--- Log opened Fri Nov 24 00:00:24 2017 00:20 -!- rpifan [~rpifan@207-244-191-189-dhcp.mia.fl.atlanticbb.net] has quit [Remote host closed the connection] 00:32 -!- darsie [~username@84-114-73-160.cable.dynamic.surfer.at] has joined ##hplusroadmap 00:40 -!- DataPacRat1 [~dan@adsl-107.itcanada.com] has quit [Ping timeout: 240 seconds] 00:41 -!- DataPacRat [~dan@adsl-107.itcanada.com] has joined ##hplusroadmap 01:00 -!- DataPacRat [~dan@adsl-107.itcanada.com] has quit [Ping timeout: 248 seconds] 01:00 -!- DataPacRat [~dan@104.254.90.170] has joined ##hplusroadmap 01:00 -!- rpifan [~rpifan@207-244-191-189-dhcp.mia.fl.atlanticbb.net] has joined ##hplusroadmap 01:16 -!- Gurkenglas_ [~Gurkengla@dslb-094-223-141-229.094.223.pools.vodafone-ip.de] has joined ##hplusroadmap 01:18 -!- augur [~augur@192.195.83.130] has quit [Remote host closed the connection] 01:23 -!- emeraldgreen [~user@188.170.73.87] has joined ##hplusroadmap 01:25 -!- emeraldgreen1 [~user@188.227.115.178] has quit [Read error: No route to host] 01:35 -!- Gurkenglas_ [~Gurkengla@dslb-094-223-141-229.094.223.pools.vodafone-ip.de] has quit [Ping timeout: 240 seconds] 01:57 -!- jtimon [~quassel@164.31.134.37.dynamic.jazztel.es] has joined ##hplusroadmap 02:06 -!- emeraldgreen [~user@188.170.73.87] has quit [Quit: Leaving.] 02:10 -!- emeraldgreen [~user@188.227.115.178] has joined ##hplusroadmap 02:18 -!- Gurkenglas_ [~Gurkengla@dslb-094-223-141-229.094.223.pools.vodafone-ip.de] has joined ##hplusroadmap 02:21 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has quit [Quit: sleep] 02:32 -!- justan0theruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 250 seconds] 03:20 -!- DataPacRat [~dan@104.254.90.170] has quit [Ping timeout: 252 seconds] 03:25 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Remote host closed the connection] 03:26 -!- rpifan [~rpifan@207-244-191-189-dhcp.mia.fl.atlanticbb.net] has quit [Ping timeout: 252 seconds] 03:50 -!- justan0theruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 03:50 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 03:55 -!- ebowden [~ebowden@2001:8003:10c9:e00:dce:73ce:826b:c351] has joined ##hplusroadmap 04:51 -!- aeiousom1thing [~aeiousome@183.82.170.54] has joined ##hplusroadmap 04:54 -!- aeiousomething [~aeiousome@183.82.170.54] has quit [Ping timeout: 258 seconds] 05:07 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Remote host closed the connection] 05:08 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 05:12 -!- Gurkenglas_ [~Gurkengla@dslb-094-223-141-229.094.223.pools.vodafone-ip.de] has quit [Ping timeout: 240 seconds] 05:38 -!- Gurkenglas_ [~Gurkengla@dslb-094-223-141-229.094.223.pools.vodafone-ip.de] has joined ##hplusroadmap 05:52 < ebowden> https://www.youtube.com/watch?v=0QrynzJ_lZ4 05:59 < kanzure> .title 05:59 < yoleaux> How carbide inserts are made by Sandvik Coromant - YouTube 06:05 -!- emeraldgreen [~user@188.227.115.178] has quit [Quit: Leaving.] 06:46 < kanzure> baseline test https://www.youtube.com/watch?v=l7BDuTiHC3I 06:47 -!- mindsForge [~nak@75-171-23-2.phnx.qwest.net] has joined ##hplusroadmap 06:50 -!- mindsForge [~nak@75-171-23-2.phnx.qwest.net] has quit [Remote host closed the connection] 06:56 -!- ebowden_ [~ebowden@2001:8003:10c9:e00:dce:73ce:826b:c351] has joined ##hplusroadmap 06:57 -!- ebowden [~ebowden@2001:8003:10c9:e00:dce:73ce:826b:c351] has quit [Ping timeout: 255 seconds] 06:57 < kanzure> ( https://www.youtube.com/watch?v=3Q-FJ203nJo ) 07:07 -!- eudoxia [~eudoxia@190.99.101.24] has joined ##hplusroadmap 08:04 -!- Nikopol_ [~NSohru@symset.filection.com] has joined ##hplusroadmap 08:07 -!- Nikopol_ [~NSohru@symset.filection.com] has quit [Client Quit] 08:46 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has joined ##hplusroadmap 08:59 -!