--- Log opened Thu Oct 26 00:00:21 2017 --- Day changed Thu Oct 26 2017 00:00 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-almbpkwjnsyyuoaz] has joined ##hplusroadmap 01:11 -!- rpifan [~rpifan@207-244-191-189-dhcp.mia.fl.atlanticbb.net] has quit [Ping timeout: 248 seconds] 01:22 -!- rpifan [~rpifan@207-244-191-189-dhcp.mia.fl.atlanticbb.net] has joined ##hplusroadmap 01:23 -!- Gurkenglas [~Gurkengla@dslb-094-223-135-191.094.223.pools.vodafone-ip.de] has joined ##hplusroadmap 01:26 -!- rpifan [~rpifan@207-244-191-189-dhcp.mia.fl.atlanticbb.net] has quit [Ping timeout: 258 seconds] 01:33 -!- hehelleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has joined ##hplusroadmap 01:37 -!- helleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has quit [Ping timeout: 248 seconds] 01:41 -!- Gurkenglas [~Gurkengla@dslb-094-223-135-191.094.223.pools.vodafone-ip.de] has quit [Ping timeout: 258 seconds] 01:50 < kanzure> had a dream where aubrey de grey's home was nuked :-( 01:58 < fenn> had a dream i was working in an iridium mine and everyone was getting cancer 01:58 < fenn> WHAT DOES IT MEAN 01:58 < kanzure> it means data is toxic 01:59 < kanzure> OK looks like i will be able to get heath/nmz787 into the dna data storage project according to email from 5 minutes ago 01:59 < kanzure> "Oh fuck really? hmmm... I think his house is pretty far from an area that would take a direct hit." you guys don't get it, his house was the target. 02:00 < pasky> how is your speech reco project going? 02:01 < kanzure> struggling to find someone to work on it 02:01 < kanzure> everyone more interested in lofty dna ideas that don't work 02:02 < kanzure> surrounded by delusionals on all 23 sides, send help asp 02:08 -!- aeiousom1thing [~aeiousome@gateway/vpn/privateinternetaccess/aeiousomething] has quit [Ping timeout: 240 seconds] 02:37 -!- augur [~augur@199-116-74-126.PUBLIC.monkeybrains.net] has quit [Remote host closed the connection] 02:44 < ebowden> What lofty, unviable DNA ideas? 03:04 -!- darsie [~username@84-114-73-160.cable.dynamic.surfer.at] has joined ##hplusroadmap 03:08 -!- aeiousomething [~aeiousome@gateway/vpn/privateinternetaccess/aeiousomething] has joined ##hplusroadmap 03:12 -!- abetusk [~abe@68.175.143.22] has quit [Ping timeout: 240 seconds] 03:19 -!- augur 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[Ping timeout: 248 seconds] 06:05 -!- aeiousomething [~aeiousome@gateway/vpn/privateinternetaccess/aeiousomething] has joined ##hplusroadmap 06:13 < kanzure> ebowden: they have been discussed 06:19 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 252 seconds] 06:35 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 06:56 -!- aeiousom1thing [~aeiousome@gateway/vpn/privateinternetaccess/aeiousomething] has joined ##hplusroadmap 06:57 -!- aeiousomething [~aeiousome@gateway/vpn/privateinternetaccess/aeiousomething] has quit [Ping timeout: 246 seconds] 07:23 -!- mindsForge [~nak@174-26-123-39.phnx.qwest.net] has joined ##hplusroadmap 07:30 -!- strages [uid11297@gateway/web/irccloud.com/x-vvokmfkzbedxxgco] has joined ##hplusroadmap 07:39 -!- rpifan [~rpifan@207-244-191-189-dhcp.mia.fl.atlanticbb.net] has joined ##hplusroadmap 07:56 -!- Gurkenglas [~Gurkengla@dslb-094-223-135-191.094.223.pools.vodafone-ip.de] has joined ##hplusroadmap 07:58 -!- jtimon [~quassel@164.31.134.37.dynamic.jazztel.es] has joined ##hplusroadmap 08:12 < JayDugger> Hm. 08:12 < JayDugger> !new Call of Cthulhu - Delta Green - A Voice from the Wilderness (pyramid article).pdf 08:12 < JayDugger> Shit. 08:24 < fltrz> lol, I just spent a day making a c spanner from scrap steel, in order to fix my bicycle 08:24 < fltrz> its got this old sturmey archer internal gear 3 speed hub 08:26 -!- JayDugger [~jwdugger@47.185.237.246] has quit [Quit: Leaving.] 08:26 < fltrz> most disassembly videos just show how to open it with a light tap from hammer and punch, since that didnt work for me I build the spanner (which otherwise cost ~ $100) 08:27 < fltrz> I finished the spanner and it fits perfectly, and ridiculous long leverage too, however my hub is so tight I now need to reassemble the spokes and wheel in order to get similar leverage on the hub... 08:28 < fltrz> I think the previous owner of the bike was paranoid about it opening up while riding and either glued the threads or used a spanner and a hammer or something unnecessary 08:44 -!- augur [~augur@2601:645:c100:1132:d511:68b7:35f8:c5c7] has joined ##hplusroadmap 08:44 -!- CRM114 [~urchin@unaffiliated/urchin] has quit [Remote host closed the connection] 09:14 -!- Gurkenglas [~Gurkengla@dslb-094-223-135-191.094.223.pools.vodafone-ip.de] has quit [Ping timeout: 255 seconds] 09:20 -!- Guest76371 is now known as abetusk 10:16 -!- augur [~augur@2601:645:c100:1132:d511:68b7:35f8:c5c7] has quit [Remote host closed the connection] 10:18 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=f81b9c9a Bryan Bishop: mention adenosine deaminase >> http://diyhpl.us/diyhpluswiki/gene-editing/ 10:28 -!- augur [~augur@2601:645:c100:1132:50c0:ce28:6853:3806] has joined ##hplusroadmap 10:33 -!- augur [~augur@2601:645:c100:1132:50c0:ce28:6853:3806] has quit [Ping timeout: 252 seconds] 11:01 -!