--- Log opened Sun Apr 09 00:00:21 2017 00:07 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Ping timeout: 240 seconds] 00:11 -!- sbodin [~sbodin@91.226.141.242] has joined ##hplusroadmap 00:43 -!- sbodin [~sbodin@91.226.141.242] has quit [Ping timeout: 240 seconds] 01:00 -!- cevi_ [~zeb@128.12.245.10] has quit [Ping timeout: 264 seconds] 01:10 -!- augur [~augur@195.158.90.129] has joined ##hplusroadmap 01:15 < kanzure> hmph. 01:39 -!- augur_ [~augur@195.158.90.129] has joined ##hplusroadmap 01:40 -!- augur_ [~augur@195.158.90.129] has quit [Remote host closed the connection] 01:41 -!- augur [~augur@195.158.90.129] has quit [Ping timeout: 252 seconds] 02:09 -!- sbodin [~sbodin@91.226.141.242] has joined ##hplusroadmap 02:09 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 02:31 -!- sbodin [~sbodin@91.226.141.242] has quit [Ping timeout: 240 seconds] 03:01 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Ping timeout: 240 seconds] 03:49 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-ydxuefskvdqwmlzq] has joined ##hplusroadmap 03:51 -!- jtimon [~quassel@70.30.134.37.dynamic.jazztel.es] has joined ##hplusroadmap 03:53 -!- darsie [~darsie@84-113-55-42.cable.dynamic.surfer.at] has joined ##hplusroadmap 04:01 -!- sbodin [~sbodin@91.226.141.242] has joined ##hplusroadmap 05:11 -!- Gurkenglas_ [~Gurkengla@dslb-094-223-131-090.094.223.pools.vodafone-ip.de] has joined ##hplusroadmap 05:12 -!- Gurkenglas [~Gurkengla@dslb-178-000-181-157.178.000.pools.vodafone-ip.de] has quit [Ping timeout: 240 seconds] 05:33 -!- sbodin [~sbodin@91.226.141.242] has quit [Ping timeout: 240 seconds] 05:43 -!- charlie [~spoar@31.24.226.138] has joined ##hplusroadmap 05:45 -!- jtimon [~quassel@70.30.134.37.dynamic.jazztel.es] has quit [Ping timeout: 252 seconds] 06:31 -!- Gurkenglas [~Gurkengla@dslb-178-005-216-097.178.005.pools.vodafone-ip.de] has joined ##hplusroadmap 06:32 -!- Gurkenglas_ [~Gurkengla@dslb-094-223-131-090.094.223.pools.vodafone-ip.de] has quit [Ping timeout: 255 seconds] 07:43 < kanzure> recent timestamps of hplusroadmap logs http://gnusha.org/logs/timestamps/2017-04-07/ 08:08 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 08:11 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap 08:14 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Ping timeout: 255 seconds] 08:18 < kanzure> "Uncharacterized bacterial structures revealed by electron cryotomography" http://biorxiv.org/content/early/2017/02/13/108191 https://twitter.com/theJensenLab/status/831281907954429952 08:18 < kanzure> "Assembly of a nucleus-like structure during viral replication in bacteria" http://science.sciencemag.org/content/355/6321/194 https://twitter.com/seth_shipman/status/822176155486846977 08:19 < kanzure> "They found that the phage assembled a nucleus-like compartment when it infected a bacterial cell. The phage genome was completely enclosed by an apparently contiguous protein shell, within which DNA replication, recombination, and transcription occurred. Translation, precursor biosynthesis, and viral assembly occurred outside the structure." 08:20 < kanzure> george church spotted in public :P https://twitter.com/johncumbers/status/792908043944099841 08:27 < kanzure> stalk stalk stalk https://sethshipman.com/publications/ 08:28 < kanzure> oh they stored 100 bytes 08:28 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 08:30 < kanzure> https://www.cbinsights.com/blog/crispr-startups-to-watch/ 08:31 < kanzure> "Poseida Therapeutics, co-founded by Dr. George Church and based in La Jolla, California, uses genome editing technologies, such as CRISPR, to develop targeted therapeutics in areas of high unmet medical need. The company currently has gene therapies in development for multiple myeloma, prostate cancer and beta-thalassemia." 08:31 < kanzure> "Caribou Biosciences, co-founded by Jennifer Doudna of Intellia Therapeutics, employs the CRISPR/Cas9 system to develop new biotechnologies in therapeutics, agriculture, research, and industrials." 08:35 -!