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03:05 < PyroChiliarch> hi
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04:35 < darsie> hi
04:35 < PyroChiliarch> hi
04:35 < darsie> hi
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04:55 < PyroChiliarch> hi
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04:56 < darsie> hi
04:56 < PyroChiliarch> hi
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05:11 < kanzure> hi
05:11 < PyroChiliarch> hi
05:11 < kanzure> hi
05:12 < PyroChiliarch> hi
05:21 < darsie> hi
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05:23 < PyroChiliarch> hi
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05:38 < archels> hi
05:40 < PyroChiliarch> hi
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05:49 < archels> .title http://www.sciencedirect.com/science/article/pii/S0048733317300422
05:49 < yoleaux> Work organization and mental health problems in PhD students
05:54 < cluckj> I can definitely attest to that
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09:29 < Iriez> anyone got any advice for the best type of doctor to see regarding the development of caffeine poisoning? I know this is a strange one, but its something that has started occuring in the last year. Previously no problems. Now if I drink a light amount of coffee for several days in a row I get very sick.
09:29 < Iriez> I compete professionally in my sport, and this is pretty much the end of my career.
09:29 < fenn> maybe someone is poisoning your coffee
09:29 < fenn> describe symptoms?
09:30 < Iriez> This is actually a serious issue that is negatively impacting my life dreams, so I would appreciate it if people took this seriously.
09:30 < fenn> it's time for another episode of IRC MD
09:30 < Iriez> Im not asking for medical advice, thanks.
09:30 < Iriez> Just asking if someone knows what realm of specialty this might fall under.
09:31 < fenn> the type of specialist you go to will determine what sort of hammer they use on the problem
09:33 < Iriez> kanzure: Nice people here.
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09:34 < fenn> i would experiment with other caffeine sources to see if it's the caffeine or the coffee
09:35 < fenn> it could be i.e. mold in your coffee maker
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09:37 < nmz787_i1> what kind of sport depends on caffeine?
09:37 < fenn> caffeine makes it easier to exercise in general
09:38 < fenn> it doesn't have any performance enhancing effects though
09:38 < fenn> well, physical performance at least
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09:57 < nmz787_i1> opentrons ads are popping up for me today
09:58 < nmz787_i1> if only their $3k machine could open screw-cap bottles too
09:58 < nmz787_i1> I sometimes feel like I should just start working on a cooking-bot... way more people eat food than biohack
09:59 < fenn> opentrons is $3k?
09:59 < fenn> isn't it just a pipette on an XYZ gantry?
09:59 < nmz787_i1> that's what the ad says
09:59 < nmz787_i1> seems so
09:59 < nmz787_i1> some extruded slot aluminum stuff for a frame
10:00 < fenn> i do wish more people would work on cooking robots
10:00 < fenn> but if it's going to cost over $9000 then what's the point
10:01 < chris_99> what would a cooking robot do?
10:01 < fenn> turn ingredients into dishes
10:01 < nmz787_i1> sudo make me chicken makhani
10:01 < fenn> the set of dishes it could prepare depends on its capabilities
10:02 < nmz787_i1> a cooking bot should essential be able to become a lab-bot
10:02 < fenn> doing anything with meat with bones in it would probably be an advanced capability
10:02 < chris_99> hmm, that could be really hard though couldn't it, if it has to do things like fry spices off, chop stuff etc
10:02 < nmz787_i1> chris_99: yeah
10:02 < fenn> a robot would do things differently than a human would
10:02 < chris_99> https://www.kickstarter.com/projects/kniterate/kniterate-the-digital-knitting-machine saw that the other day, i quite like it heh
10:02 < chris_99> yeah true fenn
10:03 < nmz787_i1> even if a cook-bot was $9k... as long as it lasted a while and maintenance was cheap and easy, I'd guess it could still be worthwhile
10:04 < nmz787_i1> 9000/365 == 24.66
10:05 < fenn> you would expect them to appear in restaurants first, but i don't even see that happening
10:05 < nmz787_i1> you could market it as 'restaurant in a box'
10:05 < nmz787_i1> fenn: if I was hacking on it, I'd expect it in my house first ;)
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10:06 < nmz787_i1> hmm, now I need a test-kitchen
10:06 < fenn> i think there are at least refrigerators that recognize what ood goes into them and when it expires
10:08 < chris_99> i think i've seen pizza making machines that are about the size of a coke machine iirc
10:08 < nmz787_i1> I've seen small-scale donut machines
10:09 < fenn> my roomate is doing "tiny cooking" with a little stove that uses tea-candles as a heat source
10:09 < nmz787_i1> I guess if you had a humanoid, you might be able to wear animatronics sensors, and record kitchen recipe sessions
10:09 < nmz787_i1> then have the robot just replay that
10:09 < fenn> no that would never work
10:09 < kanzure> momentum machines is still building their cooking machines, right?
