--- Log opened Mon Apr 24 00:00:35 2017 00:10 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has quit [Remote host closed the connection] 00:38 -!- drewbot [~cinch@50.17.125.247] has quit [Remote host closed the connection] 00:38 -!- augur [~augur@2601:640:8001:4222:449:e924:e72:c29b] has joined ##hplusroadmap 00:40 -!- augur [~augur@2601:640:8001:4222:449:e924:e72:c29b] has quit [Remote host closed the connection] 01:01 -!- augur [~augur@2601:640:8001:4222:8d0d:930f:c65d:76d0] has joined ##hplusroadmap 01:31 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has quit [Quit: sleep] 01:45 -!- augur [~augur@2601:640:8001:4222:8d0d:930f:c65d:76d0] has quit [Remote host closed the connection] 01:46 -!- augur [~augur@2601:640:8001:4222:8d0d:930f:c65d:76d0] has joined ##hplusroadmap 01:51 -!- augur [~augur@2601:640:8001:4222:8d0d:930f:c65d:76d0] has quit [Ping timeout: 255 seconds] 01:52 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 02:06 -!- drewbot [~cinch@54.81.221.125] has joined ##hplusroadmap 02:08 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Remote host closed the connection] 02:09 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 02:29 -!- CRM114 [~urchin@unaffiliated/urchin] has joined ##hplusroadmap 02:39 -!- darsie [~darsie@84-113-55-42.cable.dynamic.surfer.at] has joined ##hplusroadmap 02:52 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Ping timeout: 240 seconds] 02:57 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap 03:06 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 04:12 -!- fireprfHydra [~fireprfHy@69.5.115.4] has joined ##hplusroadmap 04:26 < kanzure> no specific thoughts on FIB 04:30 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Ping timeout: 258 seconds] 04:45 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 04:58 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Ping timeout: 260 seconds] 05:13 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 05:33 -!- jtimon [~quassel@9.31.134.37.dynamic.jazztel.es] has joined ##hplusroadmap 05:48 -!- TC [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has joined ##hplusroadmap 05:49 -!- TC is now known as Guest74157 05:51 -!- hehelleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has quit [Ping timeout: 240 seconds] 06:22 -!- JayDugger [~jwdugger@47.185.237.246] has joined ##hplusroadmap 06:28 < gnusha_> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=0ab4b598 Bryan Bishop: CDH13 rs11150556 for verbal working memory performance >> 06:28 < gnusha_> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=e4436c4b Bryan Bishop: just some leftovers >> http://diyhpl.us/diyhpluswiki/genetic-modifications/ 07:01 -!- fireprfHydra [~fireprfHy@69.5.115.4] has quit [Ping timeout: 240 seconds] 07:44 < FourFire> kanzure, what are the upper and lower bound estimates of imaging feature size required to reconstruct a brain (for uploading purposes) ? 08:00 < kanzure> synaptic receptors and weights 08:00 < kanzure> and connectivity 08:00 < kanzure> for connectivity there are techniques like dna barcoding (not requiring optical scanning) 08:01 < kanzure> synaptic receptor types and weights are not yet possible to retrieve by non-optical means but there have been proposals for recording mRNA expression data next to synaptic DNA barcodes 08:01 < kanzure> see also: 08:01 < kanzure> http://gnusha.org/logs/2016-08-19.log 08:01 < kanzure> http://gnusha.org/logs/2016-07-14.log 08:01 < kanzure> http://gnusha.org/logs/2017-01-19.log 08:06 < kanzure> there are some optical techniques for synaptic protein read-out (like FISSEQ and some antibody stuff) 08:18 -!