- charlie [~spoar@31.24.226.138] has quit [Ping timeout: 252 seconds] 08:36 -!- jtimon [~quassel@70.30.134.37.dynamic.jazztel.es] has joined ##hplusroadmap 08:38 < kanzure> "Rapid and programmable protein mutagenesis using plasmid recombineering" http://biorxiv.org/content/early/2017/04/04/124271 https://twitter.com/SavageCatsOnly/status/849669127476174848 09:07 -!- pent [~pent@138.197.129.246] has quit [Quit: BAMF] 09:33 -!- pent [~pent@138.197.129.246] has joined ##hplusroadmap 09:36 -!- augur [~augur@94.119.64.25] has joined ##hplusroadmap 09:40 -!- cevi_ [~zeb@128.12.245.10] has joined ##hplusroadmap 09:42 < kanzure> H-D-Leu-D-Thr-D-Leu-D-Arg-D-Lys-D-Glu-D-Pro-D-Ala-D-Ser-D-Glu-D-Ile-D-Ala-D-Gln-D-Ser-D-Ile-D-Leu-D-Glu-D-Ala-D-Tyr-D-Ser-D-Gln-D-Asn-D-Gly-D-Trp-D-Ala-D-Asn-D-Arg-D-Arg-D-Ser-D-Gly-D-Gly-D-Lys-D-Arg-D-Pro-D-Pro-D-Pro-D-Arg-D-Arg-D-Arg-D-Gln-D-Arg-D-Arg-D-Lys-D-Lys-D-Arg-D-Gly-OH 09:55 < kanzure> .wik vasohibin-1 09:55 < yoleaux> "Vasohibin-1 is a protein that in humans is encoded by the VASH1 gene." -- https://en.wikipedia.org/wiki/VASH1 09:59 -!- sbodin [~sbodin@91.226.141.242] has joined ##hplusroadmap 10:01 -!- yashgaroth [~yashgarot@2606:6000:cd4d:3300:f5e0:f867:a11d:8d52] has joined ##hplusroadmap 10:42 -!- charlie [~spoar@88.202.231.84] has joined ##hplusroadmap 11:05 < heath> "Keynote - Piecemeal Into Space Reliability Safety and Erlang Principles - Brian Troutwine" https://www.youtube.com/watch?v=pwoaJvrJE_U 11:06 < heath> "Instrumenting the World with the BEAM - Christopher Cote" https://www.youtube.com/watch?v=oTAgcR-rMMc&index=47 11:33 < heath> cevi_: what kind of proof are you searching for? 11:33 < heath> ah, i needed to read on: '16:48 < cevi_> ok, currently trying to figure out how to say "f is a function from integers to integers" in coq' 11:33 -!- NikopolSohru [~NSohru@109.202.102.85] has joined ##hplusroadmap 11:33 < heath> that's easy in agda and idris 11:36 < heath> literally, it's just, f : Int -> Int 11:37 < cevi_> the problem wasn't so much that this was hard, it was that the documentation didn't give any hints about how to do it 11:37 < cevi_> in the case of coq, this was because special modules had to be loaded first 11:37 < heath> what's the end goal if you don't mind me asking 11:38 < cevi_> I wanted to have a computer program that could solve problems from high school math competitions automatically 11:38 < heath> :) 11:38 < cevi_> using automated theorem proving 11:39 < heath> feels like i've read about something similar to this 11:39 < cevi_> coq is more of a proof assistant, but all proof assistants have a limited automated theorem prover built in to automate the tedious details 11:40 < cevi_> in the end, cvc3 was the only automated theorem prover I was able to install that made any real attempt to solve the problems I gave it 11:40 < cevi_> Vampire is supposed to be very good, but according to the author's website the code is not currently available 11:41 < cevi_> "Downloading Vampire is temporarily unavailable. The new version 3.0 will be released soon and available from this page!" 11:41 < cevi_> from http://www.vprover.org/download.cgi 11:44 < cevi_> honestly, I had expected the world of automated theorem proving to be a lot more polished and usable by now 11:44 < heath> personal advice is to use idris if possible, since it's so minimal. otherwise, #agda is the most active channel on freenode for theorem proving 11:45 < heath> there are a few #hplus people in #agda 11:53 < cevi_> I'll check them out (eventually) 11:53 -!- augur [~augur@94.119.64.25] has quit [Remote host closed the connection] 12:04 -!- augur [~augur@94.119.64.0] has joined ##hplusroadmap 12:14 -!- pent [~pent@138.197.129.246] has quit [Read error: Connection reset by peer] 12:14 -!- helleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has joined ##hplusroadmap 12:17 -!- cevi_ [~zeb@128.12.245.10] has quit [Ping timeout: 264 seconds] 12:18 -!- hehelleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has quit [Ping timeout: 246 seconds] 12:19 -!