10:09 < kanzure> Iriez: they are the best people.
10:10 < nmz787_i1> fenn: hmm, are these eco-friendly candles?
10:10 < fenn> no just regular candles
10:11 < fenn> the idea is you cook like 25 grams of food
10:11 < fenn> it's absurd, but it makes the robot's job easier
10:11 < nmz787_i1> oh, they're roboticizing it?
10:11 < fenn> no
10:11 < fenn> but you could
10:11 < fenn> otherwise i fear the cooking robot will be very large
10:12 < nmz787_i1> 'what is this, a buffet for ANTS?' -- zoolander 18
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10:21 < fenn> you could probably adapt transcriptic's protocol language to food cooking
10:23 < kanzure> https://groups.google.com/forum/m/#!msg/openmanufacturing/qNjuJFqq6X0/I_um1L_7xB8J
10:23 < kanzure> http://web.archive.org/web/20070112225127/http://www.anthus.com/Recipes/CompCook.html
10:25 < fenn> i will just add this to the linkdump http://autoprotocol.org/specification/
10:26 < archels> "if a product still works, it hasn't added enough features yet"
10:27 < fenn> not sure how well autoprotocol can deal with handling introspective data like computer vision results
10:27 < fenn> where everything is not known in advance
10:29 < kanzure> wouldn't this all be solved by using a giant blender
10:29 < fenn> the verb is "solvated"
10:30 < nmz787_i1> lol
10:30 < kanzure> i don't know why you humans have such an aversion to sticking stuff into a blender and commencing the blade spinning
10:31 < nmz787_i1> https://www.youtube.com/watch?v=z56kpinlwDk
10:31 < nmz787_i1> .title
10:31 < yoleaux> Rex Garvin and The Mighty Cravers - Emulsified (45 rpm) - YouTube
10:31 < kanzure> i have a song lyric stuck in my head, but it's in japanese, and i don't really know japanese.
10:31 < kanzure> how do i find it.
10:31 < nmz787_i1> call a japanese musician with a good minds-ear
10:31 < fenn> just start typing
10:32 < nmz787_i1> for american music, I have given up on apps that listen to whistling/humming... and just call my dad and leave him a voicemail
10:32 < fenn> some weeaboo will undoubtedly have typed something similar
10:32 < kanzure> well it has "hoto" in the song.. and uh..
10:32 < fenn> into google, not here
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10:37 < kanzure> oh i found it
10:37 < fenn> now spread your viral payload, memebot
10:37 < kanzure> http://www.animelyrics.com/anime/higurashikai/narakunohana.htm
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10:45 < kanzure> superkuh: definitely a robocop storyline in there.
10:46 < kanzure> standalone victim complex
10:46 < kanzure> i liked all the holograms floating around in the movie, though, that was okay.
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12:40 < abetusk> https://www.youtube.com/watch?v=GmXhiuj9w6k
12:40 < abetusk> .title
12:40 < yoleaux> Electrowetting Digital Microfludics with Feedback Drive - YouTube
12:44 < chris_99> abetusk, i was looking at this video of theirs - https://www.youtube.com/watch?v=C677yPYXWIs do you know if the droplets have to overlap the electrodes for them to be able to move, i couldn't really find out if that is the case or not (maybe the answer is obvious?, (but not to me))
12:47 < Iriez> [09:38] <F~fenn> it doesn't have any performance enhancing effects though
12:47 < Iriez> I've seen plenty of clinical studies that state otherwise.
12:47 < Iriez> Thanks for your "knowledge" on the subject, but I'll pass, thanks.
12:48 < Iriez> sorry, not 'state', but 'prove'.
