--- Log opened Wed Sep 13 00:00:16 2017 00:03 < maaku> yeah i meant more the music scene and such 00:03 < maaku> i'm sure KC is a more happening place 00:04 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Ping timeout: 248 seconds] 00:05 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 00:09 -!- jaboja [~jaboja@jaboja.pl] has quit [Ping timeout: 240 seconds] 00:28 -!- aeiousomething [~aeiousome@183.82.170.54] has quit [Ping timeout: 248 seconds] 00:28 -!- aeiousomething [~aeiousome@61.3.67.95] has joined ##hplusroadmap 01:07 < kanzure> hrm 01:09 -!- jaboja [~jaboja@jaboja.pl] has joined ##hplusroadmap 01:17 < fltrz> any news on sci-hub stuff? 01:18 -!- jaboja [~jaboja@jaboja.pl] has quit [Ping timeout: 240 seconds] 01:18 < kanzure> no. seek other avenues of communication with her, she probably just doesn't like me. :-) 01:18 -!- jaboja [~jaboja@jaboja.pl] has joined ##hplusroadmap 01:21 < kanzure> http://blog.scalyr.com/2012/10/a-systematic-look-at-ec2-io/ 01:21 < kanzure> although this was before ssd so... 01:26 < kanzure> .wik patent encumbrance of large automotive NiMH batteries 01:26 < yoleaux> "The patent encumbrance of large automotive NiMH batteries refers to allegations that corporate interests have used the patent system to prevent the commercialization of nickel metal hydride (NiMH) battery technology." — https://en.wikipedia.org/wiki/Patent_encumbrance_of_large_automotive_NiMH_batteries 01:28 -!- CRM114 [~urchin@unaffiliated/urchin] has joined ##hplusroadmap 01:55 -!- jaboja [~jaboja@jaboja.pl] has quit [Ping timeout: 260 seconds] 02:01 -!- Gurkenglas [~Gurkengla@dslb-094-223-136-111.094.223.pools.vodafone-ip.de] has joined ##hplusroadmap 02:10 -!- jaboja [~jaboja@jaboja.pl] has joined ##hplusroadmap 02:40 -!- jaboja [~jaboja@jaboja.pl] has quit [Ping timeout: 240 seconds] 02:58 < poppingtonic> http://www.openphilanthropy.org/research/cause-reports/scientific-research/mechanisms-aging 02:58 < poppingtonic> .title 02:58 < yoleaux> Mechanisms of Aging | Open Philanthropy Project 03:07 < poppingtonic> kanzure: what happened with sci-hub? 03:14 < poppingtonic> who's read through Eliasmith's How to Build a Brain? Has a neat python library called nengo 03:15 -!- esmerelda [~mabel@unaffiliated/jacco] has quit [Ping timeout: 240 seconds] 03:28 -!- traumschule [~traumschu@185.62.205.145] has joined ##hplusroadmap 03:42 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has quit [Remote host closed the connection] 04:21 -!- jaboja [~jaboja@jaboja.pl] has joined ##hplusroadmap 05:00 -!- jaboja [~jaboja@jaboja.pl] has quit [Ping timeout: 248 seconds] 05:10 -!- jaboja [~jaboja@jaboja.pl] has joined ##hplusroadmap 05:18 -!- cluckj [~cluckj@static-173-59-27-112.phlapa.ftas.verizon.net] has quit [Quit: Leaving] 05:22 < archels> https://www.cnbc.com/2017/09/12/martin-shkreli-apologizes-for-bizarre-facebook-post-about-hillary-clinton.html 05:28 -!- darsie [~username@84-113-55-42.cable.dynamic.surfer.at] has joined ##hplusroadmap 05:46 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Remote host closed the connection] 05:51 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 06:12 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Ping timeout: 248 seconds] 06:20 -!- streety_ [~streety@li761-24.members.linode.com] has quit [Ping timeout: 248 seconds] 06:21 -!- streety_ [~streety@li761-24.members.linode.com] has joined ##hplusroadmap 06:24 -!- Rmesil8O4b[m] [rmesil8o4b@gateway/shell/matrix.org/x-oqzijkfgwbfswhnx] has quit [Ping timeout: 240 seconds] 06:25 -!- entity8421[m] [entity8421@gateway/shell/matrix.org/x-ciyyxtiszwwnhsal] has quit [Ping timeout: 246 seconds] 06:32 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 06:42 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 252 seconds] 06:47 -!- entity8421[m] [entity8421@gateway/shell/matrix.org/x-mnkufjaestlssjkh] has joined ##hplusroadmap 06:57 -!- Rmesil8O4b[m] [rmesil8o4b@gateway/shell/matrix.org/x-zggosonmxroyquap] has joined ##hplusroadmap 08:18 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Remote host closed the connection] 08:22 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 08:39 -!- cluckj [~cluckj@static-173-59-27-112.phlapa.ftas.verizon.net] has joined ##hplusroadmap 08:47 -!- Gurkenglas [~Gurkengla@dslb-094-223-136-111.094.223.pools.vodafone-ip.de] has quit [Ping timeout: 240 seconds] 08:54 < kanzure> poppingtonic: scihub is still around. not sure what you're asking. 08:56 -!