--- Log opened Wed Feb 15 00:00:33 2017
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00:16 < jrayhawk> it's not clear that ApoB/endothelial interactions even matter without a host of other, vastly easier to control immunological insults
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01:52 < archels> nmz787_: Pieter@Waag.org is trolly? or someone hijacked his identity
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04:48 < ExeciN> hi kanzure
04:49 < ExeciN> kanzure: do I happen to know you from a different network? I'm ExeciN almost everywhere
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05:07 < kanzure> ExeciN: nope
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06:23 < kanzure> .title http://www8.nationalacademies.org/onpinews/newsitem.aspx?RecordID=12032015a
06:23 < yoleaux> On Human Gene Editing: International Summit Statement
06:25 < kanzure> "Human genome editing: consensus study" http://nationalacademies.org/gene-editing/consensus-study/index.htm
06:25 < kanzure> haha they want to sell the report for $80 fuckers
06:28 < kanzure> here we go http://diyhpl.us/~bryan/papers2/bio/Human%20genome%20editing%20-%20consensus%20study%20-%202017.pdf
06:32 < cluckj> haha $80?
06:33 < cluckj> yeesh
06:36 < cluckj> the president's council on bioethics at least had the decency to give away prints of their publications for free
06:36 < kanzure> i just gave you the link to the pdf
06:36 < kanzure> they charge $80 but also they have a link to a pdf for some reason
06:36 < cluckj> yes
06:37 < kanzure> anyway these baboons seem to be anti-enhancement >:(
06:50 < cluckj> against it because they're against it, or appear against it because they want it regulated?
06:52 < kanzure> because these people are evil
06:53 < cluckj> I dunno, jonathan moreno and keith wailoo are pretty decent folks :P
06:53 < kanzure> then they succumbed to peer pressure and hence are evil too
06:53 < cluckj> lol
06:59 < kanzure> cluckj: see pdf page 22
07:00 < kanzure> "Do not proceed at this time with human genome editing for purposes other than treatment or prevention of disease and disability (6.1)"
07:00 < cluckj> yeah it says "public discussion is needed," which is lame-o
07:00 < kanzure> and pdf page 122 chapter 6
07:01 < rkos_> well theyre covering their assess
07:02 < cluckj> that part of the report reads like the 10 year old president's council on bioethics book on enhancement
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07:02 < cluckj> which is to say, nothing new
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07:03 < kanzure> yes but i need my 47 seconds of hate for the day
07:03 < cluckj> there are a couple new polls folded in
07:03 < cluckj> k
07:04 < cluckj> at least this report wasn't produced by a bunch of priests and philosophers :)
07:08 < kanzure> page 214 mentions "squeeze poration", where cells are forced through narrow passages and they pick up free floating dna from the surrounding fluid
07:09 < cluckj> sweet
07:09 < rkos_> isnt that .pdf kind of weird in context of the suggested deregulation of FDA by the new administration
07:10 < cluckj> that report isn't produced by a government agency
07:11 < kanzure> "For example, Corneliu Giurgea, the Romanian chemist who synthesized Piracetam in 1964 and showed that it might act in cognitive enhancement, said, "Man is not going to wait passively for millions of years before evolution offers him a better brain" (Giurgea, 1973)."
07:14 < rkos_> yeah but its suggestions seem like they havent noticed the change
07:16 < cluckj> clearly this report was written in the last three weeks :P
07:19 < rkos_> the part about outside US regulation seemed really lacking
07:20 < rkos_> basically its just a description of UK regulation
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10:18 < kanzure> "Ichor Therapeutics, a biotechnology company that focuses on developing drugs for age-related diseases, announced a series A offering to bring its lysoclear product for age-related macular degeneration through a Phase I clinical trial. This product would be the first clinical candidate based on the SENS paradigm"
10:18 < kanzure> "lysoclear, a recombinant enzyme product that selectively localizes to the lysosomes of RPE cells where A2E accumulates, and destroys it"
10:18 < kanzure> "The company has established a partnership with Syracuse University and obtained $795,000 in dedicated program funding from Michael Greve's Kizoo Technology Ventures, SENS Research Foundation, FightAging.org, CenterState CEO, and several private investors to support its present work on LYSOCLEAR"
10:18 < kanzure> fightaging.org has venture capital?
10:20 < kanzure> http://lysoclear.com/
10:31 < maaku> I was listening to the NPR piece on that genome bioethics piece. Made me want to throw the radio out the window.