- pent [~pent@138.197.129.246] has joined ##hplusroadmap 12:35 -!- sbodin [~sbodin@91.226.141.242] has quit [Ping timeout: 252 seconds] 12:46 -!- Gurkenglas_ [~Gurkengla@dslb-178-000-215-240.178.000.pools.vodafone-ip.de] has joined ##hplusroadmap 12:47 -!- Gurkenglas [~Gurkengla@dslb-178-005-216-097.178.005.pools.vodafone-ip.de] has quit [Ping timeout: 255 seconds] 12:50 -!- augur [~augur@94.119.64.0] has quit [Remote host closed the connection] 13:20 -!- augur [~augur@94.119.64.25] has joined ##hplusroadmap 13:20 -!- TinKode [~TinKode@unaffiliated/tinkode] has joined ##hplusroadmap 13:21 -!- TinKode [~TinKode@unaffiliated/tinkode] has quit [Remote host closed the connection] 13:22 -!- TinKode [~TinKode@unaffiliated/tinkode] has joined ##hplusroadmap 13:30 -!- augur [~augur@94.119.64.25] has quit [Ping timeout: 255 seconds] 13:58 < andytoshi> http://www1.lsbu.ac.uk/water/ 13:58 < andytoshi> oh, http://www1.lsbu.ac.uk/water/water_structure_science.html is the better link 14:05 < kanzure> .title 14:05 < yoleaux> Water structure and science: Contents 14:06 < kanzure> "Another one recently published is that using the same reprogramming factors to establish pluripotency in stem cells, you can do that on a whole organism basis and it reverses aging." - george church 14:09 -!- NikopolSohru [~NSohru@109.202.102.85] has quit [Quit: Leaving] 14:16 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Quit: Leaving] 14:22 < kanzure> "What about radiation resistance? Here's a case in the literature where radiation resistance was improved 100,000-fold. 10-fold using e14-deletion. 50-fold using recA. 20-fold using yfjK. And 10-fold using dnaB. See Ecoli, Byrne et al, eLife 2014. This only requires 4 mutations. There is a wide variation in natural organisms, but the only difference here is those 4 mutations." 14:31 -!- Jen [~Jen@cpc76808-brmb10-2-0-cust571.1-3.cable.virginm.net] has joined ##hplusroadmap 14:31 -!- JenElizbeth [~Jen@cpc76808-brmb10-2-0-cust571.1-3.cable.virginm.net] has quit [Read error: Connection reset by peer] 14:34 -!- Jen3 [~Jen@cpc76808-brmb10-2-0-cust571.1-3.cable.virginm.net] has joined ##hplusroadmap 14:35 -!- Jen [~Jen@cpc76808-brmb10-2-0-cust571.1-3.cable.virginm.net] has quit [Read error: Connection reset by peer] 14:50 -!- charlie [~spoar@88.202.231.84] has quit [Quit: Leaving] 14:54 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Ping timeout: 255 seconds] 14:55 -!- Jen [~Jen@cpc76808-brmb10-2-0-cust571.1-3.cable.virginm.net] has joined ##hplusroadmap 14:55 -!- Jen3 [~Jen@cpc76808-brmb10-2-0-cust571.1-3.cable.virginm.net] has quit [Read error: Connection reset by peer] 14:59 < nmz787_> so I think I might try making some electrostatically actuated glass valves, I saw recently in a paper 14:59 < nmz787_> they said they could get they to close fully 14:59 < nmz787_> and they're glass, so I think can develop higher pressures than elastomers 15:00 < nmz787_> I guess if the dielectric doesn't break down, you might be able to use elastomer with electrostatic valves 15:05 < nmz787_> but glass doesn't allow evaporation/transpiration 15:06 < nmz787_> this paper: http://aip.scitation.org/doi/full/10.1063/1.4975369 15:07 < nmz787_> .title 15:09 < kanzure> he claims to have working vascularized organoids in his lab 15:11 < nmz787_> something I was thinking about hplus recently, was, how can we reprogram macro level things to help us... would that be more catalyzing than working on micro/nano things mostly/purely? Like ants... they seem small enough that they're cheap, but strong enough to do some useful macro stuff for us... like move building materials or landscaping/excavation, etc 15:12 < nmz787_> thoughts along that line are: is it easier to influence/alter/program the behavior of ants, rather than reprogram their inner (molecular) architecture 15:14 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-ydxuefskvdqwmlzq] has quit [Quit: Connection closed for inactivity] 15:16 < nmz787_> or even things around the house, cleaning up... or