--- Log opened Wed Feb 22 00:00:40 2017
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00:25 < nmz787_> .tell chris_99 this is a differential amplifier in an old web browser tab that I just re-opened after a month or two: http://www.analog.com/en/products/amplifiers/operational-amplifiers/ada4530-1.html#product-overview
00:25 < yoleaux> nmz787_: I'll pass your message to chris_99.
00:25 < nmz787_> .title
00:25 < yoleaux> ADA4530-1 Datasheet and Product Info | Analog Devices
00:26 < nmz787_> .tell chris_99 or this one http://www.ti.com/lit/ds/symlink/opa129.pdf
00:26 < yoleaux> nmz787_: I'll pass your message to chris_99.
00:26 < nmz787_> .tell chris_99 http://www.ti.com/lit/an/sboa061/sboa061.pdf
00:26 < yoleaux> nmz787_: I'll pass your message to chris_99.
00:27 < nmz787_> .tell chris_99 'DESIGNING PHOTODIODE AMPLIFIER CIRCUITS WITH OPA128'
00:27 < yoleaux> nmz787_: I'll pass your message to chris_99.
00:29 < nmz787_> .title http://www.electronixandmore.com/projects/simplescope/index.html
00:29 < yoleaux> Ultra-Simple Oscilloscope
00:32 < nmz787_> .tell chris_99 cheap LM358 op-amps have differential input, that's what I was playing with on a breadboard
00:32 < yoleaux> nmz787_: I'll pass your message to chris_99.
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06:00 < kanzure> hmph
06:01 < archels> nmz787_: I ordered some protoboards from aliexpress, I was too lazy to make a custom design with just pads and vias and send it to oshpark or similar
06:03 < poppingtonic> https://www.ncbi.nlm.nih.gov/pubmed/28166612
06:03 < poppingtonic> .title
06:03 < yoleaux> Acute exercise activates p38 MAPK and increases the expression of telomere protective genes in cardiac muscle. - PubMed - NCBI
06:03 < poppingtonic> "Understanding the early adaptive response of the heart to an endurance exercise bout is paramount to understanding the impact of endurance exercise on heart tissue and cells."
06:08 < archels> .title http://lists.extropy.org/pipermail/extropy-chat/2017-February/091795.html
06:08 < yoleaux> [ExI] 10 Breakthrough Technologies 2017
06:09 < kanzure> gross, a pop-tech article
06:10 < archels> funzies
06:38 < bluebear_> if someone interested, here is mine list of breakthroughs (sorry if I already posted it; I'm updating it occasionally to keep pace, but don't have much in 2017 yet): https://docs.google.com/spreadsheets/d/1vCKH3VQFMyiP0H3qqVZwvbqFQ1-E8QEmvKayJQ0Mo0A/edit?usp=sharing
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07:46 < kanzure> .g hands of transcendental quickness
07:46 < yoleaux> http://www.knowyoursong.com/Frys-Opera-by-Futurama-Lyrics.html/I-Need-Hand-Of-Transcendental-Quickness.html
08:07 < archels> bluebear_: cool
08:08 < bluebear_> archels: thanks :-) still I have lots of missing info; started it as an antidepressant (every time I have the feeling the technology does not advance, I look at it, or add new data)
08:09 < bluebear_> archels: but some interesting trends, I think, start to appear; it seems that most of the technology appears, in some form, about 10 years before it becomes a public breakthrough
08:10 < bluebear_> archels: but some few look like a pure stroke of genius, completely unexpected - Wikipedia, Facebook, Minecraft, (Undertale? - your milleage may vary)
08:11 < archels> what's Undertale?
08:12 < bluebear_> archels: a little strange (genius, in my personal opinion) retro game with terrible graphics, excellent music and strange meta-play (many NPCs know what is restarting, one boss even saves against you :-) )
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08:13 < bluebear_> archels: I see it mostly as a proof that game development become an independent art form that can evoke very strong emotions
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09:25 < streety> what set facebook apart from myspace, or bebo, or any of the other social networks that predated it?