- jaboja [~jaboja@jaboja.pl] has joined ##hplusroadmap 09:08 -!- aeiousom1thing [~aeiousome@183.82.170.54] has quit [Ping timeout: 258 seconds] 09:54 -!- jaboja [~jaboja@jaboja.pl] has quit [Ping timeout: 248 seconds] 09:59 -!- darsie is now known as braindad 10:05 -!- braindad is now known as darsie 10:13 -!- eudoxia [~eudoxia@190.99.101.24] has quit [Quit: Leaving] 10:22 < kanzure> blort 10:49 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Ping timeout: 246 seconds] 11:01 -!- eudoxia [~eudoxia@190.99.101.24] has joined ##hplusroadmap 11:17 -!- DataPacRat [~dan@adsl-107.itcanada.com] has joined ##hplusroadmap 11:19 -!- aeiousomething [~aeiousome@183.82.170.54] has joined ##hplusroadmap 11:27 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 11:33 < nmz787> so transient expression of plasmids in tissues is a problem, first obvious issue is transformation efficiency, which might be helped by electroporation somehow... but I'm not sure just how 11:34 < nmz787> maybe something like a microneedle array, where each needle can also act as an electrode 11:43 < kanzure> put the plasmids into bacteria, put the bacteria in the tissue, problem solved? 11:47 < streety> could also ask whether transient expression of a plasmid is the best approach to the task 11:52 < kanzure> oumuamua interception mission https://arxiv.org/abs/1711.03155 11:52 < kanzure> "To maximize science return decelerating the spacecraft at 'Oumuamua is highly desirable, due to the minimal science return from a hyper-velocity encounter." 11:55 -!- jtimon [~quassel@164.31.134.37.dynamic.jazztel.es] has quit [Ping timeout: 240 seconds] 11:55 < nmz787> kanzure: haha, good joke 11:56 < nmz787> streety: I don't want non-transient expression 11:58 < nmz787> I'm also thinking a modified tattoo gun could work, as the needle travels down into the tissue it could emit plasmid solution, the needle could also act as an electrode (the tip would only be conductive, the shaft being insulated)... as the needle travels down the voltage would increase on the pulses from the tip, so the field strength (volts per cm) would remain constant/similar-enough 12:18 -!- darsie [~username@84-114-73-160.cable.dynamic.surfer.at] has quit [Ping timeout: 240 seconds] 12:27 -!- rpifan [~rpifan@207-244-191-189-dhcp.mia.fl.atlanticbb.net] has joined ##hplusroadmap 12:32 -!- eudoxia [~eudoxia@190.99.101.24] has quit [Remote host closed the connection] 13:11 < streety> what effect are you looking for? If expression of some biological perhaps recombinant production of the biological and then injection would be an alternative 13:14 < nmz787> the prolactin hormone gene, to produce prolactin hormone, to achieve lactation in a single breast 13:15 -!- ebowden_ [~ebowden@2001:8003:10c9:e00:dce:73ce:826b:c351] has quit [Remote host closed the connection] 13:17 < streety> injection of recombinant protein is an option then 13:21 -!- justan0theruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 240 seconds] 13:28 -!- hehelleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has joined ##hplusroadmap 13:32 -!- Guest46305 [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has quit [Ping timeout: 260 seconds] 13:33 -!- justan0theruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 13:43 -!- yashgaroth [~yashgarot@2606:6000:cd4d:3300:f5e0:f867:a11d:8d52] has joined ##hplusroadmap 13:53 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Ping timeout: 248 seconds] 14:55 -!- NikopolSohru [~NSohru@symset.filection.com] has quit [Ping timeout: 248 seconds] 15:23 < kanzure> are there parts of the human population that undergo spontaneous age reversal? if we just monitor everyone maybe we can find someone that periodically has ~2 month cleanup as spontaneous events that can be studied. 