--- Log opened Tue Oct 10 00:00:42 2017 00:06 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has joined ##hplusroadmap 00:12 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 00:24 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-bmjzneaviaprntnk] has joined ##hplusroadmap 00:31 < archels> Nature Protocols – Look, I’m all in favor of methods development, but seriously, why don’t you just title your paper “Here are all my secrets. Please scoop me.” 00:31 < archels> haha 00:31 < archels> and elife mistaken as a dating platform. hilarious 00:35 -!- jtimon [~quassel@199.31.134.37.dynamic.jazztel.es] has joined ##hplusroadmap 00:50 < poppingtonic> http://slatestarcodex.com/2017/10/09/in-favor-of-futurism-being-about-the-future/ 01:21 -!- CRM114 [~urchin@unaffiliated/urchin] has joined ##hplusroadmap 01:59 -!- Urchin [~urchin@unaffiliated/urchin] has joined ##hplusroadmap 02:03 -!- CRM114 [~urchin@unaffiliated/urchin] has quit [Ping timeout: 258 seconds] 02:14 -!- aeiousomething [~aeiousome@183.82.170.54] has joined ##hplusroadmap 02:29 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has quit [Remote host closed the connection] 03:02 -!- JayDugger [~jwdugger@47.185.237.246] has quit [Ping timeout: 248 seconds] 03:11 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Ping timeout: 255 seconds] 03:31 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 04:10 -!- RebelCoderRU [~Yuriy@95.143.115.254] has quit [Remote host closed the connection] 04:16 -!- RebelCoder [~Yuriy@95.143.115.254] has joined ##hplusroadmap 04:35 < kanzure> nmz787: polymerase's one job is to not skip. there's no natural use for skips. 06:10 -!- JayDugger [~jwdugger@47.185.237.246] has joined ##hplusroadmap 06:12 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Remote host closed the connection] 06:14 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 06:38 -!- Urchin [~urchin@unaffiliated/urchin] has quit [Quit: Urchin] 06:42 -!- jaboja [~jaboja@jaboja.pl] has joined ##hplusroadmap 06:49 -!- Gurkenglas [~Gurkengla@dslb-094-223-135-191.094.223.pools.vodafone-ip.de] has joined ##hplusroadmap 06:49 -!- mindsForge [~nak@75-172-169-191.phnx.qwest.net] has joined ##hplusroadmap 07:16 -!- jaboja [~jaboja@jaboja.pl] has quit [Ping timeout: 248 seconds] 08:20 -!- WeirdTolkienishF [~Weird@204.48.46.11] has joined ##hplusroadmap 08:20 -!- WeirdTolkienishF [~Weird@204.48.46.11] has quit [Changing host] 08:20 -!- WeirdTolkienishF [~Weird@unaffiliated/weirdtolkienishf] has joined ##hplusroadmap 08:21 < kanzure> blort 08:40 -!- jaboja [~jaboja@5.196.225.175] has joined ##hplusroadmap 08:58 -!- jaboja [~jaboja@5.196.225.175] has quit [Ping timeout: 260 seconds] 08:59 -!- jaboja [~jaboja@jaboja.pl] has joined ##hplusroadmap 08:59 -!- sachy [~sachy@nat.brmlab.cz] has joined ##hplusroadmap 09:05 -!- gene-hacker [~gene@c-24-131-17-249.hsd1.pa.comcast.net] has quit [Ping timeout: 248 seconds] 09:06 -!- gene-hacker [~gene@c-24-131-17-249.hsd1.pa.comcast.net] has joined ##hplusroadmap 09:10 -!- jaboja [~jaboja@jaboja.pl] has quit [Ping timeout: 240 seconds] 09:30 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Ping timeout: 248 seconds] 09:36 -!- jaboja [~jaboja@jaboja.pl] has joined ##hplusroadmap 10:02 -!- HumanoidX [c5236f22@gateway/web/freenode/ip.197.35.111.34] has joined ##hplusroadmap 10:06 -!- HumanoidX [c5236f22@gateway/web/freenode/ip.197.35.111.34] has quit [Client Quit] 10:30 -!- strages [uid11297@gateway/web/irccloud.com/x-dlsaobqnuxifevui] has quit [Quit: Connection closed for inactivity] 10:32 < kanzure> blort 2 10:34 -!- jaboja [~jaboja@jaboja.pl] has quit [Ping timeout: 240 seconds] 10:36 -!- mindsForge [~nak@75-172-169-191.phnx.qwest.net] has quit [Quit: Leaving.] 10:56 -!- jaboja [~jaboja@jaboja.pl] has joined ##hplusroadmap 10:56 -!- jtimon [~quassel@199.31.134.37.dynamic.jazztel.es] has quit [Remote host closed the connection] 11:09 -!- aeiousom1thing [~aeiousome@gateway/vpn/privateinternetaccess/aeiousomething] has joined ##hplusroadmap 11:13 -!- aeiousomething [~aeiousome@183.82.170.54] has quit [Ping timeout: 255 seconds] 11:22 -!- mindsForge [~nak@75-172-169-191.phnx.qwest.net] has joined ##hplusroadmap 11:24 -!