--- Log opened Sat Jan 27 00:00:35 2018
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07:15 < kanzure> "The golgin coiled-coil proteins capture different types of transport carriers via distinct N-terminal motifs" https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-016-0345-3
07:16 < kanzure> .title https://www.youtube.com/watch?v=sKgE7oyeKUQ
07:16 < yoleaux> Mapping the cell’s internal postal code - YouTube
07:19 < kanzure> "Dorsal spine evolution in threespine sticklebacks via a splicing change in MSX2A" https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-017-0456-5
07:20 < kanzure> .tw https://twitter.com/antonioregalado/status/956639900090150916
07:20 < yoleaux> "Mini-genes." Here we explained the strategy to treat muscular dystrophy using gene therapy using "miniaturized" versions of the gigantic dystrophin gene. https://www.technologyreview.com/s/608575/doctors-plan-bold-test-of-gene-therapy-on-boys-with-muscular-dystrophy/ (@antonioregalado)
07:21 < kanzure> "Antimicrobial peptide capsids of de novo design" https://www.nature.com/articles/s41467-017-02475-3
07:21 < kanzure> "The spread of bacterial resistance to antibiotics poses the need for antimicrobial discovery. With traditional search paradigms being exhausted, approaches that are altogether different from antibiotics may offer promising and creative solutions. Here, we introduce a de novo peptide topology that—by emulating the virus architecture—assembles into discrete antimicrobial capsids. Using the ...
07:21 < kanzure> ...combination of high-resolution and real-time imaging, we demonstrate that these artificial capsids assemble as 20-nm hollow shells that attack bacterial membranes and upon landing on phospholipid bilayers instantaneously (seconds) convert into rapidly expanding pores causing membrane lysis (minutes). The designed capsids show broad antimicrobial activities, thus executing one primary ...
07:21 < kanzure> ...function—they destroy bacteria on contact."n
07:22 < kanzure> "Each will test a “microdystrophin,” meaning a foreshortened copy of the dystrophin gene that’s small enough to fit inside a virus, which is required to shuttle the genetic information into a person’s cells. The immense size of the gene is what’s prevented attempts at gene replacement until now."
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10:22 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=3b3c2399 Bryan Bishop: transcript: rusty on future bitcoin tech >> http://diyhpl.us/diyhpluswiki/transcripts/2018-01-24-rusty-russell-future-bitcoin-tech-directions/
10:25 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=56f1b2ce Bryan Bishop: add tweeter link >> http://diyhpl.us/diyhpluswiki/transcripts/2018-01-24-rusty-russell-future-bitcoin-tech-directions/
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10:36 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=81703491 Bryan Bishop: include bulletproofs link >> http://diyhpl.us/diyhpluswiki/transcripts/2018-01-24-rusty-russell-future-bitcoin-tech-directions/
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11:46 < JayDugger> Good work, kanzure. Thank you
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16:32 < kanzure> blort
17:06 < brujo_biologica>  
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18:33 < kanzure> yes
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20:55 < kanzure> http://openhardware.science/global-open-science-hardware-roadmap
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--- Log closed Sun Jan 28 00:00:36 2018