--- Log opened Sat Sep 16 00:00:19 2017
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00:30 < fenn> .title
00:30 < yoleaux> Switchable DNA Machines for Storing Information
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05:17 < kanzure> "Reconfiguration of DNA molecular arrays driven by information relay" http://science.sciencemag.org/content/early/2017/06/21/science.aan3377
06:14 < JayDugger> Good morning, everyone.
06:22 < fltrz> kanzure: yep that is the original paper
06:23 < kanzure> papers > news articles
06:26 < JayDugger> s/>/≫/
06:30 < kanzure> JayDugger: pm
06:33 < JayDugger> Got it, thanks, will do, but can't reply via pm. "486: You must log in with services to message this user"
06:34 < JayDugger> Probably my end.
06:35 < kanzure> musics https://www.youtube.com/watch?v=NpOtkhBcc8k&t=52m
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07:59 < kanzure> hrmph
08:01 < Storyteller> ?
08:05 < kanzure> what?
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08:08 < Storyteller> why did you hrmph? last i saw in the logs was a youtube post for music
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08:25 < kanzure> huh?
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10:45 < kanzure> "A number of hedge funds have recently bought and sold shares of the stock. ARK Investment Management LLC purchased a new position in Crispr Theraptc in the 2nd quarter worth about $206,000. Vanguard Group Inc. purchased a new position in Crispr Theraptc in the 2nd quarter worth about $273,000. Wells Fargo & Company MN increased its stake in Crispr Theraptc by 459.7% in the 2nd quarter. Wells ...
10:45 < kanzure> ...Fargo & Company MN now owns 7,987 shares of the company’s stock worth $128,000 after buying an additional 6,560 shares during the period. IHT Wealth Management LLC purchased a new position in Crispr Theraptc in the 1st quarter worth about $110,000. Finally, Credit Suisse AG purchased a new position in Crispr Theraptc in the 1st quarter worth about $1,742,000. 23.90% of the stock is ...
10:45 < kanzure> ...currently owned by institutional investors."
10:46 < cluckj> >_>
11:40 < kanzure> .title https://news.ycombinator.com/item?id=15265507
11:40 < yoleaux> We've failed: Pirate open access is winning and we must change our approach | Hacker News
11:40 < kanzure> .title http://onlinelibrary.wiley.com/doi/10.1002/leap.1116/full
11:40 < yoleaux> We've failed: Pirate black open access is trumping green and gold and we must change our approach - Green - 2017 - Learned Publishing - Wiley Online Library
11:41 < kanzure> "pirate black open" what..
11:55 < kanzure> i have too many draft emails (about 400) that i haven't sent. |
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12:05 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=c3cd68b9 Bryan Bishop: mention recent gwas/iq study >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
12:21 < kanzure> did fenn do the actuation calculations regarding the billion valve printer
12:23 < kanzure> nmz787: did anyone bring up a reason to not do the oligo library approach? stitch small library parts together into larger constructs? i feel like there was little/no response at all to that.
12:24 < kanzure> might be interesting to explore concept of inkjet + oligo library (so you shoot out the library components, instead of phosphoramidite chemistry reactant steps)
12:25 < kanzure> nanoneedle array for injections http://mems.seas.upenn.edu/nanoneedles.html
12:25 < kanzure> "A highly dense nanoneedle array for intracellular gene delivery" http://mems.seas.upenn.edu/publications/2012/A%20highly%20dense%20nanoneedle%20array%20for%20intracellular%20gene%20delivery.pdf
12:27 < kanzure> hmm thee nanoneedles are not individually controllable. too bad.
12:29 < kanzure> right, so, with a billion valves you already have enough for all the 4^14 14mers (268.4 million)
12:29 < kanzure> although you would probably limit it to like all the 4^8 8mers or something... so that multiple valves or entire rows can give the same library object.
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14:02 < kanzure> "Coding macromolecules: inputting information in polymers using monomer-based alphabets" http://pubs.acs.org/doi/abs/10.1021/acs.macromol.5b00890
14:07 < kanzure> "Model-based design to push the boundaries of sequence control" http://pubs.acs.org/doi/abs/10.1021/acs.macromol.6b01699
14:08 < kanzure> jflutz@unistra.fr
14:10 < kanzure> "Early contributions to the field have been made for developing peptidomimetics and foldamers, which are short oligomers that mimic the structure of proteins.[25-28]"
14:15 < kanzure> (short 1pager) "Paving the way for single-molecule sequencing on non-natural information-containing polymers" http://www.ics-cnrs.unistra.fr/~indofrench/IMG/pdf/konig-indo-french2016.pdf
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14:21 < kanzure> "Preparation of information-containing macromolecules by ligation of dyad-encoded oligomers" https://www.researchgate.net/profile/Tam_Trinh/publication/280094272_Preparation_of_Information-Containing_Macromolecules_by_Ligation_of_Dyad-Encoded_Oligomers/links/577e3e3d08aed39f59945e58.pdf
14:52 < fenn> i didn't do any calculations
14:58 < kanzure> someone at the meeting said inkjet synthesizers wouldn't be competitive with other techniques. any idea what they could have meant? perhaps they were bluffing.
14:58 < kanzure> or perhaps they meant without better printheads..
14:59 < kanzure> can't be LCD/DMD-based photolithography stuff... because there's not enough addressable elements to make that reach the same throughput/scale.
15:00 < kanzure> ah specifically the comment was "1 billion valves is not competitive"
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15:25 < kanzure> kyocera's kj4 inkjet was developed by "brother industries, ltd." apparently.