12:49 < kanzure> Iriez: fenn was talking about IRC MD because we are sometimes asked to diagnose various ailments in here. in fact, one time someone asked me to revive their mother from cryonics.  i don't know how to do that.
12:51 < kanzure> Iriez: btw i did a radio interview the other day, https://twitter.com/kanzure/status/847309877424775169
12:52 < kanzure> first ~24min is about mimblewimble stuff
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12:59 < fenn> iriez please work on your problem solving approach
13:00 < kanzure> fenn: be nice to the newbie
13:00 < fenn> attacking people who try to help you won't encourage others to engage
13:00 < kanzure> yes, entirely true
13:00 < kanzure> Iriez: btw try lots of steroids
13:02 < fenn> often i see people asking obscure questions about software configuration when what they should be doing instead is stating clearly what they are trying to do
13:04 < kanzure> are the church of bob and church of the discordianism subgenius the same thing? it's all principia discordia, right?
13:07 < fenn> Both groups were heavily influenced by the writings of Robert Anton Wilson, who is referred to by SubGenius members as "Pope Bob"
13:09 < nmz787_i1> fenn: my software isn't working and is broken, how do I fix it?
13:10 < kanzure> software can only be changed by the careful channeling of human stress into new forms of energy
13:10 < fenn> nmz787_i1: try a git rebase and force push
13:10 < kanzure> by converting human stress into new structures of knowledge, software can take many new shapes, some of which might even work
13:11 < fenn> "Caffeine mobilizes fat stores and encourages working muscles to use fat as a fuel. This delays the depletion of muscle glycogen and allows for a prolongation of exercise."
13:12 < fenn> wah.
13:14 < chris_99> https://www.newscientist.com/article/mg23431192-700-best-evidence-yet-that-hypnotised-people-arent-faking-it/
13:16 < abetusk> chris_99, I think you don't scritcly need it but it helps.  The latest OpenDrop stuff has 'teeth' on the edges of the electrode that mesh into each other
13:16 < kanzure> i am skeptical about not having exercise-in-a-pill yet; steroids seem to be not entirely the whole story.
13:17 < chris_99> abetusk, but i'm confused, do you not need a current to flow through the liquid, for electrowetting?
13:17 < kanzure> (it's creepy to have everyone exercising/sleeping and we don't know the actual mechanisms enough to induce the effect.)
13:17 < kanzure> chris_99: electrowetting uses a photoconductive material
13:17 < kanzure> er wait, only some forms.
13:17 < chris_99> kanzure, huh? does it?
13:17 < chris_99> ah
13:17 < kanzure> i am thinking of optoelectrowetting :)
13:17 < chris_99> yeah i remember you linking to a cool vid of that
13:18 < kanzure> as for current flowing through the liquid, i don't think so, it was something about surface tension of the water and dragging itself along to the next cell
13:19 < chris_99> hmm, but then what are the electrodes doing, i don't understand what they do, if they're not for causing current to flow between >1 electrode
13:20 < fenn> kanzure it would be hard to get oxidative stress in a pill, but maybe you could potentiate it by making more endogenous reactive oxygen species
13:20 < fenn> maybe this is how radiation therapy (1920's hot springs stuff) worked, if it actually worked that is
13:21 < chris_99> in https://www.liquavista.com/technology/what-is-electrowetting/ they show a single droplet, where they're applying a voltage
13:21 < chris_99> so i can't see how it could work without using 2 electrodes in the matrix version
13:26 < chris_99> also in https://core.ac.uk/download/pdf/11459959.pdf 'Electrowetting: from basics to applications' in fig1 they seem to show 2 electrodes, one below the droplet, one poking into it, like in the video above, and it does seem to call the liquid an electrolyte
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13:33 < kanzure> there is also open-air electrowetting
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13:34 < chris_99> oh but it does say it's not via electrolysis that it works, but an electric field, since theres an insulator, i'll do more reading
13:34 < chris_99> what's  open-air electrowetting?
13:44 < fenn> no glass layer above the electrodes (?)
13:49 < chris_99> i just found something called the Pellat experiment - http://www.ece.rochester.edu/~jones/IMA_pres_jones.pdf p15, with 'dielectrically coated electrodes' which looks interesting, (i was wondering if that's equivalent to two electrodes in the matrix setup, with an insulator over them, and a droplet overlapping them?)
