--- Log opened Wed Jan 03 00:00:01 2018 01:17 -!- ebowden [~ebowden@110.141.27.51] has quit [Remote host closed the connection] 01:18 -!- ebowden [~ebowden@110.141.27.51] has joined ##hplusroadmap 02:34 -!- Gurkenglas [~Gurkengla@dslb-094-223-133-187.094.223.pools.vodafone-ip.de] has joined ##hplusroadmap 03:28 -!- aeiousom1thing [aeiousomet@gateway/vpn/privateinternetaccess/aeiousomething] has joined ##hplusroadmap 03:31 -!- aeiousomething [~aeiousome@183.82.170.54] has quit [Ping timeout: 240 seconds] 03:52 -!- fluke` [~user@193.165.236.254] has quit [Ping timeout: 240 seconds] 04:24 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has joined ##hplusroadmap 04:27 -!- fenrir849 [a9fc0415@gateway/web/cgi-irc/kiwiirc.com/ip.169.252.4.21] has quit [Quit: http://www.kiwiirc.com/ - A hand crafted IRC client] 04:28 -!- NikopolSohru [~NSohru@s5596eed8.adsl.online.nl] has joined ##hplusroadmap 04:29 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has quit [Quit: Malvolio] 04:30 -!- Gurkenglas [~Gurkengla@dslb-094-223-133-187.094.223.pools.vodafone-ip.de] has quit [Ping timeout: 252 seconds] 04:33 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-dfikbasdxspykqvo] has joined ##hplusroadmap 05:26 -!- emeraldgreen [~user@188.227.115.178] has joined ##hplusroadmap 05:27 -!- NikopolSohru [~NSohru@s5596eed8.adsl.online.nl] has quit [Quit: Leaving] 05:32 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has joined ##hplusroadmap 05:34 -!- darsie [~username@84-114-73-160.cable.dynamic.surfer.at] has joined ##hplusroadmap 05:43 -!- darsie [~username@84-114-73-160.cable.dynamic.surfer.at] has quit [Ping timeout: 240 seconds] 06:17 -!- emeraldgreen [~user@188.227.115.178] has quit [Quit: Leaving.] 06:44 -!- Gurkenglas [~Gurkengla@dslb-094-223-133-187.094.223.pools.vodafone-ip.de] has joined ##hplusroadmap 06:59 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-dfikbasdxspykqvo] has quit [Quit: Connection closed for inactivity] 07:54 < kanzure> "The price of an LTO 7 tape cartridge with specified compression to provide up to 16 TB is then $0.0089 per GB. So a raw storage cost of $0.02 per GB for LTO tape (the most popular tape format) " 08:04 < kanzure> .tw https://twitter.com/readcoor/status/948531673376968707 08:04 < yoleaux> ReadCoor receives funding from Chan Zuckerberg Initiative to map cortical cells for @humancellatlas in partnership w/@Allen_Institute for Brain Science. FISSEQ will provide insight into cortical cell variation in the context of tissue microenvironments. https://goo.gl/194SpR https://pbs.twimg.com/media/DSncf6MXkAUeoZz.jpg (@readcoor) 08:08 -!- emeraldgreen [~user@178.71.239.254] has joined ##hplusroadmap 08:10 < kanzure> "Acoustically targeted chemogenetics for noninvasive control of neural circuits" https://www.biorxiv.org/content/early/2018/01/01/241406 https://twitter.com/biorxiv_neursci/status/947935675642515458 08:10 < kanzure> "Here, we introduce an approach to modulating neural circuits noninvasively with spatial, cell-type and temporal specificity. This approach, called acoustically targeted chemogenetics, or ATAC, uses transient ultrasonic opening of the blood brain barrier to transduce neurons at specific locations in the brain with virally-encoded engineered G-protein-coupled receptors, which subsequently ... 