--- Log opened Sat Feb 25 00:00:01 2017 --- Day changed Sat Feb 25 2017 00:00 -!- superobserver [~superobse@unaffiliated/superobserver] has quit [Quit: Decohered...] 01:30 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has quit [Remote host closed the connection] 01:40 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 01:46 -!- darsie [~darsie@84-113-55-42.cable.dynamic.surfer.at] has joined ##hplusroadmap 01:54 -!- Gurkenglas [~Gurkengla@dslb-178-000-183-234.178.000.pools.vodafone-ip.de] has joined ##hplusroadmap 02:30 -!- augur [~augur@c-98-210-157-162.hsd1.ca.comcast.net] has joined ##hplusroadmap 02:39 -!- drewbot [~cinch@ec2-54-81-127-56.compute-1.amazonaws.com] has quit [Remote host closed the connection] 02:39 -!- drewbot [~cinch@ec2-54-157-203-105.compute-1.amazonaws.com] has joined ##hplusroadmap 03:00 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap 03:04 -!- HEx [~HEx@hexwab.plus.com] has joined ##hplusroadmap 03:04 -!- HEx is now known as Guest55178 03:06 -!- niekt0_ is now known as niekt0 03:48 * adlai has still not seen a good argument that aging is bad... let's put it this way - aging accelerates the arrival of grey goo by removing less-colorless biomass that competes over resources with grey goo's future creators 04:13 < fenn> apologies for potentially off topic, but how can i ignore the supervillain-like name "Dr. Spectre"? https://motherboard.vice.com/en_us/article/big-data-cambridge-analytica-brexit-trump 04:22 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-pcnhbrmydvxmfwpf] has joined ##hplusroadmap 04:23 -!- augur [~augur@c-98-210-157-162.hsd1.ca.comcast.net] has quit [Remote host closed the connection] 04:24 < fenn> are there warez copies of these huge databases sold by companies like nielsen and acxiom? tools like palantir are only useful if you have the data to work with in the first place 04:36 < adlai> might someday be a viable business model alternative for ransomware devs 04:37 < fenn> they wouldn't be stealing the database from the database company, but rather from their customers 04:39 < fenn> in which case it's no sweat off the customer's back 04:52 < adlai> fwiw i wouldn't call the article OT although i wish it linked to more of Kosinski's research rather than just anecdotally cherrypicking results 05:13 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Ping timeout: 240 seconds] 05:34 < kanzure> adlai: aging is literally damage 05:35 < adlai> biological garbage collection 05:35 < adlai> realtime to boot - no global delays 05:36 < chris_99> how's it garbage collection? 05:48 * adlai used the term very liberally, roughly as "the genotypes that survive over time are those that remain fit through environmental changes, those who's fitness has decreased (whether through decay of the organism due, or inability to replicate in the changed environment) are eventually pruned" 05:49 -!- Alsike [~Alsike@45-30-147-14.lightspeed.dybhfl.sbcglobal.net] has joined ##hplusroadmap 05:52 < chris_99> ah i think i misunderstood what you meant 05:54 < chris_99> i see what you mean now 05:56 < kanzure> adlai: if you are arguing that death is good, that's one thing. but you can still kill/murder people even if they are young, so i don't see your point. 05:58 < adlai> 'aging' suggests something caused by the organism/species/phenotyptome's environment integrated over time, rather than action taken by individuals based on judgement 05:58 < streety> Why should be lay down and die to speed the arrival of grey goo? I've no fondness or allegiance wih grey goo. 05:58 < streety> Also, genotypes are pruned by extinction, not by aging and death 05:58 < adlai> no, you should work to accelerate it. otherwise it will simulate you burning in hell (computronium is conscious, duh) 05:59 < streety> even accepting that, seems separate from aging/death 06:00 < kanzure> i am very confused 06:01 < kanzure> adlai: are you arguing that aged bodies are more functional/healthy? 