--- Log opened Wed Mar 07 00:00:12 2018 00:08 -!- DataPacRat [~dan@dhcp-108-170-158-198.cable.user.start.ca] has quit [Quit: Leaving.] 00:10 -!- DataPacRat [~dan@dhcp-108-170-158-198.cable.user.start.ca] has joined ##hplusroadmap 00:18 < brujo_biologica> export BYOBU_CHARMAP=x ; . ~/.bashrc 00:19 < brujo_biologica> export BYOBU_CHARMAP=UTF-8 ; . ~/.bashrc 01:00 < brujo_biologica> : 01:02 -!- aeiousomething [~aeiousome@27.59.153.68] has joined ##hplusroadmap 01:03 -!- aeiousom1thing [aeiousomet@gateway/vpn/privateinternetaccess/aeiousomething] has quit [Ping timeout: 245 seconds] 01:04 -!- sachy [~sachy@78.108.102.220] has quit [Ping timeout: 245 seconds] 01:13 -!- aeiousomething [~aeiousome@27.59.153.68] has quit [Read error: Connection reset by peer] 01:15 -!- Hoolootwo is now known as Hooloovo0 01:16 -!- aeiousomething [aeiousomet@gateway/vpn/privateinternetaccess/aeiousomething] has joined ##hplusroadmap 01:24 -!- aeiousomething [aeiousomet@gateway/vpn/privateinternetaccess/aeiousomething] has quit [Quit: leaving] 01:30 -!- aeiousomething [aeiousomet@gateway/vpn/privateinternetaccess/aeiousomething] has joined ##hplusroadmap 02:09 -!- Douhet [~Douhet@unaffiliated/douhet] has quit [Ping timeout: 256 seconds] 02:10 -!- Douhet [~Douhet@unaffiliated/douhet] has joined ##hplusroadmap 02:19 -!- drewbot [~cinch@54.157.38.203] has joined ##hplusroadmap 02:29 -!- WeirdTolkienishF [~Weird@unaffiliated/weirdtolkienishf] has quit [Read error: Connection reset by peer] 02:29 -!- WeirdTolkienishF [~Weird@204.48.46.11] has joined ##hplusroadmap 02:29 -!- WeirdTolkienishF [~Weird@204.48.46.11] has quit [Changing host] 02:29 -!- WeirdTolkienishF [~Weird@unaffiliated/weirdtolkienishf] has joined ##hplusroadmap 02:30 -!- sachy [~sachy@78.108.102.220] has joined ##hplusroadmap 02:34 -!- aeiousomething [aeiousomet@gateway/vpn/privateinternetaccess/aeiousomething] has quit [Ping timeout: 248 seconds] 02:35 -!- aeiousomething [aeiousomet@gateway/vpn/privateinternetaccess/aeiousomething] has joined ##hplusroadmap 03:34 -!- CandleGlow [~CandleGlo@unaffiliated/candleglow] has joined ##hplusroadmap 03:36 -!- darsie [~username@84-114-73-160.cable.dynamic.surfer.at] has joined ##hplusroadmap 03:52 -!- Gurkenglas [~Gurkengla@dslb-178-005-162-043.178.005.pools.vodafone-ip.de] has joined ##hplusroadmap 04:15 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-oqfmzuhqyqjnhscb] has joined ##hplusroadmap 04:20 -!- bkero- [~bkero@66.70.187.106] has quit [Ping timeout: 260 seconds] 04:20 -!- bkero- [~bkero@66.70.187.106] has joined ##hplusroadmap 04:21 -!- void_3301 [~quassel@ec2-18-219-8-108.us-east-2.compute.amazonaws.com] has quit [Ping timeout: 260 seconds] 04:21 -!- void3301 [~quassel@ec2-18-219-8-108.us-east-2.compute.amazonaws.com] has joined ##hplusroadmap 04:32 -!- aeiousomething [aeiousomet@gateway/vpn/privateinternetaccess/aeiousomething] has quit [Ping timeout: 252 seconds] 04:32 -!- CandleGlow [~CandleGlo@unaffiliated/candleglow] has quit [Quit: ...and all my responses they stay the same.] 04:34 -!- aeiousomething [aeiousomet@gateway/vpn/privateinternetaccess/aeiousomething] has joined ##hplusroadmap 05:03 < kanzure> .title 05:03 < yoleaux> Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD | Scientific Reports 05:03 < kanzure> no 05:08 < kanzure> some bias in NIH grant process stuff towards old farts https://news.ycombinator.com/item?id=16535929 05:09 < kanzure> not that i'm complaining about bias... just that the money seems to be broken there. 