08:10 < kanzure> ...respond to systemically administered bio-inert compounds to activate or inhibit the activity of these neurons. We demonstrate this concept in mice by using ATAC to noninvasively modify and subsequently activate or inhibit excitatory neurons within the hippocampus, showing that this enables pharmacological control of memory formation. This technology allows a brief, noninvasive procedure to ... 08:11 < kanzure> ...make one or more specific brain regions capable of being selectively modulated using orally bioavailable compounds, thereby overcoming some of the key limitations of conventional brain therapies. 08:11 < kanzure> " 08:13 < kanzure> well that's... cool. 08:30 -!- NikopolSohru [~NSohru@85.150.238.216] has joined ##hplusroadmap 08:44 -!- Gurkenglas [~Gurkengla@dslb-094-223-133-187.094.223.pools.vodafone-ip.de] has quit [Ping timeout: 252 seconds] 09:08 -!- Gurkenglas [~Gurkengla@dslb-094-223-133-187.094.223.pools.vodafone-ip.de] has joined ##hplusroadmap 09:08 -!- drewbot [~cinch@54.226.240.80] has quit [Remote host closed the connection] 09:22 -!- emeraldgreen [~user@178.71.239.254] has quit [Ping timeout: 265 seconds] 09:28 -!- NikopolSohru [~NSohru@85.150.238.216] has quit [Ping timeout: 256 seconds] 09:39 -!- fluke` [~user@ip-89-103-47-53.net.upcbroadband.cz] has joined ##hplusroadmap 09:46 < kanzure> fluke`: be greeted 09:47 -!- NikopolSohru [~NSohru@s5596eed8.adsl.online.nl] has joined ##hplusroadmap 09:52 < fluke`> kanzure: thank you? 09:52 < kanzure> what bring you here? 09:52 < fluke`> kanzure: script? 09:53 < kanzure> script sent you here? 09:56 < fluke`> kanzure: you could say that :] do you know this crazy people? https://vulpinedesigns.co.uk/ 09:57 < fluke`> funny furries :] 09:59 < kanzure> "Refine the design and construct prototypes of The Geneticiser, our molecular bioprinter. Develop and release a kit for enthusiasts and professionals alike to construct Geneticisers enabling molecular bioprinting to rival 3D printing in price per print and device." 09:59 < kanzure> what does it actually do though? 10:00 < fluke`> kanzure: no real idea :] 10:00 < kanzure> if they are just printing cells then they should say so 10:01 < fluke`> kanzure: it is not "just" printing,.. but ok. I am not saying they are any good. I am saying they are crazy enough to try :] 10:02 < kanzure> this is a very strange page https://vulpinedesigns.co.uk/guess.html 10:02 < fluke`> yop 10:03 < fluke`> some people do not give a two fucks :] 10:03 < MrHindsight> looks like a 7th grade science project 10:04 < kanzure> they are furries so mentally they are probably 7th grade 10:06 < fluke`> hmm,.. anybody for animal testing? 10:08 < kanzure> sure 10:37 -!- helleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has joined ##hplusroadmap 10:39 -!- hehelleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has quit [Ping timeout: 268 seconds] 10:42 < kanzure> http://www.cnn.com/2017/12/20/health/fda-gene-therapy-blindness-bn/index.html 10:45 -!- emeraldgreen [~user@178.71.239.254] has joined ##hplusroadmap 10:50 -!- emeraldgreen1 [~user@178.71.239.254] has joined ##hplusroadmap 10:51 -!- emeraldgreen1 [~user@178.71.239.254] has quit [Client Quit] 10:52 -!- emeraldgreen [~user@178.71.239.254] has quit [Ping timeout: 240 seconds] 10:53 < MrHindsight> "genetic treatment for blindness will cost $850,000, less than the $1 million price tag that had been expected" 10:53 < MrHindsight> so a bargain 10:54 < fluke`> MrHindsight: depends how much cost less productive blind person 10:54 < fluke`> average blind person 10:56 < MrHindsight> "provides a functional copy of the RPE65 gene to act in place of a mutated RPE65 gene" 10:58 < MrHindsight> adeno-associated virus vector-based gene therapy 10:58 < kanzure> AAV is a pretty common technique 10:59 < MrHindsight> so for under $100K in lab equipment and chems one could manufacture this but without FDA approval 10:59 -!