- rpifan [~rpifan@207-244-191-189-dhcp.mia.fl.atlanticbb.net] has quit [Ping timeout: 240 seconds] 11:10 < heath> that's great news kanzure 11:11 < kanzure> you should figure out what you want your role to be 11:17 < heath> ok 11:17 < heath> nmz787: thanks for the link 11:27 -!- bluebear_ [~dluhos@80.95.97.194] has quit [Quit: Leaving.] 12:14 < nmz787> kanzure: well I did start training the deepspeech network here using the TED data... so in some sense I started working on it 12:28 < kanzure> and fenn poked at it 12:30 < heath> "Chain and conformation stability of solid-state DNA: implications for room temperature storage" https://www.ncbi.nlm.nih.gov/pubmed/19969539 12:30 < heath> "Indeed, below about 500 bp, DNA fragments underwent a very slow evolution (almost suppressed in the presence of trehalose) which could end in an irreversible denaturation." 12:37 -!- mindsForge [~nak@174-26-123-39.phnx.qwest.net] has quit [Quit: Leaving.] 12:44 < kanzure> heath: it would be really helpful if you could make an index of fusion proteins from the literature, especially anything regarding methyltransferases, deaminases, alpha-helice structures, etc. 12:50 < heath> noted. thanks 12:51 < nmz787> good thing 110 C is pretty far outside most operating specs "However, the results in Figure 3 suggested that upon heating at 110°C, some of the small DNA fragments underwent irreversible denaturation." 12:54 < nmz787> I don't have the best feeling about this paper 12:54 < nmz787> something seems a bit funky with their reasoning, or something I don't get at the moment about i 12:54 < nmz787> it 12:54 < nmz787> can't dig in more now 13:02 < nmz787> heath you might also look this up 13:02 < nmz787> .wik solid oxide fuel cell 13:02 < yoleaux> "A solid oxide fuel cell (or SOFC) is an electrochemical conversion device that produces electricity directly from oxidizing a fuel." — https://en.wikipedia.org/wiki/Solid_oxide_fuel_cell 13:31 -!- Gurkenglas [~Gurkengla@dslb-094-223-135-191.094.223.pools.vodafone-ip.de] has joined ##hplusroadmap 14:01 -!- mindsForge [~nak@174-26-123-39.phnx.qwest.net] has joined ##hplusroadmap 14:07 -!- augur [~augur@2600:380:461b:941:3191:3acd:2f25:8145] has joined ##hplusroadmap 14:08 < mrdata_> a solid fuel as opposed to a liquid one, then i guess 14:22 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has quit [Ping timeout: 252 seconds] 14:22 < kanzure> grocery store shelf-scanning robot http://www.bossanova.com/ 14:30 < kanzure> "Bottled vs canned beer: do they really taste different?" http://www.mdpi.com/2306-5710/2/4/25 14:31 < kanzure> "On the rheology of cats" https://www.drgoulu.com/wp-content/uploads/2017/09/Rheology-of-cats.pdf 14:31 -!- augur [~augur@2600:380:461b:941:3191:3acd:2f25:8145] has quit [Remote host closed the connection] 14:43 -!- augur [~augur@199-116-74-126.PUBLIC.monkeybrains.net] has joined ##hplusroadmap 14:45 -!- augur [~augur@199-116-74-126.PUBLIC.monkeybrains.net] has quit [Remote host closed the connection] 14:46 -!- augur [~augur@199-116-74-126.PUBLIC.monkeybrains.net] has joined ##hplusroadmap 14:48 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has joined ##hplusroadmap 14:59 < nmz787> n=151 and n=29 for the beer thing 14:59 < nmz787> why didn't they do HPLC and ion mass spec? 14:59 < nmz787> err, rather, let's see that paper 15:01 -!- Burnin8 [~Burn@pool-96-241-130-178.washdc.fios.verizon.net] has joined ##hplusroadmap 15:04 -!- Burn_ [~Burn@pool-96-241-130-178.washdc.fios.verizon.net] has quit [Ping timeout: 240 seconds] 15:13 -!- mindsForge [~nak@174-26-123-39.phnx.qwest.net] has quit [Remote host closed the connection] 15:37 -!- Guest57714 [~HEx@hexwab.plus.com] has quit [Ping timeout: 248 seconds] 15:43 -!- HEx [~HEx@hexwab.plus.com] has joined ##hplusroadmap 15:43 -!- HEx is now known as Guest52011 16:16 -!- preview [~quassel@2407:7000:842d:4000::3] has joined ##hplusroadmap 16:18 -!- Gurkenglas [~Gurkengla@dslb-094-223-135-191.094.223.pools.vodafone-ip.de] has quit [Ping timeout: 258 seconds] 16:49 -!- gene-hacker [~tetrapod@c-24-131-17-249.hsd1.pa.comcast.net] has quit [Ping timeout: 240 seconds] 16:50 -!- mindsForge [~nak@174-26-123-39.phnx.qwest.net] has joined ##hplusroadmap 16:50 -!- gene-hacker [~tetrapod@c-24-131-17-249.hsd1.pa.comcast.net] has joined ##hplusroadmap 16:50 -!- strages [uid11297@gateway/web/irccloud.com/x-vvokmfkzbedxxgco] has quit [Quit: Connection closed for inactivity] 17:03 < kanzure> gene-hacker: yo 17:03 < gene-hacker> hey 17:15 < gene-hacker> I wonder if this trend has continued: https://twitter.com/3d_printers/status/14590427189477376 17:16 < kanzure> .tw 17:16 < yoleaux> Inkjet Moore’s law: Every 18 months Inkjet heads “double in speed; halve in price” #Objet co-owns 3D inkjet tech. http://bit.ly/dTdg3Q (@3d_printers) 17:17 < kanzure> a bunch of people have been telling me that inkjet printhead density capped out a few decades ago because nobody needs higher resolution (for human-consumable print media) 17:24 < gene-hacker> there's still a need for speed 17:24 < gene-hacker> people still want to print spam mail and stuff faster 17:24 < kanzure> fair 17:25 < kanzure> yea i have been looking, and most places don't run nozzles faster than like 50 kHz 17:25 < kanzure> and 1 MHz was tested but "heating" 17:25 < kanzure> so... they haven't discovered the virtues of cooling and heat management.. 