seeding farm fields (with seeds, or microbial probiotics) 15:22 < kanzure> .wik recombineering 15:22 < yoleaux> "Recombineering (recombination-mediated genetic engineering) is a genetic and molecular biology technique based on homologous recombination systems, as opposed to the older/more common method of using restriction enzymes and ligases to combine DNA sequences in a specified order." -- https://en.wikipedia.org/wiki/Recombineering 15:26 < kanzure> ugh i hate this reference format wtf: 15:26 < kanzure> * Computational: Jan-2013 Mali.. Church, Cong.. Zhang, Science 15:26 < kanzure> * Paired nickases: Aug-2013 Mali.. Church, Nat Biotech. 15:26 < kanzure> * Truncated guide RNAs Jan-2014 Fu..Joung, Nat Biotech. 15:26 < kanzure> * FokI fusion Apr-2014. Tsai..Joung; Guilinger..Liu, Nat Biotech. 15:26 < kanzure> * Brief binding Apr-2015 Davis...Liu. Nat Chem Biol. 15:26 < kanzure> * Weak Cas9-dsDNA, Jan-2016 Slaymaker ... Zhang, Science 15:26 < kanzure> * Weak Cas9-ssDNA, Jan-2016 Kleinstiver..Joung, Nature 15:26 < kanzure> * First SNP specific method: Jun-2016, Chavez ... Church BioRxiv 15:26 < kanzure> this is utterly evil 15:42 < kanzure> "In vivo amelioration of age-associated hallmarks by partial reprogramming" https://www.researchgate.net/profile/Estrella_Nunez-Delicado/publication/311971118_In_Vivo_Amelioration_of_Age-Associated_Hallmarks_by_Partial_Reprogramming/links/58662f3b08ae329d62070197.pdf 15:48 < kanzure> "Evolution of extreme resistance to ionizing radiation via genetic adaptation of DNA repair" https://elifesciences.org/content/3/e01322 15:52 < gnusha_> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=159ae86f Bryan Bishop: transcript: george church (2017-01-26) >> http://diyhpl.us/diyhpluswiki/transcripts/2017-01-26-george-church/ 15:55 < gnusha_> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=fa98f093 Bryan Bishop: add tweeter link >> http://diyhpl.us/diyhpluswiki/transcripts/2017-01-26-george-church/ 15:55 < kanzure> ok, 15:55 < kanzure> here is a george church transcript: http://diyhpl.us/wiki/transcripts/2017-01-26-george-church/ 15:55 < kanzure> from the video last night 16:01 < kanzure> .tw https://twitter.com/Pipette_Ninja/status/851207653074325504 16:01 < yoleaux> @kanzure @OpenTrons_ @willcanine @SexyLikeMeiosis Also Gibson (diff for repetitive seqs), but initial GG prototype already in works. Cud u point to more info on resorces you can provide? Thx (@Pipette_Ninja, in reply to tw:851206569777909761) 16:05 -!- TinKode [~TinKode@unaffiliated/tinkode] has quit [Quit: TinKode] 16:09 -!- jtimon [~quassel@70.30.134.37.dynamic.jazztel.es] has quit [Ping timeout: 240 seconds] 16:12 < nmz787_> wow, that guy did his PhD for 11 years! 16:14 < nmz787_> http://www.nature.com/nbt/journal/vaop/ncurrent/full/nbt.3805.html 16:14 < nmz787_> .title 16:14 < yoleaux> Large-scale design of robust genetic circuits with multiple inputs and outputs for mammalian cells : Nature Biotechnology : Nature Research 16:14 < nmz787_> oh, I thought it was using boolean logic to edit genes 16:16 -!- charlie [~spoar@31.24.226.202] has joined ##hplusroadmap 16:17 < kanzure> for pig organ xenotransplantation, he proposes to do the anti-aging longevity anti-cancer virus resistance stuff in the pig organs first, rather than convincing humans to do those modifications in human families. 16:17 < kanzure> "incompatible for exchanging organs, it's that there isn't enough of us to give organs. It's more than that, though. When we produce organs, we are going to be highly motivated to do preventative medicine-- we should make organs that are pathogen resistant, aging resistant and cancer resistant." 16:23 -!- JenElizbeth [~Jen@cpc76808-brmb10-2-0-cust571.1-3.cable.virginm.net] has joined ##hplusroadmap 16:26 -!