--- Log opened Sun Nov 19 00:00:19 2017
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02:54 < kanzure> "A one-time gene therapy could help people overcome meth addiction" https://www.technologyreview.com/s/609479/gene-therapy-could-help-people-overcome-meth-addiction/ https://twitter.com/techreview/status/931810601998962689
02:54 < kanzure> "Eric Peterson, associate professor of pharmacology and toxicology, and his colleagues have packaged a gene that codes for an anti-meth antibody into an engineered virus. When injected, the therapy makes the body generate antibodies against meth. The antibodies bind to and trap methamphetamine molecules that are circulating in the bloodstream, preventing them from traveling to the brain and ...
02:55 < kanzure> ...triggering pleasurable feelings. In mice, researchers showed that the therapy lasted for over eight months, reducing the amount of meth in the brain and the stimulant effects caused by the drug."
02:55 < kanzure> various illustrations of biodiversity https://www.flickr.com/search/?tags=bookcollectionbiodiversity https://twitter.com/RobGMacfarlane/status/931914629399351296
02:57 < kanzure> "Low cost and open source multi-fluorescence imaging system for teaching and research in biology and bioengineering" http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0187163 https://twitter.com/SynBioChile/status/930957005820497925
02:58 < kanzure> whoops review might not work,
02:58 < kanzure> .tw https://twitter.com/ValerioCapraro/status/931169200126742528
02:58 < yoleaux> EXTREMELY IMPORTANT: Single-blind reviewers are significantly more likely than their double-blind counterparts to recommend for acceptance papers from famous authors, top universities, and top companies. http://www.pnas.org/content/early/2017/11/13/1707323114.full.pdf https://pbs.twimg.com/media/DOwrC1yW0AE9yzi.jpg (@ValerioCapraro)
02:58 < kanzure> .tw https://twitter.com/iGEM/status/930918069085622272
02:58 < yoleaux> The #iGEM2017 wikis have been thawed - teams can edit them until December 15! #WikiFreeze (@iGEM)
03:00 < kanzure> "Compelling reasons for repairing human germlines" http://www.nejm.org/doi/full/10.1056/NEJMp1710370 https://twitter.com/antonioregalado/status/930942024525729792
03:03 < kanzure> "It may seem tempting to draw a line for permissible gene editing at some qualitative or quantum step such as “germline versus soma” or “enhancement versus basic health,” but the reality is that we often regulate practices on the basis of ethical costs and benefits at specified points along a continuum — for example, speed limits, blood alcohol levels, and age limits. We already ...
03:03 < kanzure> ...embrace many enhancements inherited over multiple generations — generally without consulting future grandchildren — for example, education, homes, and extinction of pathogens through the use of vaccinations. The issue for many critics lies not in enhancement relative to our ancestors, but rather relative to one another. We should study cases in which technologies are equitably distributed ...
03:03 < kanzure> ...to all 7.5 billion of us, such as the extinction of smallpox and polio through global enhancement of immunity."
03:03 < kanzure> #betterthanhitler
03:04 < kanzure> .tw https://twitter.com/antonioregalado/status/930943901204131845
03:04 < yoleaux> 6/ I'm not sure the wider public realizes that the august, mainstream New England Journal of Medicine is promoting germline engineering and a brand of genetic transhumanism. (@antonioregalado, in reply to tw:930943337988788224)
03:06 < kanzure> .tw https://twitter.com/antonioregalado/status/930942024525729792
03:06 < yoleaux> George Church editorial in NEJM arguing in favor of germline engineering. I am calling all this stuff Eugenics 2.0 (THREAD) http://www.nejm.org/doi/full/10.1056/NEJMp1710370?query=featured_home (@antonioregalado)
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06:05 < fltrz> hah I bought a new backpack yesterday, and today I notice the denial tag with indelible ink is still on it (no alarm went off when I exited the shop)
06:05 < fltrz> at the moment I felt quite hurried to buy a backpack since I was cramming my stuff in my coat pockets when I go to work and back
06:06 < fltrz> and the shops were almost closing, so I bought the overpriced bag I don't even really like
06:07 < fltrz> so either I keep the bag, and somehow safely remove the tag, or I have to go back during the week (while Im pretty busy because Im supposed to wait for the police to show up any day/hour/minute when I return from work)
06:07 < fltrz> if I go back to the shop I'd prefer asking my money back in return for the bag
06:08 < fltrz> and buy a better cheaper backpack
06:08 < fltrz> since it's sunday, I might spend an hour or so looking up how to remove the tag safely, but then I risk covering myself and the bag in ink...