06:01 * adlai is also confused (most likely stemming from ignorance) about the difference between extinction and death sufficiently pluralized 06:02 < adlai> kanzure: no? i think those are orthogonal with age. i guess my point boils down to anti-aging being nice for us as individuals, but not ~necessarily~ an evolutionarily wise approach 06:03 < adlai> this is getting rather political though so let's go back to discussing how to hack politics using data 06:03 < kanzure> there ain't no evolutionary guarantees anyway, you lookin' in the wrong place 06:05 < streety> I suppose if you take it out to the extreme extinction is just the death of all members of a species. Not clear how the death of all humans would eccelerate any technological advances though 06:07 < streety> .title http://www.cell.com/cell/fulltext/S0092-8674(17)30130-7 06:07 < yoleaux> streety: Sorry, that doesn't appear to be an HTML page. 06:08 < adlai> Fasting-Mimicking Diet Promotes Ngn3-Driven beta-Cell Regeneration to Reverse Diabetes 06:08 < streety> potential regeneration of cells thought to be hard to induce proliferation in using a cycling fasting diet 06:08 < streety> thanks adlai 06:08 < streety> not sure why yoleaux had trouble with that 06:08 < adlai> probably the redirect thru elsevier 06:09 < streety> on principle? 06:32 -!- Alsike [~Alsike@45-30-147-14.lightspeed.dybhfl.sbcglobal.net] has quit [Ping timeout: 260 seconds] 06:35 -!- Alsike [~Alsike@45-30-147-14.lightspeed.dybhfl.sbcglobal.net] has joined ##hplusroadmap 07:24 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-pcnhbrmydvxmfwpf] has quit [Quit: Connection closed for inactivity] 07:28 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 07:38 -!- Alsike [~Alsike@45-30-147-14.lightspeed.dybhfl.sbcglobal.net] has quit [Quit: Alsike] 07:40 -!- Alsike [~Alsike@45-30-147-14.lightspeed.dybhfl.sbcglobal.net] has joined ##hplusroadmap 07:52 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Ping timeout: 240 seconds] 08:28 -!- helleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has quit [Ping timeout: 240 seconds] 08:51 < fenn> i never knew the story behind this painting https://en.wikipedia.org/wiki/Christina's_World 08:52 < fenn> "The woman in the painting is likely to have suffered from Charcot-Marie-Tooth disease, a genetic polyneuropathy. Wyeth was inspired to create the painting when he saw her crawling across a field" 08:56 < fenn> "The challenge to me was to do justice to her extraordinary conquest of a life which most people would consider hopeless," he wrote. "If in some small way I have been able in paint to make the viewer sense that her world may be limited physically but by no means spiritually, then I have achieved what I set out to do." 09:23 < C0MPAQ_> fenn: pathetic 09:23 < fenn> really, that's what you have to say? 09:24 -!- augur [~augur@2601:645:8300:2b03:8580:ccd6:2ed2:3fcd] has joined ##hplusroadmap 09:24 < C0MPAQ_> its a simple painting, depicting a diseased woman crawling up a hill 09:26 < fenn> wyeth spent about 20 years obsessing over this woman and depicting her life 09:29 -!- augur [~augur@2601:645:8300:2b03:8580:ccd6:2ed2:3fcd] has quit [Ping timeout: 255 seconds] 09:33 < Alsike> i see the appeal though 09:33 < Alsike> compared to more mundane subject matter 09:34 < Alsike> most paintings are simple 09:34 < Alsike> its up to the interpretation of it for anyone to make it hold value 09:39 < kanzure> what's with the pro-aging anti-nanotech anti-dna influx of users 09:40 < fenn> i don't think anyone's pro-aging 09:41 < fenn> i think adlai was saying he prefers nanotech to immortal boring people 09:42 < Alsike> anyone familiar in decellularization here 09:43 < kanzure> delinquentme was selling some sort of extracellular matrix product 09:43 < fenn> do you mean CLARITY or ghost heart stuff 09:43 < Alsike> ghost heart stuff 09:44 < Alsike> i've been decelling lots of tissue and stuff with surfactants 09:44 < fenn> i saw one they had made at counter culture but i don't know the protocol myself 09:44 < Alsike> next step is to try and get stem cells to latch on and grow, but i have no clue how i even start with that 09:45 < fenn> shove a chicken through a needle and you're set :P 09:45 < kanzure> the 3d printing tissue culture people seem to think that as long as you make enough grooves the cells will just get stuck in there 09:45 -!- casper_87 [~casper@201.52.64.90] has joined ##hplusroadmap 09:45 < kanzure> greetings casper_87 09:45 < Alsike> hm 09:46 < fenn> ok so it's more like, do a trypsin digestion and incubate in phosphate buffered saline 09:46 < fenn> ugh tissue culture is hard 09:47 < fenn> vascularized tissue is another level of hard on top of that 09:47 < kanzure> organoids seem to do it 09:48 < C0MPAQ_> are anti-pidgeon bioweapons within reach of homebrew DNA sequencing? 