--- Log opened Mon Nov 27 00:00:27 2017
00:02 <@fenn> they use mirrors now because glass isn't transparent enough
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00:28 < ebowden_> Ah, that makes sense.
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00:28 < ebowden> Sounds difficult though.
00:40 < nmz787> .title https://www.youtube.com/watch?v=SeXcz0UoUFw
00:40 < yoleaux> In Utero Electroporation - YouTube
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06:14 < kanzure> in utero electroporation is a cool technique
06:16 < kanzure> "Doubly-efficient zkSNARKs without trusted setup" https://eprint.iacr.org/2017/1132
06:41 < kanzure> http://genomicprediction.com/
06:41 < kanzure> https://www.technologyreview.com/s/609204/eugenics-20-were-at-the-dawn-of-choosing-embryos-by-health-height-and-more/
06:42 < kanzure> https://cagivf.com/finance-center/
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08:09 < kanzure> bleep bloop
08:22 < JayDugger> Hm.
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10:36 < kanzure> https://www.buzzfeed.com/stephaniemlee/these-startups-will-pay-you-for-your-dna
10:36 < kanzure> (with apologies for linking to buzzfeed)
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11:30 < kanzure> spurserh: greetings
11:30 < spurserh> hey hey
11:31 < spurserh> I'm back from the great mystery
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13:38 < kanzure> .title https://github.com/openyou/emokit/issues/224
13:38 < yoleaux> Appreciation for emokit. · Issue #224 · openyou/emokit · GitHub
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15:48 < nmz787> someone has an issue with appreciating emokit?
15:49 < nmz787> seems like they could have chose a better name for their 'issue'
15:49 < nmz787> I guess 'issue' doesn't necessarily have a negative connotation... so nevermind
15:51 < nmz787> hrmm, but I can't really think of a quick sentence where "issue" is used very positively
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15:59 < JayDugger> "Doctor, I have a problem. My ears issue blood when I hear people use issue when they mean problem."
16:12 < kanzure> nmz787: journals have issues
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16:57 < streety> as do stocks and bonds
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17:27 < kanzure> why is everyone so boring
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18:14 < ebowden_> nmz787: "There's a new issue out! Yaaaaaaaay!"
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19:11 < yashgaroth> bep
19:11 < yoleaux> 26 Nov 2017 14:29Z <kanzure> yashgaroth: wouldn't cell-free reactions get around a lot of GMO complaints?
19:12 < yashgaroth> yeah I got that email too, sadly cell-free expression sucks
19:13 < yashgaroth> I suppose if they're in some terrible country that doesn't like GMOs then it's a sort of workaround
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20:02 < kanzure> yashgaroth: i know jojack means well but when he says "ascension is promoting blockchain gene therapy".......
20:02 < kanzure> https://technical.ly/dc/2017/10/31/dc-biohakers-blockchainers-take-hiv/
20:03 < kanzure> "Ascendance Biomedical is trying to skirt the FDA’s lengthy approval process by not marketing their treatment as medicine at all, but rather, a product you can research yourself."
20:03 < yashgaroth> someone needs to edit that "put a bird on it!" sketch to say blockchain instead
20:03 < kanzure> not sure that's gonna work..... you might as well just say "regulatory risk is high" instead of saying "well it's research" (FDA regulates even research drugs yo.. that's why clinical trials are regulated).
20:04 < kanzure> yashgaroth: anyway... if you want to do an ICO you should just do it (under a pseudonym).
20:04 < yashgaroth> welcome to our online shop, here's 50 milligrams of highly purified plasmid for you to feed your houseplant with
20:05 < yashgaroth> I don't know what the hell all that stuff is about, p.s. a ton of random people irl are talking about bitcoin now
20:05 < yashgaroth> I was like 'what'd you buy in at' and one was like 'oh, $7000'
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20:06 < kanzure> well i'm around to answer questions i guess.
20:06 < yashgaroth> fuckin' sell before people figure it out imho, then again I didn't buy in when it was a dollar a btc
20:06 < kanzure> ICOs are basically hyper scammy... and people are going to shift to "bitcoin forks" i think, now that each one is launching with a $1 billion market cap easy peasy.
