--- Log opened Wed Oct 25 00:00:56 2017 00:07 -!- c0rw1n_ [~c0rw1n@cpc109847-bagu17-2-0-cust223.1-3.cable.virginm.net] has quit [Ping timeout: 240 seconds] 00:09 -!- c0rw1n_ [~c0rw1n@cpc109847-bagu17-2-0-cust223.1-3.cable.virginm.net] has joined ##hplusroadmap 00:22 -!- c0rw1n_ [~c0rw1n@cpc109847-bagu17-2-0-cust223.1-3.cable.virginm.net] has quit [Ping timeout: 248 seconds] 00:45 < nmz787> http://ieeexplore.ieee.org/document/4134977/ 00:45 < nmz787> .title 00:45 < yoleaux> Low-energy Electron-beam Lithography of ZEP-520 Positive Resist - IEEE Conference Publication 00:45 < nmz787> "At 10 keV ~ 20 keV energy, we were able to achieve line gratings of about 25 nm width and 80 nm pitch in ZEP-520 films of 180 nm-thickness on silicon substrate. It is found that the main limitation in achieving high resolution and dense pattern exposure at low energy is the electron forward scattering effect for thicker resist film. Using 60nm thickness of ZEP-520 resist, we have achieved 15 nm 00:46 < nmz787> line width with 60 nm pitch grating structures" 00:46 < nmz787> my SEM is 30keV 01:05 -!- esmerelda [~mabel@174-24-250-207.tukw.qwest.net] has quit [Ping timeout: 240 seconds] 01:06 -!- jtimon [~quassel@164.31.134.37.dynamic.jazztel.es] has quit [Ping timeout: 246 seconds] 01:12 -!- Gurkenglas [~Gurkengla@dslb-094-223-135-191.094.223.pools.vodafone-ip.de] has joined ##hplusroadmap 01:13 -!- pepesza [~pepesza@185.83.218.228] has quit [Quit: ZNC 1.6.3+deb1 - http://znc.in] 01:14 -!- rpifan [~rpifan@207-244-191-189-dhcp.mia.fl.atlanticbb.net] has quit [Ping timeout: 260 seconds] 01:30 -!- ebowden_ [~ebowden@110.141.11.39] has quit [Remote host closed the connection] 01:30 -!- esmerelda [~mabel@174-24-250-207.tukw.qwest.net] has joined ##hplusroadmap 01:33 -!- helleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has joined ##hplusroadmap 01:34 -!- CRM114 [~urchin@unaffiliated/urchin] has joined ##hplusroadmap 01:37 -!- hehelleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has quit [Ping timeout: 246 seconds] 01:37 -!- sachy [~sachy@nat.brmlab.cz] has quit [Quit: Leaving.] 01:43 -!- augur [~augur@199-116-74-126.PUBLIC.monkeybrains.net] has quit [Remote host closed the connection] 01:57 -!- darsie [~username@84-114-73-160.cable.dynamic.surfer.at] has joined ##hplusroadmap 02:12 -!- ebowden [~ebowden@2001:8003:1074:bc00:90d5:aae5:bb4c:6570] has joined ##hplusroadmap 02:19 -!- ebowden [~ebowden@2001:8003:1074:bc00:90d5:aae5:bb4c:6570] has quit [Ping timeout: 252 seconds] 02:31 -!- ebowden [~ebowden@2001:8003:1074:bc00:90d5:aae5:bb4c:6570] has joined ##hplusroadmap 02:31 -!- augur [~augur@2601:645:c100:1132:bc04:9c67:cfe1:f6bd] has joined ##hplusroadmap 02:37 -!- augur [~augur@2601:645:c100:1132:bc04:9c67:cfe1:f6bd] has quit [Ping timeout: 252 seconds] 02:39 -!- CRM114 [~urchin@unaffiliated/urchin] has quit [Remote host closed the connection] 02:58 -!- aeiousomething [~aeiousome@183.82.170.54] has joined ##hplusroadmap 03:21 < kanzure> .grave von neumann 03:21 < kanzure> hmph 03:34 < kanzure> some folks complaining about a stem cell study https://www.reddit.com/r/science/comments/78f3wg/antiaging_stem_cell_treatment_proves_successful/dotd0ep/ https://news.ycombinator.com/item?id=15547266 03:35 -!- bluebear_ [~dluhos@80.95.97.194] has joined ##hplusroadmap 04:07 -!- ebowden [~ebowden@2001:8003:1074:bc00:90d5:aae5:bb4c:6570] has quit [Remote host closed the connection] 04:19 -!- ebowden [~ebowden@110.141.11.39] has joined ##hplusroadmap 04:42 -!- aeiousom1thing [~aeiousome@gateway/vpn/privateinternetaccess/aeiousomething] has joined ##hplusroadmap 04:44 -!- aeiousomething [~aeiousome@183.82.170.54] has quit [Ping timeout: 240 seconds] 05:16 -!- jtimon [~quassel@164.31.134.37.dynamic.jazztel.es] has joined ##hplusroadmap 05:46 < archels> kanzure: https://awni.github.io/speech-recognition/ 05:52 < ebowden> “I look at these results (Fig. 2 from the journal article, supposedly demonstrating an improvement in frailty markers) and just see noise. No dose-response. No consistent benefit across measures for different treatment groups. 