09:48 < C0MPAQ_> I might want to contribute to make that happen 09:48 < kanzure> you mean dna synthesis, not sequencing 09:48 < C0MPAQ_> yes 09:49 < kanzure> you are never going to make viable bioweaponry if you get the fucking details wrong 09:50 < kanzure> anyway, pick an appropriate avian virus genome and manufacture it https://www.ncbi.nlm.nih.gov/genomes/GenomesGroup.cgi?taxid=10239 09:52 < fenn> i thought the point of organoids was that they were not vascularized 09:52 * kanzure chex https://en.wikipedia.org/wiki/Organoid 09:52 < fenn> they're small enough to be ok with just diffusion 09:53 < fenn> less than the size of a sesame seed 09:53 < C0MPAQ_> those are all too dangerous, maybe a virus that just causes excessive vomiting would be appropriate 09:54 < fenn> "Lacking a blood supply, cerebral organoids reach about 4 mm across" 09:54 < kanzure> ah. 09:55 < kanzure> hm. 09:55 < kanzure> maybe there's a cancer somewhere that causes excessive vascularization and we should just steal those mutations 09:55 < kanzure> lots of tumors end up vascularized, right? 09:56 < C0MPAQ_> good point 09:56 < fenn> a better anti-pigeon bioweapon is the peregrine falcon 09:56 < fenn> "In urban areas, the main component of the peregrine's diet is the rock or feral pigeon, which comprise 80% or more of the dietary intake for peregrines in some cities." 09:58 < casper_87> he llo sirs cheers 09:59 < fenn> ok this is a use of the word "hack" i hadn't heard of: https://en.wikipedia.org/wiki/Hack_(falconry) 10:02 < kanzure> "Non-interactive zero knowledge proofs of discrete log equivalence" https://moderncrypto.org/mail-archive/curves/2017/000850.html 10:04 < casper_87> this is cool https://www.technologyreview.com/s/603492/10-breakthrough-technologies-2017-reversing-paralysis/?utm_medium=native_social&utm_source=facebook&utm_campaign=10bt_traffic&utm_content=paralysis_story 10:05 < casper_87> some one have a paper or stuff about how control brain of animals ? 10:06 < casper_87> Anyone can give to me a reference ? 10:06 < kanzure> casper_87: http://diyhpl.us/~bryan/papers2/neuro/implants/ 10:06 < kanzure> casper_87: or the optogenetics papers in http://diyhpl.us/~bryan/papers2/neuro/ 10:08 < fenn> .title https://www.youtube.com/watch?v=p2TcAA7VqmM&t=1474s 10:08 < yoleaux> The future of genetic codes and BRAIN codes - YouTube 10:08 < fenn> hmm 10:09 < fenn> george church strikes again 10:09 -!- y0no [~y0no@2001:bc8:212d:201:ff01::a] has quit [Ping timeout: 240 seconds] 10:10 < kanzure> like a ninja 10:11 < kanzure> did you see the 2016-05-10 transcripts? 10:11 < kanzure> http://diyhpl.us/wiki/transcripts/hgp-write/2016-05-10/ 10:11 < kanzure> http://diyhpl.us/wiki/transcripts/hgp-write/2016-05-10/from-recoli-to-1-million-genomes/ 10:12 -!- y0no [~y0no@2001:bc8:212d:201:ff01::a] has joined ##hplusroadmap 10:19 < kanzure> just bought airfare yesterday to go to the may 2017 version of that conference 10:19 < kanzure> will be out of town may 7 through june 1st 10:23 < kanzure> .title http://bamos.github.io/2016/08/09/deep-completion/ 10:23 < yoleaux> Image Completion with Deep Learning in TensorFlow 10:25 < kanzure> "Also, you can perform vector arithmetic on the z input space. The following is on a network trained to produce faces." 10:43 -!- helleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has joined ##hplusroadmap 10:49 < fenn> how are you supposed to make 3 billion edits in a single organism? 10:49 < fenn> (from that transcript q&a) 10:50 < kanzure> whole genome synthesis 10:50 < kanzure> that's what the new human genome project is about 10:50 < kanzure> (hgp-write) 10:50 < fenn> but that would have the same genome for every cell 10:50 < fenn> he's talking about 3 billion cells each with a different genotype (different by 1 mutation) 10:51 < kanzure> his MAGE technique is one way; but yeah he wants really really high throughput write capability :). 10:51 < kanzure> you could do microfluidics and inject a custom genotype into each cell 10:51 < fenn> into a mouse? what? 10:51 < kanzure> maybe i should look at context 10:52 < fenn> maybe my brain isn't working right or maybe there isn't enough information there to make sense of what he's saying 10:52 < kanzure> oh the haplo-insufficiency question? 