- Gurkenglas [~Gurkengla@dslb-188-103-222-233.188.103.pools.vodafone-ip.de] has joined ##hplusroadmap 08:40 -!- cluckj [~cluckj@static-98-114-125-87.phlapa.ftas.verizon.net] has quit [Quit: Leaving] 08:41 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Quit: Leaving.] 09:03 -!- fireprfHydra [~fireprfHy@69.5.115.4] has joined ##hplusroadmap 09:23 -!- Gurkenglas [~Gurkengla@dslb-188-103-222-233.188.103.pools.vodafone-ip.de] has quit [Ping timeout: 240 seconds] 09:26 -!- nmz787_i [~ntmccork@134.134.139.83] has joined ##hplusroadmap 09:28 -!- nmz787_i1 [ntmccork@nat/intel/x-svqimzatqxuzasou] has joined ##hplusroadmap 09:28 -!- nmz787_i [~ntmccork@134.134.139.83] has quit [Remote host closed the connection] 09:33 -!- nmz787_i1 [ntmccork@nat/intel/x-svqimzatqxuzasou] has quit [Quit: Leaving.] 10:00 -!- nmz787_i [~ntmccork@134.134.139.73] has joined ##hplusroadmap 10:11 -!- Gurkenglas [~Gurkengla@dslb-188-103-222-233.188.103.pools.vodafone-ip.de] has joined ##hplusroadmap 10:20 -!- nmz787_i [~ntmccork@134.134.139.73] has quit [Quit: Leaving.] 10:29 -!- nmz787_i [~ntmccork@134.134.139.83] has joined ##hplusroadmap 10:29 -!- nmz787_i [~ntmccork@134.134.139.83] has quit [Client Quit] 10:30 -!- nmz787_i [~ntmccork@134.134.139.74] has joined ##hplusroadmap 10:30 < nmz787_i> /me yawn 10:30 < kanzure> /me yawn 10:31 < nmz787_i> I want that FIB... but not sure how to convince you without feeling entitled (I guess you did ask originally) 10:32 < kanzure> they want $1500? 10:32 < nmz787_i> that is starting bid, I am not sure if it will have a 'reserve' 10:32 < kanzure> are you going to have trouble moving it around? what happens if you move? 10:32 < nmz787_i> if I move, I will have a few tons of stuff to plan on moving 10:33 < nmz787_i> my buddy with the trailer said it might be $1500 in scrap steel at that weight 10:33 < kanzure> will it still be around mid-May? 10:33 < nmz787_i> though that would be a horrible fate 10:33 < nmz787_i> not sure, the listing ends tomorrow at 1PM 10:33 < nmz787_i> if it is unsold, it might get relisted at a lower price, or.... 10:33 < nmz787_i> who knows 10:33 < kanzure> let's offer him $500 and we'll reconsider in mid-May 10:34 < nmz787_i> that seems pretty low, considering it says at factory specs... but I won't be opposed to you trying 10:35 < nmz787_i> re: moving, I have a mortgage, so moving isn't something that I want to do for a few reasons 10:35 < kanzure> oh i thought you were renting. 10:35 < nmz787_i> no, got forced out of that about 2 years ago 10:36 < nmz787_i> (they sold the house I was renting, and the rental market sucked at the time) 10:39 < kanzure> link again? 10:41 < nmz787_i> http://www.ebay.com/itm/Seiko-SMI3200-FIB-system-/201896619232 10:41 < nmz787_i> dual monitors are a good sign, and the icons look like maybe Windows XP 10:48 < nmz787_i> http://sb.cs.cmu.edu/OrientEdges/ 10:48 < nmz787_i> "Discovering Pathways by Orienting Edges in Protein Interaction Networks" 10:51 < nmz787_i> https://github.com/agitter/meo 10:51 < nmz787_i> .title 10:51 < yoleaux> GitHub - agitter/meo: Maximum Edge Orientation: Discovering Pathways by Orienting Edges in Protein Interaction Networks 10:54 -!- fireprfHydra [~fireprfHy@69.5.115.4] has quit [Ping timeout: 245 seconds] 10:57 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Quit: Leaving] 11:07 < kanzure> was there a prize at the end of the red queen's race or was it just a farce the whole time? 11:07 < nmz787_i> is that Alice in Wonderland trivia? 