--- Log opened Fri Feb 03 00:00:23 2017 00:17 -!- sandeepkr [~Sandeepkr@103.49.155.114] has joined ##hplusroadmap 00:48 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Ping timeout: 258 seconds] 01:04 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 01:15 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Read error: Connection reset by peer] 01:17 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 01:38 < archels> .t https://gizmodo.com/the-fda-is-cracking-down-on-rogue-genetic-engineers-1791760888 01:38 < yoleaux> archels: Sorry, I don't know what timezone that is. If in doubt, see https://en.wikipedia.org/wiki/List_of_tz_database_time_zones for a list of options. 01:38 < archels> .title https://gizmodo.com/the-fda-is-cracking-down-on-rogue-genetic-engineers-1791760888 01:38 < yoleaux> The FDA Is Cracking Down On Rogue Genetic Engineers 01:39 -!- jenelizabeth [~jenelizab@cpc76810-brmb10-2-0-cust4.1-3.cable.virginm.net] has quit [Ping timeout: 240 seconds] 01:40 < nmz787> archels: yeah, there's a comment form here: https://www.regulations.gov/document?D=FDA-2008-D-0394-0279 01:40 < archels> incidentally, those glowing plants are still not on sale? disappointing 01:41 < nmz787> they didn't have the drugs like the animals do, so nobody wants them anymore 01:53 -!- nmz787_w [~ntmccork@134.134.139.83] has joined ##hplusroadmap 01:57 -!- nmz787_w [~ntmccork@134.134.139.83] has quit [Client Quit] 02:04 < archels> holy shit. https://www.liveleak.com/view?i=168_1486001903 02:04 < archels> .title 02:04 < yoleaux> LiveLeak.com - Boston Dynamics New Wheeled Robot Called Handle - Leaked Clip ? 02:07 -!- rkos [rkos@228.ip-176-31-189.eu] has joined ##hplusroadmap 02:07 < rkos> hello 02:10 < archels> hi 02:12 < rkos> anyone know about predictive coding/dysconnection hypothesis? 02:15 < archels> predictive coding yes; what's the disconnection hypothesis? 02:17 < rkos> https://www.ncbi.nlm.nih.gov/pubmed/27450778?dopt=Abstract 02:17 < rkos> bayesian neurology stuff 02:24 < archels> oh, right, I remember 02:32 -!- CRM114 [~urchin@unaffiliated/urchin] has quit [Ping timeout: 252 seconds] 02:33 -!- justan0theruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 240 seconds] 02:38 -!- CRM114 [~urchin@unaffiliated/urchin] has joined ##hplusroadmap 02:39 -!- jenelizabeth_ [~jenelizab@cpc76810-brmb10-2-0-cust4.1-3.cable.virginm.net] has joined ##hplusroadmap 02:42 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Ping timeout: 256 seconds] 02:56 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 03:10 -!- jtimon [~quassel@245.30.134.37.dynamic.jazztel.es] has quit [Ping timeout: 240 seconds] 03:18 -!- jenelizabeth_ [~jenelizab@cpc76810-brmb10-2-0-cust4.1-3.cable.virginm.net] has quit [Read error: No route to host] 03:18 -!- jenelizabeth__ [~jenelizab@cpc76810-brmb10-2-0-cust4.1-3.cable.virginm.net] has joined ##hplusroadmap 03:19 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Ping timeout: 260 seconds] 03:27 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap 03:29 -!- sandeepkr_ [~Sandeepkr@139.167.33.229] has joined ##hplusroadmap 03:30 -!- sandeepkr_ [~Sandeepkr@139.167.33.229] has quit [Remote host closed the connection] 03:31 -!- sandeepkr [~Sandeepkr@103.49.155.114] has quit [Ping timeout: 252 seconds] 03:32 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 03:48 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Read error: Connection timed out] 03:49 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 03:54 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has left ##hplusroadmap [] 04:15 -!- hehelleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has joined ##hplusroadmap 04:16 -!- helleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has quit [Ping timeout: 245 seconds] 04:38 < fenn> .wik Limitless_(TV_series) 04:38 < yoleaux> "Limitless is an American dramedy television series based on the 2011 film of the same name, that originally aired on CBS from September 22, 2015 to April 26, 2016. It stars Jake McDorman as Brian Finch, who discovers the power of a mysterious nootropic drug by the name of NZT-48." -- https://en.wikipedia.org/wiki/Limitless_(TV_series) 04:38 < superkuh> Yet another FBI-glorifying authoritarian television show aimed as young male demographics. 04:39 < superkuh> s/as/at/ 04:39 < cluckj> it was a pretty good show 04:39 < fenn> if only real life FBI agents took intelligence enhancing drugs 04:40 < cluckj> hah 04:41 < fenn> i liked the movie and had never heard of this tv series 04:41 < cluckj> if you liked the movie, you will like the show 04:41 < superkuh> I liked the movie. The show is terrible. 04:41 < rkos> i saw a bit of that show and it had like this fbi red cell trying to invent creative ways to pentest the USG against revolution 04:44 < cluckj> the overall narrative about nootropics was interesting (in part because nobody else does it), and did push on the "BRAIN DRUGS IS BAD"/"WE CANT HAVE SMART PEOPLE" bullshit 04:45 < fenn> the feeling portrayed in the movie was remarkably similar to my own experience with [REDACTED] 04:45 < cluckj> haha 04:46 < chris_99> heh 04:46 < yoleaux> 1 Feb 2017 05:34Z chris_99: that chipseasy thing looks pretty cool... my first thought/hope was that it had an SD/microSD card on-board, to keep a copy of any inventory... but it says the software is open-source so maybe that would be easy to add (if needed for backup, or for trading off the unit between people/teams, maybe adding a touchscreen interface, etc) 04:46 < fenn> how do i get an answer as to whether a drug is legal or not? 04:47 < cluckj> if it's scheduled by the DEA it is illegal 04:47 < fenn> afaik it's never been the subject of a trial 04:47 < cluckj> it's probably legal, then 04:47 < fenn> the wording of the analogue act is ambiguous 04:48 < cluckj> hmm 04:49 < fenn> i mean just look at this https://en.wikipedia.org/wiki/Federal_Analogue_Act#Definition 04:49 < fenn> if law were code this would never compile 04:52 < cluckj> you're not using the right compiler :P 04:52 < fenn> it all hinges around "substantially similar" which unfortunately is entirely subjective 04:52 < cluckj> want to send me the specifics and I can do some research on it? 04:56 -!- Guest94197 is now known as abetusk 04:57 -!- chris_999 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap 04:59 < kanzure> something, something ice batteries 04:59 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Ping timeout: 240 seconds] 04:59 -!- chris_999 is now known as chris_99 05:08 -!- sandeepkr [~Sandeepkr@103.49.155.114] has joined ##hplusroadmap 05:10 < cluckj> IDIC of chemical compounds means some debugging is required 05:12 < fenn> IDIC means what? 05:15 -!- weles [62af9cfb@gateway/web/freenode/ip.98.175.156.251] has joined ##hplusroadmap 05:19 < fenn> i'm guessing... indicated dose for internal consumption 05:26 < cluckj> infinite diversity in infinite combination 05:26 < cluckj> nerd card revoked.... 05:28 < fenn> spoiler alert!!! 05:31 < cluckj> hah 05:31 -!- Gurkenglas [~Gurkengla@dslb-188-103-065-237.188.103.pools.vodafone-ip.de] has joined ##hplusroadmap 05:32 < fenn> "Elizabeth's importance as the first known alien-Human hybrid was such that, following her death, the delegates from the conference for the Coalition of Planets asked to attend the child's funeral services." 