10:52 < kanzure> oh oh okay, 10:52 < fenn> the first question 10:52 < kanzure> so he's talking about doing a billion different genotypes and testing each embryo 10:52 < kanzure> and then checking the outcomes 10:52 < fenn> does that mean 3 billion mice? 10:53 < kanzure> no, these are just cell blobs 10:53 < kanzure> small cell blobs at most 10:54 < kanzure> perhaps the video is more clear 10:54 < fenn> i am watching this part of the video for the fourth time 10:54 < kanzure> link is wrong in the file, it's 39m 50s 10:54 < kanzure> (the start is 39m 50s) 10:55 < fenn> maybe the key phrase here is "in principle" 10:55 -!- helleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has quit [Ping timeout: 268 seconds] 10:55 < kanzure> "To some extent the cis-regulatory element, if they are subtle, they are independent... they are not necessarily influencing heterzygous state in gene B, so you could change them simultaneously and then read them out in parallel in every cell of the body." 10:55 < kanzure> that's probably: every cell *type* of the body 10:56 < kanzure> oh, no, it's george church so he might really mean eveyr cell in parallel heh 10:57 -!- helleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has joined ##hplusroadmap 11:05 < fenn> they gotta be kidding if they expect "oh no we're just doing this in somatic cells, not germline" to quell the inevitable shitstorm 11:06 < kanzure> it's DRM basically and i hate them for it 11:06 < fenn> as if it's all that different a protocol 11:06 < kanzure> it doesn't prevent me from using genome synthesis tech to make that chromosome 11:06 < fenn> it's the exact same protocol 11:06 < kanzure> yes, it's completely insulting 11:08 < fenn> backing up, if there is in fact a way to speed up genome analysis by 3 billion times, that seems pretty important 11:09 < kanzure> i think a lot of it is just "do combinatorial things" and there hasn't been any engineering put into that setup yet (or funding?) 11:09 < fenn> so MAGE does directed evolution by causing mutation systematically 11:09 < fenn> but this would only work for analyzing single cell organism genomes 11:09 < fenn> i guess he's saying it doesn't matter that cells interact? 11:11 < kanzure> maybe he's hoping a lot of the gene products are steady-state regardless of interaction 11:22 -!- Urchin[emacs] [~user@unaffiliated/urchin] has quit [Ping timeout: 260 seconds] 11:24 < nmz787_> http://sam.zeloof.xyz/ 11:24 < nmz787_> .title 11:24 < yoleaux> Sam Zeloof - DIY Electronics Projects 11:24 < nmz787_> @home semiconductor fab 11:26 < fenn> swapping codons for virus resistance is a neat idea 11:26 < fenn> not sure i'd want my children to require a DNA synthesizer to breed though 11:27 < nmz787_> that's the best way to breed 11:27 < fenn> .wik ooloi 11:27 < yoleaux> "Lilith's Brood is a collection of three works by Octavia Butler. The three volumes of this science fiction series (Dawn, Adulthood Rites, and Imago) were previously collected in the now out of print volume, Xenogenesis. The collection was first published under the current title of Lilith's Brood in 2000." -- https://en.wikipedia.org/wiki/Ooloi 11:27 < nmz787_> I mean the most trendy 11:47 -!- helleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has quit [Ping timeout: 268 seconds] 11:50 -!- c0rw1n [~c0rw1n@109.128.250.25] has quit [Remote host closed the connection] 11:50 -!- c0rw1n [~c0rw1n@109.128.250.25] has joined ##hplusroadmap 11:57 -!- c0rw1n [~c0rw1n@109.128.250.25] has quit [Remote host closed the connection] 11:57 -!- c0rw1n [~c0rw1n@109.128.250.25] has joined ##hplusroadmap 11:59 -!- augur [~augur@2601:645:8300:2b03:8580:ccd6:2ed2:3fcd] has joined ##hplusroadmap 11:59 -!- augur [~augur@2601:645:8300:2b03:8580:ccd6:2ed2:3fcd] has quit [Remote host closed the connection] 12:00 -!- augur [~augur@c-98-210-157-162.hsd1.ca.comcast.net] has joined ##hplusroadmap 12:04 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 12:05 -!- augur [~augur@c-98-210-157-162.hsd1.ca.comcast.net] has quit [Ping timeout: 268 seconds] 12:09 -!- augur [~augur@2601:645:8300:2b03:8580:ccd6:2ed2:3fcd] has joined ##hplusroadmap 12:11 < kanzure> yep 12:13 -!- helleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has joined ##hplusroadmap 12:39 < kanzure> fenn: they are still accepting project proposals for hgp-write 12:40 < fenn> i don't really know what that means 12:40 < kanzure> it's grant money basically 12:40 < kanzure> http://engineeringbiologycenter.org/wp-content/uploads/2016/12/Pilot-Project-Proposal-Form.pdf 12:40 < fenn> that's just a blank piece of paper 12:41 < kanzure> for example, the "make essential fatty acid synthesis part of the human genome" was one of the submitted proposals and i think they are funding that now 12:41 < kanzure> ( http://diyhpl.us/wiki/transcripts/hgp-write/2016-05-10/synthesizing-a-prototrophic-human-genome/ ) 12:41 < fenn> oh i thought they wanted like, "super awesome scheme for assembling light directed oligos" 12:42 < kanzure> i hope they do stuff like that too 12:42 < fenn> don't we have a zillion potential genome edits already? 12:42 < fenn> the obvious one is to fix vitamin C synthesis 12:42 < kanzure> small edits yes, although i think they are looking for more justifications for large-scale synthesis and big edits not just small changes 12:43 < kanzure> yes i think vitamin c is missing on that page 12:44 < fenn> so obvious it's apparently not on that last link :D 12:44 < kanzure> it's on http://diyhpl.us/wiki/genetic-modifications/ at least 12:48 < fenn> nutritional stuff seems easier to implement with a custom microbiome 12:50 < fenn> eh but then you have to figure out how to keep the good bugs alive 12:50 -!- yashgaroth [~yashgarot@2602:306:35fa:d500:f5e0:f867:a11d:8d52] has joined ##hplusroadmap 12:50 < fenn> i think i need to sleep 12:50 -!- WizJin [WizJin@gateway/shell/fnordserver.eu/x-mcwwczuqrgtczwsy] has quit [Quit: https://fnordserver.eu] 12:50 -!- Qfwfq [Qfwfq@gateway/shell/fnordserver.eu/x-pivgrktnlytnewrc] has quit [Ping timeout: 252 seconds] 12:50 < fenn> in any case i'm not going to come up with a grant proposal right now 12:57 -!- justan0theruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 12:59 < yashgaroth> prototrophic humans are great and all, but surely it's a lot easier to engineer a plant to produce all sufficient nutrients...unless you're in some edge case where a person has to survive on glucose for a year 13:01 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 240 seconds] 13:01 < yashgaroth> or at least get gut bacteria to do it, I mean it's kind of a pain in the ass to engineer humans vs. any other organism 13:03 < kanzure> well they mentioned space travel, 13:03 < kanzure> but sure go ahead and propose your super potato 13:03 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Ping timeout: 240 seconds] 13:03 < yashgaroth> or super radiation-eating fungus; that'll be my third proposal if I don't burn out writing them 13:04 < kanzure> it is not clear to me hwat quality they are expecting 13:05 < kanzure> maybe just "here's a few paragraphs, if you think this has legs then i'll write up something better" 13:05 < kanzure> because it seems rather informal to me at the moment 13:05 < yashgaroth> two page limit is very kind of them 13:08 < kanzure> https://www.reddit.com/r/DrugNerds/comments/5w01qx/the_neurotoxic_mechanisms_of_amphetamine_step_by/ 13:09 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-wjkmtsgiyzpucyqa] has joined ##hplusroadmap 13:17 -!- Alsike [~Alsike@45-30-147-14.lightspeed.dybhfl.sbcglobal.net] has quit [Quit: Alsike] 13:19 -!- Alsike [~Alsike@45-30-147-14.lightspeed.dybhfl.sbcglobal.net] has joined ##hplusroadmap 13:19 -!- yorick_ [~yorick@oftn/oswg-member/yorick] has joined ##hplusroadmap 13:19 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 13:25 -!- WizJin [WizJin@gateway/shell/fnordserver.eu/x-gtveczwylyrbocdn] has joined ##hplusroadmap 13:27 < kanzure> greetings WizJin 13:31 -!- UnknownRogue [~UnknownRo@93.190.141.162] has joined ##hplusroadmap 13:31 -!- Qfwfq [Qfwfq@gateway/shell/fnordserver.eu/x-jnjdugecooenqnvx] has joined ##hplusroadmap 13:42 < kanzure> electroporator has been shipped https://cibolo.us/pipermail/open_electroporator/2017-February/000411.html 13:50 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Ping timeout: 240 seconds] 13:59 -!