17:26 < gene-hacker> you can buy 1 MHz piezos 17:26 < gene-hacker> for making fog and humidifying the air 17:26 < kanzure> possibly they limit the firing rate because positional accuracy limitations on moving the surface and/or printhead 17:27 < kanzure> no that doesn't make sense. hmm. 17:27 < gene-hacker> driving electronics then? 17:27 < kanzure> electronics for 1 MHz should be doable... 17:27 < kanzure> where is captain hindsight when you need him 17:37 -!- helleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has joined ##hplusroadmap 17:39 -!- hehelleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has quit [Ping timeout: 240 seconds] 17:42 -!- CaptHindsight [~2020@unaffiliated/capthindsight] has joined ##hplusroadmap 17:42 < CaptHindsight> printhead overheating? 17:43 < CaptHindsight> let the smoke out? 17:43 < CaptHindsight> kanzure: ^^ 17:46 < CaptHindsight> you can only squeeze fluids through an orifice so fast 17:48 < kanzure> CaptHindsight: hi. yes, i am wondering why they don't do cooling. 17:49 < kanzure> gene-hacker: ping 17:50 < gene-hacker> probably because it's difficult to 17:51 < kanzure> just blast liquid nitrogen at it, right? right? 17:51 < CaptHindsight> it depends on what you jetting 17:52 -!- hazzy [6bc258ef@gateway/web/cgi-irc/kiwiirc.com/ip.107.194.88.239] has joined ##hplusroadmap 17:52 < CaptHindsight> UV fluids typically use heated heads to lower the fluids viscosity 17:52 < kanzure> CaptHindsight: i'm also wondering about costs for engineering >100k nozzles or something 17:52 < CaptHindsight> 100khz nozzels? 17:52 < kanzure> yes but i meant 100,000 nozzles 17:53 < CaptHindsight> in what area? 17:53 < kanzure> dealer's choice :-) 17:53 < CaptHindsight> 100K linear array, 100 x 1000?? 17:53 < kanzure> hmm yeah i would be okay with linear array 17:57 < CaptHindsight> the fastest heads out have ~5k nozzles and fire up to ~60khz, thats around 300 million drops per second 17:57 < kanzure> so.. why 5k? is this an engineering challenge of some kind? 17:58 < CaptHindsight> think about the data bandwidth 17:58 < CaptHindsight> and the power required to fire 5k at once 17:58 < CaptHindsight> so you stitch heads together 17:59 < kanzure> data bandwidth- trivial, this ain't a data center 17:59 < kanzure> power-- trivial, we're not smelting steel 17:59 < CaptHindsight> one can already print with inkjet as fast as an offset press can run 18:04 < CaptHindsight> if the nozzles are binary then your transferring 300m bits per second min into the head 18:05 < kanzure> caching can do this 18:06 < CaptHindsight> you would have much to gain from building some actual hardware 18:06 -!- preview [~quassel@2407:7000:842d:4000::3] has quit [Remote host closed the connection] 18:07 < CaptHindsight> firing speeds have little to do with overheating 18:07 < CaptHindsight> in fact it would help in many situations to have extra heat 18:08 < kanzure> sounds like liquid material choices, then? 18:08 < CaptHindsight> the fluid has to match the head and the waveforms used to fire them 18:08 < CaptHindsight> it's a balance of them all 18:09 < CaptHindsight> you want discrete drops without satellites 18:09 < CaptHindsight> and you can only move the heads so fast before air turbulence becomes an issue 18:10 < CaptHindsight> also drop velocity vs distance to the substrate 18:10 -!- preview [~quassel@2407:7000:842d:4000::3] has joined ##hplusroadmap 18:10 -!- evilroot [~evilroot@unaffiliated/evilroot] has joined ##hplusroadmap 18:11 < CaptHindsight> it's like a bomb dropped from a moving plane 18:11 < CaptHindsight> only a liquid vs a solid 18:12 < evilroot> Hmm, this channel seems relevant to my interests :-D 18:13 < CaptHindsight> there are a bunch of patents on MEMS 18:13 < CaptHindsight> printheads 18:13 < kanzure> evilroot: be greeted 18:14 < kanzure> CaptHindsight: are most of the patents expired by now? inkjet is oooold 18:14 < evilroot> kanzure: thanks 18:15 < CaptHindsight> no, they game the system by overlapping 18:15 < evilroot> Exactly 18:15 < CaptHindsight> plus the mems patents are in the past 10 years 18:15 < evilroot> They patent a new improvement and by doing so keep the whole thing under patent 18:15 < CaptHindsight> https://www.memjet.com/ 18:16 < evilroot> Each manufacturer uses slightly different methods 18:17 < CaptHindsight> https://player.vimeo.com/video/231635697 ~70k mems nozzels 18:17 < evilroot> memjet is super nifty 18:17 < evilroot> Can be used for 3d printing too 18:17 < kanzure> "Memjet® printheads pack 70,400 nozzles into a 1,600 dpi device" 18:18 < evilroot> Other tech has higher resolution and more nozzles 18:18 < evilroot> But isn't effective for large scale commercial applications 18:20 < kanzure> evilroot: http://bioinformatics.org/pogo/ 18:21 < kanzure> evilroot: http://diyhpl.us/wiki/dna/synthesis/notes/ 18:22 -!