- darsie [~username@84-114-73-160.cable.dynamic.surfer.at] has joined ##hplusroadmap 11:02 < MrHindsight> "estimated 1,000 to 2,000 people in the United States stand to benefit from this option" 11:02 < MrHindsight> limited market 11:03 < MrHindsight> so it must have been easy/lower cost than usual to get the approval 11:05 < kanzure> yes FDA has a program called "orphaned drugs" 11:07 -!- drewbot [~cinch@54.227.46.176] has joined ##hplusroadmap 11:16 < kanzure> hmm i am need find someone to do open-source erythropoietin 11:16 < kanzure> maybe gabe 11:18 < kanzure> andrew says a few teams are going after $1k IVF scheme (using stem cells of course... which isn't developed yet.. so..) 11:32 -!- Gurkenglas [~Gurkengla@dslb-094-223-133-187.094.223.pools.vodafone-ip.de] has quit [Read error: Connection reset by peer] 11:42 -!- aeiousom1thing [aeiousomet@gateway/vpn/privateinternetaccess/aeiousomething] has quit [Ping timeout: 268 seconds] 11:48 -!- NikopolSohru [~NSohru@s5596eed8.adsl.online.nl] has quit [Ping timeout: 260 seconds] 11:49 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-oztbsxvyhembhdwx] has joined ##hplusroadmap 12:34 -!- darsie [~username@84-114-73-160.cable.dynamic.surfer.at] has quit [Ping timeout: 252 seconds] 13:20 -!- jaboja [~jaboja@jaboja.pl] has joined ##hplusroadmap 13:31 -!- eudoxia [~eudoxia@r186-50-8-139.dialup.adsl.anteldata.net.uy] has joined ##hplusroadmap 13:58 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-oztbsxvyhembhdwx] has quit [Quit: Connection closed for inactivity] 13:59 -!- fluke` [~user@ip-89-103-47-53.net.upcbroadband.cz] has quit [Ping timeout: 265 seconds] 14:07 -!- ebowden [~ebowden@110.141.27.51] has quit [Remote host closed the connection] 14:08 -!- ebowden [~ebowden@110.141.27.51] has joined ##hplusroadmap 14:12 -!- ebowden [~ebowden@110.141.27.51] has quit [Ping timeout: 248 seconds] 14:38 -!- ebowden [~ebowden@110.141.27.51] has joined ##hplusroadmap 14:46 < kanzure> hmph 15:01 -!- Gurkenglas [~Gurkengla@94.223.133.187] has joined ##hplusroadmap 15:02 -!- Gurkenglas [~Gurkengla@94.223.133.187] has quit [Remote host closed the connection] 15:02 -!- Gurkenglas [~Gurkengla@dslb-094-223-133-187.094.223.pools.vodafone-ip.de] has joined ##hplusroadmap 15:04 < JayDugger> harumph. 15:16 -!- eudoxia [~eudoxia@r186-50-8-139.dialup.adsl.anteldata.net.uy] has quit [Quit: Leaving] 15:25 -!- SkunkFox [~Foxie@cpe-2606-A000-A441-9100-10AD-2CA3-A943-2FA1.dyn6.twc.com] has quit [Ping timeout: 250 seconds] 15:26 -!- jaboja [~jaboja@jaboja.pl] has quit [Remote host closed the connection] 15:26 -!- jaboja [~jaboja@jaboja.pl] has joined ##hplusroadmap 15:34 -!- fluke` [~user@193.165.236.254] has joined ##hplusroadmap 15:37 -!- yorick [~yorick@oftn/oswg-member/yorick] has quit [Remote host closed the connection] 16:17 < kanzure> https://www.reddit.com/r/Bitcoin/comments/7npeh6/lightning_network_megathread/ 16:26 < nmz787> https://gitlab.vulpinedesigns.co.uk/TheGUESSUniversalEditingSuiteandSDK/DNA_Computing 16:26 < nmz787> mentions helixworks 16:29 -!- SkunkFox [~Foxie@cpe-107-15-31-224.nc.res.rr.com] has joined ##hplusroadmap 16:52 -!- jaboja [~jaboja@jaboja.pl] has quit [Quit: Leaving] 16:57 -!- hehelleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has joined ##hplusroadmap 17:01 -!- helleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has quit [Ping timeout: 250 seconds] 17:11 -!- berndj [~berndj@mail.azna.co.za] has quit [Quit: ZNC - http://znc.in] 17:13 -!- berndj [~berndj@mail.azna.co.za] has joined ##hplusroadmap 17:14 -!- ExeciN [ExeciN@bnc.stormbit.net] has quit [Ping timeout: 240 seconds] 17:14 -!- SkunkFox [~Foxie@cpe-107-15-31-224.nc.res.rr.com] has quit [Ping timeout: 268 seconds] 17:14 -!- balrog [~balrog@unaffiliated/balrog] has quit [Ping timeout: 240 seconds] 17:15 -!- darsie [~username@84-114-73-160.cable.dynamic.surfer.at] has joined ##hplusroadmap 17:18 -!- balrog [~balrog@unaffiliated/balrog] has joined ##hplusroadmap 17:22 -!- ExeciN [ExeciN@bnc.stormbit.net] has joined ##hplusroadmap 17:29 -!- SkunkFox [~Foxie@cpe-2606-A000-A441-9100-D8CA-2984-CEBB-4A04.dyn6.twc.com] has joined ##hplusroadmap 17:30 -!- hehelleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has quit [Ping timeout: 264 seconds] 17:31 < kanzure> "Ultrasound approach tracks gut microbes 17:31 < kanzure> " 17:31 < kanzure> https://www.nature.com/articles/d41586-017-08911-0 17:31 < kanzure> "Acoustic reporter genes for noninvasive imaging of microorganisms in mammalian hosts" https://www.nature.com/articles/nature25021 17:31 < kanzure> https://spectrum.ieee.org/the-human-os/biomedical/imaging/ultrasound-tracks-therapeutic-microbes-deep-inside-the-body 17:53 -!- helleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has joined ##hplusroadmap 18:07 -!- SkunkFox [~Foxie@cpe-2606-A000-A441-9100-D8CA-2984-CEBB-4A04.dyn6.twc.com] has quit [Ping timeout: 276 seconds] 18:13 -!- yashgaroth [~yashgarot@2606:6000:cd4d:3300:f5e0:f867:a11d:8d52] has joined ##hplusroadmap 18:41 < kanzure> MrHindsight: is 500 watts reasonable power draw for a 6-printhead system like kemmishtree was talking about yesterday? 18:53 -!- ebowden [~ebowden@110.141.27.51] has quit [Ping timeout: 248 seconds] 19:25 -!- adlai [~adlai@unaffiliated/adlai] has quit [Ping timeout: 240 seconds] 19:25 < mrdata> kanzure, seems like a lot of juice, to me 19:26 < mrdata> what is being printed? 19:29 -!- adlai [~adlai@unaffiliated/adlai] has joined ##hplusroadmap 19:29 < kanzure> (2006) "In vitro fertilization (IVF): a review of 3 decades of clinical innovation and technological advancement" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1936357/ 19:29 < kanzure> (2015) "A global perspective on assisted reproductive technology fertility treatment: an 8-country fertility specialist survey" https://rbej.biomedcentral.com/articles/10.1186/s12958-015-0131-z 19:30 < kanzure> mrdata: no just asking for a rough upper bound 19:30 < kanzure> mrdata: liquids 19:31 < mrdata> well, if it uses stepper motors, it's a significant thing that those draw the most current when theyre holding their position 19:32 < kanzure> (2017) "Systematic review of worldwide trends in assisted reproductive technology 2004–2013" https://rbej.biomedcentral.com/articles/10.1186/s12958-016-0225-2 20:11 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has quit [Quit: ORGANS IN MAINS] 20:33 -!- Gurkenglas [~Gurkengla@dslb-094-223-133-187.094.223.pools.vodafone-ip.de] has quit [Remote host closed the connection] 20:34 -!- Gurkenglas [~Gurkengla@dslb-094-223-133-187.094.223.pools.vodafone-ip.de] has joined ##hplusroadmap 20:40 -!- Gurkenglas [~Gurkengla@dslb-094-223-133-187.094.223.pools.vodafone-ip.de] has quit [Ping timeout: 240 seconds] 20:47 -!