05:52 < ebowden> I would happily bet an amount of money that mattered to me that this result would fail to be replicated in a randomized, placebo-controlled study.” 06:03 -!- mindsForge [~nak@174-26-21-211.phnx.qwest.net] has joined ##hplusroadmap 06:04 -!- mindsForge [~nak@174-26-21-211.phnx.qwest.net] has quit [Client Quit] 06:14 < ebowden> "Every time there is a positive article on Reddit, the top comment is a statement like yours" 06:15 < ebowden> SirT6's response: 06:15 < ebowden> “Don't let cynicism get the better of you. I even made a post recently about how sometimes the breakthroughs you read about on Reddit are real: https://www.reddit.com/r/science/comments/6wzuzn/sometimes_something_actually_comes_of_the/ 06:15 < ebowden> There is lots of hype and plenty of bs out there. But don't become so jaded that you miss out on the good stuff!” 06:16 -!- Gurkenglas [~Gurkengla@dslb-094-223-135-191.094.223.pools.vodafone-ip.de] has quit [Ping timeout: 240 seconds] 06:42 < nsh> what cool things should a play with via rtl-sdr [nooelec e4000]? cc superkuh 06:47 < nsh> nm your page is pretty comprehensive 07:02 < JayDugger> Guilty as charged. That microfiction account usually has better stuff than the sexbot thread. 07:03 < kanzure> eliezer is asking for fat cell destruction methods https://twitter.com/Sam_Dumitriu/status/922072539974774784 07:04 < kanzure> wonder if he knows the brain is mostly fat 07:26 < kanzure> or about cxr3 antagonists. or downregulating IKK-beta. 07:30 -!- KVc [~kvc@unaffiliated/kvc] has joined ##hplusroadmap 07:32 -!- Gurkenglas [~Gurkengla@dslb-094-223-135-191.094.223.pools.vodafone-ip.de] has joined ##hplusroadmap 07:34 -!- c0rw1n_ [~c0rw1n@cpc109847-bagu17-2-0-cust223.1-3.cable.virginm.net] has joined ##hplusroadmap 07:35 < kanzure> "Overexpression of Fatty-Acid-𝜷-Oxidation-Related Genes Extends the Lifespan of Drosophila melanogaster" https://www.hindawi.com/journals/omcl/2012/854502/ 07:35 < kanzure> "Inflammation and mitochondrial fatty acid β-oxidation link obesity to early tumor promotion" http://www.pnas.org/content/106/9/3354.full 07:37 -!- TinKode [~TinKode@unaffiliated/tinkode] has quit [Quit: TinKode] 07:50 -!- TinKode [~TinKode@unaffiliated/tinkode] has joined ##hplusroadmap 07:51 -!- mindsForge [~nak@174-26-21-211.phnx.qwest.net] has joined ##hplusroadmap 07:53 -!- TinKode [~TinKode@unaffiliated/tinkode] has quit [Client Quit] 07:54 -!- sachy [~sachy@nat.brmlab.cz] has joined ##hplusroadmap 07:58 -!- rpifan [~rpifan@207-244-191-189-dhcp.mia.fl.atlanticbb.net] has joined ##hplusroadmap 08:05 < kanzure> https://cos.io/blog/community-driven-science-interview-eartharxiv-founders-chris-jackson-tom-narock-and-bruce-caron/ 08:06 < kanzure> "... many communities to launch preprint services in late 2016 (Socarxiv, PsyArXiv, engRxiv) and then another cluster in early 2017 (PaleoRxiv, AgriXiv, MindRxiv, SportRxiv, LawArXiv, etc.)" 08:07 < kanzure> just spam it all over why not. bleh. 08:08 < JayDugger> You do seem to get more from Twitter than I do, kanzure. 08:10 < JayDugger> I am trying (and failing) right now to avoid arguing with a basic income guarantee advocate by pretending the original post expressed wonder at automation trends. 08:12 < JayDugger> nsh, see http://corganlabs.com/blog/, the bitcoin by satellite stuff, and the darpa sdr hackfest (check the logs). 08:12 < kanzure> don't argue on twitter.. it's solely for baseless self-congratulation or whatever. 08:13 < JayDugger> Yeah, I have an opt-in "Regularly Rebarbative" collection on G+ where I post such. 08:14 < JayDugger> I maintain that Twitter is better in Japanese, but even then you still get "self-congratulation." 08:26 < heath> any ideas how companies like https://www.persistencemarketresearch.com/ go about researching a field to come up with estimated size and future growth? 