- darsie [~username@84-114-73-160.cable.dynamic.surfer.at] has quit [Ping timeout: 248 seconds] 18:22 < evilroot> Interesting 18:24 < evilroot> I see issues though, namely that printheads are only made to work with very specific ink formulations 18:24 < evilroot> That's why 3rd party ink can cause damage, even if nearly identical 18:25 < CaptHindsight> damage is generally either solvent incompatibility or particles being too large 18:25 < evilroot> Exactly 18:25 < CaptHindsight> there lots of spooky stories to try and keep people using name brand inks 18:26 < CaptHindsight> you make money on the inks 18:26 < evilroot> Well of course, but I've been fixing printers for 20+ years 18:26 < evilroot> There is actual substance, heh 18:26 < evilroot> The worst was with the Xerox Phaser machines that used solid ink 18:27 < CaptHindsight> Tek heads with wax 18:27 < evilroot> Yep 18:27 < CaptHindsight> I like those 18:27 < evilroot> My gf called them "printer crayons" 18:27 < evilroot> An apt description 18:28 < evilroot> Oh they're great when they work right, but have a lot of downsides 18:28 < CaptHindsight> thats piezo heads in general 18:28 < evilroot> If you ever turned them off it would burn like $40 worth of ink repriming 18:28 < CaptHindsight> you look at them wrong and they act up 18:28 < evilroot> On for too long without printing and the ink would "cook" 18:29 < evilroot> And the earlier models used fricking halogen light bulbs as drum heaters 18:29 < CaptHindsight> as long as they waste ink 18:29 < evilroot> Two of them 18:30 < evilroot> Can't tell you how many times I went to Lowes to buy a $3 bulb to fix a $2k printer 18:30 < evilroot> Retarded design 18:31 < evilroot> Meanwhile a Laserjet 4000 was all but unbreakable. The fuckers NEVER stop working 18:31 < evilroot> I saw million plus page machines that were still happily churning with no more maintenance than changing the rollers 18:32 < evilroot> Hell I STILL see them 18:32 < evilroot> I think that's why HP started building failure points into later designs 18:32 < evilroot> And used lower quality gears/etc 18:33 < evilroot> Can't make money if the old stuff never breaks 18:35 < CaptHindsight> kanzure: not sure who told you that heat from high speed jetting is a problem 18:38 < kanzure> nobody. just went out looking for papers. didn't see much, one was complaining about heat. 18:40 < CaptHindsight> yeah, heat is not really a problem 18:41 < CaptHindsight> the difficulty with building a small head with lots of high speed nozzles are the patents 18:41 < CaptHindsight> I considered making printheads in China but dd not find suitable partners there 18:42 < kanzure> is it TMSC who would do the mems? 18:43 < kanzure> or smaller facilities..? 18:43 < CaptHindsight> http://www.tsmc.com/english/default.htm Taiwan 18:44 < CaptHindsight> https://en.wikipedia.org/wiki/Semiconductor_Manufacturing_International_Corporation is in China 18:45 < kanzure> CaptHindsight: the dna data storage stuff is with the semiconductor research corporation https://www.src.org/ 18:46 < CaptHindsight> how do you get funded to make anything for them? 18:46 < CaptHindsight> is it run by crazy people? 18:48 < evilroot> Heating can be a problem in certain types of designs 18:48 < evilroot> But not modern ones 18:48 < kanzure> well it seems to be IARPA 18:49 < evilroot> And it only really comes into play with high speed applications like commercial label printers 18:52 -!- yashgaroth [~yashgarot@2606:6000:cd4d:3300:f5e0:f867:a11d:8d52] has joined ##hplusroadmap 18:53 < CaptHindsight> https://www.iarpa.gov/index.php/research-programs/felix 18:54 < CaptHindsight> you mean like custom viruses made with an inkjet and some editing tools? 18:55 < CaptHindsight> dissent suppression via https://www.iarpa.gov/index.php/research-programs/proteos 18:57 < kanzure> they want dna data storage 18:58 < CaptHindsight> it's just to dumb an idea for that application 18:58 < CaptHindsight> data storage on paper boats 18:59 < CaptHindsight> long life balloons 19:00 < CaptHindsight> why chemical storage of data? 19:04 < evilroot> Biological storage of data makes sense 19:04 < CaptHindsight> I usually get asked for proposals for research that is plausible but has some kind of wow factor 19:05 < evilroot> The amount of information that can be stored using nucleic acids is staggering 19:05 < CaptHindsight> those get funded 19:05 < evilroot> And plausible. Imagine DNA or RNA with a checksum? 19:05 < evilroot> Not currently practical, but certainly plausible 19:05 < CaptHindsight> why? for density? erasability? 19:06 < CaptHindsight> biodegradability 19:06 < evilroot> Heh 19:06 < evilroot> Technically it can be used as rewritable media 19:06 < kanzure> it's very high density 19:06 < CaptHindsight> copper is higher 19:07 < evilroot> Though honestly quantum storage and computing is far more attainable 19:07 < evilroot> CaptHindsight: high in information storage density? 