13:54 < kanzure> open-air electrowetting is where the droplet is exposed to the air on all sides except the plane that has the electrodes, yes
13:54 < kanzure> yes it was 'electrowetting on dielectrics' or something
14:01 < chris_99> ah gotcha
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14:21 < abetusk> chris_99, I have to admit I'm pretty ignorant as to how the whole thing works but as I understand it, no, no current flows.  Rub a comb with fur, then put it near a faucet, you see the water bend: https://www.youtube.com/watch?v=BIDPviyrsvs
14:22 < abetusk> review: http://zhao.lnm.cn/group/pdf/RAA_electrowetting_review.pdf
14:22 < abetusk> I think the idea is that you're shoving atoms of some polarity to one side preferentially to another with enough force to change shape
14:53 < nmz787_i1> "microgrid & resilience summit" -- hard to tell without further research, if this was about MEMS grids (for TEM specimen holding), or electrical grids
14:53 < nmz787_i1> (turns out the latter)
14:59 < kanzure> shouldn't intel have an unlimited quantity of mems people for you to interrogate?
15:11 < nmz787_i1> eh, idk... not too much MEMS going on
15:11 < nmz787_i1> http://www.neuroplustech.com/TMS_preorder.htm
15:11 < nmz787_i1> .title
15:11 < yoleaux> rTMS device preorder
15:11 < nmz787_i1> via: http://hackaday.com/2017/03/31/transcranial-electrical-stimulation-with-arduino-hot-glue/
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15:25 < kanzure> "Hypocretin underlies the evolution of sleep loss in the Mexican cavefish" http://biorxiv.org/content/early/2017/03/31/122903 https://twitter.com/biorxivpreprint/status/847901395277754374
15:25 < kanzure> "The duration of sleep varies dramatically between species, yet little is known about genetic bases or evolutionary factors driving this variation in behavior. The Mexican cavefish, Astyanax mexicanus, exists as surface populations that inhabit rivers, and multiple independently derived cave populations with convergent evolution on sleep loss. The number of Hypocretin/Orexin (HCRT)-positive hy...
15:25 < kanzure> ...pothalamic neurons is increased significantly in cavefish, and HCRT is upregulated at both the transcript and protein levels. Pharmacological inhibition of HCRT signaling increases sleep duration in cavefish without affecting sleep in surface fish, suggesting enhanced HCRT signaling underlies sleep loss in cavefish. Ablation of the lateral line or starvation, manipulations that selectively pro...
15:25 < kanzure> ...mote sleep in cavefish, inhibit hcrt expression in cavefish while having little effect in surface fish. These findings provide the first evidence of genetic and neuronal changes that contribute to the evolution of sleep loss, and support a conserved role for HCRT in sleep regulation."
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15:40 < kanzure> "We have previously identified the convergent evolution of sleep loss in the blind Mexican cavefish, Astyanax mexicanus, resulting in a striking 80% reduction in total sleep duration in independently derived cave-dwelling populations compared to extant surface fish without apparent adverse impacts on health or development (Dubou? et al., 2011)."
15:41 < kanzure> oh interesting, there are multiple isolated separate cavefish populations that have evolved similar sleep loss and vision loss phenotypes
15:41 < kanzure> due to different disconnected caves
15:46 < kanzure> "selective HCRTR2 pharmacological inhibitor, TCS0X229 (Plaza-Zabala et al., 2012)"
15:51 < fenn> 80% reduction is not sleepless
15:52 < fenn> this implies sleep is still necessary, even in completely sun-decoupled ecosystems
15:52 < fenn> if they weren't so damn inacessible, i expect we'd find the same thing at hydrothermal vents
15:53 < kanzure> "HCRT neurons send projections to numerous areas implicated in behavioral regulation including the periventricular hypothalamus, the raphe, and thalamic nuclei (Panula, 2010). Evidence suggests that wake-promoting role of HCRT neurons is dependent norepinephrine signaling, and optogenetic activation of HCRT neurons activates the locus coeruleus (Singh et al., 2015), raising the possibility tha...