11:07 < kanzure> ""Well, in our country," said Alice, still panting a little, "you'd generally get to somewhere else--if you run very fast for a long time, as we've been doing."" 11:07 < kanzure> ""A slow sort of country!" said the Queen. "Now, here, you see, it takes all the running you can do, to keep in the same place. If you want to get somewhere else, you must run at least twice as fast as that!"" 11:12 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap 11:34 -!- nmz787_i1 [~ntmccork@134.134.139.76] has joined ##hplusroadmap 11:34 -!- nmz787_i1 [~ntmccork@134.134.139.76] has quit [Client Quit] 11:36 -!- nmz787_i [~ntmccork@134.134.139.74] has quit [Remote host closed the connection] 11:57 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has joined ##hplusroadmap 12:21 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Remote host closed the connection] 12:26 -!- nmz787_i [~ntmccork@134.134.137.71] has joined ##hplusroadmap 12:30 -!- fireprfHydra [~fireprfHy@69.5.115.4] has joined ##hplusroadmap 12:33 < nmz787_i> https://en.wikipedia.org/wiki/Matanuska_Valley_Colony 12:34 < nmz787_i> "[Federal Emergency Relief Administration (FERA)] commissioned applicants from the northern states of Minnesota, Wisconsin, and Michigan to colonize a tract of land in the Territory of Alaska. The administration chose these three northern states because of their climate and belief that representatives would be well suited to survive harsh elements of subarctic winters. The hope was that the colony candidates would be good farmers with the necessar 12:34 < nmz787_i> sufficiency in the harsh Alaskan environment." 12:35 < nmz787_i> well doesn't that just sound like state-sponsored eugenics... 12:37 -!- m4l3z [~m4l3z@2a01cb040226f200203a9b113da54501.ipv6.abo.wanadoo.fr] has joined ##hplusroadmap 12:40 < nmz787_i> "On one hand, they aimed to recruit hardy self-sufficient farmers that were true pioneers. On the other hand, they were trying to get people off of federal aid. They were to choose on the basis of need. In effect, successful farmers were best off staying put, while the less successful farmers were the ones available to colonize the Matanuska valley. The recruitment also suffered from the enthusiasm of the candidates: they might have presented them 12:40 < nmz787_i> actually were. The results revealed themselves early in the colony. Many left, many struggled, and many apparently did very little." 12:40 < nmz787_i> pretty bad eugenics I guess 12:56 -!- fireprfHydra [~fireprfHy@69.5.115.4] has quit [Quit: Leaving] 13:05 < kanzure> wat 13:22 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has joined ##hplusroadmap 13:37 < nmz787_i> you think it was well planned? 13:38 < kanzure> no i'm just busy lost in wonderland 14:00 -!- cevi__ [~zeb@128.12.245.10] has quit [Ping timeout: 258 seconds] 14:11 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has joined ##hplusroadmap 14:17 -!- nmz787_i1 [~ntmccork@134.134.139.76] has joined ##hplusroadmap 14:17 -!- nmz787_i1 [~ntmccork@134.134.139.76] has quit [Client Quit] 14:21 -!- nmz787_i [~ntmccork@134.134.137.71] has quit [Ping timeout: 240 seconds] 14:31 -!- nmz787_i [ntmccork@nat/intel/x-svxmyjdquthzmhjm] has joined ##hplusroadmap 14:33 -!- m4l3z [~m4l3z@2a01cb040226f200203a9b113da54501.ipv6.abo.wanadoo.fr] has quit [Ping timeout: 258 seconds] 15:30 -!