06:09 < fltrz> waiting for the police to show up is not connected to the backpack in anyway...
06:29 < kanzure> what
06:29 < kanzure> also, hi..
06:31 < fltrz> hi, I know, lol
06:38 < fltrz> pff I lose time either way, and it may even cause me to miss the police visit
06:38 < fltrz> shops hate transaction reversals, so since I lost my time either way going back, I'll just cause them a transaction reversal
06:39 < fltrz> then both parties just lost time
06:43 < streety> can you not contact the police to ensure you don't miss them?
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06:54 < fltrz> streety: its for domiciliation, so you give up the hours you are normally home (in my case mornings or afternoons depending on odd/even week, since 2 shift system)
06:54 < fltrz> they explicitly say you can't make an appointment, I guess the idea is to prevent incorrect domiciliation
06:55 < fltrz> or perhaps its just too complicated for the police to work out a good scheduling algorithm that works for all their target audiences
06:57 < fltrz> or perhaps because efficiency implicates less man hours needed for the task, implicates future decrease in funding, implicates job cuts?
06:58 < fltrz> but probably just a weak method of preventing incorrect domiciliation
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07:00 < streety> interesting, I have not heard of such a system before
07:01 < streety> how long do you need to wait for them?
07:06 < fltrz> for the police? I guess they would keep passing by until succesful, whenever they pass they slip a note in the mailbox
07:06 < fltrz> so you see when they passed
07:06 < fltrz> but yeah life goes on, so sometimes you have to go shopping (or return a backpack because the denial tag is still on there...)
07:08 < fltrz> also communication of the exact hours is suboptimal, you basically tick of boxes for mornings, afternoons etc... I ticked both, and in the comments described which weeks morning vs afternoon, but not exact hours
07:08 < fltrz> also fridays we start earlier and leave earlier, theres not enough space to convey when youre normally home
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07:09 < fltrz> then when you actually are home when they pass, you let them in and show your room, show you have a table, chair and bed
07:11 < fltrz> they will probably ask me some more questions, since I didn't keep my domicile up to date for the last I guess 7 years, I stopped caring when I lived in the student dorm, and the university did not allow me to domicile there
07:11 < fltrz> I didn't get along very well with my parents
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07:12 < fltrz> I kind of got along with my father though I did not grow up there, so I didn't really know him well
07:13 < fltrz> but he moved out of the city I lived and studied in, so I could no longer get my mail... anyway, if the university simply allowed me to place my domicile in the dorm I probably would have kept it in order throughout the years
07:19 < fltrz> the law requires to domicile where you effectively live, and for me that was the students dorm, so in fact it was illegal of the university to deny me this right
07:20 < fltrz> most students in the dorm come from outside of the city, and even though they live in the dorm, their domicile is kept at their parents for financial reasons
07:21 < fltrz> their parents pay their dorm rent, I payed my own dorm rent
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07:22 < fltrz> but it was real cheap given my low income
07:27 < fltrz> looks like it needs on the order of 5000 Gauss and 60 Kg of force to release
07:27 < fltrz> perhaps even 10KG
07:32 < kanzure> "Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing" https://www.nature.com/articles/nbt.4005 https://motherboard.vice.com/en_us/article/ywbkzw/crispr-virus-nanoparticle-mit-rna
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07:38 < kanzure> good to see that steve jurvetson is still around
07:41 < fltrz> ah this is how they work http://www.mrports.com/2007/03/how-to-remove-security-ink-tag.html
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08:08 < fltrz> now I'm worried that I must take the tag off succesfully lest they not accuse me of having stolen the bag
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09:14 < spurserh> @fltrz dremel tool?
