--- Log opened Thu Apr 27 00:00:38 2017
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04:45 < kanzure> yes there are various ways to cause phosphenes
05:30 < kanzure> meh, some boring attempts at thinking about superintelligence https://news.ycombinator.com/item?id=14205042
05:39 < fenn> what paper is that photoacoustic tomography image from?
05:39 < fenn> very nice angiogram
05:41 < kanzure> i just randmoly searched for photoacoustic tomography on google images.
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08:47 < kanzure> something about turning bridges into harps? http://dimainstone.com/project/human-harp/
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09:12 < kanzure> .wik halyuronic acid
09:12 < yoleaux> "Hyaluronic acid (HA; conjugate base hyaluronate), also called hyaluronan, is an anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues." -- https://en.wikipedia.org/wiki/Hyaluronic_acid
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09:17 < kanzure> sup eudoxia
09:17 < eudoxia> hi kanz
09:17 < eudoxia> what's up?
09:17 < kanzure> http://diyhpl.us/~bryan/2017-04-18-bioviva.txt
09:18 < eudoxia> oh, are you getting the telomere therapy?
09:18 < kanzure> no they told me to fuck off, "we are only focusing on actually ill people for now"
09:21 < eudoxia> interesting, is the Max referenced Max More?
09:21 < kanzure> yashgaroth
09:21 < eudoxia> oh right
09:23 < eudoxia> well, I'm sure the therapy will be available to non-sick people at some point soon-ish
09:23 < kanzure> not through these guys.
09:23 < kanzure> i only want a few changes: http://diyhpl.us/wiki/genetic-modifications/
09:28 < eudoxia> >Provides resistance to HIV and plague. Increases risk from West Nile virus, but who gives a fuck about that.
09:28 < eudoxia> interesting
09:28 < eudoxia> is gabriel also someone from this channel
09:28 < kanzure> gabriel is a friend but no
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10:20 < kanzure> "HardwareX is an open access journal established to promote free and open source designing, building and customizing of scientific infrastructure (hardware)."
10:20 < kanzure> https://www.journals.elsevier.com/hardwarex/
10:21 < kanzure> articles http://www.sciencedirect.com/science/journal/24680672
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11:04 < nmz787_i> has someone posted on this? http://hackaday.com/2017/04/27/osm-pronounced-awesome/
11:04 < nmz787_i> .title
11:04 < yoleaux> OSM (Pronounced Awesome) Hardware Makes DNA in Space | Hackaday
11:05 < nmz787_i> using tDt.. nothing arbitrary-sequence at this point
11:08 < nmz787_i> kanzure: link for the photoacoustic tomography?
11:08 < nmz787_i> oh, nevermind, saw fenns same ask
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11:44 < kanzure> "For instance, we're working on an electrowetting on dielectric device (see right) as a stand-in for conventional microfluidic devices commonly used in space"
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11:45 < kanzure> "We want to use a new method of DNA synthesis using enzymes"
11:45 < kanzure> "Ah-li-go-new-klee-o-tide"
11:45 < kanzure> "Why space? Well, first of all, space is cool. But more seriously, access to arbitrary DNA in space could accelerate research in a plethora of fields, and the ability to genetically engineer bacteria to produce substances (say on a martian colony) could mean the difference between death and a life-saving shot. In short, it's hard to predict the exact DNA one might need for research or practi...
11:45 < kanzure> ...cal use before hand.
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13:17 < archels_> [[
13:17 < archels_> King's Day
13:17 < archels_> Inbox
13:17 < archels_> x
13:17 < archels_> Dear All,
13:17 < archels_> Unfortunately, I spent most of this evening out and about, so I am not capable of presenting tomorrow.  And, I will be sleeping in.
13:17 < archels_> Therefore, I need to cancel my journal club presentation.
13:17 < archels_> I apologize.
13:17 < archels_> ]]
13:18 < archels_> (names redacted to protect the guilty)
13:18 < archels_> it's only 22:18 here, geez (mail is from 8 minutes ago)
13:26 < nmz787_i> what time was the presentation scheduled for?
13:27 < nmz787_i> is King's day a U.K. holiday?
13:27 < nmz787_i> maybe they are wasted drunk?
13:27 < nmz787_i> (and thus know they will be hung-over tomorrow)?
13:27 < chris_99> i've never heard of it, if it is heh
13:27 < yoleaux> 21 Apr 2017 22:42Z <nmz787_> chris_99: moss grows like a champ here in western Oregon... so many people have moss-covered roofs (that means they are lazy to clean it)... it would be pretty cool!
13:27 < chris_99> oh yeah on roofs it could look cool
13:28 < nmz787_i> or pathways
13:28 < chris_99> mm
13:28 < chris_99> i was thinking in a pot it'd look silly
13:34 < archels_> nmz787_i: it's a Dutch thing
13:35 < archels_> today, we celebrate the King's 50th birthday
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13:49 < nmz787_i> archels_: and do people usually get very drunk?
13:53 < archels_> yeah, I suppose
13:53 < archels_> it's a sort of carnival and there's lots of streetlife
13:54 < kanzure> do a journal club about fun alcohol things
13:57 < kanzure> fluorescent yeast stuff, i dunno. (not really fun.)