05:34 < fenn> "if another season was indeed approved, the baby would live, but if the series was canceled, the child would die. The writers hoped the baby would live, as they expected it would make for "a great storyline." However, the death of Baby Elizabeth echoes the fact that Enterprise was canceled at the end of its fourth season. 05:35 < fenn> nice attempt at keeping the show running 05:35 < fenn> too bad it was terrible 05:40 < JayDugger> Huh? What horrible awful show does this warn against? 05:40 < fenn> star trek enterprise 05:40 < JayDugger> Oh, duh. Sorry. Enterprise. 05:41 < JayDugger> Right there, two lines back. 05:41 < fenn> it could have been worse i suppose 05:43 < kanzure> did you know n55 is a person 05:43 < fenn> what makes you say that? 05:44 < kanzure> michigan people say so 05:44 < fenn> i know ion has been the driving force for a long time 05:46 < kanzure> asking 05:47 < fenn> "N55 have now tested the new XYZ CARGO BIKE" 05:47 < fenn> the verb tense and prominent use of the pronoun "we" indicates N55 is plural 05:50 < kanzure> might take a while to receive reply, commence thumb twiddling! 05:50 < fenn> roger 05:51 < kanzure> says gridbeam tobias says yes just ion 05:51 < kanzure> disregard twiddling 05:54 -!- hehelleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has quit [Ping timeout: 245 seconds] 05:58 < kanzure> they are building LCD dlp 3d printer... hopefully i can convince him to add reduction lenses for microfabrication. 05:59 * fenn notes that LCD and DLP are opposites 05:59 < kanzure> someone from outpost was asking about diyhpl.us/laser_etcher/laser_etcher/ stuff 05:59 < fenn> i saw 06:00 < kanzure> ah true. i think he said LD and... SLA? anyway, a photopolymer cures based on LCD mask. 06:00 < kanzure> *LCd 06:00 < kanzure> blah phonetyping still sucks 06:01 -!- sandeepkr_ [~Sandeepkr@139.167.33.229] has joined ##hplusroadmap 06:04 -!- sandeepkr [~Sandeepkr@103.49.155.114] has quit [Ping timeout: 256 seconds] 06:04 < kanzure> i am still unhappy aout my maze-solving-only nootropic thing, why do brains have to be difficult? 06:06 < kanzure> same setup could be used for finding a microbes and cysts that cause beneficial sleep effects, even that would be more generally beneficial than a nootropic made from optimizing maze solving performance 06:06 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Quit: Leaving] 06:09 -!- sandeepkr_ [~Sandeepkr@139.167.33.229] has quit [Max SendQ exceeded] 06:09 -!- sandeepkr_ [~Sandeepkr@139.167.33.229] has joined ##hplusroadmap 06:10 -!- sandeepkr_ [~Sandeepkr@139.167.33.229] has quit [Read error: Connection reset by peer] 06:12 -!- sandeepkr_ [~Sandeepkr@103.49.155.114] has joined ##hplusroadmap 06:16 < kanzure> .title http://www.pnas.org/content/105/51/20404.full 06:16 < yoleaux> One-step assembly in yeast of 25 overlapping DNA fragments to form a complete synthetic Mycoplasma genitalium genome 06:16 < kanzure> "The limitations of assembly methods in yeast remain unknown. We recently assembled an entire synthetic M. genitalium genome using a combination of in vitro enzymatic recombination in early stages and in vivo yeast recombination in the final stage to produce the complete genome (8). In the first stage, overlapping ?6-kb DNA cassettes were joined four at a time to form 25 ?24-kb A-series as... 06:17 < kanzure> ...semblies. Three A-series assemblies were then joined to make 1/8 genome ?72-kb B-series assemblies, and then two B-series assemblies were assembled to make each of the ?145-kb quarter-genome C-series assemblies. We accomplished the final assembly in yeast using three quarter-genome fragments and a fourth quarter fragment that had been cleaved by a restriction enzyme