09:25 < kanzure> .tw https://twitter.com/antonioregalado/status/930944427547332610
09:25 < yoleaux> 7/ Scientists own statements are very confused. Do we a moratorium? Do we want one? Designer babies? How about we sound like we are cautiously against it while actually being for it. (@antonioregalado, in reply to tw:930943901204131845)
09:30 < kanzure> https://www.nyse.com/publicdocs/nyse/The_Entrepreneurs_Roadmap.pdf
09:58 < fltrz> yes, I used dremel, but it took me longer than expected
09:59 < fltrz> apparently the layout of my ink tag was such that the vials and the release mechanism were on the same half of the tag...
10:00 < fltrz> so I was happily dremiling, until I saw some coils... and then something blue, so i assumed it to be the PCB for the alarm? drilling round some more saw some red so again thought of red PCB.. wait why 2 PCB's... ink vial alert!!!
10:00 < spurserh> someone even posted a guide online :-p https://sites.google.com/site/inktagremoval/
10:01 < fltrz> yeah I checked those
10:01 < spurserh> I didn't even know there was ink inside of those
10:01 < fltrz> mine was different
10:01 < fltrz> its to ruin the clothes/bag whatever
10:01 < spurserh> yeah I get it
10:01 < spurserh> clever
10:02 < fltrz> at some point I switched to snippers as it was faster and more controlled than the dremel, which just accumulated on the tool, and melted the plestic over and over again
10:03 < fltrz> there were some creepy moments though, everytime expecting the next instant to be ... eh ... "colourful"
10:04 < kanzure> alright back to world domination topic plzkthx
10:05 < fltrz> anyway, yeah, I guess they are relatively effective, in the sense that you dont have the time discretion etc to break the thing apart properly in the shop, but if the alarm doesnt go off... half an hour work is nothing compared to the value of many of the items sold...
10:05 < fltrz> as I looked up more about how to break this apart before I tried, I learnt quite some more about antitheft issues
10:06 < spurserh> @kanzure hey, a geek's gotta eat
10:07 < kanzure> no we should be talking about boiling the ocean or using abandoned volcano tubes as lairs
10:07 < spurserh> I'm listening
10:07 < fltrz> i.e. since it is a large cost for shops to install antitheft tags (say RFID, magnetoaccoustic or magnetic hysteresis harmonics based) many items are source tagged at the factory they are made
10:07 < kanzure> well it just seems more efficient to use the tubes than cutting out your own rooms in a volcano
10:08 < spurserh> hmm, probably most lava tubes are too remote for Dominos delivery
10:08 < spurserh> maybe on Hawaii
10:08 < spurserh> there is one in delivery range
10:08 < fltrz> but since not all shops use the alarm system gates, people are constantly wandering around with tags that were never deactivated, causing a lot of false alarms in shops that do use the antitheft gates
10:09 < spurserh> haha.. that's weird. they want the deterrent effect of the tags without spending money on the gate? and they don't even remove the tags for their customers?
10:09 < fltrz> I don't think the alarm went off when I went outside, I certainly didnt notice, so I assume the tag was deactivated, and she simply forgot to remove the tag on the magnet
10:10 < spurserh> THERE OUGHTA BE A LAW
10:11 < fltrz> spurserh: no, those shops without gates simply decide that the cost of security (gates, guard at the gates, deactivation equipment) is more trouble than the loss of theft, or simply charge higher prices to compensate for theft
10:12 < fltrz> but they buy clothes and so on from manufacturers, and its cheaper for the manufacturer to have a single flow of items, than to have to maintain 2 stocks of the same item
10:12 < fltrz> so the shops that dont specifically want the tags still get them, and those tags are never deactivated
10:13 < fltrz> well, unless the user notices the tag and decides to remove it
10:13 < fltrz> but in a shopping street, people often buy things from multiple shops, so the tags are still on
10:14 < fltrz> so when the alarm goes off, without theft taking place, its usually somebody who just bought an item at a shop without security gates
10:16 < fltrz> anyway, Im still returning the backpack
10:19 < fltrz> and if they stall me on the spot in order to dissuade me from returning the bag (i.e. by pushing irrelevant 'customer feedback forms' or whatever I don't legally need to fill in in order to get refunded) I will symmetrically push irrelevant information (perhaps my theory on the female orgasm), while occupying on cashier so it costs them time too
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10:20 < spurserh> uh
10:20 < spurserh> okay
10:20 < spurserh> you have a lot of free time eh
10:26 < fltrz> I think my approach would tend to speed up the refund
10:26 < spurserh> how much does this backpack cost?