08:27 < kanzure> fermi estimation probably 08:40 < kanzure> https://numenta.com/papers/why-does-the-neocortex-have-layers-and-columns/ 09:12 < maaku> heath: there's standard methods tought in MBA schools 09:12 < maaku> they're all junk though 09:12 < maaku> it's a lemon market 09:13 -!- Gurkenglas [~Gurkengla@dslb-094-223-135-191.094.223.pools.vodafone-ip.de] has quit [Ping timeout: 255 seconds] 09:36 -!- KVc [~kvc@unaffiliated/kvc] has quit [Ping timeout: 240 seconds] 09:52 -!- KVc [~kvc@unaffiliated/kvc] has joined ##hplusroadmap 09:59 < Aurelius> fermi estimation is the only real answer 09:59 < Aurelius> heath : I worked as a market research middle man--it's all lies and plagiarism 10:04 < heath> http://www.cyclotronroad.org/how-to-apply 10:05 < heath> thanks for the feedback on market research 10:14 < Aurelius> heath: the only people that might potentially have reasonable numbers are if you can find a market research firm that focuses, quite literally, on one field/subfield--and that's all they do 10:32 -!- gene-hacker [~tetrapod@c-24-131-17-249.hsd1.pa.comcast.net] has quit [Ping timeout: 248 seconds] 10:32 -!- aeiousom1thing [~aeiousome@gateway/vpn/privateinternetaccess/aeiousomething] has quit [Ping timeout: 246 seconds] 10:45 -!- rpifan [~rpifan@207-244-191-189-dhcp.mia.fl.atlanticbb.net] has quit [Ping timeout: 255 seconds] 11:40 -!- jtimon [~quassel@164.31.134.37.dynamic.jazztel.es] has quit [Remote host closed the connection] 11:50 -!- gene-hacker [~tetrapod@c-24-131-17-249.hsd1.pa.comcast.net] has joined ##hplusroadmap 12:01 -!- bluebear_ [~dluhos@80.95.97.194] has quit [Quit: Leaving.] 12:12 -!- augur [~augur@2600:380:857c:ff38:f544:3f96:3436:496] has joined ##hplusroadmap 12:57 -!- KVc [~kvc@unaffiliated/kvc] has quit [Ping timeout: 248 seconds] 13:12 -!- augur [~augur@2600:380:857c:ff38:f544:3f96:3436:496] has quit [Remote host closed the connection] 13:45 -!- esmerelda [~mabel@174-24-250-207.tukw.qwest.net] has quit [Ping timeout: 240 seconds] 13:46 -!- esmerelda [~mabel@174-24-250-207.tukw.qwest.net] has joined ##hplusroadmap 13:46 -!- jtimon [~quassel@164.31.134.37.dynamic.jazztel.es] has joined ##hplusroadmap 13:58 -!- sachy [~sachy@nat.brmlab.cz] has quit [Quit: Leaving.] 14:14 < kanzure> "Double spend races" https://arxiv.org/pdf/1702.02867.pdf 14:25 -!- augur [~augur@2600:380:442b:4d38:81ac:5273:8c17:9c88] has joined ##hplusroadmap 14:41 -!- jaboja [~jaboja@jaboja.pl] has joined ##hplusroadmap 14:43 -!- augur [~augur@2600:380:442b:4d38:81ac:5273:8c17:9c88] has quit [Remote host closed the connection] 14:48 -!- delinquentme [~delinquen@108-235-112-153.lightspeed.sntcca.sbcglobal.net] has joined ##hplusroadmap 14:56 -!- KVc [~kvc@unaffiliated/kvc] has joined ##hplusroadmap 14:58 -!- augur [~augur@199-116-74-126.PUBLIC.monkeybrains.net] has joined ##hplusroadmap 15:01 -!- augur [~augur@199-116-74-126.PUBLIC.monkeybrains.net] has quit [Remote host closed the connection] 15:02 -!- augur [~augur@199-116-74-126.PUBLIC.monkeybrains.net] has joined ##hplusroadmap 15:02 -!- delinquentme [~delinquen@108-235-112-153.lightspeed.sntcca.sbcglobal.net] has quit [Quit: Leaving] 15:32 < heath> ion torrent vs nanopore, which is currently more accurate and whish is faster? 15:32 < heath> s/whish/which 15:32 < heath> or just tell me to do my homework, that's reasonable 15:36 < heath> ah. https://www.hindawi.com/journals/bmri/2012/251364/ 15:36 < heath> Comparison of Next-Generation Sequencing Systems 15:37 < heath> "Nanopore sequencing possesses a number of fruitful advantages over existing commercialized next-generation sequencing technologies. Firstly, it potentially reaches long read length >5 kbp with speed 1 bp/ns [19]. Moreover, detection of bases is fluorescent tag-free. Thirdly, except the use of exonuclease for holding up ssDNA and nucleotide cleavage [24], involvement of enzyme is remarkably 15:37 < heath> obviated in nanopore sequencing [22]." 