- ebowden [~ebowden@2001:8003:11a6:8600:4937:8302:30f7:db22] has joined ##hplusroadmap 20:48 < MrHindsight> mrdata: ~32000 inkjet nozzles 20:49 < MrHindsight> kanzure: depends on the heads used, motors driving the stage, vacuum pumps, etc 20:49 < kanzure> no vacuum 20:50 < kanzure> less than 0.1 meter/sec total movement 20:54 < MrHindsight> 500-1Kw with those Kyocera head not including the controller 20:55 < kanzure> per head? 20:55 < MrHindsight> with RPSA heads maybe 8x that 20:56 < MrHindsight> all the heads 20:56 < kanzure> thanks 20:56 < MrHindsight> just ballparks 20:56 < kanzure> yeah sure 20:56 < MrHindsight> do you need to run from batteries? 20:56 < kanzure> non 20:56 < kanzure> no 20:57 < kanzure> ballparks are good, thanks for the assist 20:57 < kanzure> we are in magic napkin math territory 20:57 < MrHindsight> usually a minor concern 20:59 < kanzure> if we wanted to make custom inkjet printheads, do you have any contacts that you could pursue on this? 20:59 < kanzure> e.g. with custom valve counts 20:59 < kanzure> for a few million bucks 21:02 < MrHindsight> sure 21:02 < kanzure> great thanks 21:02 < mrdata> 32000 nozzles? are you spraying peptides?? 21:02 < MrHindsight> then you could tweak them for biofluids vs inks 21:03 < kanzure> mrdata: more like a billion valves 21:03 < kanzure> er, nozzles 21:03 < mrdata> yeah 21:03 < mrdata> this is fail 21:03 < kanzure> not peptides, but there's probably some cool stuff that can be done with peptides + inkjets 21:03 < MrHindsight> 3 billion drop locations, 2 fluids 21:38 < MrHindsight> we'd make MEMS heads in China or Taiwan for that 21:39 < kanzure> cool 21:40 < MrHindsight> just keep it on the down low 21:40 < MrHindsight> avoid the trolls 21:49 -!- fenrir849 [a9fc0415@gateway/web/cgi-irc/kiwiirc.com/ip.169.252.4.21] has joined ##hplusroadmap 21:54 < kanzure> hi fenrir849 21:55 < fenrir849> yo 21:57 < nmz787> wazzup 22:09 < nmz787> https://blogs.scientificamerican.com/observations/a-neuroscientist-explores-the-sanskrit-effect/ 22:10 < nmz787> .title 22:10 < yoleaux> A Neuroscientist Explores the "Sanskrit Effect" - Scientific American Blog Network 22:10 < nmz787> "MRI scans show that memorizing ancient mantras increases the size of brain regions associated with cognitive function" 22:19 -!- yashgaroth [~yashgarot@2606:6000:cd4d:3300:f5e0:f867:a11d:8d52] has quit [Quit: Leaving] 22:57 < MrHindsight> is there a lower cost MRI scanner out there? 22:57 < MrHindsight> I worked on designs for Siemens in the early 90's 22:58 < MrHindsight> they were all >>300K 23:23 -!- sachy [~sachy@78.108.102.220] has quit [Quit: Leaving.] 23:25 < nmz787> no I bet with inflation they've gone up in price 23:33 < fenrir849> is this related to the fact that mindfulness meditation increases grey matter? because I think it's more about focused attention than WHAT you're actually studying 23:39 <@fenn> citation please 23:42 <@fenn> a study from 2011 showed increase in hippocampus grey matter, this article also shows increase in hippocampus grey matter 23:42 <@fenn> they are probably the same thing 23:47 <@fenn> https://scholar.harvard.edu/sara_lazar/publications/mind-hype-critical-evaluation-and-prescriptive-agenda-research-mindfulness by the author of that paper, seems like required reading for anyone who is interested in this stuff 23:54 <@fenn> alright i give up 23:54 <@fenn> the internet has become unusable --- Log closed Thu Jan 04 00:00:02 2018