--- Log opened Sat Feb 04 00:00:23 2017
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01:34 < abetusk> https://3dprint.nih.gov/
01:34 < abetusk> .title https://3dprint.nih.gov/
01:34 < yoleaux> NIH 3D Print Exchange | A collection of biomedical 3D printable files and 3D printing resources supported by the National Institutes of Health (NIH)
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07:13 < kanzure> nmz787: yep, sure, throw those brains into a blender yo
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10:28 < kanzure> blort
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13:55 < kanzure> blastocyst injection is a cool idea
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16:17 < kanzure> regenesis is a good book
16:18 < kanzure> also it cites the 2007 version of hplusroadmap
16:18 < kanzure> and mentions us directly in chaptertext
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16:46 < kanzure> .wik repository for germinal choice
16:46 < yoleaux> "The Repository for Germinal Choice (originally known as the Hermann J. Muller Repository for Germinal Choice) was a sperm bank that existed in Escondido, California from 1980 to 1999. The repository is commonly believed to have accepted only donations from Nobel Prize laureates, although in fact it accepted donations from non-Nobelists, also." -- https://en.wikipedia.org/wiki/Repository_For_Germinal_Choice
16:46 < kanzure> "Founded by Robert Klark Graham, the repository was dubbed the "Nobel prize sperm bank" by media reports at the time.[2] The only contributor who became known publicly was William Shockley, Nobel laureate in physics."
16:47 < kanzure> "In late 1957, eight of Shockley's researchers, who would come to be known as the "traitorous eight", resigned after Shockley decided not to continue research into silicon-based semiconductors.[31] In his later life, Shockley was a professor of electrical engineering at Stanford University and became a proponent of eugenics.[1][2]"
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16:48 < kanzure> wtf "When Kimble died in 1998 the combined relatives of both men decided to close down the bank. All sperm samples were destroyed; it remains unclear what happened to the Repository's records.[1]"
16:51 < kanzure> http://q13fox.com/2014/10/08/nobel-prize-sperm-bank-babies-are-all-grown-up-so-how-did-they-turn-out/
16:51 < kanzure> ""I'd take the tanks of liquid nitrogen in Dr. Graham's Cadillac and drive up to CalTech and talk to the students (and professors)," she told Lisa Ling. If someone was willing, she provided him a cup."
17:23 < kanzure> 'synthetic minigenome' with only 151 genes (why did he pick those 151?)
17:25 < kanzure> "Other replication speed demons are flies (midges and fruit flies) due to their boom and bust lifestyle. Flies crawl around starving. Then suddenly a piece of fruit appears, and the flies that manage to convert that piece of fruit into fly eggs fastest win. The best flies lay an egg every forty minutes. But even more impressive, some of its genomes-- indeed whole nuclei-- can divide in six min...
17:25 < kanzure> ...utes, beating ecoli, but only by cheating, since whole nuclei depend on prefabricated ribosomes lurking in the vast resources of the newly fertilized fly egg."
17:25 < kanzure> then why not feed ribosomes to vibrio and speed it up
17:26 < kanzure> "Environmentally controlled invasion of cancer cells by engineered bacteria." http://www.sciencedirect.com/science/article/pii/S0022283605013380
17:28 < kanzure> transgenic mouse production of humanized antibodies https://en.wikipedia.org/wiki/Genmab#Technology
17:33 < yashgaroth> if it's anything like j craig's synthetic e.coli, those 151 genes were chosen because knocking any of them out was lethal, regardless of whether they knew the gene's function or not
17:35 < yashgaroth> egg cells are packed with DNA replication/nuclear structure proteins and ribosomes so replication is often faster than during steady-state growth; more ribosomes aren't usually the limiting factor in prokaryotes, iirc it's time to complete genome replication
17:38 < yashgaroth> I do find it funny that the Genmab antibodies are classified as murine (*-mumab) even though they have a human sequence, but I've ranted about biology nomenclature plenty
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17:41 < kanzure> huh? i thought venter did the knockout stuff and found that he needed 400+ genes.
17:41 < yashgaroth> as for the bacteria invading cancer stuff, I can think of at least three things wrong with the approach
17:41 < yashgaroth> well I don't know what synthetic minigenome you're talking about so I just made the analogy
17:54 < kanzure> it's a non-venter minimum genome project from church apparently
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21:00 < RedSector> hello
21:02 < yashgaroth> sup
21:02 < RedSector> watching some UFC, and programming
21:02 < RedSector> you?
21:02 < yashgaroth> killing time on the internet
21:03 < RedSector> the internet is good for that
21:03 < yashgaroth> indeed
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--- Log closed Sun Feb 05 00:00:24 2017