to provide a site for i... 06:17 < kanzure> ...nsertion of the vector DNA. Thus, some individual yeast cells have the capacity to simultaneously take up the overlapping genome and vector DNA fragments (a total of six pieces) and recombine them to produce the full 592-kb circular JCVI-1.0 genome. At the time, we wondered whether it would be possible to assemble DNA fragments from earlier stages into a complete genome in a single step in yea... 06:17 < kanzure> ...st." 06:17 < kanzure> okay.. but why not say more words about why you did not try earlier stages with yeast? 06:18 < kanzure> "Statistics for Yeast DNA Uptake. 06:18 < kanzure> "An individual yeast cell must take up at least one each of the 25 DNA pieces to assemble the complete genome. If a cell randomly takes up exactly 25 pieces, then the probability that it takes up one of each is 25!/2525 = 1.7 x 10-10--a very rare occurrence. Thus, the average yeast cell likely took up substantially more than 25 pieces, given the results we observed. If a yeast cell randoml... 06:18 < kanzure> ...y takes up n > 25 equally represented pieces, what is the probability of getting all 25 different pieces? This is an example of the "collector's problem" (11). An approximate calculation of the probabilities for different n can be readily obtained by computer simulation. Fig. 6 shows that if a cell takes up ?90 pieces, then it has about a 50% chance of taking up all 25 different pieces. ... 06:18 < kanzure> ...In a typical experiment, 108 yeast cells are exposed to DNA. Therefore, even if the average cell were to take up only 40 pieces, about 1 in 1000 would get a complete set of pieces. The efficiency of DNA uptake and assembly in yeast is unknown. If recombination is highly efficient, then only a few yeast cells in the population might need to take up a complete set of overlapping pieces. If the e... 06:18 < kanzure> ...fficiency is low, then relatively more yeast cells would require a complete set. Independent measurements of the quantity of DNA taken up per cell would help answer some of these questions." 06:18 < kanzure> what? use microinjection and put a million DNA fragments into a single cell... 06:19 < kanzure> "Exploring the Capacity of DNA Assembly in Yeast. 06:19 < kanzure> "We still do not know the limits of DNA assembly in yeast. Once we assembled the synthetic M. genitalium genome from six pieces, we wondered whether we could have assembled it from 25. Now we wonder whether this genome could have been assembled from cotransformation of all 101 DNA cassettes (8). We also do not yet know the size limit for DNA assembly in yeast; however, YACs as large as 2.3 Mb ... 06:19 < kanzure> ...have been cloned (,12)." 06:20 < kanzure> We have made use of yeast's remarkable capacity to take up and recombine numerous overlapping DNA molecules to assemble a complete genome. Assembling large, genome-size molecules in host organisms by in vivo recombination is not a new concept. Holt et al. (17) proposed using the lambda Red recombination system to assemble an 1830-kb Haemophilus influenzae genome within an E. coli cell. Itaya e... 06:20 < kanzure> ...t al. (18) and Yonemura et al. (19) developed methods for assembling large DNA segments in Bacillus subtilis. But these DNA molecules are built in the host organism only after stepwise addition of subfragments. Genome assembly in yeast, as we have described it, is accomplished not by the addition of overlapping segments one at a time, but rather by cotransformation of 25 different pieces at on... 06:21 < kanzure> ...ce." 06:23 -!- sachy [~sachy@2001:67c:2190:c0de:da50:e6ff:feed:cf14] has quit [Quit: Leaving.] 