10:26 < fltrz> 40 euros
10:27 < spurserh> are you a student or something?
10:27 < fltrz> I desperately needed a backpack, and it was almost closing time, on a saturday
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10:28 < fltrz> 7 hours from now I will wake up and leave for work, so I was in a hurry to get a backpack, the first shop that had a backpack I bought one
10:28 < fltrz> I thought it a very bad deal, but due to lack of time when shops are open on weekdays, I felt obliged to buy the backpack
10:29 < spurserh> well, I am just surprised anyone goes to so much trouble over 40 euros
10:29 < fltrz> now that I will have to return anyway, this time-pressured buy makes little sense, and I want my money back (I bought the overpriced backpack exactly because of a lack of time, if it ends up costing me time anyway, I will happily arrange a refund)
10:34 < fltrz> usually I just refuse or throw away the receipt when I buy something, but since I was buying a bag, it overrode my reflex, and I simply put the receipt in the bag...
10:34 < kanzure> where is yashgaroth
10:34  * kanzure summons
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11:34 < nmz787> kanzure: another idea after lactating men... is just to convince elon musk he needs DNA synthesis to get to (or terraform) mars
11:47 < fltrz> what is the lactating men idea?
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12:41 < nmz787> fltrz: started as my idea to enable myself to breastfeed my future child... but also as a way to stir up massive media controversy and get GMO stuff to be more popular
12:42 < fltrz> why not let your wife breastfeed the child?
12:44 < nmz787> she might want to go into work that day
12:44 < nmz787> seems more convenient for me to just produce milk, rather than having her pump, store, etc
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13:04 < DataPacRat> Today's self-improvements: I've inherited an old familial monitor, so my pocket desk-battlestation is up to two screens, and I'm yak-shaving by getting it set up and capable of doing me actual good; and I've bought some St. John's Wort and omega-3 oil pills as a possible start to a cheap-as-possible stack.
13:04 < DataPacRat> (Current use of second screen: Chat window, while browsing/working on my main one. But I'm about to start twiddling with settings which may upset the whole OS.)
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13:27 < kanzure> "simply convince a billionaire!"
13:27 < kanzure> .title https://www.youtube.com/watch?v=nXARrMadTKk
13:27 < yoleaux> The Ballad of Big Yud (Eliezer Yudkowsky) - YouTube
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13:53 < kanzure> zephyr1: hi.
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14:54 < kanzure> hmph
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18:12 < kanzure> yashgaroth_: tell me about a new protein i don't know about
18:13 < CaptHindsight> http://www.sciencealert.com/amish-community-rare-genetic-mutation-protects-against-ageing-serpine1  so it's not the anti-tech lifestyle  :)
18:13 < CaptHindsight> http://advances.sciencemag.org/content/3/11/eaao1617.full
18:14 < yashgaroth_> any particular function in mind kanzure
18:15 < kanzure> nope
18:16 < kanzure> .title
18:16 < yoleaux> A null mutation in SERPINE1 protects against biological aging in humans | Science Advances
18:17 < yashgaroth_> well there's ACE-2494, acceleron's new myostatin inhibitor that I was trying to make in e. coli...didn't really work, but I think the reason they're not in phase I yet is that it's immunostimulatory
18:19 < yashgaroth_> they filed a patent on using it with a PDL1 inhibitor in cancer treatment but there's no more specifics than that
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23:11 < kanzure> https://sphlab.wordpress.com/2017/11/20/gamma-ray-x-ray-imaging/
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23:49 < nmz787> .title https://www.youtube.com/watch?v=GafZSH2GztQ
23:49 < yoleaux> These Supercows Are Genetically Bred To Fetch Six Figures At Auction (HBO) - YouTube
23:50 < nmz787> embryos from the best mothers are fertilized with high-quality sperm, then flushed from the mother and examined, then implanted into surrogates... meaning these top-quality mothers can produce instead of 1 calf per year, they can produce 10 per month (via surrogates)
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--- Log closed Mon Nov 20 00:00:20 2017