--- Log opened Mon Jan 15 00:00:24 2018
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03:04 < kanzure> https://www.reddit.com/r/EngineeringPorn/comments/7qgrwk/colibri_motion_sculpture
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08:08 < kanzure> https://medium.com/@GaryMarcus/in-defense-of-skepticism-about-deep-learning-6e8bfd5ae0f1
08:11 < kanzure> i am need a review of hyper-exotic dna nanopore sequencing theory or design
08:12 < kanzure> dna can go through a nanopore at 100 kbp/sec, but not necessarily sequenced
08:15 < kanzure> i like juul's indium tin oxide idea for electrowetting on glass
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08:39 < kanzure> .title https://www.youtube.com/watch?v=IuSQZ_wIPgEn
08:39 < yoleaux> Active Digital Microfluidic Paper Chips with Inkjet-Printed Patterned Electrodes - YouTube
08:46 < kanzure> http://diyhpl.us/~bryan/papers2/microfluidics/Active%20digital%20microfluidic%20paper%20chips%20with%20inkjet-printed%20patterned%20electrodes%20-%202014.pdf
08:49 < kanzure> "High performance organic transistor active-matrix driver developed on paper substrate" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377355/
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09:18 < kanzure> davidru: hi.
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10:23 < kanzure> inkjet history stuff http://diyhpl.us/~bryan/papers2/inkjet/The%20dynamics%20of%20the%20piezo%20inkjet%20printhead%20operation%20-%202010.pdf
11:19 < kanzure> "Valve multiplexing enables exponentially complex function with fewer pneumatic inputs, leading to increasingly smaller devices. For example, binary multiplexers can regulate “n” separate sample channels with 2×log2(n) pneumatic microfluidic control valves (e.g. 20 valves regulates 1024 samples) [26], and another combinatorial multiplexer scheme is even more efficient and uses “N” ...
11:19 < kanzure> ...control valves to regulate N!/(((N/2)!)^2) individual sample channels [28]."
11:20 < kanzure> from a 4-valve 16-well multiplexer paper http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0074480
11:20 < kanzure> (they got the notation wrong for [28] actually)
11:20 < kanzure> [28] A versatile microreactor platform featuring a chemical-resistant microvalve array for addressable multiplex syntheses and assays https://deepblue.lib.umich.edu/bitstream/handle/2027.42/49051/jmm6_8_001.pdf
11:25 < kanzure> how do microfluidic systems deal with the wrong chemicals hanging out by a closed valve? you just wash the system thoroughly and hope that your solvent flowed everywhere even down the low-velocity flow areas?
11:27 < kanzure> or is the idea that the total volume left over in the channels is so small that it doesn't matter?
11:33 < kanzure> or is the idea that there is a fluid resistance due to nowhere for the liquid to flow, therefore minimal mixing occurs?
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11:35 < kanzure> anyway, with this multiplexing method, using only 32 valves you can differentially address 600 million spots
11:37 < nmz787> kanzure: a lot of micro/nano fluidic research today is looking at materials which are atomically smooth, so rinsing is more effective and you don't need to wait for diffusion into weird nanocavities that might want to retain chemicals
11:37 < nmz787> kanzure: mutiplexing is just binary expansion... so however many integers you can store with a number of bits, is equivalent to the number of valves you can MUX with that number of control lines
11:38 < kanzure> explain tho. how do you rinse a binary tree?
11:38 < kanzure> all channels are traveled until blockage
11:38 < nmz787> well the tree is just for adjusting the state of the valves
11:39 < nmz787> one of those valves might be for controlling rinse solvent
11:39 < nmz787> (or one rinse valve for each chemical valve)
11:39 < kanzure> next time you open the valve, the rinse solvent would go to your reaction well, which isn't what you wanted- you just wanted to clean the addressing channels.
11:39 < nmz787> not if you turned off that valve first
11:40 < nmz787> the injector valve
11:40 < nmz787> (rxn injector valve)
11:40 < kanzure> ok, so you want a drain valve that is universally controlled just before all chambers?
11:40 < nmz787> yeah that's one way... but with enough MUXing you don't need it to be global, it could be per-reaction too
11:49 < kanzure> nmz787: a <40 valve system is interesting to me. i'd consider valves, for a sufficiently simple design.