15:40 < heath> http://omicsomics.blogspot.com/2016/03/oxfords-no-thanks-ive-already-got-one.html 15:57 < nmz787> heath: ion torrent is a form of "seqeuncing by synthesis" so more indirection in getting the sequence data 15:58 < nmz787> heath: that said, oxford nanopore reads are apparently not reading single bases directly, due to the thickness of the nanopore (i.e. multiple bases block the through-hole current)... so I guess it is some de-noising algorithm that they are using to pull the single-base resolution data out of the multi-base reads 15:59 < nmz787> i.e. if the nanopore was 3 bases thick, it might read "AGT" but that would show up as something unique-enough to understand that it was composed of "A" "G" and "T" 16:00 < nmz787> i.e. AGT has a different signal effect vs ATT, AGG, ACC, ACT, etc... 16:00 < nmz787> idk how thick the nanopore is, to say how many combinations they have to try determining 16:17 < kanzure> "Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage" https://www.nature.com/nature/journal/vaap/ncurrent/full/nature24644.html 16:17 < kanzure> "RNA editing with CRISPR-Cas13" http://science.sciencemag.org/content/early/2017/10/24/science.aaq0180 16:17 < kanzure> via https://www.technologyreview.com/s/609203/crispr-20-is-here-and-its-way-more-precise/ 16:18 < kanzure> "We evolved a tRNA adenosine deaminase to operate on DNA when fused to a catalytically impaired CRISPR-Cas9. Extensive directed evolution and protein engineering resulted in seventh-generation ABEs (e.g., ABE7.10), that convert target A•T to G•C base pairs efficiently (~50% in human cells) with very high product purity (typically ≥ 99.9%) and very low rates of indels (typically ≤ ... 16:18 < kanzure> ...0.1%). ABEs introduce point mutations more efficiently and cleanly than a current Cas9 nuclease-based method, induce less off-target genome modification than Cas9, and can install disease-correcting or disease-suppressing mutations in human cells. Together with our previous base editors, ABEs advance genome editing by enabling the direct, programmable introduction of all four transition ... 16:18 < kanzure> ...mutations without double-stranded DNA cleavage." 16:23 < kanzure> and, 16:23 < kanzure> "Type VI CRISPR-Cas systems contain the programmable single-effector RNA-guided RNases Cas13. Here, we profile Type VI systems to engineer a Cas13 ortholog capable of robust knockdown and demonstrate RNA editing by using catalytically-inactive Cas13 (dCas13) to direct adenosine to inosine deaminase activity by ADAR2 to transcripts in mammalian cells. This system, referred to as RNA Editing ... 16:23 < kanzure> ...for Programmable A to I Replacement (REPAIR), which has no strict sequence constraints, can be used to edit full-length transcripts containing pathogenic mutations. We further engineer this system to create a high specificity variant and minimize the system to facilitate viral delivery." 16:29 -!- jaboja [~jaboja@jaboja.pl] has quit [Ping timeout: 240 seconds] 16:30 < nmz787> didn't fenn recently post that one? 16:31 < nmz787> or maybe you re-tweeted it 16:31 < nmz787> aside from that... we should make a plant that screams when it's cut/chewed 16:31 < nmz787> so vegans reconsider their species-ism 16:32 < nmz787> there's a restaurant that is all vegan, and from their menu it almost seesm like they're aiming to maximize number of species used 16:32 < kanzure> no this is a different one from today 16:32 < kanzure> the previous one was a cytidine deaminase 16:32 < kanzure> this is an adenosine deaminase 16:33 < nmz787> I def saw the one "without cleavage" 16:33 < nmz787> maybe it had that too? 16:34 < kanzure> the vSLENDR thing? 16:35 < nmz787> nah, just grepped, I guess the prev paper also mentioned without cleavage 16:39 -!