05:17 < kanzure> "A new approach to deanonymization of unreachable bitcoin nodes" https://eprint.iacr.org/2018/243 05:25 < kanzure> "Spatial organization of the somatosensory cortex revealed by cyclic smFISH" https://www.biorxiv.org/content/early/2018/03/04/276097 https://twitter.com/gottapatchemall/status/970739509859049472 05:26 < kanzure> .tw https://twitter.com/ian_wickersham/status/970691894383702016 05:26 < yoleaux> Our new paper on second-generation rabies virus is now live. New tool for retrograde delivery of Cre or Flp to projection neurons. Certified nontoxic (structure and function of indiv. neurons tracked for months), broader tropism than CAV or AAV2-retro. https://www.nature.com/articles/s41593-018-0091-7 https://pbs.twimg.com/media/DXiVDb9X4AEx_nW.jpg (@ian_wickersham) 05:27 < kanzure> "A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters" http://synthneuro.org/publications/publicationdetail/293/25 05:39 -!- emeraldgreen [~user@70.ip-145-239-90.eu] has joined ##hplusroadmap 05:40 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 05:43 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has left ##hplusroadmap [] 06:07 < kanzure> alright so if semiconductor fabs really truly cost $100m per stepper (or whatever....) multiple times over, then what if i wave my hands about dna origami masks and something 06:19 < kanzure> https://www.rcgroups.com/forums/showthread.php?2853660-110m-Euro-most-expensive-production-machine-ever 06:22 < kanzure> https://en.wikipedia.org/wiki/Stepper 06:24 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-oqfmzuhqyqjnhscb] has quit [Quit: Connection closed for inactivity] 06:24 < kanzure> "Eventually however, the desired line widths became narrower than what was possible using mercury lamps, and near the middle of the 2000s, the semiconductor industry moved towards steppers that employed krypton-fluoride (KrF) excimer lasers producing 248 nm light. Such systems are currently being used to produce lines in the 110 nm range. Lines as low as 32 nm are being resolved by ... 06:24 < kanzure> ...production-capable steppers using argon-fluoride (ArF) excimer lasers that emit light with a wavelength of 193 nm. Although fluoride (F2) lasers are available that produce 157 nm light, they are not practical because of their low power and because they quickly degrade photoresist and other materials used in the stepper." 06:25 < kanzure> okay well just have fiber optic lines throughout your building and deliver light from a generator somewhere.. 06:25 < kanzure> "Ultimately, other sources of illumination will have to be put to use, such as electron beams, x-rays or similar sources of electromagnetic energy with wavelengths much shorter than visible light. However, in order to delay as long as possible the vast expense and difficulty of adopting a whole new type of illumination technology, manufacturers have turned to a technique, previously used in ... 06:25 < kanzure> ...microscopes, for increasing the numerical aperture of the lens by allowing the light to pass through water instead of air. This method, called immersion lithography, is...." 06:26 < kanzure> alright well the first mistake is relying on fancypants optics 06:31 < kanzure> why dna origami and not protein sheet masks? 06:31 -!- aeiousomething [aeiousomet@gateway/vpn/privateinternetaccess/aeiousomething] has quit [Quit: leaving] 06:31 -!- aeiousomething [aeiousomet@gateway/vpn/privateinternetaccess/aeiousomething] has joined ##hplusroadmap 06:32 -!