06:27 < kanzure> http://diyhpl.us/~bryan/irc/2017-02-03-beacon.pdf 07:09 < kanzure> "Midbrain dopamine neurons control judgment of time" http://science.sciencemag.org/content/354/6317/1273 07:33 -!- weles [62af9cfb@gateway/web/freenode/ip.98.175.156.251] has quit [Quit: Page closed] 07:34 < kanzure> google's site reliability engineering book https://landing.google.com/sre/book/ 07:38 < kanzure> https://landing.google.com/sre/book/chapters/dealing-with-interrupts.html 07:43 < kanzure> comments https://news.ycombinator.com/item?id=13503161 07:44 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap 07:50 < archels> .gc "RNA.subroutine" 07:50 < yoleaux> 76 (site), 71 (end) 07:51 < archels> (via "How many bts does it take to kill a human?" -- bunnie huang) 07:52 < archels> I love his use of computer jargon for genomics there 07:52 < archels> "NOP sleds" 07:53 < kanzure> biology is just a more messy form of reverse engineering, so it makes sense 07:58 < superkuh> I enjoyed the bunnie article. Influenza was kind of an obsession of mine for a handful of years. His CS-centric intro for new people gets right to the point. 08:03 -!- augur [~augur@2601:640:8001:4222:7849:9df7:2166:351] has joined ##hplusroadmap 08:11 < archels> https://futureoflife.org/bai-2017/ 08:19 -!- helleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has joined ##hplusroadmap 08:47 -!- nmz787_w [~ntmccork@134.134.139.76] has joined ##hplusroadmap 09:01 -!- jenelizabeth__ [~jenelizab@cpc76810-brmb10-2-0-cust4.1-3.cable.virginm.net] has quit [Ping timeout: 255 seconds] 09:05 < kanzure> .title 09:05 < yoleaux> Beneficial AI 2017 - Future of Life Institute 09:30 -!- Zer0_cool [~Zer0_cool@162.216.46.26] has joined ##hplusroadmap 09:35 -!- sachy [~sachy@2001:67c:2190:c0de:da50:e6ff:feed:cf14] has joined ##hplusroadmap 09:42 -!- jtimon [~quassel@245.30.134.37.dynamic.jazztel.es] has joined ##hplusroadmap 09:51 < chris_99> kanzure, have you used any pdf parsing libs in python per chance? i'm just playing with pdfrw, but it seems a mystery how to extract text, so just wondering if theres anything better 09:51 < kanzure> pdfminer3? 09:51 < chris_99> ta, i'll look at that 09:51 < kanzure> lots of "life uh... finds a way." posters here 09:56 -!- Netsplit *.net <-> *.split quits: saturn2 09:56 -!- gnusha [~gnusha@unaffiliated/kanzure/bot/gnusha] has joined ##hplusroadmap 09:56 -!- Topic for ##hplusroadmap: biohacking, nootropics, transhumanism, open hardware | sponsored by lobsters everywhere, banned by the Federal Death Administration (5 times) | this channel is LOGGED: http://gnusha.org/logs | http://diyhpl.us/wiki | "ray kurzweil is a pessimist" - george church 09:56 -!- Topic set by kanzure [~kanzure@unaffiliated/kanzure] [Wed May 20 12:46:25 2015] 09:56 [Users ##hplusroadmap] 09:56 [ __mz_o ] [ cluckj ] [ helleshin] [ mf1008 ] [ QuadIgni ] [ superkuh ] 09:56 [ abetusk ] [ Cory ] [ HEx1 ] [ midnightmagic] [ rancyd ] [ superobserver] 09:56 [ adlai ] [ crescend1 ] [ hylleddin] [ nanotube ] [ rancyd_ ] [ Taek ] 09:56 [ aedla ] [ CRM114 ] [ indiebio ] [ nickjohnson ] [ redlegion ] [ thundara ] 09:56 [ archels ] [ darsie ] [ JayDugger] [ niekt0 ] [ Regex ] [ TMA ] 09:56 [ augur ] [ dequ ] [ Jenda` ] [ night ] [ resolute1 ] [ vikraman ] 09:56 [ Aurelius2] [ docl ] [ Joshchamp] [ nmz787 ] [ Reventlov ] [ WizJin ] 09:56 [ balrog ] [ Douhet ] [ jrayhawk ] [ nmz787_w ] [ rkos ] [ wrldpcmbl ] 09:56 [ berndj ] [ drewbot ] [ jtimon ] [ nnnn20430 ] [ sachy ] [ y0no ] 09:56 [ bkero ] [ duper ] [ juri_ ] [ nsh ] [ sandeepkr_] [ yoleaux ] 09:56 [ blueskin ] [ dustinm ] [ juul ] [ pasky ] [ saurik ] [ yorick ] 09:56 [ BobaMa ] [ EnabrinTain] [ kanzure ] [ pent ] [ sivoais ] [ Zer0_cool ] 09:56 [ bsm117532] [ ensign_ ] [ kwgwk ] [ pompolic ] [ Solgriffin] 09:56 [ Burnin8 ] [ fenn ] [ maaku ] [ poohbear ] [ souljack ] 09:56 [ c0rw1n ] [ gnusha ] [ Madars ] [ proofoflogic ] [ strages ] 09:56 [ catern ] [ Gurkenglas ] [ Malvolio ] [ Proteus ] [ streety ] 09:56 [ chris_99 ] [ heath ] [ marciogm ] [ Qfwfq ] [ sumie-dh ] 09:56 -!