--- Log opened Wed Dec 20 00:00:48 2017
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01:08 < abetusk> http://news.cornell.edu/stories/2017/12/engineers-scrap-stethoscope-measure-vital-signs-radio-waves
01:08 < abetusk> .title
01:08 < yoleaux> Engineers scrap the stethoscope, measure vital signs with radio waves | Cornell Chronicle
01:08 < abetusk> .title.pdf https://www.nature.com/articles/s41928-017-0001-0
01:08 < abetusk> .title https://www.nature.com/articles/s41928-017-0001-0
01:08 < yoleaux> Monitoring vital signs over multiplexed radio by near-field coherent sensing | Nature Electronics
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09:05 <@fenn> "Aging, n.  the process by which objects or materials acquire desirable qualities by being left undisturbed for some time under specific conditions."
09:08 <@fenn> how was the heartbeat tracker in "aliens" supposed to work? was that just doppler radar?
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09:19 < mrdata> technobabble
09:19 < mrdata> to move the story along
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09:26 <@fenn> cameron's technobabble turns out to be fairly plausible most of the time
09:26 <@fenn> .title http://www.sciencedirect.com/science/article/pii/S0263224115001062#!
09:26 < yoleaux> Evaluation of a Doppler radar sensor system for vital signs detection and activity monitoring in a radio-frequency shielded room - ScienceDirect
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10:38 <@fenn> where's waldo? https://pbs.twimg.com/media/DRezf3BU8AASJRT.jpg:large
10:40 <@fenn> "affordable rapid bootstrapping of space industry and solar system civilization" https://arxiv.org/pdf/1612.03238.pdf
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12:59 <@kanzure> .title https://news.ycombinator.com/item?id=15972771
12:59 < yoleaux> US Federal Ban on Making Lethal Viruses Is Lifted | Hacker News
13:00 <@kanzure> "This is definitely one of those cases where I feel like a lot of people are demonstrating some very magical thinking about the effectiveness of regulations, with all due respect to those involved. Does Kim Jong Un care that some people in Washington DC say that it's illegal to make lethal viruses? Does China? Russia? Iran? Europe? Anyone else in the world, really? Or a small criminal lab ...
13:00 <@kanzure> ...located in the United States? Or a criminal with access to a lab in the United States? It's not like there's literally people standing on top of every single gene sequencer in the world, or the US, stopping people from doing things."
13:10 <@fenn> regulations at least stop accidents from happening
13:11 <@kanzure> as an employee at a regulated company i am obligated by the regulation brain slugs to confirm and agree with this
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17:30  * adlai pours salt on kanzure's brain
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17:41 < JayDugger> Hypersaline cranial irrigation only works if first preceded by trepanation.
17:42 < JayDugger> And then only because light coming in through the hole scares the brain slugs away. The salt just keeps them from moving back in.
17:43 < adlai> sunlight is the nest is infectend
17:47 < JayDugger> Yup.
18:00 <@kanzure> "A novel human pain insensitivity disorder caused by a point mutation in ZFHX2" https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awx326/4725107
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18:03 <@kanzure> "Following filtering and verification by Sanger sequencing, two novel coding variants were confirmed to co-segregate with the pain-insensitive phenotype: SUPT3H (NM_003599:c.G409A:p.A137T) and ZFHX2 (NM_033400:c.G5738A:p.R1913K). The variant in SUPT3H is annotated as benign by both the M-CAP and PolyPhen-2 (HumVar) tools and is also predicted to not alter splicing (NNSPLICE). In contrast, the ...
18:03 <@kanzure> ...point mutation in ZFHX2 (Fig. 1C) was indicated to be deleterious (M-CAP, PolyPhen-2 and SIFT), was absent from public SNP databases (1000 Genomes and dbSNP147) and the ExAC and Institutional (UCL) exome datasets, and so was prioritized for further analysis. "
18:03 <@kanzure> "ZFHX2 encodes a large protein of 2572 amino acids (NP_207646) that comprises 17 zinc finger motifs, two of which are adjacent to either side of the central PRDM9-like domain, and three homeodomains (Fig. 1D and Supplementary Fig. 1), features common to transcriptional regulators (Komine et al., 2006). The predicted PRDM9-like fold domain has no common active site tyrosines essential for ...
18:03 <@kanzure> ...methyl transferase activity (Wu et al., 2013) but may still exhibit nucleosome binding properties. The p.R1913K mutation identified in the pain-insensitive individuals maps within the second homeodomain (Fig. 1D) and to a residue that is invariant across all known orthologous Tetrapoda Zfhx2 genes (HomoloGene 52657) (Fig. 1E).
18:03 <@kanzure> "
18:04 <@kanzure> "Next, a BAC transgenic mouse model was generated in which arginine-1907, the orthologous amino acid to arginine-1913 in human ZFHX2, was mutated to lysine. Acute pain behaviour assays (Fig. 4 and Supplementary Fig. 4) showed that transgenic mice expressing the ZFHX2 p.R1907K mutant protein had significant deficits in sensitivity to noxious heat. Strikingly, the noxious heat pain thresholds ...
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18:05 <@kanzure> ...were significantly higher in mice with the highest genomic BAC copy number (four to five genomic copies) (Fig. 4B and D). Furthermore, calcium imaging experiments conducted on cultured DRG neurons from these mice showed that they had a reduced response to capsaicin (1 µM) compared to wild-type neurons (Fig. 4E–G)."
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19:30 <@fenn> http://lesswrong.com/lw/mjl/immortality_roadmap/ definitely don't agree with their timeline, but i can rationalize that it was simplified for an easy to read layout
19:33 <@fenn> also there's way too much stuff about an AI reading your facebook profile etc and way too little about post-death brain scanning
19:45 < adlai> jesus L (for azarus) christ can't you let the dead die already!?
19:46 < adlai> honestly, your precious heartbeat timejoules are better spent learning latin instead of masturbating about reversing neuroptosis
19:46 < adlai> it prunes for a reason.
19:50 <@kanzure> it prunes because you suck at biology
19:52  * adlai hasn't yet classified whether biology is something that can be sucked at or from, or merely sucks, period
19:58 <@fenn> all of the above
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--- Log closed Thu Dec 21 00:00:49 2017