- strages [uid11297@gateway/web/irccloud.com/x-kwpioajveyzndjxn] has quit [Quit: Connection closed for inactivity] 06:39 < kanzure> .tw https://twitter.com/arxiv/status/971377713146671110 06:39 < yoleaux> We'll be making our new #arXivNG beta search available for testing soon. If you'd like to be on the mailing list for testing, info on joining on the #arXiv wiki: https://confluence.cornell.edu/x/QsJRF (@arxiv) 06:39 < kanzure> .tw https://twitter.com/PLOSBiology/status/971392531865903106 06:39 < yoleaux> Year-long #fMRI study of 6-yr-old kids as they #LearnToRead: how the "#reading brain" (VWFA) is gradually recruited from areas initially related to tool and face recognition #PLOSBiology http://plos.io/2FlPv3w https://pbs.twimg.com/media/DXrqoopXcAEqO6F.jpg (@PLOSBiology) 06:41 < kanzure> "Hydrogels with reversible chemical environments for in vitro cell culture" http://iopscience.iop.org/article/10.1088/1748-605X/aab45d 06:44 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 06:45 < kanzure> blah blah blah "do code review when publishing scientific articles" https://www.nature.com/articles/d41586-018-02741-4 ok 06:47 < kanzure> "Semiconductor–metal structural phase transformation in MoTe2 monolayers by electronic excitation" http://cacs.usc.edu/papers/Krishnamoorthy-MoTe2-Nanoscale18.pdf?platform=hootsuite https://twitter.com/CSatUSC/status/971163219531190272 06:47 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Remote host closed the connection] 06:48 < kanzure> "Non-interactive zaps of knowledge" https://eprint.iacr.org/2018/228 06:49 < kanzure> "A new constant-size accountable ring signature scheme without random oracles" https://eprint.iacr.org/2018/242 06:51 < kanzure> "Worm-level control through search-based reinforcement learning" https://arxiv.org/pdf/1711.03467.pdf 07:06 -!- aeiousomething [aeiousomet@gateway/vpn/privateinternetaccess/aeiousomething] has quit [Ping timeout: 240 seconds] 07:17 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has joined ##hplusroadmap 07:44 -!- jaboja64 [~jaboja@jaboja.pl] has joined ##hplusroadmap 07:52 -!- jaboja64 [~jaboja@jaboja.pl] has quit [Quit: Leaving] 07:58 -!- aeiousomething [aeiousomet@gateway/vpn/privateinternetaccess/aeiousomething] has joined ##hplusroadmap 08:02 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has quit [Ping timeout: 264 seconds] 08:02 -!- strages [uid11297@gateway/web/irccloud.com/x-rzahqfkeqvhoxble] has joined ##hplusroadmap 08:08 -!- augur [~augur@2600:380:8775:4a37:cc34:41db:9bb3:53c9] has joined ##hplusroadmap 08:08 < archels> cool map: https://www.entsoe.eu/Documents/Publications/maps/2017/Map_Continental-Europe-2.500.000_400dpi.pdf 08:47 < JayDugger> Huh. Do you know if a similar scan series has been done for second language acquisition? 08:47 < JayDugger> I'd expect little change unless you went to a different script from native language. 09:13 < fenn> it's a power grid map of europe 09:22 < archels> apparently the balkans have been lagging the grid by 6 minutes since mid January 09:22 < archels> that is, the 50 Hz timebase is 6 minutes behind 09:42 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has joined ##hplusroadmap 09:57 -!- aeiousomething [aeiousomet@gateway/vpn/privateinternetaccess/aeiousomething] has quit [Ping timeout: 240 seconds] 10:19 -!- suhdood [~Thaelim@2601:4a:c101:d1de:e8d5:2122:85ba:58cd] has joined ##hplusroadmap 11:00 -!- atrus6 [~atrus6@72.241.82.247] has joined ##hplusroadmap 11:22 -!