08 < kanzure> "In bactofection strategy, bacteria containing the naked plasmid DNA under the control of eukaryotic promoters can enter mammalian cells. Then, bacterial vectors may escape from phagosome to the cytosol of infected host cells to replicate and deliver the DNA directly into these cells [27, 28]. The recent studies have illustrated that some other bacteria like Shigella flexneri [27,29,30], Salmo...
09:08 < kanzure> ...nella spp [27,31], E. coli [27,29,30,32], and Yersinia enterocolitica [33] can be used as transport molecules. Since the Salmonella, Yersinia, and E. coli stay inside the vacuolar phagosome of infected host cells, entering into the host cells' nuclei, where transcription of plasmid DNA occurs, is fundamentally unknown, yet according to different studies, releasing of the plasmid DNA happens ...
09:08 < kanzure> ...either spontaneously or by antibiotics or application of auxotrophic mutants [29, 30]."
09:09 < kanzure> [27] Wild-type intracellular bacteria deliver DNA into mammalian cells.
09:09 < kanzure> [28] Eukaryotic expression plasmid transfer from the intracellular bacterium Listeria monocytogenes to host cells
09:09 < kanzure> [29][ Gene transfer from bacteria to mammalian cells
09:09 < kanzure> [30] Attenuated bacteria as a DNA delivery vehicle for DNA-mediated immunization
09:09 < kanzure> [31] Oral somatic transgene vaccination using attenuated S. typhimurium
09:10 < kanzure> [32] Functional gene transfer from intracellular bacteria to mammalian cells.
09:13 < kanzure> "Bacteria-mediated delivery of nanoparticles and cargo into cells" http://www.cyto.purdue.edu/archive/flowcyt/research/pdfs/2007/akin_2007.pdf
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13:02 < kanzure> "The neurotrophic parasite toxoplasma gondii increases dopamine metabolism" http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0023866
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13:08 < kanzure> i wonder about brain sleep and those parasites, maybe you can do CLOCK disruption stuff
13:40 < kanzure> some index of various open-source vhdl projects http://freerangefactory.org/cores.html
13:40 < chris_99> i just grabbed their book to have a look at
14:07 < kanzure> "Parasite manipulation of brain monoamines in California killifish (Fundulus parvipinnis) by the trematode Euhaplorchis californiensis" http://rspb.royalsocietypublishing.org/content/276/1659/1137
14:07 < kanzure> "Furthermore, high E. californiensis density was associated with increased dopaminergic activity in the hypothalamus and decreased serotonergic activity in the hippocampus"
14:16 -!- saurik_ is now known as saurik
14:16 < kanzure> "Brains of verbal memory specialists show anatomical differences in language, memory and visual systems" https://pdfs.semanticscholar.org/8649/8e854f651498ba239e44b51373a965192045.pdf
14:18 < kanzure> "White matter microstructure correlates of mathematical giftedness and intelligence quotient" http://onlinelibrary.wiley.com/doi/10.1002/hbm.22355/abstract
14:19 < kanzure> "A hippocampal marker of recollection memory ability among healthy young adults: contributions of posterior and anterior segments" http://popmem.com/s/Poppenk_2011_Neuron.pdf
14:22 < kanzure> "CA3 size predicts the precision of memory recall" https://www.researchgate.net/profile/Heidi_Bonnici/publication/264634582_CA3_size_predicts_the_precision_of_memory_recall/links/5432b87e0cf22395f29c350a.pdf
14:28 < kanzure> well okay. let's make those cells bigger.
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14:32 < kanzure> "Spatial memory and hippocampal enhancement" https://www.researchgate.net/profile/Monica_Munoz-Lopez/publication/274737022_Spatial_memory_and_hippocampal_enhancement/links/5566d7bf08aec22682ff2575.pdf
14:33 < kanzure> "Interestingly, a 2 base pair (bp) deletion in exon 6 of the CHRFAM7A gene (a partial duplication of CHRNA7) with presumed dominant negative effects on a7 was associated with poor delayed recall in the Wechsler memory scale test of logical memory, suggesting an a7 contribution to human memory [50]."
14:42 < kanzure> "Artichoke Extract is known to be the safest and most effective PDE4 Inhibitor"
14:43 < kanzure> "Rolipram, an antidepressant that increases the availability of cAMP, transiently enhances wakefulness in rats." http://www.ncbi.nlm.nih.gov/pubmed/9700966
14:43 < kanzure> "Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory." https://www.ncbi.nlm.nih.gov/pubmed/9844008
14:48 < kanzure> "Facilitation of task performance and removal of the effects of sleep deprivation by an ampakine (CX717) in nonhuman primates" http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.0030299
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14:51 < kanzure> .wik CX717
14:51 < yoleaux> "CX717 is an ampakine compound created by Christopher Marrs and Gary Rogers in 1996 at Cortex Pharmaceuticals. It affects the neurotransmitter glutamate, with trials showing the drug improves cognitive functioning and memory." -- https://en.wikipedia.org/wiki/CX717
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15:04 < kanzure> .wik encenicline
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18:44 < kanzure> bloort
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20:33 < kanzure> "Genetic variation of the RASGRF1 regulatory region affects human hippocampus-dependent memory" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010733/
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20:34 < kanzure> trying to find a paper that shows hippocampus microanatomy differences between great memories vs low memory performance
20:45 < kanzure> "Unexpected benefits of intermittent hypoxia" http://physiologyonline.physiology.org/content/29/1/39.short not quite...
20:58 < kanzure> "Associative memory formation increases the observation of dendritic spines in the hippocampus" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2740640/
21:04 < kanzure> "High levels of estrogen enhance associative memory formation in ovariectomized females" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289540/
21:07 < kanzure> .... "Over the 5-day estrous cycle of the rat, spine density can fluctuate as much as 30%"
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21:18 < kanzure> "Neurobiological changes in the hippocampus during normative aging" http://jamanetwork.com/journals/jamaneurology/fullarticle/797469
21:21 < kanzure> "... a human autopsy study published in 1986 linked selective post-hypoxic damage to CA1 with clinically evident memory impairments; as noted by the authors, the affected patient showed marked anterograde amnesia, little if any retrograde amnesia, and showed no signs of cognitive impairment other than memory"
21:21 < kanzure> [1] Zola-Morgan S, Squire LR, Amaral DG. Human amnesia and the medial temporal region: enduring memory impairment following a bilateral lesion limited to field CA1 of the hippocampus. J Neurosci 1986;6:2950-67
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21:24 < kanzure> "As of April 2011, we obtained brains from 137 individuals participating in The 90+ Autopsy Study"
21:31 < kanzure> all i wanted was a postmortem/autopsy study showing the differences in hippocampus microanatomy between high memory and low memory people....
21:38 < superobserver> kanzure: but which kind of memory?
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--- Log closed Mon Jan 30 00:00:19 2017