- jaboja [~jaboja@jaboja.pl] has quit [Ping timeout: 255 seconds] 11:53 < nmz787> kanzure: well misincorporation is a thin, with the error-prone PCR via manganese approach 11:54 < nmz787> kanzure: I was watching the video I recorded in NYC on DNA and microfluidics 11:54 < nmz787> and in that, a guy mentioned if you could synthesize repeats, and somehow later use something in inverse to remove the repeats 11:55 < nmz787> i.e. if you can't deliver a single base to a tDt... but 100 can be, then maybe you can find a polymerase that would skip 99 bases on replication to de-dupe 11:55 < nmz787> just a passing thought 11:56 < nmz787> kanzure: I'm sure nature will prove you wrong about no reason for skips 11:56 < nmz787> kanzure: when, idk... 12:52 -!- jaboja [~jaboja@jaboja.pl] has joined ##hplusroadmap 13:10 < kanzure> "Biological insights into muscular strength: Genetic findings in the UK biobank" https://www.biorxiv.org/content/early/2017/10/10/201020 https://twitter.com/biorxivpreprint/statuses/917812089938423808 13:11 < kanzure> "In our discovery analysis of 223,315 individuals, we identified 101 loci associated with grip strength at genome-wide significance (P<5e-8). Of these, 64 were associated (P<0.01 and consistent direction) also in the replication dataset (N=111,610). Many of the lead SNPs were located in or near genes known to have a function in developmental disorders (FTO, SLC39A8, TFAP2B, TGFA, CELF1, TCF4, ... 13:11 < kanzure> ...BDNF, FOXP1, KIF1B, ANTXR2), and one of the most significant genes based on a gene-based analysis (ATP2A1) encodes SERCA1, the critical enzyme in calcium uptake to the sarcoplasmic reticulum, which plays a major role in muscle contraction and relaxation. Further, we demonstrated a significant enrichment of gene expression in brain-related transcripts among grip strength associations." 13:14 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=c3ecec5e Bryan Bishop: add hand grip strength >> http://diyhpl.us/diyhpluswiki/genetic-modifications/ 13:50 -!- mindsForge [~nak@75-172-169-191.phnx.qwest.net] has quit [Quit: Leaving.] 14:32 -!- jaboja [~jaboja@jaboja.pl] has quit [Ping timeout: 240 seconds] 14:35 -!- WeirdTolkienishF [~Weird@unaffiliated/weirdtolkienishf] has quit [Read error: Connection reset by peer] 14:42 -!- darsie [~username@84-114-73-160.cable.dynamic.surfer.at] has quit [Ping timeout: 255 seconds] 14:51 -!- TinKode [~TinKode@unaffiliated/tinkode] has joined ##hplusroadmap 15:28 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has joined ##hplusroadmap 15:32 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has quit [Remote host closed the connection] 15:47 -!- pc_ [~pc@62.210.14.63] has joined ##hplusroadmap 15:50 -!- pc_ [~pc@62.210.14.63] has left ##hplusroadmap ["Quitte"] 16:00 -!- aeiousom1thing [~aeiousome@gateway/vpn/privateinternetaccess/aeiousomething] has quit [Ping timeout: 240 seconds] 16:00 -!- aeiousomething [~aeiousome@183.82.170.54] has joined ##hplusroadmap 16:08 -!- mindsForge [~nak@75-172-169-191.phnx.qwest.net] has joined ##hplusroadmap 16:13 -!- mindsForge [~nak@75-172-169-191.phnx.qwest.net] has quit [Remote host closed the connection] 16:14 -!- jaboja [~jaboja@jaboja.pl] has joined ##hplusroadmap 16:27 -!- strages [uid11297@gateway/web/irccloud.com/x-xcuduchvnsqlouuc] has joined ##hplusroadmap 16:28 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has joined ##hplusroadmap 16:30 -!- Darius [~quassel@66-215-89-229.dhcp.psdn.ca.charter.com] has joined ##hplusroadmap 16:33 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has quit [Remote host closed the connection] 16:35 -!- aeiousomething [~aeiousome@183.82.170.54] has quit [Ping timeout: 255 seconds] 16:37 < kanzure> .tw https://twitter.com/ClarksysCorner/status/917380974706679808 16:37 < yoleaux> Jean-Marc Aury - smaller yeast chromosomes (1 & 6) can be entirely covered by a single @nanopore read. #NanoSeq2017 (@ClarksysCorner) 16:37 < kanzure> .tw https://twitter.com/J_M_Aury/status/917473761389051905 16:37 < yoleaux> @mattloose @86Dominik @ClarksysCorner @nanopore Yes, two yeast chr were spanned by a single nanopore read from telomere to telomere (~220Kb). Could send the reads if interested! (@J_M_Aury, in reply to tw:917410699315503104) 16:37 < kanzure> .tw https://twitter.com/ZaminIqbal/status/917690820832251905 16:37 < yoleaux> First whole chromosomes to be sequenced in single reads, molecule passing through the pore end to end! @nanopore !! https://twitter.com/J_M_Aury/status/917473761389051905 (@ZaminIqbal) 