11:49 < nmz787> are these mechanical valves, or electrical valves (i.e. electrostatic or something)... or just a huge grid of electrowetting type electrodes?
11:52 < kanzure> well that's based on total switching time.... you have multiple separate wavefronts traveling through the multiplexer. if the valves are too slow then you wont be able to deliver liquids to everywhere multiple times per second.
11:55 < nmz787> well IMO it's just like clock domains in SoCs... they need to be synced properly
11:56 < nmz787> lately I've been considering just using electrophoresis or whatever the new buzzword is, electrokinesis, etc... no mechanical valves if I can get away with it
11:57 < nmz787> I saw some stuff about static electric fields being useful to limit diffusion too
12:01 < kanzure> electrowetting seems to be reasonably fast https://www.youtube.com/watch?v=4FDbC5Opv2w&t=4m4s
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12:01 < kanzure> "25 ms per electrode activation"
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12:03 < kanzure> .title https://www.youtube.com/watch?v=pSls9L_h3Q0
12:03 < yoleaux> OpenDrop Digital Microfludics - Speed Test - YouTube
12:23 < kanzure> i like this figure 1 from the c. elegans paper: http://diyhpl.us/~bryan/papers2/microfluidics/An%20automated%20microfluidic%20multiplexer%20for%20fast%20delivery%20of%20C.%20elegans%20populations%20from%20multiwells%20-%202013.fig1.png
12:35 < maaku> "worm delivery channel" is the stuff of nightmares
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13:52 < kanzure> .wik COX7A1
13:52 < yoleaux> "Cytochrome c oxidase polypeptide 7A1, mitochondrial is an enzyme that in humans is encoded by the COX7A1 gene." — https://en.wikipedia.org/wiki/COX7A1
13:52 < kanzure> oh right
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14:19 < andytoshi> https://www.theatlantic.com/science/archive/2018/01/brain-cells-can-share-information-using-a-gene-that-came-from-viruses/550403/?single_page=true
14:19 < andytoshi> .title
14:19 < yoleaux> Brain Cells Share Information With Virus-Like Capsules - The Atlantic
14:22 < andytoshi> .title http://www.pnas.org/content/114/34/9182
14:22 < yoleaux> Arc restores juvenile plasticity in adult mouse visual cortex
14:29 < kanzure> that's not the paper that people are excited about tho, it's the other one, https://www.sciencedirect.com/science/article/pii/S0092867417315040
14:31 < andytoshi> o wow
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15:06 < kanzure> nmz787: page 8 bottom right paragraph https://web.stanford.edu/group/foundry/technology/MicrofluidicsLSI/revbio_may07.pdf
15:13 < nmz787> kanzure: ah yeah, I've seen that before. yup
15:19 < kanzure> no i mean the contamination
15:19 < kanzure> it's right there
15:25 < kanzure> .title https://www.youtube.com/watch?v=DP8xSEM9bd8
15:25 < yoleaux> Zero knowledge, subversion resistance, and concrete attacks | Steven Goldfeder | RWC 2018 - YouTube
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15:49 < kanzure> .wik equipment trust certificate
15:49 < yoleaux> "An equipment trust certificate (ETC) is a financial security used in aircraft finance, most commonly to take advantage of tax benefits in North America." — https://en.wikipedia.org/wiki/Equipment_trust_certificate
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17:20 < maaku> Reminds me of the juggler planet "carrier birds" in Turquoise Days
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19:20 < kanzure> hmm
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19:27 < kanzure> "zero-knowledge contingent payments: attacks and payments for services" http://stevengoldfeder.com/papers/ZKCSP.pdf
19:40 < Hooloovo0> yeah, ZKPOK are cool
19:41 < kanzure> hi
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19:55 < Hooloovo0> hi
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21:47 < kanzure> .title https://www.youtube.com/watch?v=zqE-ultsWt0
21:47 < yoleaux> BFR | Earth to Earth - YouTube
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23:05 < nmz787> kanzure: contamination? they say their binary tree addresses that
23:16 < kanzure> hm.
23:16 < kanzure> alright
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--- Log closed Tue Jan 16 00:00:25 2018