- chris_99 [~chris_99@unaffiliated/chris-99/x-3062929] has quit [Quit: Leaving] 15:31 -!- Burninate [~Burn@pool-108-18-203-134.washdc.fios.verizon.net] has quit [Quit: Leaving] 15:31 -!- Burninate [~Burn@pool-108-18-203-134.washdc.fios.verizon.net] has joined ##hplusroadmap 15:56 -!- Gurkenglas [~Gurkengla@dslb-188-103-222-233.188.103.pools.vodafone-ip.de] has quit [Ping timeout: 260 seconds] 16:24 -!- nmz787_ [~nmz787@unaffiliated/nmz787] has quit [Ping timeout: 268 seconds] 16:24 -!- heath [~ybit@unaffiliated/ybit] has quit [Ping timeout: 245 seconds] 16:24 -!- jrayhawk [~jrayhawk@unaffiliated/jrayhawk] has quit [Ping timeout: 260 seconds] 16:24 -!- kanzure [~kanzure@unaffiliated/kanzure] has quit [Ping timeout: 268 seconds] 16:25 -!- fenn [~fenn@unaffiliated/fenn] has quit [Ping timeout: 240 seconds] 16:38 -!- heath [~ybit@unaffiliated/ybit] has joined ##hplusroadmap 16:38 -!- kanzure [~kanzure@unaffiliated/kanzure] has joined ##hplusroadmap 16:39 -!- jrayhawk [~jrayhawk@unaffiliated/jrayhawk] has joined ##hplusroadmap 16:51 -!- gnusha [~gnusha@unaffiliated/kanzure/bot/gnusha] has joined ##hplusroadmap 16:51 -!- Topic for ##hplusroadmap: biohacking, nootropics, transhumanism, open hardware | sponsored by lobsters everywhere, banned by the Federal Death Administration (5 times) | this channel is LOGGED: http://gnusha.org/logs | http://diyhpl.us/wiki | "ray kurzweil is a pessimist" - george church 16:51 -!- Topic set by kanzure [~kanzure@unaffiliated/kanzure] [Wed May 20 12:46:25 2015] 16:51 [Users ##hplusroadmap] 16:51 [ abetusk ] [ CoOlCyrus ] [ ExeciN ] [ juri_ ] [ pasky ] [ strages ] 16:51 [ adlai ] [ Cory ] [ FourFire ] [ justan0theruser] [ pent ] [ streety ] 16:51 [ aedla ] [ crescendo ] [ gnusha ] [ juul ] [ pompolic ] [ superkuh ] 16:51 [ AgenttiX_alt] [ CRM114 ] [ Guest74157] [ kwgwk ] [ proofoflogic] [ Taek ] 16:51 [ andytoshi ] [ darsie ] [ gwillen ] [ maaku ] [ Proteus ] [ thundara ] 16:51 [ archels_ ] [ dequ ] [ HEx1 ] [ Madars_ ] [ rancyd ] [ TMA ] 16:51 [ augur ] [ docl_ ] [ hylleddin1] [ Malvolio ] [ Reventlov ] [ vikraman ] 16:51 [ Aurelius ] [ Douhet ] [ iaglium ] [ marciogm ] [ sachy ] [ wrldpcmbl] 16:51 [ balrog ] [ drewbot ] [ indiebio ] [ mf1008 ] [ sandeepkr ] [ y0no ] 16:51 [ berndj ] [ Dumuzi ] [ Iriez ] [ midnightmagic ] [ satori_ ] [ yoleaux ] 16:51 [ bkero ] [ duper ] [ JayDugger ] [ nanotube ] [ saturn2 ] [ yorick ] 16:51 [ blueskin ] [ dustinm ] [ jcorgan ] [ nickjohnson ] [ saurik ] 16:51 [ BobaMa ] [ EnabrinTain ] [ Jen ] [ night ] [ sivoais ] 16:51 [ Burninate ] [ ensign ] [ Jenda` ] [ nmz787_i ] [ Solgriffin ] 16:51 [ c0rw1n ] [ entity8421[m]] [ Joshchamp ] [ nnnn20430 ] [ souljack ] 16:51 [ catern ] [ esmerelda ] [ jtimon ] [ nsh ] [ soylentbomb ] 16:51 -!- Irssi: ##hplusroadmap: Total of 91 nicks [0 ops, 0 halfops, 0 voices, 91 normal] 16:51 -!- Channel ##hplusroadmap created Thu Feb 25 23:40:30 2010 16:51 -!- Irssi: Join to ##hplusroadmap was synced in 12 secs 16:56 -!- jrayhawk [~jrayhawk@unaffiliated/jrayhawk] has joined ##hplusroadmap 16:56 -!- Darius [~quassel@66-215-89-229.dhcp.psdn.ca.charter.com] has joined ##hplusroadmap 16:56 -!- kanzure [~kanzure@unaffiliated/kanzure] has joined ##hplusroadmap 16:56 -!- heath [~ybit@unaffiliated/ybit] has joined ##hplusroadmap 16:57 < kanzure> bloooop 16:58 -!- nmz787 [~nmz787@unaffiliated/nmz787] has joined ##hplusroadmap 16:59 -!