- casper_87 [~casper@201.52.64.90] has quit [Ping timeout: 268 seconds] 14:12 < kanzure> md5 collision demo http://www.mscs.dal.ca/~selinger/md5collision/ 14:14 < kanzure> webkit svn still broken today https://arstechnica.com/security/2017/02/watershed-sha1-collision-just-broke-the-webkit-repository-others-may-follow/ 14:19 < JayDugger> Fenn, do yourself a favor and don't read Butler's Xenogenesis trilogy. It's a very thinly veiled polemic. 14:21 < JayDugger> In the author's defense, she can write. So unlike other such attacks (cough! Atwood, The Handmaid's Tale, cough) the books aren't boring screeds. 14:21 < archels> "A private connection to cibolo.us can't be established because your computer's date and time (Saturday, February 25, 2017 at 11:20:10 PM) are incorrect." 14:22 < kanzure> archels: you're in the future 14:22 < JayDugger> If you're going to read Butler, stick to Mind of Mind and Patternmaster, which have the merit of being straightforward junk SF. 14:22 < JayDugger> Alright, today's good deed done. 14:23 < fenn> too late 14:23 < JayDugger> Shit. 14:23 < JayDugger> I tried. 14:23 < archels> oh, I missed the title in copy & paste. Chrome actually says "Your clock is ahead" 14:23 < fenn> i thought the writing was bad but the ideas were solid 14:23 * archels is halfway through Altered Carbon 14:23 < kanzure> archels: just saying that this stuff is now shipping physical units to some peeps https://github.com/kanzure/culture_shock 14:24 < archels> kanzure: my interest in it is the high-voltage power supply and related switching/sequencing 14:24 < JayDugger> Which ones? "cancer as a trade good" was pretty neat. 14:25 < kanzure> archels: jcline had a lot of complaints about the power supply that i don't remember any more. also you could pester nmz787_ if you want some details about this one. 14:25 < archels> incidentally, it's annoying when you commit electronics schematics as a .sch for some random CAD software but without a PDF dump 14:26 < kanzure> yea i guess we should pester john to fix this 14:26 < fenn> JayDugger: just the general structure of the 3 sexes was novel 14:27 < fenn> 3rd sex as mediator/recombinase organelle 14:27 -!- casper_87 [~casper@201.52.64.90] has joined ##hplusroadmap 14:27 < JayDugger> Geez...I'd forgotten how old these books were. 14:28 < fenn> the aliens were always right though, it's not like she's shouting some obvious message like "slavery is bad mmkay" 14:29 < fenn> the problem was the humans were all worthless shits 14:30 < JayDugger> Somewhere, I think, IIRC, there's a literary analysis comparing Lovecraft's "A Shadow Over Innsmouth" to Butler's Xenogenesis. Let me know if that's of interest, and I'll see if I can dig up the details. 14:30 < kanzure> sure, we could use some more lovecraft up in this joint 14:31 < fenn> there's the generalized fear of tentacles 14:31 < fenn> or lust for tentacles 14:31 < fenn> or something 14:31 < JayDugger> I read them a few years after when they were first published, and I don't think they've held up well. 14:32 < JayDugger> http://search.informit.com.au/documentSummary;dn=374890677138870;res=IELAPA 14:32 < JayDugger> "Unlikely Utopians: Ecotopian Dreaming in H.P. Lovecraft's 'The Shadow over Innsmouth' and Octavia Butler's Lilith's Brood" 14:33 < JayDugger> Yes, that's a "real" paper. 14:33 < fenn> i don't understand, was xenogenesis supposed to be a dystopia? 14:33 < JayDugger> Ah? Post atomic war alien invasion? 14:33 < fenn> i mean it turned out pretty well all things considered 14:33 < JayDugger> Oh, and they really are to fuck you and steal your kids? 14:34 < JayDugger> Sorry, "are here to" 14:34 < fenn> still not seeing any problems 14:34 < fenn> near immortality, cure all disease, economic abundance, peace on earth, etc etc 14:35 < JayDugger> Did you miss the part about the human survivors being sterilzed? 14:35 < fenn> but mah freedoms 14:35 < fenn> they took er jahbs 14:36 < JayDugger> Yeah...the aliens' abilities could've handled that a lot better, but then the author wouldn't have had a story. 14:43 -!- augur [~augur@2601:645:8300:2b03:8580:ccd6:2ed2:3fcd] has quit [Read error: Connection reset by peer] 14:43 -!- augur [~augur@2601:645:8300:2b03:8580:ccd6:2ed2:3fcd] has joined ##hplusroadmap 14:50 -!- Alsike [~Alsike@45-30-147-14.lightspeed.dybhfl.sbcglobal.net] has quit [Read error: Connection reset by peer] 14:50 -!