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09:39 < bluebear_> streety: I think they just had good timing, the time was ripe for something like that, nothing more (but that's just my opinion)
09:43 < streety> yeah, that was my thinking, so curious why you included facebook in the list of "but some few look like a pure stroke of genius, completely unexpected"
09:43 < streety> good execution but not obviously anything truly novel
09:44 < streety> perhaps falling into the trap of hindsight being 20/20 though
09:44 < bluebear_> streety: ummm... yes, you are right; that was also an iterative process but the previous ones were not so widespread
09:53 < nmz787_w> streety: I'd say advertising your updates to all your friends was new... I don't remember anything besides MySpace really, I used Orkut a bit but don't think it was much diff than MySpace
09:54 < nmz787_w> live/deadjournal was similar in that you would post, and hoped people would see it... but it wouldn't actually push others to see it
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10:28 < andytoshi> live nasa conference http://www.cnbc.com/2017/02/22/watch-nasas-new-findings-on-exo-planets--planets-that-orbit-stars-other-than-our-sun.html
10:28 < andytoshi> taking lots of questions from twitter, i'm not sure how to ask
10:29 < mz_o> bluebear_: streety: i'd thought that theyre success was tied into their lack of customization (no personal theming) and naming conventions ('friends' 'wall' etc etc)
10:29 < mz_o> its all in how they set it up that got everyone hooked
10:29 < mz_o> they made it really simple.. so that even old people could use it lol
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10:30 < mz_o> but also, timing
10:32 < bluebear_> mz_o: lack of customization might be a factor, but I never considered facebook UI especially intuitive
10:33 < mz_o> i remember it being fairly intuitive when there weren't as many options
10:33 < mz_o> dont have a fb so i cant compare lol
10:35 < nmz787_w> almost like a marriage of MySpace and BBforum
10:35 < nmz787_w> or phpBB, etc
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10:36 < chris_99> i _think_ with MySpace all profiles where open right, unlike FB?
10:36 < yoleaux> 08:25Z <nmz787_> chris_99: this is a differential amplifier in an old web browser tab that I just re-opened after a month or two: http://www.analog.com/en/products/amplifiers/operational-amplifiers/ada4530-1.html#product-overview
10:36 < yoleaux> 08:26Z <nmz787_> chris_99: or this one http://www.ti.com/lit/ds/symlink/opa129.pdf
10:36 < yoleaux> 08:26Z <nmz787_> chris_99: http://www.ti.com/lit/an/sboa061/sboa061.pdf
10:36 < yoleaux> 08:27Z <nmz787_> chris_99: 'DESIGNING PHOTODIODE AMPLIFIER CIRCUITS WITH OPA128'
10:36 < yoleaux> 08:32Z <nmz787_> chris_99: cheap LM358 op-amps have differential input, that's what I was playing with on a breadboard
10:36 < chris_99> oh cheers nmz787_w
10:37 < chris_99> i've got 'TEXAS INSTRUMENTS  THS4521IDGKT' in a farnell basket atm for diff amps
10:43 < nmz787_w> chris_99: something I took a while to get over (and maybe still haven't fully) is my desire for BETTER AND FASTER... but this can actually cause problems if you get a part that is 'too fast' because you might add a bunch of additional headache/problems... because when signals get faster, you have to worry more and more about signal integrity and looking at things as transmission lines (i.e. wave action, reflection, wave interference)
10:45 < chris_99> ah, what kind of signal are you talking about
10:45 < chris_99> and what freq?
10:45 < nmz787_w> so while I don't know how fast a photodiode amplifier should ideally be for my application, overbuilding/over-speccing parts has possibly been a waste of time for me (I guess I have the knowledge of the experience, but all my research time could have been devoted to making a slow/crappy circuit work as well as it could, before knowing I needed to upgrade some component or another)
10:45 < nmz787_w> so not actually a waste, but maybe not the approach I would recommend if I were doing it again, or had a friend who was learning
10:46 < nmz787_w> idk, hard to say what the 'right approach' to learning all this complex stuff is
10:46 < nmz787_w> chris_99: my problem was I didn't actually know what freq to target for something like the x-ray detector I was building
10:47 < chris_99> by x-ray detector what do you mean, don't you use an image sensor + scintillator for that?
10:48 < nmz787_w> I just sort of assumed photons would be pouring in insanely fast, and if I wanted to count/quantify them/their-energy... I'd need all the performance I could get
10:48 < nmz787_w> chris_99: this idea is based on PIN photodiodes
10:48 < chris_99> oh interesting
10:48 < nmz787_w> here at work, I think anything below 1GHZ is considered
10:48 < nmz787_w> 'low speed'
10:48 < chris_99> heh
10:49 < nmz787_w> https://www.researchgate.net/profile/FJ_Ramirez-Jimenez/publication/229038928_X-Ray_Spectroscopy_with_PIN_diodes/links/0c960529df0e63c066000000/X-Ray-Spectroscopy-with-PIN-diodes.pdf
10:49 < chris_99> https://en.wikipedia.org/wiki/Silicon_photomultiplier -- dunno if that's of any use but they seem interesting
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10:51 < nmz787_w> chris_99: seen any parts for sale like that wiki link shows?