- rpifan [~rpifan@207-244-191-189-dhcp.mia.fl.atlanticbb.net] has joined ##hplusroadmap 16:43 < nmz787> nature24644.html 16:43 < nmz787> grrr 16:43 < nmz787> http://www.diatome.ch/en/products/pdf/perfectloop_flyer_ENG.pdf 16:43 < nmz787> that's what I meant 16:43 < nmz787> "The PERFECT LOOP allows you to pick up sections consistently, without causing them any damage" 16:50 < rpifan> adderal has been good 17:07 < nmz787> adderal is so 1990s 17:08 < night> the cool kids do ritalin now 17:08 < rpifan> im prescribed 17:08 < rpifan> for my narcolepsy 17:08 < kanzure> fudan http://2017.igem.org/Giant_Jamboree/Program/Abstracts 17:13 -!- strages [uid11297@gateway/web/irccloud.com/x-wnixkolsosbnoqgx] has quit [Quit: Connection closed for inactivity] 17:28 < heath> nmz787: re: "I guess it is some de-noising algorithm that they are using to pull the single-base resolution data out of the multi-base reads"... see last link from me. 17:30 < heath> nmz787: thanks for feedback. it's nice to actually have feedback 17:30 < heath> for anyone interested in functional programming, here's a giant link dump from me: https://dailydripcommunity.slackarchive.io/fp/ 17:56 < nmz787> heath: reading now 17:56 < nmz787> just got to a slide mentioning a neural network 17:56 < nmz787> ... 18:14 -!- HEx1 [~HEx@hexwab.plus.com] has quit [Ping timeout: 258 seconds] 18:31 -!- mrdata [~mrdata@unaffiliated/mrdata] has joined ##hplusroadmap 18:44 -!- yashgaroth [~yashgarot@2606:6000:cd4d:3300:f5e0:f867:a11d:8d52] has joined ##hplusroadmap 18:45 < kanzure> yashgaroth: adenosine deaminase in the research today 18:46 < rpifan> how do i fix my misaligned teeth with some genes 18:46 < fenn> hire a dentist with good genes 18:47 < rpifan> idk 18:47 < rpifan> my right tooth is hurting 18:47 < rpifan> cause of the bad movement now 18:47 < yashgaroth> RNA editing, what's even the point 18:47 < rpifan> i certainly cant get barces 18:47 < rpifan> brace 18:48 < kanzure> yashgaroth: i dunno, rna interference? 18:48 < yashgaroth> then just do RNA interference bleh, anyway I'll check the paper out 18:55 < kanzure> .wik strand displacement 18:55 < yoleaux> kanzure: Sorry, that command (.wik) crashed. 18:55 < kanzure> perfect. 18:57 < kanzure> fenn: https://scholar.google.com/scholar?q=strand+displacement+adder&hl=en&as_sdt=0&as_vis=1&oi=scholart&sa=X&ved=0ahUKEwiOzbPwl43XAhVhxFQKHdc4A9IQgQMIJTAA 18:57 -!- KVc [~kvc@unaffiliated/kvc] has quit [Ping timeout: 248 seconds] 18:58 < kanzure> "A full-adder based on reconfigurable DNA-hairpin inputs and DNAzyme computing modules" https://www.researchgate.net/profile/Ron_Orbach/publication/263506910_A_Full-Adder_Based_on_Reconfigurable_DNA-Hairpin_Inputs_and_DNAzyme_Computing_Modules/links/54ff60cc0cf2672e2246280b.pdf 18:59 < fenn> ERROR 429: Too Many Requests 19:00 < kanzure> oh. 19:00 < heath> http://pubs.rsc.org/en/content/articlelanding/2014/sc/c4sc00914b#!divAbstract 19:00 < heath> ^ 19:00 < heath> fenn 19:00 < kanzure> for someone who's sleeping you sure are posting a bunch of research links 19:01 -!- darsie [~username@84-114-73-160.cable.dynamic.surfer.at] has quit [Ping timeout: 248 seconds] 19:01 < heath> i want to be sleeping, but alex decided to make banana nut bread, so i'm just checking in on irc 19:01 < kanzure> fenn doesn't believe in dna computation 19:01 < heath> hah 19:01 < nmz787> .title 19:01 < yoleaux> A full-adder based on reconfigurable DNA-hairpin inputs and DNAzyme computing modules - Chemical Science (RSC Publishing) 19:02 < heath> curious about the thought process 19:02 < nmz787> researchgate worked for me 19:02 < kanzure> RECALIBRATE https://www.youtube.com/watch?v=kC6Cu6PAlpo 19:02 < heath> i need to be sleeping. every other sentence is incomprehensible at this point 19:02 < nmz787> heath: have you done anything like an added in a SAT solver? 19:02 < nmz787> haha 19:02 < nmz787> ttyl then 19:03 < fenn> is it just me or is this abstract intentionally difficult to read 19:03 < heath> a better paper... 