19:07 < CaptHindsight> yeah and old 19:08 < CaptHindsight> but also like to oxidize 19:09 < CaptHindsight> well thats their story anyway on the DNA 19:10 < CaptHindsight> fast synthesis and editing would be handy for medicine 19:11 < CaptHindsight> if in 50 years if nobody from illness only accidents what would the world be like? 19:11 < CaptHindsight> nobody were to die from 19:15 < CaptHindsight> an actuary the other day mentioned that based on the current population they estimated that people might reach 150 years before the odds of an accident would do them in 19:16 < CaptHindsight> if people would not die from age or illness 19:23 < kanzure> "longevity escape velocity" 19:24 < evilroot> Read the Ringworld series? 19:25 < evilroot> You can essentially live forever if you like, but most people get sick of it and choose not to 19:27 < evilroot> I could also see people taking increasingly dangerous risks and extreme sports and the like to feel "alive" in the absence of fea rof death 19:31 < kanzure> ok 19:32 < kanzure> evilroot: get back to work http://diyhpl.us/~bryan/papers2/longevity/ 19:36 < CaptHindsight> kanzure: who is working on decoding all the dark or junk DNA? 19:39 < kanzure> huh? it's not junk-- it's mostly transcriptional regulators 19:41 < CaptHindsight> formerly known as junk :) 19:41 < CaptHindsight> aka dodo DNA 19:51 < evilroot> kanzure: interesting reads 19:52 < evilroot> Though a lot has been discredited 19:53 < evilroot> In more recent research, given a better understanding of how intricate cellular structures and biochemistry works 19:53 < evilroot> No Fountain of Youth yet 19:54 < evilroot> And in absence if that how people with actually behave is purely speculation 19:54 < evilroot> I mean who in 2010 could have imagined Donald Trump being POTUS, haha. 19:56 < CaptHindsight> Mike Judge? 19:56 < CaptHindsight> http://www.imdb.com/title/tt0387808/ 19:57 < superkuh> Simpsons writers. 19:59 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 252 seconds] 20:00 < evilroot> haha 20:00 < evilroot> superkuh: only because they thought it was the funniest and most stupid and impractical idea ever 20:02 < evilroot> Too bad people really are that stupid 20:02 < kanzure> evilroot: we know many of the alleles for exceptional longeity, next step is to deploy it to everyone http://diyhpl.us/wiki/genetic-modifications/ 20:03 < kanzure> *longevity 20:05 < heath> https://jesuscoin.network/ 20:06 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 20:07 < kanzure> .title https://gizmodo.com/when-hope-runs-out-cancer-patients-are-making-their-ow-1819405332 20:07 < yoleaux> When Hope Runs Out, Cancer Patients Are Making Their Own DIY Immunotherapy Treatments 20:28 < evilroot> Except those are experimental and effects aren't terribly well understood 20:29 < kanzure> sounds like life 20:30 < evilroot> I'm all for hope and cutting edge medicine, germline editing is a really big IF in terms of effects 20:30 < evilroot> Its one thing to help someone that is sick 20:30 < kanzure> "in terms of effects" huh? 20:31 < evilroot> But when you start messing with embryos you don't know what you might be screwing with 20:32 < kanzure> huh? are you a biologist? 20:33 < evilroot> The simplest question is society. Those who can afford the procedure can have kids that won't get certain diseases 20:33 < CaptHindsight> no but I play one on TV 20:34 < evilroot> Or possibly better cognitive functions. Longer lives. Bigger muscles. The implications grow pretty fast 20:34 < kanzure> "afford the procedure" but you haven't even asked me for my prices 20:34 < kanzure> it's free because it's a plague/virus that infects everyone 20:34 < evilroot> Instead of just being rich, kids from rich families could be "genetically superior" in a real sense 20:35 < evilroot> kanzure: just like healthcare should be free? 20:36 < evilroot> Everybody gets sick after all 20:36 < kanzure> yes, viruses work 20:36 < kanzure> if you wanted to freely deploy this to everyone then you would use a virus 20:36 < ebowden> Don't they usually mutate very, very quickly? 20:36 < kanzure> people who complain about costs/price or whatever are also the same people who don't understand biology 20:36 * evilroot is pretty sure kanzure is going to start the Zombie Apocalypse 20:36 < kanzure> dude you have no idea 20:37 < ebowden> I hope he is joking. 20:37 < kanzure> evilroot: http://diyhpl.us/~bryan/irc/2017-02-03-beacon.pdf#page=15 20:37 < ebowden> I really hope he is joking, deliberately saying something stupid. 20:37 < CaptHindsight> but start with a beach party 20:37 < evilroot> I understand Biology. Very well, as in multiple Graduate level courses 20:37 < evilroot> OH GOD 20:38 < evilroot> Toxoplasmosa gondii 20:38 < evilroot> YOU REALLY DO WANT ZOMBIES 20:38 < kanzure> over 80% of the human population is infected, relax 20:38 < CaptHindsight> evilroot: have you tried #reprap full of 3d printer con men, it could use some cleaning up 20:38 < evilroot> HENCE ZOMBIES 20:39 * evilroot breathes deeply 20:39 < kanzure> zombie apocalypsii are over-rated... look, if you want to cheaply distribute genetic upgrades to the population, then you use gene therapy, viruses, etc. 20:40 < evilroot> kanzure: I've read that entire paper now 20:40 < evilroot> You're awesome :-D 20:40 < kanzure> thank you 20:41 < evilroot> Please tell me you submitted that for something 20:41 < evilroot> An assignment, anything 20:41 < kanzure> those were just some slides for a presentation i gave in detroit earlier this year 20:41 < kanzure> no wait.. somewhere in michigan. 