- Jen [~Jen@cpc76808-brmb10-2-0-cust571.1-3.cable.virginm.net] has quit [Ping timeout: 255 seconds] 16:30 < gnusha_> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=49a9f783 Bryan Bishop: add george church's wishlist to genetic modifications file >> http://diyhpl.us/diyhpluswiki/genetic-modifications/ 16:43 < kanzure> "Whereas if you change an adult cognitively, that could spread through weeks on the internet where everyone is doing do-it-yourself gene therapy on their brain. And that sounds ludicrous, but we live in a time of exponential change and I personally know several people already doing do-it-yourself gene therapy on themselves too and these are not wealthy individuals either. I'm "not" encouraging... 16:43 < kanzure> ... you to do this, but I'm just reporting that there are people doing this." 16:45 < kanzure> sounds like we got the green light from him, let's do a virus for hippocampus size, sleep minimization, and one for working memory. 16:47 < kanzure> "Reading has improved over 3 million fold, mostly in the past few years. Writing of short oligonucleotides has improved over a billion fold in that period of time. I think both of them can improve by another maybe 1000x to 1 million fold. Don't ask me when and don't remind me when it doesn't happen. But anyway, that's my guess. And so far we have all underpredicted it, rather than overpredicti... 16:47 < kanzure> ...ng it." 16:51 < kanzure> fenn: "People with the mutation tend to be night owls because it keeps them on a perpetual 24 1/2 hour schedule -- close to the Martian 24 hour, 39 minute day, researchers reported in the journal Cell" 16:51 < kanzure> "Mutation of the human circadian clock gene CRY1 in familial delayed sleep phase disorder" http://www.cell.com/cell/abstract/S0092-8674(17)30346-X 17:06 -!- Gurkenglas_ [~Gurkengla@dslb-178-000-215-240.178.000.pools.vodafone-ip.de] has quit [Ping timeout: 252 seconds] 17:07 -!- darsie [~darsie@84-113-55-42.cable.dynamic.surfer.at] has quit [Ping timeout: 240 seconds] 17:45 -!- charlie [~spoar@31.24.226.202] has quit [Ping timeout: 240 seconds] 17:50 -!- charlie [~spoar@31.24.231.222] has joined ##hplusroadmap 17:57 < kanzure> '"I have had more than one IVF specialist tell me that they can screen for other desirable traits, such as desired eye and hair color," Glenn told me. "It is not advertised, just via word of mouth."' 17:58 -!- charlie [~spoar@31.24.231.222] has quit [Ping timeout: 240 seconds] 18:04 -!- Jenda`_ is now known as Jenda` 18:06 -!- charlie [~spoar@31.24.231.222] has joined ##hplusroadmap 18:10 < kanzure> http://lesswrong.com/lw/b10/modest_superintelligences/639d 18:10 < kanzure> graverobbing expedition needs to get planned out some more 18:28 < kanzure> yashgaroth: tell me things about copying genes on the same chromosome and using mutants. terrible idea? 18:34 -!- charlie [~spoar@31.24.231.222] has quit [Ping timeout: 240 seconds] 18:35 -!- JenElizbeth [~Jen@cpc76808-brmb10-2-0-cust571.1-3.cable.virginm.net] has quit [Ping timeout: 240 seconds] 18:35 -!- charlie [~spoar@31.24.226.202] has joined ##hplusroadmap 18:37 < charlie> kanzure, what do you mean? 18:37 < charlie> "tell me things about copying genes on the same chromosome and using mutants. terrible idea?" 18:41 < kanzure> if i knew then why would i ask? 18:41 < charlie> but what did you want to ask kanzure 18:42 < charlie> using "mutants"? 18:50 < yashgaroth> kanzure how do you mean, like duplicating genes and then mutating one of them? 18:51 -!- charlie [~spoar@31.24.226.202] has quit [Ping timeout: 255 seconds] 19:14 < kanzure> yashgaroth: yes using a different version. 19:14 < kanzure> i suppose this is probably a per-protein answer, not all proteins will tolerate double expression 19:14 < kanzure> er.. or whatever. 19:15 < yashgaroth> well you could drop the expression for both of them, but that's on a per-promoter basis if you want to figure out how to get 50% expression 19:16 < yashgaroth> a remarkable number of genes will tolerate higher expression, downs syndrome being the most famous example 19:17 < kanzure> it would be interesting to test out mutants by using an eternal signal (like some drug you take) to reversibly switch between two mutants 19:17 < kanzure> switching could be something like, adding/removing lots of methylation 19:17 < kanzure> to the gene of interest. 