--- Log opened Fri Mar 24 00:00:07 2017
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05:15 < bluebear_> hi h+ers :-) do you have any opinion on this? --> http://www.cell.com/cell/fulltext/S0092-8674(17)30246-5 (free access)
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05:57 < kanzure> "A modified FOXO4-p53 interfering peptide causes p53 nuclear exclusion in senescent cells"
05:57 < kanzure> "This FOXO4 peptide induces targeted apoptosis of senescent cells (TASC)"
05:57 < kanzure> "TASC restores fitness, hair density, and renal function in fast and naturally aged mice"
06:02 < archels> link: http://www.cell.com/cell/fulltext/S0092-8674(17)30246-5
06:02 < archels> (just came across same)
06:03 < archels> ah, bluebear_ already posted it
06:04 < archels> hmm, it seems they used really few mice
06:07 < archels> and they used "fast-aging mice"
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07:52 < bluebear_> archels: according to the article, they also tried on normally aged mice (I didn't yet found what number of animals they used)
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10:06 < kanzure> "A new firefly species was discovered outside of Los Angeles in 2015 (1), a new species of moth was discovered in southern California earlier this year (2), the California shoreline yielded a new species of nudibranch last year (3), a 2015 initiative by the California Academy of Sciences resulted in 30 new species of phorid fly being found by people checking their backyards (4)" https://www.re...
10:06 < kanzure> ...ddit.com/r/news/comments/6187ay/couple_donates_bug_collection_worth_10m_a/dfcp1j0/
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10:46 < nmz787_i> amazon is getting shitty, they list things as "Prime" but then tell you on the checkout page that it won't be in stock for a week... so you won't really get it for a week and a half
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12:48 < kanzure> Alpha703: greetings.
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13:05 < Iriez> Have I finally find the gold mine? I think I have. Greetings fellow lobsters.
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13:07 < kanzure> Iriez: yep.
13:08 < kanzure> here is a thing http://diyhpl.us/wiki/genetic-modifications/
13:10 < Iriez> Is that just a general canidate list for proposed genetic modifiers? It seems to be all over the map
13:29 < kanzure> it's a list of interesting and useful mutations
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13:55 < nmz787_i> sup
13:56 < kanzure> immanentizing the eschaton
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15:54 < kanzure> russell says "Gave a super secret @BrainBackups talk at #Alcor NYC in the Empire State Building yesterday, if we're friends DM me and I'll fill you in."
15:58 < nmz787_> DM?
15:58 < nmz787_> typo for PM?
15:59 < chris_99> direct message maybe?
15:59 < nmz787_> mmm
16:05 < nmz787_> soo, I'm not sure what to do with my weekend
16:19 < kanzure> science!
16:29 < kanzure> "Neuronal brain region-specific DNA methylation and chromatin accessibility are associated with neuropsychiatric disease heritability" http://biorxiv.org/content/early/2017/03/24/120386
16:29 < kanzure> ".. we compared prefrontal cortex, anterior cingulate gyrus, hippocampus and nucleus accumbens from 6 individuals, performing whole genome bisulfite sequencing for DNA methylation ... We found substantial neuron- and brain region-specific differences in both DNA methylation and chromatin accessibility which were largely non-overlapping, and were greatest between nucleus accumbens and the other...
16:29 < kanzure> ... regions. Several classes of transcription factor binding sites were enriched at regions of differential methylation and accessibility, including many that respond to synaptic activity."
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17:35 < Iriez> http://www.skytopia.com/project/fractal/mandelbulb.html
17:35 < Iriez> We have all known since we were kids about the Mandelbrot set in 2D which is the quintiessential depiction of fractals. It was 2D because it had to have the axis of real and imaginary numbers. So extending this into an uneven number of dimensions i.e. 3D was not trivial. This was finally done in 2009 and the result is the Mandelbulb which is pretty cool.
17:35 < Iriez> Those are some incredible renders.
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18:33 < Iriez> Has anyone here or anyone here know someone who has gotten stem cell treatment for a joint problem?
18:36 < kanzure> eh, i think we know someone who was setting up stem cell clinics, does that count
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19:20 < Iriez> looking for data on the subject
19:21 < Iriez> thinking about doing it, but need more clinical data.
19:21 < kanzure> it was the fightaging.org person
20:05 < kanzure> "Liquid-handling Lego robots and experiments for STEM education and research" http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2001413
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23:53 < maaku> I have been victim to a targeted social engineering attack on my online persona. if you received emails from me in the last 4 hours, please assume it was not me and let me know privately
--- Log closed Sat Mar 25 00:00:08 2017