- Irssi: ##hplusroadmap: Total of 97 nicks [0 ops, 0 halfops, 0 voices, 97 normal] 09:56 -!- Channel ##hplusroadmap created Thu Feb 25 23:40:30 2010 09:56 -!- Netsplit *.net <-> *.split quits: Joshchamp, jrayhawk, docl, fenn 09:56 -!- gwillen [~gwillen@unaffiliated/gwillen] has joined ##hplusroadmap 09:56 -!- Irssi: Join to ##hplusroadmap was synced in 12 secs 09:56 -!- Netsplit over, joins: jrayhawk, fenn 09:56 -!- Netsplit *.net <-> *.split quits: thundara, heath 09:56 < nmz787_w> yeah I think that's what I used for I was scraping property listings that had the address info stored in a PDF 09:56 -!- Netsplit over, joins: thundara, heath 09:57 < chris_99> heh cool 09:57 -!- saturn2 [~visitant@unaffiliated/clone-of-saturn/x-2509460] has joined ##hplusroadmap 09:57 -!- Joshchamp [sid159459@gateway/web/irccloud.com/x-gqkvxczpypzegkfv] has joined ##hplusroadmap 10:01 -!- docl [~docl@159.203.115.16] has joined ##hplusroadmap 10:01 -!- augur [~augur@2601:640:8001:4222:7849:9df7:2166:351] has quit [Remote host closed the connection] 10:11 < nmz787_w> chris_99: here's that code http://pastebin.com/zgRSCJy5 10:19 < chris_99> ah cheers 10:45 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has joined ##hplusroadmap 10:52 -!- nmz787_w [~ntmccork@134.134.139.76] has quit [Remote host closed the connection] 10:57 -!- night [~Adifex@unaffiliated/adifex] has quit [Ping timeout: 240 seconds] 11:00 -!- Aurelius2 [~cpopell@50.35.79.117] has quit [Ping timeout: 240 seconds] 11:08 -!- Aurelius [~cpopell@50.35.79.117] has joined ##hplusroadmap 11:37 -!- esmerelda [~andares@2607:fb90:82a6:4ed:d9ab:1e9f:2a3e:79fb] has joined ##hplusroadmap 11:37 -!- esmerelda [~andares@2607:fb90:82a6:4ed:d9ab:1e9f:2a3e:79fb] has quit [Changing host] 11:37 -!- esmerelda [~andares@unaffiliated/jacco] has joined ##hplusroadmap 11:42 -!- night [~Adifex@unaffiliated/adifex] has joined ##hplusroadmap 12:14 -!- esmerelda [~andares@unaffiliated/jacco] has quit [Ping timeout: 255 seconds] 12:14 -!- esmerelda 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[~apoelstra@wpsoftware.net] has quit [Changing host] 18:03 -!- andytoshi [~apoelstra@unaffiliated/andytoshi] has joined ##hplusroadmap 18:17 < kanzure> bloop 18:22 -!- yashgaroth [~yashgarot@2602:306:35fa:d500:f5e0:f867:a11d:8d52] has joined ##hplusroadmap 18:23 < cluckj> beep 18:25 < yorick> huh 18:29 < andytoshi> blop 18:36 < cluckj> wut 18:45 < abetusk> I heard something about a $100 Illumina genome...is that mostly hype or is that slated to be real sometime soon? 19:43 -!- cynsia_ [cyn@2600:3c03::f03c:91ff:fe79:d5d] has joined ##hplusroadmap 19:43 -!- cynsia [cyn@2600:3c03::f03c:91ff:fe79:d5d] has quit [Remote host closed the connection] 20:04 -!- Gurkenglas [~Gurkengla@dslb-188-103-065-237.188.103.pools.vodafone-ip.de] has quit [Ping timeout: 256 seconds] 20:08 < kanzure> uhh i think that's on the maybe pile 20:31 < kanzure> .wik selegiline 20:31 < yoleaux> "Selegiline, also known as L-deprenyl, is a substituted phenethylamine. At normal clinical doses, it is a selective irreversible MAO-B inhibitor. In larger doses it loses its specificity and also inhibits MAO-A." -- https://en.wikipedia.org/wiki/Selegiline 20:31 < kanzure> .wik metformin 20:31 < yoleaux> "Metformin, marketed under the tradename Glucophage among others, is the first-line medication for the treatment of type 2 diabetes. This is particularly true in people who are overweight." -- https://en.wikipedia.org/wiki/Metformin 20:31 < kanzure> also for mammal longevity stuff tho 20:32 -!