19:03 < kanzure> all abstracts are intentionally shit 19:03 < kanzure> lest the reader might steal an idea from them 19:05 < fenn> "By introducing all the three inputs the sequential inter-input hybridization leads to the reconfiguration of the inputs into polymer wires." wtf is this even 19:05 < heath> DNA as a universal substrate for chemical kinetics 19:05 < heath> http://www.pnas.org/content/107/12/5393.full.pdf 19:06 < heath> that's kind of the foundational paper on which most of the dna computing research is based on 19:06 < heath> most of the current dna computing research 19:06 < heath> at least, if you're using dna strand displacement 19:07 < heath> nmz787: i haven't used an adder in a sat solver, why do you ask? 19:07 < nmz787> it seems relevant to the DNA computing 19:07 < nmz787> transforming logic into vastly different abstractions 19:08 < kanzure> heath: nmz787: i recommend making a google doc and listing out all the ideas. or a spreadsheet, and then we each weight the different projects using our own scoring system. 19:08 < nmz787> (or at least seemingly vastly different) 19:12 < kanzure> nmz787: heath: what you guys need to do is figure out the maximum amount of opportunity that you can seize with only $5k, $10k, $20k, etc. if the prototype isn't whizbang enough to get superinvestment from that, then maybe pick a different project. we have many projects on the (metaphorical) list. so need an actual physical list. 19:15 < heath> i'm interested in dna data storage. 19:15 < heath> starting with synthesis first 19:18 < fenn> you could probably do electrochemical synthesis with an arduino and the appropriate chemicals 19:18 < kanzure> i am sorting out the dna data storage thing at the moment, trying to see if i can add people to the project 19:19 -!- Gurkenglas [~Gurkengla@dslb-094-223-135-191.094.223.pools.vodafone-ip.de] has joined ##hplusroadmap 19:19 < kanzure> but you both might have to settle for working on e.g. the speech recognition project or a generic directed evolution play (which nobody is doing yet wtf) 19:20 < fenn> evolution is a slippery beast 19:20 < fenn> it's very good at satisfying the constraints in the wrong way 19:21 < fenn> half the battle is figuring out how to implement the selection process 19:21 < nmz787> play as in performance art on a stage? 19:21 < nmz787> 'directed evolution... the play' 19:22 < fenn> a hip-hop musical 19:22 < nmz787> definitely 19:24 < kanzure> fenn: there are many many low-hanging fruits in many industries that use bacteria 19:25 < kanzure> or anything using enzymes 19:25 < kanzure> or anything that uses ... life. 19:25 < kanzure> and often it's the same physical setup anyway 19:25 < kanzure> so you can get costs down really low by optimizing shared infrastructure/design 19:27 < ebowden> http://www.smbc-comics.com/ 19:27 < ebowden> http://www.smbc-comics.com/comics/1508937349-20171025-fixed1.png 19:29 < nmz787> kanzure: sweatshop labor uses life 19:29 < kanzure> sure 19:30 -!- HEx [~HEx@hexwab.plus.com] has joined ##hplusroadmap 19:30 < kanzure> this way, you can stay ahead of the machines 19:30 -!- HEx is now known as Guest57714 19:33 -!- mindsForge [~nak@174-26-21-211.phnx.qwest.net] has quit [Quit: Leaving.] 19:36 < ebowden> kanzure, I suppose people could use genetically engineered slaves that aren't technically human. 19:37 < ebowden> In the current day, this probably be far more expensive than just automating whatever process they are supposed to be used for. 19:37 < ebowden> *this would probably be far 19:37 < kanzure> that's not quite what heath is asking for... he wants something that can get him income within the next 3-6 weeks. 19:38 < ebowden> Set up a tiny factory that manufactures sex toys. 19:39 < fenn> could you explain the thought process that resulted in that being presented as a useful option? 19:40 < ebowden> The sex toys one? 19:40 < fenn> ya 19:40 < ebowden> People buy sex toys. 19:40 < ebowden> A lot. 19:40 < kanzure> requesting stack trace 19:40 < ebowden> And many are sold for a decent markup. 