- fenn [~fenn@unaffiliated/fenn] has joined ##hplusroadmap 17:13 < nmz787> some docs for that FIB, I was right on Windows XP ;) http://diyhpl.us/~nmz787/pdf/Rev2_2%20SMI3200%20FIB.pdf 17:14 < nmz787> 1.7kVa avg after startup... so max 1700W I think (but probably less) 17:14 < kanzure> "Resetting biological pathways for defending against and repairing deterioration from human aging" https://patentscope.wipo.int/search/docservicepdf_pct/id00000037440163/PAMPH/WO2017062311.pdf 17:14 < kanzure> Metchnikoff's Hypothesis of Aging (Metchnikoff E., 1901) 17:14 < kanzure> Rate of Living Theory of Aging (Rubner M., 1908; Pearl R., 1928) 17:14 < kanzure> The Calorie Restriction Theory of Aging (McCay C., 1935) 17:14 < kanzure> The Free Radical Theory of Aging (Harmon D., 1956) 17:14 < kanzure> The Somatic Mutation Theory of Aging (Szilard L., 1959) 17:14 < kanzure> The Methylation Theory of Aging (Vanyushin B., 1967) 17:14 < kanzure> Disposable Soma Theory of Aging (Kirkwood T. and Rose M., 1991) 17:14 < kanzure> Inflammaging Theory of Aging (Franceschi C., 2007) 17:15 < kanzure> Retrotransposon Theory of Aging (Laurent G., 2010) 17:15 < kanzure> Redox Stress Hypothesis of Aging (Sohal R., 2012) 17:20 -!- cluckj [~cluckj@98.114.125.87] has joined ##hplusroadmap 17:21 < kanzure> "Restoration of the thymus in aging mice by in vivo zinc supplementation" http://www.ncbi.nlm.nih.gov/pubmed/8453784 (1993) 17:39 -!- Darius [~quassel@66-215-89-229.dhcp.psdn.ca.charter.com] has quit [Ping timeout: 258 seconds] 17:49 -!- Aurelius is now known as Aurelius`gym 17:51 -!- darsie [~darsie@84-113-55-42.cable.dynamic.surfer.at] has quit [Ping timeout: 240 seconds] 18:08 -!- Darius [~quassel@66-215-89-229.dhcp.psdn.ca.charter.com] has joined ##hplusroadmap 18:09 -!- CRM114 [~urchin@unaffiliated/urchin] has quit [Ping timeout: 260 seconds] 18:56 -!- Darius [~quassel@66-215-89-229.dhcp.psdn.ca.charter.com] has quit [Remote host closed the connection] 19:20 -!- abetusk [~abe@68.175.143.22] has quit [Ping timeout: 260 seconds] 19:21 < kanzure> why not just extend childhood by a few decades instead of all the anti-aging stuff. 20:06 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 20:07 -!- cevi__ [~zeb@128.12.245.10] has joined ##hplusroadmap 20:23 -!- jtimon [~quassel@9.31.134.37.dynamic.jazztel.es] has quit [Ping timeout: 240 seconds] 20:51 -!- abetusk [~abe@68.175.143.22] has joined ##hplusroadmap 20:51 -!- abetusk is now known as Guest63160 20:51 -!- Guest63160 is now known as abetusk 20:58 -!- nmz787_i [ntmccork@nat/intel/x-svxmyjdquthzmhjm] has quit [Quit: Leaving.] 21:06 < nmz787> kanzure: I've thought that about myself, as my beard has been 'coming in' for 15 years... so I assume I am still more childlike than the dude I knew who started and finished growing his old-man beard between age 15 and 16 21:17 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Ping timeout: 252 seconds] 21:58 -!- sbodin [~sbodin@91.226.141.241] has joined ##hplusroadmap 22:08 -!- sbodin [~sbodin@91.226.141.241] has quit [Ping timeout: 255 seconds] 23:01 -!- m4l3z [~m4l3z@2a01cb040226f200203a9b113da54501.ipv6.abo.wanadoo.fr] has joined ##hplusroadmap 23:02 -!- Gurkenglas [~Gurkengla@dslb-188-103-222-233.188.103.pools.vodafone-ip.de] has joined ##hplusroadmap 23:06 -!- m4l3z [~m4l3z@2a01cb040226f200203a9b113da54501.ipv6.abo.wanadoo.fr] has quit [Remote host closed the connection] 23:12 -!- Gurkenglas [~Gurkengla@dslb-188-103-222-233.188.103.pools.vodafone-ip.de] has quit [Ping timeout: 260 seconds] --- Log closed Tue Apr 25 00:00:36 2017