15:53 < kanzure> ...t activation of this arousal pathway is enhanced in Pach?n cavefish. We previously demonstrated that treating cavefish with the ?-adrenergic inhibitor propranolol restores sleep in cavefish without affecting sleep in surface fish.."
15:53 < kanzure> fenn have you considered just eating lots of orexin
15:53 < fenn> it's a protein
15:53 < kanzure> i'm sure you can buy it concentrated in bulk
15:54 < fenn> i'm going to try the metamed/yudkowsky melatonin protocol
15:55 < kanzure> orexin will probably make you fat but at least you wouldn't be sleeping through the singularity
15:55 < fenn> why isn't intranasal melatonin a thing?
16:00 < fenn> i guess sublingual is good enough
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16:04 < kanzure> there are orexin receptor antagonists but no agonists? bleh
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17:48 < kanzure> "Gamma and beta bursts during working memory read-out suggest roles in its volitional control" http://biorxiv.org/content/early/2017/03/31/122598
17:48 < kanzure> very vague. what.
17:50 < kanzure> "FlyPi: a 3d printable open-source platform for fluorescence microscopy and optogenetics" http://biorxiv.org/content/early/2017/03/31/122812 https://twitter.com/biorxiv_neursci/status/847886429757853696
17:52 < kanzure> diffusion MRI and "local connectome fingerprinting" to predict various "social, biological and cognitive attributes" http://biorxiv.org/content/early/2017/03/31/122945
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19:37 < nmz787_> talked with kosuri today for ~ an hour... got a bunch of names of people to look up and check into
19:37 < nmz787_> also got my MOSFETs and schottky diodes today
19:37 < nmz787_> going to try desoldering now
19:47 < kanzure> "Microbial arms race: Ballistic "nematocysts" in dinoflagellates represent a new extreme in organelle complexity" http://advances.sciencemag.org/content/3/3/e1602552.full
19:53 < kanzure> cool. single cells shooting out projectiles at each other.
19:57 < superkuh> Do the .mov in the supplementary play for you?
19:57 < superkuh> I've downloaded two but I can't get anything out of them.
19:58 < superkuh> Oh, the second is mpg. But it also didn't play.
19:58 < superkuh> Nevermind. Only the mov won't play.
20:01 < kanzure> you have to download the full file first :(
20:01 < kanzure> they are not animated, just some spinning diagrams of SEM results or whatever.
20:13 < nmz787_> new transistors are installed ;) now to figure out where to try jamming these diodes in
20:17 < nmz787_> wow, I definitely saw what looked like a tow-hook in movie s1
20:19 < nmz787_> sweet find!
20:38 < kanzure> something about 'mechanical bonds' (paywalled) "Mastering the non-equilibrium assembly and operation of molecular machines" http://pubs.rsc.org/en/Content/ArticleLanding/2017/CS/C7CS00068E#!divAbstract
20:47 < kanzure> 'electron microscope pixel array detector'   "We can extract local strains, tilts, rotations, polarity and even electric and magnetic fields"   "The EMPAD records an image frame in less than a millisecond and can detect from one to a million primary electrons per pixel, per image frame," Muller explained. "This is 1,000 times the dynamic range, and 100 times the speed of conventional electron ...
20:47 < kanzure> ...image sensors."
20:47 < kanzure> "Multiplex genome editing for synthetic biology in Vibrio natriegens" http://biorxiv.org/content/early/2017/03/30/122655
20:49 < kanzure> apparently conventional medical comas are maintained by looking at EEG readouts and adjusting propofol infusion http://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1003284
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21:39 < EFknockr>  THIS NETWORK IS BLOWJOBS! GET ON SUPERNETS FOR COLD HARD CHATS NOW
21:39 < EFknockr>                                                                     
21:39 < EFknockr>                                                                     
21:39 < EFknockr>                                                                     
21:39 < EFknockr>                                                                     
21:39 < EFknockr>                                                                     
21:39 < EFknockr>  IRC.SUPERNETS.ORG | PORT 6667/6697 (SSL) | #SUPERBOWL | IPV6 READY
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21:41 < jrayhawk> but am i enough of a stone cold motherfucker to survive on supernets?
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22:23 < nmz787_> whaaa?
22:23  * nmz787_ has high-voltage again
23:35 < nmz787_> sorta
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--- Log closed Sat Apr 01 00:00:14 2017