19:41 < fenn> people also buy hot dogs and beer 19:41 < ebowden> Hmm. Heath, do you know anything about chemistry? 19:41 < ebowden> He could also brew and sell beer. 19:41 -!- docl [~docl@159.203.115.16] has quit [Read error: Connection reset by peer] 19:41 -!- docl [~docl@159.203.115.16] has joined ##hplusroadmap 19:41 < ebowden> What he chooses to do depends on what he might actually be able to do differently. 19:42 < ebowden> Differently in such a way as to actually be able to break into the market. 19:42 < ebowden> Heath, there is always prostitution. 19:42 < ebowden> Some scientists have payed for their research that way. 19:43 < fenn> yeah stand around on a street corner with a sign "will fuck for DNA" 19:43 < kanzure> you guys are bad at this 19:44 < ebowden> Are you going to tell me that prostitution isn't a good way to make money now? 19:45 < fenn> it isn't a good way to make money 19:45 < heath> i know of at least 2 people highly interested in fermentation. one who knows a little more about the science then the guy who wrote the book on it 19:45 < ebowden> Oh, well you might be able to make a very tasty beer then. 19:45 < heath> already have 19:45 < ebowden> What do you want this money for? 19:46 < heath> i don't care about money 19:46 < ebowden> Then why do you need a way to make more of it? 19:46 < heath> i didn't say i did 19:46 < ebowden> Oh. 19:46 < ebowden> Well I have no idea where this conversation came from. 19:46 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 240 seconds] 19:47 < kanzure> fuck off 19:47 < ebowden> Did I say something wrong kanzure? 19:47 < kanzure> can't believe i have to deal with this 19:47 < kanzure> yes 19:47 < ebowden> What mean thing did I say? 19:48 < kanzure> alright now i know you're trolling 19:48 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 19:48 < ebowden> I have ASD, these things are very difficult for me. 19:48 < ebowden> Was it the prostitution suggestion? 19:49 -!- mrdata [~mrdata@unaffiliated/mrdata] has quit [Read error: Connection reset by peer] 19:49 < ebowden> I suppose that could be seen as mean and cruel. 19:49 < kanzure> you're not mean you're just an idiot 19:49 < kanzure> mean would be an improvement 19:49 < kanzure> anyway, 19:49 < fenn> mean would require actually knowing something about heath 19:49 < kanzure> er that too. 19:50 < ebowden> So, this conversation was not about raising funds for some cool project? 19:50 -!- aeiousomething [~aeiousome@gateway/vpn/privateinternetaccess/aeiousomething] has joined ##hplusroadmap 19:50 < kanzure> huh? 19:51 < ebowden> that's not quite what heath is asking for... he wants something that can get him income within the next 3-6 weeks. 19:51 < ebowden> OH. Maybe he just needs the income to live. 19:51 < kanzure> what does that have to do with raising funds? 19:52 < kanzure> what kind of aspie are you anyway 19:52 < ebowden> Income can be saved up kanzure. 19:52 < ebowden> The literal hand flapping, rocking back and forth sort. 19:53 < kanzure> so is everyone else in here. that doesn't explain it. 19:54 < ebowden> I very much doubt that, but I suppose I also have a poor brain-to-keyboard filter. 19:55 < fenn> <- not aspie, only an aspirational aspie 19:55 < kanzure> my mistake 19:56 < ebowden> lol 19:57 < ebowden> People avoid me on trams because I have the mannerisms one expects of someone with mental retardation. 19:57 < kanzure> i don't care 19:57 < fenn> i have a lot of sensory issues, not sure if it's related 19:58 < ebowden> What are your sensory issues? 19:59 < fenn> over sensitive to smells, unable to ignore noise, touching rough things hurts 19:59 < fenn> like i can't use a wooden pencil because of the sound it makes on paper 20:00 < ebowden> I used to have high sensitivity to noises like that. 20:00 < kanzure> way to stay on topic 20:00 < ebowden> It seems to have massively lowered. 20:02 < ebowden> Pardon me my liege. 