- augur [~augur@2600:380:8775:4a37:cc34:41db:9bb3:53c9] has quit [Remote host closed the connection] 11:45 -!- augur [~augur@104-244-24-85.PUBLIC.monkeybrains.net] has joined ##hplusroadmap 11:47 -!- suhdood [~Thaelim@2601:4a:c101:d1de:e8d5:2122:85ba:58cd] has quit [Remote host closed the connection] 11:51 -!- Schattie [~Weird@204.48.46.11] has joined ##hplusroadmap 11:52 -!- Gurkenglas_ [~Gurkengla@178.5.162.43] has joined ##hplusroadmap 11:52 -!- Urchin [~urchin@unaffiliated/urchin] has joined ##hplusroadmap 11:55 -!- Gurkenglas [~Gurkengla@dslb-178-005-162-043.178.005.pools.vodafone-ip.de] has quit [Ping timeout: 264 seconds] 11:55 -!- WeirdTolkienishF [~Weird@unaffiliated/weirdtolkienishf] has quit [Ping timeout: 264 seconds] 12:57 -!- augur [~augur@104-244-24-85.PUBLIC.monkeybrains.net] has quit [Remote host closed the connection] 13:00 -!- Urchin [~urchin@unaffiliated/urchin] has quit [Ping timeout: 264 seconds] 13:42 -!- MultiColoredHatz [~MultiColo@92.86.76.186] has joined ##hplusroadmap 14:07 -!- spurserh [68840151@gateway/web/freenode/ip.104.132.1.81] has joined ##hplusroadmap 14:14 -!- atrus6 [~atrus6@72.241.82.247] has quit [Quit: Leaving] 14:19 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has joined ##hplusroadmap 14:24 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has quit [Ping timeout: 240 seconds] 14:40 < emeraldgreen> An interesting (for me) theoretical thought: is it possible at all to engineer (in parrots or in mice) brain areas patterned with stereotypical neural structures capable of rapidly learning a pattern loaded into this area from properly designed serial input channel when stimulated chemically (to ensure learning only when uploading data into the area) (uploading, how - optogenetics? direct electrical stimulation?), and if it is po 14:40 < emeraldgreen> ssible then what stops synbio engineers from doing this? The application of such structure is obvious: addressable nonvolatile memory, ability to store firmware-like patterns in living animals. For example one could imagine a parrot with such brain area loaded with common english phrases, and (assuming there are neuroplastic mechanisms to convert these patterns into motor activity) able to instinctively talk in english (perhaps wi 14:40 < emeraldgreen> th further pavlovian conditioning it would be possible to train the animal to talk meaningful phrases much more rapidly) 14:47 < emeraldgreen> i.e. a "neural firmware lobe" 14:52 < emeraldgreen> on the other hand if there were good neuron-semiconductor interfaces this design would be mostly irrelevant (but note that with neuron-semiconductor interfaces we are stuck with connecting semiconductor into semi-random individual brain, while with engineered neuro-memory we could in theory design specific connections with various other brain areas by engineering axon guidance 14:52 < emeraldgreen> also, engineering high-performance, low-inflammation, low-degreadation brain-computer interface genetically seems interesting 14:54 < emeraldgreen> i.e. "just" design a brain patch with known connection pattern, large enough uniform conductive pads, good isolation and with tags for immune system to be more lax around it (for warding off phagocytes and white cells) 14:58 -!- ebowden [~ebowden@128.250.0.211] has quit [Remote host closed the connection] 14:58 -!- ebowden [~ebowden@128.250.0.211] has joined ##hplusroadmap 15:03 -!- ebowden [~ebowden@128.250.0.211] has quit [Ping timeout: 256 seconds] 15:07 -!- ebowden [~ebowden@128.250.0.211] has joined ##hplusroadmap 15:18 -!