20:41 < evilroot> "Bruteforce mutagenesis is pretty great!" 20:41 < evilroot> I started just laughing 20:42 < kanzure> yea that's how we got 50x better enzymes 20:42 < kanzure> very common lab technique 20:42 < evilroot> A very large number! 20:42 < evilroot> So very good! 20:43 < evilroot> Also known as the "bigger hammer approach" 20:43 < kanzure> evilroot: http://diyhpl.us/wiki/transcripts/diy-human-gene-therapy-with-crispr/ 20:44 < evilroot> Whoever wrote that transcript should know about spell check 20:44 < kanzure> i type 200wpm no time for spellcheck 20:45 < evilroot> And grammer. 20:45 < kanzure> who? 20:45 * kanzure wanders off 20:45 < evilroot> Grammar, haha 20:46 < evilroot> Your company is called "The Odin"? 20:51 < evilroot> Ahh, you have a website that sells basic kits and supplies for wanna be DIY biologists 20:53 < evilroot> Classroom level stuff like adding a color to yeast 20:55 < CaptHindsight> Odin is that guy from UofC 20:55 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Quit: WeeChat 1.7.1] 20:55 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 20:56 < evilroot> "UofC"? 20:57 < CaptHindsight> kanzure: what is Zayner up to? 20:57 < evilroot> University of Conmen? 20:58 < CaptHindsight> he has George Church on his site as an adviser 20:58 < CaptHindsight> he needs a DNA printer on the website 21:00 < evilroot> I doubt Dr. Church would be behind the stuff he showed 21:00 < CaptHindsight> he's on the site 21:01 < evilroot> But he is kind of an odd guy 21:01 < CaptHindsight> http://www.the-odin.com/about-us/ 21:01 < evilroot> I saw 21:02 < evilroot> Having been in college listing someone as an "Advisor" means absolutely nothing 21:03 < CaptHindsight> could be intellectual overlord 21:03 < evilroot> I went to a talk he had a Duke 21:03 < CaptHindsight> ale house or university? 21:04 < evilroot> University, heh 21:04 < evilroot> Students tried to ask questions but he just went full politician and never answered anything 21:04 < evilroot> And asked questions to questions 21:06 < evilroot> My mother was a professor and alumni. I think she wanted to show me how silly academics can be. 21:07 < evilroot> I mean he clearly knew his shit. Understood the topic. But then just danced around everything and talked about possibilities and discovery. 21:09 < evilroot> Some people just want to make a name for themselves with ideas and arguments because then they can write articles and get funding 21:09 < evilroot> And never do anything in reality 21:10 < evilroot> Sell snake oil 21:10 * evilroot sighs 21:10 < hazzy> I am afraid that is most of modern academia, it is all about "getting the funding for that one" 21:11 < ebowden> kanzure, does this get a lot of sales? http://www.the-odin.com/the-iliad-project-kit-find-new-antibiotics-at-home/ 21:11 < evilroot> heh 21:12 -!- preview [~quassel@2407:7000:842d:4000::3] has quit [Ping timeout: 255 seconds] 21:14 < kanzure> evilroot: not his duke talk, but here's his berkeley talk http://diyhpl.us/wiki/transcripts/2017-01-26-george-church/ 21:14 < ebowden> kanzure, heard of those little soil bacteria screeners that get put in the ground, so can screen for antibiotics from soil bacteria that won't grow in commercially available growth medium? 21:14 < kanzure> evilroot: i am not sure i would characterize george church as not having done anything in reality (crispr) 21:15 -!- rpifan [~rpifan@207-244-191-189-dhcp.mia.fl.atlanticbb.net] has joined ##hplusroadmap 21:15 < kanzure> evilroot: https://scholar.google.com/citations?user=SfDzdgEAAAAJ&hl=en&oi=ao 21:16 < kanzure> ebowden: i do not operate the-odin.com 21:16 < kanzure> that's josiah zayner 21:16 < ebowden> Ah, ok. That guy looks very different to anything I would imagine you looking like. 21:17 < rpifan> hello agian 21:17 < evilroot> Are you saying Church made CRISPR? 21:17 < kanzure> http://www.linklotus.com/quotelotus/wp-content/uploads/2015/11/credible-hulk.jpg 21:17 -!- preview [~quassel@2407:7000:842d:4000::3] has joined ##hplusroadmap 21:18 < kanzure> evilroot: church lab was heavily involved in the recent crispr litigation, go look for yourself 21:18 < evilroot> Are you saying that litigation is science? 21:18 < rpifan> scientology? 21:18 < kanzure> evilroot: i am saying i have given you a reference. and yes they cited their work during the litigation. not sure why you think they wouldn't..? 21:18 < ebowden> Kanzure, I love that image. 21:18 < kanzure> the crispr litigation was entirely about who the fuck made crispr 21:19 < kanzure> so how would this be irrelevant to your question? 21:19 < kanzure> argh 21:19 < rpifan> scientology church lab? 21:19 * evilroot chuckles 21:19 < kanzure> it's like the only biggest biology lawsuit in the last 10 years 21:19 < kanzure> aaaaaaaa 21:20 < rpifan> ?? 21:21 < kanzure> .tw https://twitter.com/Neuro_Skeptic/status/923676441748889601 21:21 < yoleaux> Lots of comments on my "does high IQ cause illness?" post http://blogs.discovermagazine.com/neuroskeptic/2017/10/22/intelligence-risk-illness/ Some good ones (@Neuro_Skeptic) 21:21 < rpifan> yes it does 21:21 < kanzure> i don't know if we should care; low iq but super high memory would be an acceptable outcome. 