10:32 < maaku> Nevermind the right to self-modify, the basic logic was missing. "We must be very careful when introducing changes that will permanently exist in the genetic population.." nevermind that the -exact same technology- would let you remove a gene in the next generation
10:37 < maaku> If that's your concern, here's a recommendation: Commercial use of this technology must include payment into a fund sufficient to support IVF + gene therapy for descendents of the child who want the modifications electively removed from their children
10:37 < maaku> that shouldn't be much more than a small factor more than the cost of one operation today
10:42 < kanzure> these people aren't really interested in solutions, tho
10:44 < kanzure> i think there's at least one off-shore medical tourism clinic already offering embryo genome editing
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16:08 < kanzure> bloop
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17:02 < __mz_o_> bleep bleep
17:21 < catern> beeeeeeep
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18:31 < kanzure> https://github.com/terryum/awesome-deep-learning-papers
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19:25 < kanzure> http://hackaday.com/2017/02/15/taking-apart-a-vintage-oscilloscope/
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19:28 < kanzure> .title https://www.statnews.com/2017/02/15/crispr-patent-ruling/
19:28 < yoleaux> Broad Institute prevails in heated dispute over CRISPR patents
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19:29 < kanzure> https://assets.documentcloud.org/documents/3462190/Broad/Cal/Decision/on/Motions.pdf
19:31 < kanzure> http://hackaday.com/2017/02/15/speakers-make-a-laser-scanning-microscope/
19:32 < kanzure> "Broadband spectral responses in visual cortex revealed by a new MEG denoising algorithm" http://biorxiv.org/content/early/2017/02/15/108993
19:33 < kanzure> "Designed cell consortia as fragrance-programmable analog-to-digital converters" http://www.nature.com/nchembio/journal/v13/n3/full/nchembio.2281.html
19:33 < kanzure> "Synthetic biology advances the rational engineering of mammalian cells to achieve cell-based therapy goals. Synthetic gene networks have nearly reached the complexity of digital electronic circuits and enable single cells to perform programmable arithmetic calculations or to provide dynamic remote control of transgenes through electromagnetic waves. We designed a synthetic multilayered gaseou...
19:34 < kanzure> ...s-fragrance-programmable analog-to-digital converter (ADC) allowing for remote control of digital gene expression with 2-bit AND-, OR- and NOR-gate logic in synchronized cell consortia. The ADC consists of multiple sampling-and-quantization modules sensing analog gaseous fragrance inputs; a gas-to-liquid transducer converting fragrance intensity into diffusible cell-to-cell signaling compounds...
19:34 < kanzure> ...; a digitization unit with a genetic amplifier circuit to improve the signal-to-noise ratio; and recombinase-based digital expression switches enabling 2-bit processing of logic gates. Synthetic ADCs that can remotely control cellular activities with digital precision may enable the development of novel biosensors and may provide bioelectronic interfaces synchronizing analog metabolic pathways...
19:34 < kanzure> ... with digital electronics."
19:34 < kanzure> hmm i'm not particularly impressed by 2 bits, don't we already have that with optogenetics?
19:38 < kanzure> https://www.broadinstitute.org/crispr/journalists-statement-and-background-crispr-patent-interfer
19:39 < kanzure> http://news.berkeley.edu/2017/02/15/berkeley-statement-regarding-patent-boards-decision-on-crispr-cas9-gene-editing-technology/
19:40 < kanzure> https://www.broadinstitute.org/files/news/pdfs/106048OrderJudgment.pdf
19:40 < kanzure> https://www.broadinstitute.org/files/news/pdfs/106048DecisiononMotions.pdf
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19:41 < kanzure> "development timeline since 2011" https://www.broadinstitute.org/files/news/pdfs/timeline.pdf
19:43 < kanzure> "Broad Institute is working with Addgene, a non-profit plasmid repository, to offer Zhang lab CRISPR plasmids and reagents to accelerate academic research. Since February 2013, Addgene has shared more than 37,000 plasmids and reagents with more than 2,000 institutions across 59 countries. In addition we have non-exclusively licensed many industry partners for development of research tools and ...
19:43 < kanzure> ...reagents and will continue to do so."
19:44 < kanzure> https://www.addgene.org/crispr/zhang/
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21:07 < nmz787_> archels: eh, I don't know. Just after I said that, they actually did reply to my ask for explaining their position... but what they said sounded to me like the opposite of DIYbio being hijacked. So who knows.
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21:35 < nmz787_> hmm, the photodiode in that laser scanning microscope from speakers is the same one I was using for my xray detector
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--- Log closed Thu Feb 16 00:00:34 2017