16:37 < kanzure> .tw https://twitter.com/nanopore/status/917691026969645056 16:37 < yoleaux> Watch the talk here https://nanoporetech.com/resource-centre/talk/rapid-epi-genomic-classification-brain-tumors-using-nanopore-sequencing-0 https://twitter.com/clarksyscorner/status/917688935316418560 (@nanopore) 16:38 < kanzure> "Massively parallel de novo protein design for targeted therapeutics" http://www.nature.com/nature/journal/vaop/ncurrent/full/nature23912.html https://twitter.com/grocklin/status/913095168340877312 16:38 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has joined ##hplusroadmap 16:40 < kanzure> .tw https://twitter.com/gringene_bio/status/917732916502814720 16:40 < yoleaux> @Clive_G_Brown @ZaminIqbal @KevinADavies @nanopore > Human next I think you're being a tad optimistic that @nanopore can go from 200 kb single-molecule to 60 Mb without intermediate steps (@gringene_bio, in reply to tw:917730564383404032) 16:40 -!- jaboja [~jaboja@jaboja.pl] has quit [Ping timeout: 240 seconds] 17:07 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has quit [Read error: Connection reset by peer] 17:17 -!- Gurkenglas [~Gurkengla@dslb-094-223-135-191.094.223.pools.vodafone-ip.de] has quit [Ping timeout: 264 seconds] 17:19 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has joined ##hplusroadmap 17:29 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has quit [Remote host closed the connection] 17:36 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has joined ##hplusroadmap 17:44 -!- Darius [~quassel@66-215-89-229.dhcp.psdn.ca.charter.com] has quit [Remote host closed the connection] 17:49 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has quit [Remote host closed the connection] 18:01 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has joined ##hplusroadmap 18:12 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has quit [Remote host closed the connection] 18:12 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has joined ##hplusroadmap 18:29 -!- rpifan [~rpifan@73.106.74.255] has joined ##hplusroadmap 18:44 -!- yashgaroth [~yashgarot@2606:6000:cd4d:3300:f5e0:f867:a11d:8d52] has joined ##hplusroadmap 18:48 -!- delinquentme [~delinquen@h-66-167-121-75.snva.ca.dynamic.globalcapacity.com] has joined ##hplusroadmap 19:03 -!- streety [streety@2a01:7e00::f03c:91ff:feae:ded6] has quit [Quit: ZNC - http://znc.in] 19:08 < kanzure> yashgaroth: hi2you 19:13 -!- mindsForge [~nak@75-172-169-191.phnx.qwest.net] has joined ##hplusroadmap 19:16 -!- delinquentme [~delinquen@h-66-167-121-75.snva.ca.dynamic.globalcapacity.com] has quit [Quit: Leaving] 19:20 -!- docl [~docl@159.203.115.16] has quit [Read error: Connection reset by peer] 19:20 -!- docl [~docl@159.203.115.16] has joined ##hplusroadmap 19:28 < yashgaroth> oh hey 19:38 -!- Proteus [~Proteus@unaffiliated/proteus] has quit [Quit: Leaving.] 20:12 < kanzure> yep 20:23 -!- rpifan_ [~rpifan@73.106.75.83] has joined ##hplusroadmap 20:25 -!- rpifan [~rpifan@73.106.74.255] has quit [Ping timeout: 240 seconds] 20:27 < kanzure> .wik nail clubbing 20:27 < yoleaux> "Nail clubbing, also known as digital clubbing, is a deformity of the finger or toe nails associated with a number of diseases, mostly of the heart and lungs." — https://en.wikipedia.org/wiki/Nail_clubbing 20:34 < kanzure> wut, 20:34 < kanzure> https://blog.frontiersin.org/2017/06/12/blue-brain-team-discovers-a-multi-dimensional-universe-in-brain-networks/ 20:47 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has quit [Remote host closed the connection] 21:06 -!- HEx1 [~HEx@hexwab.plus.com] has quit [Remote host closed the connection] 22:14 -!- darsie [~username@84-114-73-160.cable.dynamic.surfer.at] has joined ##hplusroadmap 22:20 -!- augur [~augur@208.70.31.232] has joined ##hplusroadmap 22:29 -!- augur [~augur@208.70.31.232] has quit [Remote host closed the connection] 22:31 -!- mindsForge [~nak@75-172-169-191.phnx.qwest.net] has quit [Quit: Leaving.] 22:31 -!- augur [~augur@208.70.31.232] has joined ##hplusroadmap 22:49 -!- yashgaroth [~yashgarot@2606:6000:cd4d:3300:f5e0:f867:a11d:8d52] has quit [Quit: Leaving] 22:59 -!- augur [~augur@208.70.31.232] has quit [Quit: Leaving...] 23:03 -!- rpifan_ [~rpifan@73.106.75.83] has quit [Quit: Leaving] 23:36 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap --- Log closed Wed Oct 11 00:00:42 2017