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15:55 < kanzure> "Whole transcriptome profiling of the human hippocampus suggests an involvement of the KIBRA rs17070145 polymorphism in differential activation of the MAPK signaling pathway" http://onlinelibrary.wiley.com/doi/10.1002/hipo.22731/full
15:55 < kanzure> "To achieve a better understanding of the pathways modulated by rs17070145 and its associated functional variant(s), we used laser capture microdissection (LCM) and RNA-sequencing to investigate the effect of rs17070145 genotypes on whole transcriptome expression in the human hippocampus (HP) of 22 neuropathologically normal individuals, with a specific focus on the dentate gyrus (DG) and at t...
15:55 < kanzure> ...he pyramidal cells (PC) of CA1 and CA3 sub-regions. Differential expression analysis of RNA-seq data within the HP based on the rs17070145 genotype revealed an overexpression of genes involved in the MAPK signaling pathway, potentially driven by the T/T genotype. The most important contribution comes from genes dysregulated within the DG region. Other genes significantly dysregulated, and not ...
15:55 < kanzure> ...involved in the MAPK pathway (Adj P < 0.01 and Fold Change > |1.00|) were: RSPO4 (HP); ARC, DUSP5, DNAJB5, EGR4, PPP1R15A, WBP11P1, EGR1, GADD45B (DG); CH25H, HSPA1A, HSPA1B, TNFSF9, and NPAS4 (PC). Several evidences suggested that the MAPK signaling pathway is linked with memory and learning processes."
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16:08 < nmz787_i> hippocampus - where smart hungry hungry hippos go to school
16:09 < nmz787_i> (hungry for knowledge)
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18:31 < kanzure> bloooot.
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18:51 < anachronick> hey kanzure, you there?
18:52 < anachronick> what can you tell me about Pancratistatin?
18:57 < kanzure> .wik pancratistatin
18:57 < yoleaux> "Pancratistatin (PST) is a natural compound initially extracted from spider lily, a Hawaiian native plant, belonging to the family Amaryllidaceae (AMD)." -- https://en.wikipedia.org/wiki/Pancratistatin
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19:05 < anachronick> yes, but search what they say about it on pubmed
19:10 < kanzure> no you
19:11 < anachronick> https://www.ncbi.nlm.nih.gov/pubmed/28220885
19:14 < kanzure> .title
19:14 < yoleaux> Cancer Cell Mitochondria Targeting by Pancratistatin Analogs is Dependent on Functional Complex II and III. - PubMed - NCBI
19:15 < kanzure> "Professor Sergio Canavero, Director of the Turin Advanced Neuromodulation Group, is aiming to carry out the first human head transplant within 10 months and then wants to begin trials on brain transplants. [...] Speaking to the German magazine Ooom, he said he planned to awaken patients frozen by the Alcor Life Extension Foundation which is based in Arizona. "We will try to bring the first of...
19:15 < kanzure> ... the company's patients back to life, not in 100 years. As soon as the first human head transplant has taken place, i.e. no later than 2018, we will be able to attempt to reawaken the first frozen head," said Prof Canavero. "We are currently planning the world's first brain transplant, and I consider it realistic that we will be ready in three years at the latest."
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20:01 < streety> what is the consent process around reviving cryopreserved brains?
20:01 < streety> How many of the potential candidates want to be the first?
20:02 < kanzure> andytoshi was recently filling out the paperwork for this
20:02 < kanzure> you specify the conditins under which you would like to be attempted to be resuscitated
20:03 < kanzure> you can also choose things like "please don't revive me if the entire human race has been taken over by a galactic super intelligence entity"
20:05 < streety> interesting, not sure I would be too worried about that side of things but I would probably want a decent chance of the procedure being successful
20:05 < streety> for some measure of decent
20:05 < yashgaroth> if you offer to be first do you get a discount?
20:06 < kanzure> if you want a higher chance of success, you would wait for cryoresuscitation studies.. the current vitirification methods are not necessarily ideal.
20:06 < streety> but if you are dying with some terminal disease you don't have the option of waiting
20:07 < streety> I think I would want a ~90% discount for being among the first 10.
20:09 < kanzure> it should be free, in that case
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20:55 < nmz787_> https://emcrit.org/pulmcrit/metabolic-sepsis-resuscitation/
20:56 < nmz787_> http://www.sciencedirect.com/science/article/pii/S0012369216625643
20:56 < nmz787_> .title
20:56 < yoleaux> Hydrocortisone, Vitamin C and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study
20:57 < nmz787_> "For example, a patient with high-output heart failure (from thiamine deficiency) and sympathetic nervous system failure (from vitamin C deficiency) would develop profound shock."
20:58 < nmz787_> "Intestinal absorption of vitamin C is saturable. Given the increased metabolic consumption of Vitamin C in critical illness, the only way to replete Vitamin C in this context is intravenously."
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21:17 < nmz787_> "The use of vitamin C to treat scurvy is based on a single-center open-label trial involving twelve sailors."
21:30 < nmz787_> 'Marik Cocktail'   https://i0.wp.com/emcrit.org/wp-content/uploads/2017/03/bond.gif
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--- Log closed Fri Apr 28 00:00:38 2017