- Alsike [~Alsike@45-30-147-14.lightspeed.dybhfl.sbcglobal.net] has joined ##hplusroadmap 14:53 -!- augur [~augur@2601:645:8300:2b03:8580:ccd6:2ed2:3fcd] has quit [Remote host closed the connection] 14:58 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Quit: Leaving] 15:17 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 15:19 -!- justan0theruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 240 seconds] 15:24 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has joined ##hplusroadmap 15:34 -!- Gurkenglas [~Gurkengla@dslb-178-000-183-234.178.000.pools.vodafone-ip.de] has quit [Ping timeout: 255 seconds] 16:08 < CheckDavid> When will we have human level AI? 16:08 < kanzure> what level of confidence do you need 16:09 < kanzure> you can put in your numbers here http://theuncertainfuture.com/ 16:18 -!- fleshtheworld [~fleshthew@2602:306:cf0f:4c20:6111:7eb1:a9bd:7e55] has joined ##hplusroadmap 16:20 < CheckDavid> 50% kanzure 16:21 < kanzure> yea use the applets 16:23 < CheckDavid> I'm on mobile. Will try it tomorrow 16:24 < CheckDavid> It's not loading here 16:24 < kanzure> probably wont work on mobile 16:28 < kanzure> "Moving towards user activated soft fork activation" https://lists.linuxfoundation.org/pipermail/bitcoin-dev/2017-February/013643.html 16:36 < kanzure> "Since miners already have the protocol level right to select whatever transaction they prefer (and not mine those they don't), it would be better if a miner could chose to not participate in triggering activation of something they won't use, but, without being a veto to the process (and all the ire they may have to experience as a consequence)." 16:37 -!- darsie [~darsie@84-113-55-42.cable.dynamic.surfer.at] has quit [Ping timeout: 240 seconds] 16:53 -!- drewbot_ [~cinch@ec2-107-22-46-46.compute-1.amazonaws.com] has joined ##hplusroadmap 16:53 -!- drewbot [~cinch@ec2-54-157-203-105.compute-1.amazonaws.com] has quit [Remote host closed the connection] 17:02 < kanzure> https://www.benzinga.com/pressreleases/17/02/p9080499/kernel-acquires-krs-to-build-next-generation-neural-interfaces 17:02 < kanzure> "Company adds Adam Marblestone as Chief Strategy Officer and Ed Boyden as Senior Scientific Advisor" 17:02 < kanzure> well there's your answer... 17:03 < kanzure> re: http://kernel.co/ and marblestone employment 17:05 < kanzure> "Challenges for brain emulation: why so difficult?" http://synapticlink.org/Brain%20Emulation%20Challenges.pdf (2012) 17:07 < kanzure> author was a lifer (20+ years) at sun http://cattell.net/rick/index.html 17:23 < kanzure> http://lifeboat.com/blog/2017/02/interview-liz-parrish (warning: video) 17:40 -!- c0rw1n [~c0rw1n@109.128.250.25] has quit [Quit: Leaving] 17:40 -!- Alsike [~Alsike@45-30-147-14.lightspeed.dybhfl.sbcglobal.net] has quit [Quit: Alsike] 17:40 -!- c0rw1n [~c0rw1n@109.128.250.25] has joined ##hplusroadmap 17:58 < yashgaroth> kanzure: ok I wrote those two proposals...they're not gonna, like, steal it and get patents right? first to file is a bitch 17:58 < yashgaroth> not that I know or think these are necessarily patent-worthy, but still 18:00 < kanzure> welll, we could make some crypto proofs 18:00 < kanzure> gimme the files by email and i can create some timestamps that would prove the existence of the text as of ~today 18:00 < yashgaroth> well yes there is that, but first to file tho 18:01 < yashgaroth> I was gonna bcc you on the email anyway so that would work nicely 18:01 < kanzure> slap on a patent pending statement? :P 18:01 < yashgaroth> pending in my head, not sure if that counts 18:01 < kanzure> IANAL 18:02 < yashgaroth> yeah ok fuck it, I swear on george church's great bushy beard that I will have my vengeance on them if they pull anything 18:03 < kanzure> shit this guy is serious 18:05 < kanzure> ok creating timestamps 18:05 < yashgaroth> ty 18:07 < kanzure> sent 18:08 < yashgaroth> I don't really know how they work, but I'll scatter them across all my drives 18:08 < kanzure> great diagram 18:10 < yashgaroth> they took up the vast majority of my time, but I read through the text and was like "jeez even I need a diagram to understand this" 18:10 < kanzure> yashgaroth: so what is your personal estimation regarding the feasibility of recA assembly vs forcing/optimizing yeast to figure out