15:30 < kanzure> printhead cleaning device thing https://www.youtube.com/watch?v=ZcP74VBDYxo
15:32 < kanzure> visualization of continuous inkjet head (using pressure i guess) https://www.youtube.com/watch?v=99Jz2JFmp1c
15:45 < kanzure> "thin film piezos" hmm
15:46 < kanzure> like https://www.konicaminolta.jp/about/research/technology_report/2015/pdf/12_mawatari.pdf
15:48 < kanzure> "tested to 160 kHz."
15:49 < kanzure> (according to xaar)
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15:52 < kanzure> fujifilm dimatix claims 15 billion drops/sec https://www.youtube.com/watch?v=jUw_USixLDI
15:52 < kanzure> (warning: marketing video)
15:56 < kanzure> seems like their best printhead has 2048 nozzles firing up to 100 kHz each http://www.fujifilmusa.com/shared/bin/PDS00105_SambaPHDK_2_12_15.pdf
15:56 < kanzure> that's only 200 million/sec.  where's the 15 billion coming from?
15:58 < kanzure> http://www.fujifilmusa.com/products/industrial_inkjet_printheads/technology/samba/index.html#features
16:04 < kanzure> xaar 5601 has 5600 nozzles "MEMs technology makes possible 1200 nozzles per inch" 3 pl drop size
16:04 < kanzure> "Xaar 2001+ has four rows, each with 500 nozzles." ~40 kHz
16:08 < kanzure> .title https://www.youtube.com/watch?v=7ZQ8yO2QI0c
16:08 < yoleaux> Thin film piezo demo - YouTube
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17:21 < nmz787> kanzure: hmm, no, I guess we didn't really pitch it too hard...
17:27 < kanzure> i thought one of the big companies was doing an oligo library technique for data storage. this was something i heard maybe last year or earlier.
17:29 < nmz787> hmm
17:30 < nmz787> maybe I should contact that glass-valve manufacturing company for microfluidic, if they are still around
17:30 < nmz787> then the challenge becomes aligning the various layers of glass and semiconductor and/or metal
17:31 < nmz787> wasn't someone in here talking about the valves using heaters and wax's volumetric growth-with-heat ?
17:32 < nmz787> I can't remember if they switch fast or slow
17:37 < nmz787> kanzure: inkjet droplet volume is?
17:37 < kanzure> depends on the machine but i've been seeing anywhere from 4 to 80 picoliters
17:46 < kanzure> dna droplet ejection at 26 kHz https://link.springer.com/article/10.1007/s00542-015-2729-7
17:48 < kanzure> inkjet printing of mems devices http://www.mdpi.com/2072-666X/8/6/194/htm
17:49 < kanzure> "For example, a conductor can be printed from conductive colloid [5,6] or molten solder [5,7]. Inkjet printing methods readily make passive electrical components, like a planar conductor, a planar inductor (coil), even a coplanar air capacitor. [...] printing is inexpensive and effective to make arrays of MEMS or sub-millimeter sensors and actuators distributed over a large area. For example, ...
17:49 < kanzure> ...the inkjet printing method has successfully been used to print: (1) a microlens array as the areal light diffuser in the light guide plate of a display [8]; (2) air-gap MEMS switches on plastic lamination for RF power transmission [9]. Recently, the printing method even makes distributed and flexible sensors and actuators for the application to robotic skin or environmental monitoring. One of ...
17:49 < kanzure> ...the impressive examples is a large-area electro-adhesive pad as grippers [10]. Calvert (2001) [5] presented a review of inkjet printing of electrical and optical micro-parts, mostly electrically passive. Wallace et al. (2007) [7] reviewed the use of inkjet printing as the manufacturing tool for passive components such as solder bumps and microlenses. Bessonov and Kirikova (2015) [11] reviewed ...
17:49 < kanzure> ...flexible sensors based on roll-to-roll printing or screen printing. Yet, few have reported the inkjet printing of MEMS actuators or sensors due to complexity in the making of moving elements. In the following sections of this paper, we shall review the successful and exciting development of printable MEMS devices as sensors and actuators, in addition to printing methods and materials."
17:51 < kanzure> "Such printed metallic lines can make a resonant LC circuit for a radio-frequency identifier (RFID) tag. For example, Figure 5 shows a spiral silver coil [6] of 10 turns and 1.3 mm wide printed out of five layers of silver nanoparticle ink with a layer thickness of 100 nm on a substrate of polyimide film. Such a metallic coil together with air capacitance makes an LC circuit to absorb radio ...
17:51 < kanzure> ...frequency signal at 150 MHz.
17:51 < kanzure> "
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18:25 < kanzure> couldn't you use multiple piezo elements inside each nozzle's reservoir to print more drops at a density higher than the nozzle density?
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18:30 < kanzure> "Electrical characterization of inkjet printed conductive traces using LinuxCNC" http://ieeexplore.ieee.org/abstract/document/7151568/
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18:44 < kanzure> "Future, opportunities and challenges of inkjet technologies" https://www.repository.cam.ac.uk/bitstream/handle/1810/244791/Castrejon-circulation.pdf;sequence=1
18:44 < kanzure> "A variation on the electrospray technique is the Tonejet system, [15, 16]. In this case there are no nozzles but instead a comb-like array of pointed electrodes (ejectors) beneath the surface of a liquid containing charged toner particles suspended in an inert carrier such as isoparaffins. An electric field between any of the ejectors and an external common electrode causes the charged toner ...
18:44 < kanzure> ...particles to be concentrated and ejected in a liquid drop. The concentration of toner in the ejected stream is much higher than that in the bulk liquid. The amount of ink ejected can be controlled by the time for which the field is applied so that there is a grey-level capability for each pixel."
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19:58 < kanzure> why piezo guns and not mems shutter valves
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20:49 < nmz787> demonpore?
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--- Log closed Sun Sep 17 00:00:20 2017