21:22 < rpifan> i do often wish i wasnt so "smart" 21:22 < rpifan> its a pain in the ass 21:22 < rpifan> and then ppl think ur being presumptious 21:22 < kanzure> you're not smart. 21:22 < CaptHindsight> at least the Chinese are using CRISPER publicly on human cells 21:22 < rpifan> thanks kanzure 21:23 < rpifan> i will treasure ur love and affection 21:23 < kanzure> not saying i'm smart either. just for the record. 21:23 < rpifan> lol 21:23 < rpifan> i think if we are on irc and talking about cripsr 21:23 < rpifan> thats pretty smart 21:23 < ebowden> I suspect the Chinese want to increase their industrial output by rolling out enhancements to everyone. 21:23 < kanzure> that's called cheerleading 21:23 < rpifan> cheerleading? 21:24 < kanzure> ebowden: nah, nobody 'cept us really thinks about free voluntary upgrades 21:24 < CaptHindsight> how do you envision the CRISPER patent ending up? 21:24 < rpifan> but why is there stuff so shit tho 21:24 < kanzure> CaptHindsight: no idea. MPEG-LA (the guys who own the video patents) are trying to make a crispr patent pool... 21:24 < ebowden> kanzure, I have no idea if the Chinese want these upgrades to be voluntary. 21:24 < CaptHindsight> or will it become obsolete by some other process? 21:24 < CaptHindsight> before the litigation is over 21:24 < kanzure> rpifan: the ability to talk about science news is merely cheerleading; actual projects, actual work, that's totally different. 21:25 < rpifan> maybe idk 21:25 < rpifan> i think this kind of chat is work 21:25 -!- evilroot [~evilroot@unaffiliated/evilroot] has quit [Ping timeout: 258 seconds] 21:25 < kanzure> CaptHindsight: i believe a big milestone in the litigation was recently met. not sure if an appeal will be successful. 21:25 < rpifan> its useful and spread knowledge 21:25 < rpifan> its like debating philosophy 21:25 < kanzure> one of the rules around here is no philosophy 21:25 < ebowden> "i think this kind of chat is work" lol 21:25 < rpifan> but everything is philosophy 21:25 < rpifan> it is work 21:26 < rpifan> its not idle chatter 21:26 < kanzure> that's just depression 21:26 < CaptHindsight> gimmie a C, gimmie a R, gimmie a I 21:26 < kanzure> "everything is work" is depression talking 21:26 < ebowden> gimme a S, gimme a P, gimme an R 21:26 < rpifan> but work is good 21:26 < rpifan> i mean i dont like to go to work 21:26 < rpifan> but i liek to work 21:26 < CaptHindsight> I'm working on artificial stupidity to take over the world 21:27 < kanzure> CaptHindsight: i mean, the point was that cheerleading should not be encouraged. you can go on reddit and get that. 21:27 < rpifan> its not like a lot of ppl ar eout there injecting themselves iwth dna 21:27 < CaptHindsight> not yet anyway 21:28 < rpifan> maybe not ever 21:28 < CaptHindsight> but like guns if that is what me happy i should be able to do it... 21:28 < rpifan> i mean i was looking at 3d printed braces 21:28 < CaptHindsight> as long as it doesn't encroach on your rights 21:28 < rpifan> my teeth hurt so badly recently cause of the way they are moving and crash on top of each other 21:28 < rpifan> but you obviously cant just go 3d print your own braces 21:28 < rpifan> cause thats not fda approved 21:28 < rpifan> and while i get why its not 21:28 < kanzure> the point is that there are people injecting htemselves 21:28 < rpifan> its a pain in the ass 21:29 < CaptHindsight> it doesn't last, when you get older they wear out and fall out 21:29 < rpifan> teeth? 21:29 < CaptHindsight> yes 21:29 < rpifan> well 21:29 < CaptHindsight> not DNA 21:30 < CaptHindsight> well that to 21:30 < rpifan> if they are taken care of the ycan last a whole life 21:30 < rpifan> but most ppl dont have good acces to dental care 21:30 < rpifan> i live in the MURICA land and i still dont 21:30 < CaptHindsight> uh murica? 21:30 < rpifan> MURICA!!!! 21:30 < ebowden> I have access to excellent dental care. 21:30 < rpifan> you must be rich 21:31 < CaptHindsight> lol 21:31 < CaptHindsight> bbl 21:31 < ebowden> I live in Australia. 21:31 < rpifan> oh 21:31 < rpifan> of course then 21:31 < rpifan> have them fix my teeth 21:31 < rpifan> they hurt 21:31 -!- jtimon [~quassel@164.31.134.37.dynamic.jazztel.es] has quit [Remote host closed the connection] 21:31 < ebowden> Better earn some cash and pay a dentist. 21:32 < rpifan> hard currency 21:32 < rpifan> and u mean buy a dentist 21:32 < hazzy> or get a dremel tool 21:32 < rpifan> at least thats how the american system works 21:32 < rpifan> well they need to straightened 21:32 < rpifan> and cleaned 21:32 < rpifan> not drilled 21:32 < rpifan> i did manage to get that done the drilling 21:34 < kanzure> what actual skills do you have, again? and why should i not ban you. i forget. 21:36 < rpifan> you can ban me if u want to 21:36 -!- mode/##hplusroadmap [+o kanzure] by ChanServ 21:36 -!- mode/##hplusroadmap [+o fenn] by kanzure 21:36 -!- mode/##hplusroadmap [+o nmz787] by kanzure 21:36 < rpifan> oh no 21:36 < rpifan> the end is neigh 21:37 -!- mode/##hplusroadmap [-o kanzure] by kanzure 21:39 < ebowden> rpifan, that I live in Australia isn't the only reason though. 