20:02 < ebowden> heath, what would you say was so delicious about your beer? 20:05 < fenn> hmm well that's enough reading about strand displacement for one day. now to let it simmer 20:10 < kanzure> heath: nmz787: you might have to work on a project that nets you a bunch of money even if it isn't dna synthesis 20:10 < nmz787> I hate the feeling of gypsum or dry corn starch 20:10 < heath> ebowden: probably carbonic anhydrase if i had to guess 20:11 < ebowden> A very delicious beer could make you a decent income. 20:11 < heath> kanzure: this is more of a hobby, honestly 20:13 < kanzure> beer? yes 20:13 < heath> i'm talking about dna based data storage 20:16 -!- aeiousomething [~aeiousome@gateway/vpn/privateinternetaccess/aeiousomething] has quit [Quit: leaving] 20:17 -!- aeiousomething [~aeiousome@gateway/vpn/privateinternetaccess/aeiousomething] has joined ##hplusroadmap 20:22 < nmz787> .wik graphene nanoribbons 20:22 < yoleaux> "Graphene nanoribbons (GNRs, also called nano-graphene ribbons or nano-graphite ribbons) are strips of graphene with width less than 50 nm. Graphene ribbons were introduced as a theoretical model by Mitsutaka Fujita and coauthors to examine the edge and nanoscale size effect in graphene." — https://en.wikipedia.org/wiki/Graphene_nanoribbons 20:26 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has quit [Ping timeout: 255 seconds] 20:28 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has joined ##hplusroadmap 20:32 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has quit [Ping timeout: 240 seconds] 20:47 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has joined ##hplusroadmap 20:57 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has quit [Ping timeout: 248 seconds] 21:09 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 248 seconds] 21:25 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 21:49 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 260 seconds] 21:52 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has joined ##hplusroadmap 22:00 -!- c0rw1n_ [~c0rw1n@cpc109847-bagu17-2-0-cust223.1-3.cable.virginm.net] has quit [Quit: Leaving] 22:02 -!- jtimon [~quassel@164.31.134.37.dynamic.jazztel.es] has quit [Ping timeout: 240 seconds] 22:03 -!- c0rw1n_ [~c0rw1n@cpc109847-bagu17-2-0-cust223.1-3.cable.virginm.net] has joined ##hplusroadmap 22:03 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 22:11 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has quit [Ping timeout: 248 seconds] 22:30 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has joined ##hplusroadmap 22:30 -!- yashgaroth [~yashgarot@2606:6000:cd4d:3300:f5e0:f867:a11d:8d52] has quit [Quit: Leaving] 22:48 -!- aeiousom1thing [~aeiousome@183.82.170.54] has joined ##hplusroadmap 22:49 -!- aeiousomething [~aeiousome@gateway/vpn/privateinternetaccess/aeiousomething] has quit [Ping timeout: 240 seconds] 22:50 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has quit [Ping timeout: 264 seconds] 22:53 -!- aeiousom1thing [~aeiousome@183.82.170.54] has quit [Ping timeout: 240 seconds] 22:56 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has joined ##hplusroadmap 22:59 -!- aeiousomething [~aeiousome@223.237.47.177] has joined ##hplusroadmap 23:16 -!- aeiousomething [~aeiousome@223.237.47.177] has quit [Ping timeout: 240 seconds] 23:19 -!- aeiousomething [~aeiousome@183.82.170.54] has joined ##hplusroadmap 23:21 -!- aeiousom1thing [~aeiousome@gateway/vpn/privateinternetaccess/aeiousomething] has joined ##hplusroadmap 23:23 < nmz787> https://cdr.lib.unc.edu/indexablecontent/uuid:da41c21d-a148-4906-81fe-c4b4461f8afd 23:24 -!- aeiousomething [~aeiousome@183.82.170.54] has quit [Ping timeout: 255 seconds] 23:24 < nmz787> oO, this one is pretty nice 23:24 < nmz787> heath ^ 23:24 < nmz787> "DEVELOPMENT OF NANOFLUIDIC DEVICES FOR SINGLE-MOLECULE DNA DIAGNOSTICS" 23:30 -!- Gurkenglas [~Gurkengla@dslb-094-223-135-191.094.223.pools.vodafone-ip.de] has quit [Ping timeout: 240 seconds] --- Log closed Thu Oct 26 00:00:21 2017