15:23 < kanzure> by age reversal i mean minor age reversal (months or a year at most) 15:23 < kanzure> certainly seems like aging gets stuck for long stretches of time until sufficiently stressed (or whatever) 15:25 -!- yashgaroth_ [~yashgarot@2606:6000:cd4d:3300:f5e0:f867:a11d:8d52] has joined ##hplusroadmap 15:27 -!- yashgaroth [~yashgarot@2606:6000:cd4d:3300:f5e0:f867:a11d:8d52] has quit [Ping timeout: 240 seconds] 15:28 < kanzure> i think we can stall aging but i wouldn't count on fixing it 15:28 < kanzure> also there's lots of longevity alleles, and even extended prepubescence alleles 15:57 -!- aeiousomething [~aeiousome@183.82.170.54] has quit [Ping timeout: 248 seconds] 16:10 -!- ebowden [~ebowden@2001:8003:1074:bc00:5bf:e7d7:2984:15b4] has joined ##hplusroadmap 16:11 < kanzure> "When taking antibiotics, people report having wild, vivid dreams. ... Clindamycin, doxycycline, and quinolone antibiotics" 16:13 < rpifan> kanzure, i agree with that 16:13 < rpifan> on both statements 16:13 < rpifan> i know for a fact ppl who lose age 16:13 < rpifan> or who look a lot younger then they should 16:13 < rpifan> and also when i was one bactrim for pnuemonia 3 times a day 16:13 < rpifan> it kept me up more then adderal 16:15 < gradstudentbot> I don't know whether I am Turing dreaming that I am a machine, or a machine dreaming that I am Turing! 16:15 < rpifan> oh 16:28 -!- jaboja [~jaboja@jaboja.pl] has joined ##hplusroadmap 16:30 < kanzure> "That’s what Dani Clode’s Third Thumb project... The thumb, 3D printed from a variant of Thermoplastic Polyurethane (TPU) called Ninjaflex, sits right beside your little finger. It’s connected to a smart-bracelet that receives its commands via bluetooth from the wearer’s foot. Pressure sensors are placed on the soles of the feet and any force you apply with your foot is perceived as a ... 16:30 < kanzure> ...signal by the bracelet i.e., if you press down with one foot, the thumb flexes inwards, grasping whatever you’re holding." 16:31 < kanzure> "in this case, an extra thumb. With the aim of adding to human’s possibilities, rather than replacing what’s lost" 16:31 < kanzure> .title https://vimeo.com/220291411 16:32 < yoleaux> The Third Thumb Project on Vimeo 16:54 -!- Gurkenglas_ [~Gurkengla@dslb-094-223-141-229.094.223.pools.vodafone-ip.de] has quit [Ping timeout: 250 seconds] 16:56 -!- augur [~augur@192.195.83.130] has joined ##hplusroadmap 17:13 -!- jtimon [~quassel@164.31.134.37.dynamic.jazztel.es] has joined ##hplusroadmap 17:19 < kanzure> https://www.fietsenwinkel.nl/fietsen/-/elektrische_fietsen/speed_pedelecs/ 17:20 < kanzure> https://www.brompton.com/Brompton-Electric 17:30 -!- Gurkenglas_ [~Gurkengla@dslb-094-223-141-229.094.223.pools.vodafone-ip.de] has joined ##hplusroadmap 17:34 < kanzure> why doesn't lab equipment travel with the scientist 17:35 < kanzure> who came up with the "leave it at school" model? 18:00 -!- DataPacRat [~dan@adsl-107.itcanada.com] has quit [Ping timeout: 260 seconds] 18:00 < kanzure> https://www.newscientist.com/article/mg23631520-100-biohackers-are-using-crispr-on-their-dna-and-we-cant-stop-it/ 18:00 < kanzure> full text available here http://postbiota.org/pipermail/tt/2017-November/020889.html 18:10 < ebowden> I wonder how much of a drop in cancer rates you could get with a bunch of extra copies of P53. 18:10 < kanzure> it's listed multiple times on http://diyhpl.us/wiki/genetic-modifications/ 18:22 < ebowden> I wonder if there are any APP mutations that reduce Alzheimer's risk. 18:26 < kanzure> do you just not read my links? :( 18:26 < kanzure> do you not love me? 18:27 -!- mindsForge [~nak@75-171-23-2.phnx.qwest.net] has joined ##hplusroadmap 18:33 < ebowden> I did read it. 18:34 < ebowden> APP (Alzheimer's) 18:34 < ebowden> "More than 50 different mutations in the APP gene can cause early-onset Alzheimer disease, which begins before age 65." 