19:17 < kanzure> *external signal 19:18 < kanzure> anyway, here is a thing http://diyhpl.us/wiki/transcripts/2017-01-26-george-church/ 19:18 < yashgaroth> you could incorporate a tet-on/tet-off pair for regulation, but if you want to retain native expression...some sort of DNA-binding protein and complimentary sequence just upstream of each gene but different for each 19:19 < yashgaroth> yeah, I'm happy he keeps his own list of potential genetic enhancements 19:19 < kanzure> i think our list is better at this point :) 19:19 < yashgaroth> well of course 19:20 < kanzure> also i added his things to the list anyway. 19:20 < yashgaroth> and he's a bit more optimistic about e.g. telomerase 19:20 < kanzure> "If you enhance an embryo with cognitive improvements, it's going to be 20 years before you see any impact on society from that. Whereas if you change an adult cognitively, that could spread through weeks on the internet where everyone is doing do-it-yourself gene therapy on their brain. And that sounds ludicrous, but we live in a time of exponential change and I personally know several people... 19:20 < kanzure> ... already doing do-it-yourself gene therapy on themselves too and these are not wealthy individuals either. I'm "not" encouraging you to do this, but I'm just reporting that there are people doing this." 19:20 < yashgaroth> and ghr-/- for tiny cancer-resistant people 19:20 < kanzure> well maybe you turn off the growth hormone later in life, instead 19:21 < kanzure> he also seems to agree with "feed everyone lots of metformin" 19:21 < yashgaroth> well it's heavily downregulated in adulthood anyway, but I'd be interested in mouse data for that 19:22 < yashgaroth> idk if liz parrish counts as "not wealthy" 19:25 < yashgaroth> actually nm she does count at this point 19:26 < kanzure> also let's fix fenn's non-24 hour sleep disorder, they found the mutation that causes it, http://www.cell.com/cell/abstract/S0092-8674(17)30346-X 19:28 < yashgaroth> does...does he want it fixed? 19:29 < kanzure> http://diyhpl.us/~bryan/papers2/neuro/sleep/Mutation%20in%20the%20human%20circadian%20clock%20gene%20CRY1%20in%20familial%20delayed%20sleep%20phase%20disorder%20-%202017.pdf 19:29 < kanzure> yes 19:29 < yashgaroth> well I'll put him on the waiting list 19:30 < kanzure> cas9 + lentivirus? 19:32 < yashgaroth> idk how good cas9 is at fixing SNPs at the moment, but something like that probably 19:33 < yashgaroth> neurobio, like immuno, is its own separate field at this point 19:33 < yashgaroth> oh wait if it's an exon deletion mutant you can do that yeah 20:11 < kanzure> .wik beggars in spain 20:11 < yoleaux> "Beggars in Spain is a 1993 science fiction novel by Nancy Kress. It was originally published as a novella with the same title in Isaac Asimov's Science Fiction Magazine and as a limited edition paperback by Axolotl Press in 1991." -- https://en.wikipedia.org/wiki/Beggars_in_spain 20:36 -!- dnukem [~dnukem@c-71-234-96-215.hsd1.ma.comcast.net] has joined ##hplusroadmap 20:42 < fenn> this would have been nice for skdb: https://pythonhosted.org/uncertainties/ "The uncertainties package is a free, cross-platform program that transparently handles calculations with numbers with uncertainties (like 3.14?0.01)" 20:44 < fenn> it would need to be integrated with measurement units somehow 21:03 -!- dnukem [~dnukem@c-71-234-96-215.hsd1.ma.comcast.net] has quit [Quit: KVIrc 4.9.2 Aria http://www.kvirc.net/] 21:06 -!- Jen [~Jen@cpc76808-brmb10-2-0-cust571.1-3.cable.virginm.net] has joined ##hplusroadmap 21:47 -!- cevi_ [~zeb@128.12.245.10] has joined ##hplusroadmap 22:07 -!- yashgaroth [~yashgarot@2606:6000:cd4d:3300:f5e0:f867:a11d:8d52] has quit [Quit: Leaving] 22:42 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 23:48 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Ping timeout: 255 seconds] 23:56 -!- charlie [~spoar@104.238.169.42] has joined ##hplusroadmap --- Log closed Mon Apr 10 00:00:22 2017