10:53 < chris_99> i think they're not overly expensive let me have a looky
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10:55 < chris_99> http://sensl.com/product-category/sipm-evaluation-boards/ theres some eval boards, they are dearer than i thought though
10:56 < chris_99> there was an interesting device
10:56 < chris_99> that used them
10:57 < kanzure> .title https://news.ycombinator.com/item?id=13707547
10:57 < yoleaux> Seven earth-sized planets discovered circling a star 39 light years from Earth | Hacker News
10:57 < chris_99> https://arxiv.org/abs/1606.01196
10:57 < chris_99> .t
10:57 < yoleaux> Wed, 22 Feb 2017 18:57:45 UTC
10:57 < chris_99> ' The Desktop Muon Detector: A simple, physics-motivated machine- and electronics-shop project for university students '
10:58 < chris_99> that uses a SiPM
11:01 < nmz787_w> hmm
11:01 < nmz787_w> not cheap, but if they are easy to interface with... it could actually be cheaper than my wasted design/debug time
11:01 < nmz787_w> definitely seems like they should be sensitive enough!
11:01 < chris_99> mm
11:02 < kanzure> .title http://www.nature.com/nature/journal/v542/n7642/full/nature21360.html
11:02 < yoleaux> Seven temperate terrestrial planets around the nearby ultracool dwarf star TRAPPIST-1 : Nature : Nature Research
11:03 < chris_99> the part they use is 60035-SMT, is $132 apparently
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12:33 < streety> I don't know if it was that story but Nature was down for me a while ago
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13:40 < kanzure> it's the springer part of nature acting up again
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15:58 < kanzure> 9032ravidsjdh8422uadshfpuqhufaf
16:17 < jrowe47> hmm, insightful +3
16:17 < kanzure> hi.
16:18 < kanzure> obvious slashdot user
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16:35 < jrowe47> didnt even think of that
16:36 < jrowe47> lol
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19:32 < kanzure> "In vivo three-photon imaging of activity of GCaMP6-labeled neurons deep in intact mouse brain" http://www.nature.com/nmeth/journal/vaop/ncurrent/full/nmeth.4183.html
19:38 < kanzure> something about hearing loss and stem cells http://www.frequencytx.com/our-approach/publications.php
19:41 < kanzure> "Host cell attachment elicits posttranscriptional regulation in infecting enteropathogenic bacteria" http://science.sciencemag.org/content/355/6326/735
19:41 < kanzure> "Katsowich et al. investigated how the PAI virulence genes of enteropathogenic E. coli (EPEC) respond when the bacterium attaches to a host gut cell. EPEC first sticks to the host by means of pili and then uses a PAI-encoded type 3 secretion system (T3SS) to inject multiple effectors into the host cell. But not all virulence mediators are injected. For example, CesT, a bacterial chaperone, del...
19:41 < kanzure> ...ivers virulence effectors into the T3SS apparatus. Then, within the bacterial cytoplasm, it interacts with a gene repressor called CsrA, which reprograms bacterial gene expression to help the bacteria to adapt to epithelial cell-associated life."
19:41 < kanzure> maybe useful for gut biome modification stuff.
19:44 < kanzure> some sort of mechanical instrument for laproscopic surgery (seems to minimize the range of motion strokes?) https://www.youtube.com/watch?v=YziKqmbjCik http://flexdex.com/
19:45 < kanzure> "Mutation effects predicted from sequence co-variation" http://www.nature.com/nbt/journal/v35/n2/full/nbt.3769.html http://evmutation.org/
19:45 < kanzure> "present EVmutation, an unsupervised statistical method for predicting the effects of mutations that explicitly captures residue dependencies between positions. We validate EVmutation by comparing its predictions with outcomes of high-throughput mutagenesis experiments and measurements of human disease mutations."
19:57 < jrayhawk> https://www.youtube.com/watch?v=9oka8hqsOzg brain typing implant
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23:35 < crescendo> TRAPPIST seems really interesting... yoleaux
23:35 < crescendo> target for colony?
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--- Log closed Thu Feb 23 00:00:41 2017