18:34 < ebowden> Amyloid precursor protein 18:35 < ebowden> It did not mention mutants with lower risk. 18:37 < ebowden> kanzure, ^ 18:38 < ebowden> https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2740882/pdf/373.pdf 18:38 < ebowden> THIS amused me. 18:45 < rpifan> ebowden, direct drive is better 18:53 < nmz787> we should genetically knock-out the knee-jerk reaction 19:23 -!- jaboja [~jaboja@jaboja.pl] has quit [Remote host closed the connection] 19:24 -!- rpifan [~rpifan@207-244-191-189-dhcp.mia.fl.atlanticbb.net] has quit [Remote host closed the connection] 19:26 -!- redlegion [~x@unaffiliated/redlegion] has quit [Ping timeout: 255 seconds] 19:29 -!- redlegion [~x@104.219.54.200] has joined ##hplusroadmap 19:29 -!- redlegion [~x@104.219.54.200] has quit [Changing host] 19:29 -!- redlegion [~x@unaffiliated/redlegion] has joined ##hplusroadmap 19:31 < nmz787> hmm, U.S. units are /not/ Imperial 19:31 < nmz787> .wik Comparison_of_the_imperial_and_US_customary_measurement_systems 19:31 < yoleaux> "Both the imperial and United States customary systems of measurement derive from earlier English systems used in the Middle Ages, that were the result of a combination of the local Anglo-Saxon units inherited from German tribes and Roman units brought by William the Conqueror after the Norman Conquest of England in 1066." — https://en.wikipedia.org/wiki/Comparison_of_the_imperial_and_US_customary_measurement_systems 19:32 < nmz787> "At one time the definition of the nautical mile was based on the sphere whose surface is the same as the Clarke Ellipsoid. In the US, the full value of 1853.256 metres was used, but in the Commonwealth, this was rounded to 6080 feet (1853.184 m). These have been replaced by the international version, which rounds the sixtieth part of the 45° to the nearest metre, as 1852 metres." 19:41 -!- DataPacRat [~dan@adsl-107.itcanada.com] has joined ##hplusroadmap 19:50 < ebowden> A mutation (A673T) in the APP gene protects against Alzheimer’s disease. This substitution is adjacent to the beta secretase cleavage site and results in a 40% reduction in the formation of amyloid beta in vitro.[ 19:50 < ebowden> \:D/ 19:59 -!- preview [~quassel@2407:7000:842d:4056:37a0:7f9f:fec0:da74] has quit [Quit: No Ping reply in 180 seconds.] 20:00 -!- preview [~quassel@2407:7000:842d:4054:d5cf:344e:df10:15a2] has joined ##hplusroadmap 20:07 -!- Gurkenglas_ [~Gurkengla@dslb-094-223-141-229.094.223.pools.vodafone-ip.de] has quit [Ping timeout: 240 seconds] 20:53 < ebowden> kanzure, ^ 20:54 < ebowden> (From the wikipedia article.) 22:03 -!- DataPacRat [~dan@adsl-107.itcanada.com] has quit [Quit: Leaving.] 22:13 -!- ebowden_ [~ebowden@110.141.92.153] has joined ##hplusroadmap 22:13 -!- ebowden [~ebowden@2001:8003:1074:bc00:5bf:e7d7:2984:15b4] has quit [Ping timeout: 255 seconds] 22:15 -!- DataPacRat [~dan@adsl-107.itcanada.com] has joined ##hplusroadmap 22:19 -!- darsie [~username@84-114-73-160.cable.dynamic.surfer.at] has joined ##hplusroadmap 22:25 -!- mindsForge [~nak@75-171-23-2.phnx.qwest.net] has quit [Remote host closed the connection] 22:48 -!- yashgaroth_ [~yashgarot@2606:6000:cd4d:3300:f5e0:f867:a11d:8d52] has quit [Quit: Leaving] 23:07 -!- justan0theruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 258 seconds] 23:19 -!- justan0theruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 23:38 -!- preview_ [~quassel@2407:7000:842d:4000::2] has joined ##hplusroadmap 23:38 -!- preview [~quassel@2407:7000:842d:4054:d5cf:344e:df10:15a2] has quit [Ping timeout: 255 seconds] 23:39 -!- rpifan [~rpifan@207-244-191-189-dhcp.mia.fl.atlanticbb.net] has joined ##hplusroadmap 23:55 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has quit [Quit: sleep] --- Log closed Sat Nov 25 00:00:25 2017