21:39 < ebowden> We go to a private dentist. 21:39 < heath> nmz787: the advisor for the DEVELOPMENT OF NANOFLUIDIC DEVICES FOR 21:39 < heath> SINGLE-MOLECULE DNA DIAGNOSTICS paper 21:40 < heath> DEVELOPMENT OF NANOFLUIDIC DEVICES FOR 21:40 < heath> argh 21:40 < heath> https://patents.google.com/?inventor=Steven+A.+Soper 21:40 < rpifan> ebowden, well still even private doctors can be shit here 21:40 < rpifan> in american land 21:41 < ebowden> They have public doctors for non-veterans? 21:41 < ebowden> Well, also, we have medicare, which pays out to private doctors and destists. 21:41 < ebowden> Even orthodontists. 21:42 < rpifan> yea the us doesnt have orthontist coverage at all 21:42 < ebowden> Hmmm. 21:42 < rpifan> its all out of pocket 21:42 < ebowden> Maybe we did pay for that privately. 21:42 < rpifan> but its also like that in Ecuador 21:42 < ebowden> But the dental is partially covered. 21:43 -!- evilroot [~evilroot@cpe-76-182-34-156.nc.res.rr.com] has joined ##hplusroadmap 21:43 < ebowden> Also, there are some drugs not covered by Medicare. 21:43 < rpifan> im currently getting an obamacare insurancep lan 21:43 < rpifan> but its shit 21:43 < rpifan> and i just moved states 21:43 < rpifan> so now i dont have insurance 21:43 < rpifan> but because of the disease i have i will get specific coverage that isnt insurance 21:43 < rpifan> for that disease 21:45 < ebowden> Is Obamacare shit? 21:46 < rpifan> mostly 21:46 < rpifan> its complicated 21:46 < rpifan> because there is a lot of opposition 21:46 < rpifan> and so it was ham stringed from the beginning 21:46 < rpifan> and now trump is making it fall apart much worse 22:15 < Aurelius> Man, I see 'rpifan' and think of my alma mater. 22:15 < rpifan> marcus? 22:16 < Aurelius> I'm a fan of him in a few ways 22:16 < rpifan> funny how marcus is often a black name 22:23 -!- yashgaroth [~yashgarot@2606:6000:cd4d:3300:f5e0:f867:a11d:8d52] has quit [Quit: Leaving] 23:09 -!- mindsForge [~nak@174-26-123-39.phnx.qwest.net] has quit [Remote host closed the connection] 23:15 < CaptHindsight> rpifan: I used to think that the Chinese were out of touch being kept behind the Great Firewall.... 23:16 < CaptHindsight> but it's more amazing to me seeing how in the USA a barrier to facts and reality is not required anymore ... 23:17 < CaptHindsight> they block out things on their own. 23:18 < rpifan> its a sad world we live in 23:18 < rpifan> but then again 23:18 < rpifan> if u arent trained in finding info 23:19 < rpifan> how do u know how to look 23:19 < CaptHindsight> or having that impulse discourage from age 5 and up 23:19 -!- Gurkenglas [~Gurkengla@dslb-094-223-135-191.094.223.pools.vodafone-ip.de] has joined ##hplusroadmap 23:20 < rpifan> yea thats true 23:20 < rpifan> and thats where i sorta agree iwth a lot of the ancap and libertarians 23:20 < rpifan> about education 23:22 < CaptHindsight> http://www.johntaylorgatto.com/ he's done a pretty good job of explaining what's happened in US public schools 23:22 -!- aeiousom1thing [~aeiousome@gateway/vpn/privateinternetaccess/aeiousomething] has quit [Ping timeout: 264 seconds] 23:22 -!- aeiousomething [~aeiousome@59.93.94.150] has joined ##hplusroadmap 23:23 < CaptHindsight> I found it to be worse than what he describes 23:23 < rpifan> tl;dr? 23:26 < CaptHindsight> ex NY teacher pf the year 23:26 < rpifan> whats he say tho 23:26 < CaptHindsight> wrote several books on the school system 23:26 < rpifan> also ny edcuation for me is one of the worst 23:27 < rpifan> its so limited 23:27 < CaptHindsight> and how he underminded it from within 23:27 < CaptHindsight> worth a look if you are interested 23:28 < rpifan> ive got so much to read 23:28 < rpifan> im almost done with the jungle by upton sinclair 23:28 < rpifan> great book 23:28 < rpifan> really engaging 23:29 < CaptHindsight> yeah, no surprise to me why we have a fearless leader that's an arrogant moron 23:29 < CaptHindsight> also see http://www.imdb.com/title/tt0387808/ Idiocracy (2006) 23:30 < rpifan> ive seen that movie 23:30 < rpifan> it was sad 23:30 < rpifan> really sad 23:30 < CaptHindsight> and funny 23:30 < CaptHindsight> but yes 23:30 < CaptHindsight> sad 23:30 < rpifan> i found it sad 23:30 < rpifan> im too much of a deep thinker sometimes 23:30 < CaptHindsight> Reality Bites 23:31 < rpifan> and yet theres where we are headed 23:31 < CaptHindsight> not everyone but it's good for the king 23:32 < CaptHindsight> since as Mel Brooks stated " It's good to be the king" 23:33 < rpifan> https://en.wikipedia.org/wiki/Damocles 23:33 < CaptHindsight> https://www.youtube.com/watch?v=StJS51d1Fzg it's GOOD to be the KING 23:34 -!- Gurkenglas [~Gurkengla@dslb-094-223-135-191.094.223.pools.vodafone-ip.de] has quit [Ping timeout: 240 seconds] 23:37 < rpifan> except u could always get cut off 23:38 -!- night [~Adifex@unaffiliated/adifex] has quit [Ping timeout: 260 seconds] 23:41 -!- night [~Adifex@unaffiliated/adifex] has joined ##hplusroadmap 23:48 -!- c0rw1n_ [~c0rw1n@cpc109847-bagu17-2-0-cust223.1-3.cable.virginm.net] has quit [Ping timeout: 248 seconds] --- Log closed Fri Oct 27 00:00:18 2017