assembly from short fragments 18:12 < yashgaroth> well I know most of the parts will work in vitro, but at least it's relatively easy to try out - the exonuclease I'm not 100% about it working correctly, eg the actual homology scanning might expose the ends so they get degraded prematurely 18:12 < kanzure> using an enzymatic system is nice because less moving parts, but it also seems more magical 18:12 < yashgaroth> man if you don't think yeast are magic I don't even know 18:12 < kanzure> they are magic but it's a different kind of magic 18:13 < kanzure> hm 18:13 < yashgaroth> definitely be a lot of optimizing ratios of all the enzymes and other components involved, but nothing too crazy 18:14 < yashgaroth> but I use the core recombinase enzymes erryday and I can detect 40 copies of target DNA in 10 minutes, so they must be doing an okay job 18:16 < kanzure> yeah, okay. 18:18 < yashgaroth> not to say that yeast couldn't do it too, but they're several levels above '5 enzymes in a tube' wrt complexity; certainly you can do some directed evolution but you still need robots for that 18:19 < yashgaroth> and they are convenient in the sense you can grow them up easy, but all these proteins express so well you can get a million reactions from a liter of e.coli 18:19 < yashgaroth> of course, I am biased 18:20 < kanzure> no, no, better to prefer simple enzyme systems if possible, i agree 18:34 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-wjkmtsgiyzpucyqa] has quit [Quit: Connection closed for inactivity] 19:33 -!- UnknownRogue [~UnknownRo@93.190.141.162] has quit [Ping timeout: 255 seconds] 19:39 -!- UnknownRogue [~UnknownRo@38.132.117.108] has joined ##hplusroadmap 19:43 -!- fleshtheworld [~fleshthew@2602:306:cf0f:4c20:6111:7eb1:a9bd:7e55] has quit [Quit: Leaving] 20:05 -!- helleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has quit [Ping timeout: 268 seconds] 20:10 -!- UnknownRogueX [~UnknownRo@162.244.81.235] has joined ##hplusroadmap 20:11 -!- UnknownRogueX [~UnknownRo@162.244.81.235] has quit [Read error: Connection reset by peer] 20:12 -!- UnknownRogueX [~UnknownRo@162.244.80.234] has joined ##hplusroadmap 20:14 -!- UnknownRogue [~UnknownRo@38.132.117.108] has quit [Ping timeout: 255 seconds] 21:06 -!- C0MPAQ [~l0rd@dslb-146-060-147-036.146.060.pools.vodafone-ip.de] has joined ##hplusroadmap 21:10 -!- C0MPAQ_ [~l0rd@dslb-088-076-216-181.088.076.pools.vodafone-ip.de] has quit [Ping timeout: 259 seconds] 21:31 -!- pasky_ [~pasky@nikam.ms.mff.cuni.cz] has joined ##hplusroadmap 21:33 -!- pasky [~pasky@nikam.ms.mff.cuni.cz] has quit [Ping timeout: 252 seconds] 21:36 -!- UnknownRogueX [~UnknownRo@162.244.80.234] has quit [Quit: Leaving] 21:44 -!- Dumuzi [Dumuzi@Dont.Blink.PanicBNC.org] has quit [Ping timeout: 240 seconds] 21:52 -!- Dumuzi [Dumuzi@Dont.Blink.PanicBNC.org] has joined ##hplusroadmap 22:28 < nmz787_> I mean the most trendy 22:28 < nmz787_> oops 22:29 < nmz787_> yashgaroth: that's kinda what i've been thinking re: first to file 22:30 < yashgaroth> yeah, especially after the crispr ruling fiasco 22:30 < nmz787_> or just keep shit a trade secret and get bought out 22:31 < nmz787_> writing papers sucks anyway 22:32 < yashgaroth> writing patents too, hell, reading patents is worse than writing papers 22:40 < nmz787_> nah 22:40 < nmz787_> reading isn't as bad as writing 22:40 < nmz787_> imo 22:44 < yashgaroth> after you read the 400th claim, I feel that patents about 5%, about 10%, about 15%, about 20% worse 22:45 < yashgaroth> in certain embodiments, anyway 22:48 < yashgaroth> sorry, bad patent jokes 22:50 < nmz787_> maybe I just read wayyy less patents 22:51 < yashgaroth> I hope so, for your sanity 22:52 < nmz787_> .tell chris_99 I am reading this now http://web.mit.edu/8.13/8.13d/manuals/keithly-602-electrometer.pdf (got one of these today).. thinking of hooking that PIN photodiode up to it, to check for x-rays in the FIB 22:52 < yoleaux> nmz787_: I'll pass your message to chris_99. 22:52 < nmz787_> does .tell chris_99 work mid-sentence? 22:52 < nmz787_> nope 23:07 -!- yashgaroth [~yashgarot@2602:306:35fa:d500:f5e0:f867:a11d:8d52] has quit [Quit: Leaving] 23:21 -!- casper_87 [~casper@201.52.64.90] has quit [Quit: Leaving] 23:45 -!- jrowe47 is now known as jrowe47_gone --- Log closed Sun Feb 26 00:00:43 2017