20:06 < yashgaroth> yeah I figured the combination of sketchy fundraising and sketchy unregulated gene therapy might be a little too much
20:07 < kanzure> one way to make it less scammy would be to make it something about pre-orders
20:07 < kanzure> but yeah, if you want to be unregulated then don't put your face on it
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20:09 < yashgaroth> I mean plasmids are cheap, was brian hanley the one who spent 10 grand on plasmid from a contract manufacturer? he got ripped off
20:09 < kanzure> keep giving me project proposals plz
20:10 < kanzure> i know i dropped the ball on some of your earlier proposals :-(
20:10 < kanzure> but we can do ~some~ things
20:11 < yashgaroth> for real, you could do crude designer babies today...shit an IVF clinic just went outta business in MA, could've picked up a whole facility for pennies I tells ya
20:11 < yashgaroth> well, the equipment in the facility, but none of it's that complicated to operate
20:11 < kanzure> yeah we could go on an equipment buying spree at some point...
20:14 < yashgaroth> it pops up fairly often, if you've got a year to outfit a lab you can pay like 5% the price vs. needing everything right now
20:14 < yashgaroth> company folds and drops 200 bioreactors onto the market, they go for nothing
20:16 < kanzure> am i right to expect better results from IVF + gene editing than gene therapy right now?
20:16 < kanzure> like for example, the WWC1/KIBRA mutation for +19% working memory... seems hard to get that edited in every cell in the body via gene therapy.
20:17 < yashgaroth> especially into the brain
20:17 < kanzure> well technically i don't think we know whether that mutation has to occur in the brain to get that effect :-)
20:18 < kanzure> but ok
20:18 < yashgaroth> true, but still it's a pain, like stem cells are sheathed in a protective pocket of support cells so I doubt you can even target them effectively
20:19 < kanzure> yea we need a particle accelerator to poke holes through the entire body
20:19 < kanzure> and then use high power vacuum to insert plasmids through all the through-holes
20:19  * kanzure nods
20:19 < yashgaroth> I did just spot a particle accelerator on ebay...oh nope someone bought it already
20:20 < kanzure> people can survive a particle accelerator blast through the kidney, right? beam diameter maybe 100 nm.
20:21 < yashgaroth> hell that one guy survived a blast to the brain
20:21 < yashgaroth> ahh anatoli bugorski
20:22 < kanzure> good times
20:24 < yashgaroth> anyway germline therapy is gonna be far superior to gene therapy for a long time, still a lot of hard problems to solve with delivery...alternatively there's reprogramming somatic cells into egg cells like that japanese paper
20:25 < yashgaroth> you can get a lot more DNA into reprogrammed cells, but the accumulated mutations in somatic cells are always a worry
20:27 < yashgaroth> though to be fair you could reprogram a fairly young somatic cell from some discarded embryo or w/e, still far more malleable than a differentiated egg cell but without too much damage accumulated in the genome
20:29 < yashgaroth> still, start with regular IVF, then move into reprogrammed egg cells in a year or two
20:32 < kanzure> sounds like a plan let's go
20:35 < yashgaroth> this IVF manual is only 250 pages, shit I thought it would be way longer
20:39 < kanzure> link?
20:40 < yashgaroth> there's a few on libgen, this one seems decent but I'll have to check them all out http://libgen.io/ads.php?md5=2E4365ABA3C43CECD44CADF14ABA8252
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20:45 < kanzure> http://diyhpl.us/~bryan/papers2/bio/books/Kay%20Elder,%20Brian%20Dale-In-Vitro%20Fertilization,%20Third%20Edition-Cambridge%20University%20Press%20(2011).pdf
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22:52 < justanotheruser> kanzure: you reference "Diamond Surfaces and Diamond Mechanosynthesis" in http://diyhpl.us/wiki/nanotech/molecular-manufacturing/ however it doesn't appear to have ever been completed, http://www.molecularassembler.com/DSDM.htm Is that an accurate assessment? Is the incomplete textbook available anywhere?
22:54 < justanotheruser> same question goes for "Fundamentals of Nanomechanical Engineering"
23:09 < poppingtonic> Landes Bioscience published so many awesome books. The Nanomedicine series, Aubrey de Grey's books...
23:10 < poppingtonic> Cue for a sentence that starts on a high note and ends with disappointment: "A full analysis of how to use programmable positional assembly to synthesize most arrangements of atoms permitted by physical law would be, at present, prohibitively complex"
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--- Log closed Tue Nov 28 00:00:28 2017