- ebowden [~ebowden@128.250.0.211] has quit [Ping timeout: 240 seconds] 15:18 -!- ebowden [~ebowden@128.250.0.211] has joined ##hplusroadmap 15:34 -!- MultiColoredHatz [~MultiColo@92.86.76.186] has quit [Quit: Leaving] 15:35 -!- MultiColoredHat [~MultiColo@92.86.76.186] has joined ##hplusroadmap 15:36 -!- MultiColoredHat [~MultiColo@92.86.76.186] has quit [Client Quit] 15:36 -!- MultiColoredHat [~MultiColo@92.86.76.186] has joined ##hplusroadmap 15:52 < razzy> emeraldgreen: well, old school dictaphone is not enough? 15:53 < razzy> emeraldgreen: what you described can be achieved with shock collar and training room :L] 15:53 -!- balrog [~balrog@unaffiliated/balrog] has quit [Quit: Bye] 15:54 < emeraldgreen> razzy shock collar and training room are very long and damaging 15:55 < emeraldgreen> my approach would allow for factory-like approach of imprinting organisms in factory 15:58 -!- balrog [~balrog@unaffiliated/balrog] has joined ##hplusroadmap 16:08 -!- CandleGlow [~CandleGlo@unaffiliated/candleglow] has joined ##hplusroadmap 16:19 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has joined ##hplusroadmap 16:39 < emeraldgreen> emeraldgreen I reread my previous msg and it sounds funny, time to go to bed, I guess 16:41 -!- emeraldgreen [~user@70.ip-145-239-90.eu] has quit [Quit: Leaving.] 17:38 -!- strages [uid11297@gateway/web/irccloud.com/x-rzahqfkeqvhoxble] has quit [Quit: Connection closed for inactivity] 17:46 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[~Gurkengla@178.5.162.43] has quit [Ping timeout: 256 seconds] 21:30 -!- aeiousomething [~aeiousome@27.59.221.12] has joined ##hplusroadmap 21:45 < brujo_biologica> === 21:55 -!- augur [~augur@192.195.83.130] has quit [Remote host closed the connection] 22:05 -!- yashgaroth [~yashgarot@2606:6000:c308:f700:38fc:c516:3be3:2392] has quit [Quit: Leaving] 22:28 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has quit [Quit: sleep] 22:36 < nmz787> .tell emeraldgreen programming a fresh brain might need to be accomplished by other cells traversing through and setting up weights or other chemical states. https://twitter.com/TommyVierbuchen/status/969808674968481792 22:36 < yoleaux> nmz787: I'll pass your message to emeraldgreen. 22:36 < nmz787> .tw https://twitter.com/TommyVierbuchen/status/969808674968481792 22:36 < yoleaux> Gasped when I saw this: "...putative microglial cell that moves rapidly in an amoeboid fashion across bundles of axons and a cell body" Supp Movie #5 from http://www.cell.com/cell/fulltext/S0092-8674(18)30151-X https://video.twimg.com/ext_tw_video/969807762174615552/pu/vid/1168x720/mm9Y9bQk8Wg3piBg.mp4 (@TommyVierbuchen) 23:02 -!- sachy [~sachy@78.108.102.220] has left ##hplusroadmap [] 23:03 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=c07bc801 Nathan McCorkle: fixed img link, added table of dye info stuff >> http://diyhpl.us/diyhpluswiki/projects/microfluidics.txt 23:05 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=4acbc04e Nathan McCorkle: renamed file extension so ikiwiki parses it as markdown (hopefully) >> http://diyhpl.us/diyhpluswiki/projects/microfluidics.txt 23:10 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=5a75a9bb Nathan McCorkle: fixed three dye images' markdown >> http://diyhpl.us/diyhpluswiki/projects/microfluidics/ 23:12 < nmz787> kanzure: yeah self-assembly based methods are definitely something some people think they might want 23:12 -!- Douhet 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