- darsie [~darsie@84-113-55-42.cable.dynamic.surfer.at] has quit [Ping timeout: 255 seconds] 20:33 < kanzure> .wik NSI-189 20:33 < yoleaux> "NSI-189 is an experimental, potential antidepressant that is under investigation by Neuralstem, Inc. for the treatment for major depressive disorder (MDD), as well as for cognitive impairment and neurodegeneration." -- https://en.wikipedia.org/wiki/NSI-189 20:34 < kanzure> "The mechanism of action of NSI-189 appears to be activation of neurogenesis in the hippocampus and possible enlargement of this structure,[2] but how the drug mediates these effects is unknown and binding studies have so far failed to identify any certain molecular targets for the drug.[3] As stated by Neuralstem, NSI-189 is a "new chemical entity with [a] novel mechanism of action, molecular... 20:34 < kanzure> ... target yet unknown, but not mediated by SSRI or SNRI or by BDNF release or via any known GPCRs, kinases, or channels." The drug was discovered via high-throughput screening of a library of 10,269 compounds for neurogenic effects in vitro.[3]" 20:35 < kanzure> .wik rapastinel 20:35 < yoleaux> "Rapastinel (INN) (former developmental code names GLYX-13, BV-102) is a novel antidepressant that is under development by Allergan (previously Naurex) as an adjunctive therapy for the treatment of treatment-resistant major depressive disorder." -- https://en.wikipedia.org/wiki/Rapastinel 20:43 < kanzure> .wik cerebrolysin 20:43 < yoleaux> "Cerebrolysin is a mixture of peptides purified from pig brains, including (and not limited to) brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), nerve growth factor (NGF), and ciliary neurotrophic factor (CNTF)." -- https://en.wikipedia.org/wiki/Cerebrolysin 20:45 < kanzure> .wik semax 20:45 < yoleaux> "Semax is a drug produced and prescribed mostly in Russia and Ukraine for a broad range of conditions but predominantly for its purported nootropic, neuroprotective, and neurogenic/neurorestorative properties." -- https://en.wikipedia.org/wiki/Semax 21:07 -!- cynsia_ [cyn@2600:3c03::f03c:91ff:fe79:d5d] has quit [Quit: Leaving] 21:08 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has quit [Remote host closed the connection] 21:17 -!- jtimon [~quassel@245.30.134.37.dynamic.jazztel.es] has quit [Ping timeout: 258 seconds] 21:17 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has quit [Ping timeout: 258 seconds] 21:18 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has joined ##hplusroadmap 21:46 -!- augur [~augur@2602:304:cdac:e260:e46e:6b61:e549:97cb] has joined ##hplusroadmap 21:51 -!- augur [~augur@2602:304:cdac:e260:e46e:6b61:e549:97cb] has quit [Ping timeout: 255 seconds] 22:09 -!- delinquentme [~delinquen@108-235-112-153.lightspeed.sntcca.sbcglobal.net] has joined ##hplusroadmap 22:21 -!- delinquentme [~delinquen@108-235-112-153.lightspeed.sntcca.sbcglobal.net] has quit [Quit: Leaving] 22:36 -!- sandeepkr_ [~Sandeepkr@103.49.155.114] has quit [Remote host closed the connection] 22:36 -!- sandeepkr_ [~Sandeepkr@103.49.155.114] has joined ##hplusroadmap 22:57 -!- yashgaroth [~yashgarot@2602:306:35fa:d500:f5e0:f867:a11d:8d52] has quit [Quit: Leaving] 23:25 < nmz787> kanzure: I know a guy with animals, is there some $$$ in brain extracts? 23:56 -!- maaku [~quassel@173-228-107-141.dsl.static.fusionbroadband.com] has quit [Quit: No Ping reply in 180 seconds.] 23:57 -!- maaku [~quassel@173-228-107-141.dsl.static.fusionbroadband.com] has joined ##hplusroadmap --- Log closed Sat Feb 04 00:00:23 2017