- jaboja [~jaboja@jaboja.pl] has quit [Ping timeout: 248 seconds] 08:56 < kanzure> "Assembly of a biocompatible triazole-linked gene by one-pot click-DNA ligation" http://www.nature.com/nchem/journal/vaop/ncurrent/full/nchem.2850.html 08:56 < kanzure> "Here we present a fully chemical one-pot method for the assembly of oligonucleotides into a gene by click-DNA ligation. We synthesize the 335 base-pair gene that encodes the green fluorescent protein iLOV from ten functionalized oligonucleotides that contain 5ʹ-azide and 3ʹ-alkyne units. The resulting click-linked iLOV gene contains eight triazoles at the sites of chemical ligation, and ... 08:56 < kanzure> ...yet is fully biocompatible; it is replicated by DNA polymerases in vitro and encodes a functional iLOV protein in Escherichia coli. We demonstrate the power and potential of our one-pot gene-assembly method by preparing an epigenetically modified variant of the iLOV gene." 08:57 < kanzure> nooo why would you demonstrate the method with such a small gene 09:07 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Quit: Leaving.] 09:15 -!- Storyteller [~Storytell@unaffiliated/storyteller] has joined ##hplusroadmap 09:21 < kanzure> "“Our approach is a significant breakthrough in gene synthesis,” University of Southampton Chemical Biology Professor and Lead Researcher Ali Tavassoli said in a press release. “Not only have we demonstrated assembly of a gene using click-chemistry, we have also shown that the resulting strand of DNA is fully functional in bacteria, despite the scars formed by joining fragments.”" 09:21 -!- Gurkenglas [~Gurkengla@dslb-094-223-136-111.094.223.pools.vodafone-ip.de] has joined ##hplusroadmap 09:30 < kanzure> nmz787: we should probably check to see if any of those authors are going to be at the event tomorrow.... or we should just read it anyway. 09:47 -!- Storyteller [~Storytell@unaffiliated/storyteller] has left ##hplusroadmap ["Leaving"] 09:59 -!- aeiousom1thing [~aeiousome@gateway/vpn/privateinternetaccess/aeiousomething] has joined ##hplusroadmap 10:01 -!- aeiousomething [~aeiousome@61.3.67.95] has quit [Ping timeout: 240 seconds] 11:49 -!- Urchin[emacs] [~user@unaffiliated/urchin] has joined ##hplusroadmap 12:44 -!- aeiousom1thing [~aeiousome@gateway/vpn/privateinternetaccess/aeiousomething] has quit [Ping timeout: 240 seconds] 12:45 -!- psztorc [~psztorc@ool-45726efb.dyn.optonline.net] has joined ##hplusroadmap 12:55 -!- aeiousomething [~aeiousome@183.82.170.54] has joined ##hplusroadmap 13:09 -!- augur [~augur@198-27-215-123.static.sonic.net] has joined ##hplusroadmap 13:14 -!- aeiousomething [~aeiousome@183.82.170.54] has quit [Quit: leaving] 13:30 < kanzure> dnascript has raised $13M series A 13:57 -!- traumschule [~traumschu@185.62.205.145] has quit [Ping timeout: 248 seconds] 14:02 -!- preview [~quassel@2407:7000:842d:4000::3] has joined ##hplusroadmap 14:44 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has quit [Remote host closed the connection] 14:46 -!- augur [~augur@198-27-215-123.static.sonic.net] has quit [Remote host closed the connection] 14:46 -!- augur [~augur@198-27-215-123.static.sonic.net] has joined ##hplusroadmap 14:51 -!- augur [~augur@198-27-215-123.static.sonic.net] has quit [Ping timeout: 240 seconds] 15:07 < kanzure> "What's the rationale behind the similarities between chlorophyll and hemoglobin?" someone suggests, "It could be that both molecules are extremely important for biosynthesis and have similar structure for stability sake. The density of conjugated double bonds and circular (multi-arch) structure could simply be a manifestation of molecular stability." 15:32 -!- Gurkenglas [~Gurkengla@dslb-094-223-136-111.094.223.pools.vodafone-ip.de] has quit [Ping timeout: 240 seconds] 15:33 -!- Gurkenglas [~Gurkengla@dslb-094-223-136-111.094.223.pools.vodafone-ip.de] has joined ##hplusroadmap 15:39 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has joined ##hplusroadmap 15:41 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has quit [Remote host closed the connection] 15:41 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has joined ##hplusroadmap 16:24 < darsie> Heme* 16:25 < darsie> Heme has the formula C2952H4664O832N812S8Fe4. 16:26 < darsie> Hemoglobin* 16:26 < darsie> damn :) 16:29 -!- Urchin[emacs] [~user@unaffiliated/urchin] has quit [Quit: ERC (IRC client for Emacs 24.5.1)] 17:10 < jrayhawk> uh... what? carbon-carbon pi-bonds require relatively little energy to change 17:10 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 17:10 < jrayhawk> typically that instability is a desirable entry point for enzymatic processes 17:13 < jrayhawk> (and typically undesirable for unmanaged processes such as oxidation) 17:36 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 240 seconds] 18:14 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 18:38 -!- helleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has joined ##hplusroadmap 18:46 -!- yashgaroth [~yashgarot@2606:6000:cd4d:3300:f5e0:f867:a11d:8d52] has joined ##hplusroadmap 18:48 < fltrz> ugh, organs being stolen from refugees :S 19:23 -!- justan0theruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 19:23 -!- justan0theruser [~justanoth@unaffiliated/justanotheruser] has quit [Client Quit] 19:23 -!- justan0theruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 19:26 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 264 seconds] 19:26 -!- Gurkenglas [~Gurkengla@dslb-094-223-136-111.094.223.pools.vodafone-ip.de] has quit [Ping timeout: 240 seconds] 20:29 -!- strangewarp [~strangewa@c-76-25-206-3.hsd1.co.comcast.net] has joined ##hplusroadmap 20:35 < kanzure> https://tatourian.blog/2016/11/19/building-ultra-reliable-software/ 20:36 -!- darsie [~username@84-113-55-42.cable.dynamic.surfer.at] has quit [Ping timeout: 240 seconds] 20:37 < fltrz> kanzure: yes formal methods are extremely important, a lot of people are also unaware of things like metamath 20:37 < fltrz> a main obstacle for actual usage of formal methods is that we have not formalized daily life concepts yet 20:38 < fltrz> this is in fact what we call "philosophizing", I predict it to be a large future market 20:38 < kanzure> nmz787: they increased my presentation time from 3 minutes to 10 minutes. i had only 2 slides like they requested. whoops. 20:39 < fltrz> i.e. finding verifiable contradictions in advertised formal belief systems 20:39 -!- aeiousomething [~aeiousome@117.195.135.148] has joined ##hplusroadmap 20:46 < kanzure> nmz787: i'll wake up just before 7am. 20:48 < fltrz> most formal methods are restricted to verification of computations, i.e. verifying software, for designing software in a way that you can prove desired/required things about the program 20:49 < fltrz> but systems like metamath are general mathematical proof systems, you can enter any kinds of axiom be they mathematical, physical ("postulates"), ... 20:50 < fltrz> also compared to the few formal verifiers I looked up, metamath was the most minimalist one, it is relatively easy (i.e. order days or weeks) to understand and reimplement the verification algorithm 20:53 < fltrz> I predict future legislative blockchains to be based on such verification algorithms.. as comprehensive laws/contracts (i.e. ignoring the simpler 'vending machine' style contracts) etc are simplest to describe in mathematical sense 20:55 < fltrz> there would of course still be 'witnessing'/'evidence' some of which will be vending style contracts etc 21:05 < fltrz> does anybody know where I can find more details about the toda protocol? they are quite secretive about the details, and there is no clear whitepaper, but they describe some of its properties in a youtube video 21:06 < fltrz> I always discounted it as a croc of sh*t, but then silvio micali from brilliant algorand paper partnered with them... 21:08 < fltrz> also the todachain website is horribly done 21:20 < fltrz> huh never found this before: https://github.com/Toufi/Whitepaper 21:45 < maaku> .title https://spectrum.ieee.org/automaton/robotics/industrial-robots/autonomous-robots-plant-tend-and-harvest-entire-crop-of-barley 21:45 < yoleaux> Autonomous Robots Plant, Tend, and Harvest Entire Crop of Barley - IEEE Spectrum 21:47 -!- entity8421[m] [entity8421@gateway/shell/matrix.org/x-mnkufjaestlssjkh] has quit [Ping timeout: 276 seconds] 21:51 -!- entity8421[m] [entity8421@gateway/shell/matrix.org/x-pyqhdmpxggsswflb] has joined ##hplusroadmap 22:06 -!- yoleaux [~yoleaux@xn--ht-1ia18f.nonceword.org] has quit [Ping timeout: 276 seconds] 22:07 -!- yoleaux [~yoleaux@xn--ht-1ia18f.nonceword.org] has joined ##hplusroadmap 22:20 -!- hehelleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has joined ##hplusroadmap 22:24 -!- helleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has quit [Ping timeout: 240 seconds] 22:46 < fltrz> pff that toda protocol 'whitepaper' is still vague as fuck, perhaps I should just send a mail 22:50 -!- yashgaroth [~yashgarot@2606:6000:cd4d:3300:f5e0:f867:a11d:8d52] has quit [Quit: Leaving] 22:58 -!- aeiousomething [~aeiousome@117.195.135.148] has quit [Ping timeout: 248 seconds] 23:14 -!- ExeciN [ExeciN@bnc.stormbit.net] has quit [Ping timeout: 240 seconds] 23:29 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 23:35 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Ping timeout: 264 seconds] 23:44 -!- aeiousomething [~aeiousome@117.195.135.148] has joined ##hplusroadmap 23:54 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap --- Log closed Thu Sep 14 00:00:17 2017