--- Log opened Fri Mar 09 00:00:13 2018
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06:38 < kanzure> folate cyclics! of course, of course.
06:43 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=ab80229f Bryan Bishop: transcript: more MAST stuff >> http://diyhpl.us/diyhpluswiki/transcripts/bitcoin-core-dev-tech/2018-03-06-merkleized-abstract-syntax-trees-mast/
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08:28 < archels> but it's 2018 and we still haven't eliminated this damned rhinovirus
08:28 < kanzure> if you nuke all the humans then there will be no more hosts for the virus to replicate in
08:30 < archels> let's do that first thing post-upload
08:31 < archels> incidentally, watched Cronenberg's The Fly a few days ago—better make sure there aren't any hitchhikers when we engage the upload process
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08:46 < emeraldgreen> https://www.sciencedirect.com/science/article/pii/S1385894716313766
08:46 < kanzure> .title
08:46 < yoleaux> Large-scale graphene production by ultrasound-assisted exfoliation of natural graphite in supercritical CO2/H2O medium - ScienceDirect
08:46 < kanzure> oh okay
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08:51 < emeraldgreen> Also, people, what do you think about "next-gen organic molecule compiler" ? So far I have read about http://chematica.net/#/ http://onlinelibrary.wiley.com/doi/10.1002/anie.201202209/abstract and https://en.wikipedia.org/wiki/Click_chemistry . Is it feasible or are there huge roadblocks ? When one will be able to make a large array of organic molecules without organic chemistry PhD with an order of 100000$ investment ?
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09:30 < kanzure> MADE: hi.
09:30 < kanzure> emeraldgreen: well the reactionware stuff looked okay
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10:00 < MADE> ...
10:03 < kanzure> music! https://www.youtube.com/watch?v=hkJZDjj4RmM
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11:07 < JayDugger> Good afternoon.
11:10 < emeraldgreen> hi
11:59 < kanzure> i've figured out how to make artificial wombs work
12:01 < kanzure> for humans
12:01 < emeraldgreen> (another question): do you think it is rational to eat some form of curcumin to get anti-inflammatory (perhaps anti-aging) and cognitive benefits? Looks like one could replicate dosage of a recent study https://www.sciencedirect.com/science/article/pii/S1064748117305110 with merely 1.6$ per day
12:02 < emeraldgreen> kanzure how ?
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12:05 < kanzure> it's pretty obvious. i think someone can guess.
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12:16 < nmz787> kanzure: comatose femals?
12:17 < nmz787> kanzure: name your daughters "artificial"?
12:17 < kanzure> no
12:18 < nmz787> mix telomerase with a fresh placenta?
12:18 < kanzure> why what?
12:18 < nmz787> idk you said guess
12:22 < kanzure> how would telomerase mixing help?
12:23 < nmz787> can I just say "it's pretty obvious. i think someone can guess."?
12:24 < nmz787> obviously adding telomerase will extend the telomeres and allow the placenta to reach past the hayflick limit, geez
12:26 < nmz787> maybe your answer is to hack the human genome to cut out all genes related to high/conscious brain development
12:26 < nmz787> such that any 'babies' would be no more than digester+womb
12:27 < kanzure> it might require some genetic engineering but i think it might be possible to do without genetic changes
12:27 < kanzure> and my idea is not "evolve a better placenta duh!!!!"
12:27 < nmz787> cutting brain out of embryos then
12:27 < kanzure> no
12:28 < nmz787> fusing a hamster and human embryo?
12:28 < nmz787> I'm kind of running low on guesses
12:29  * nmz787 need more players plz
12:30 < kanzure> it's really simple and i am pretty sure it will work
12:30 < kanzure> basically you take a thousand embryos and you do this a thousand times or more
12:30 < kanzure> in parallel i guess
12:30 < nmz787> catch an elf, make him use his magic
12:31 < kanzure> your goal is to instrument each techwomb with as many sensors as possible and assess the development in real-time and do lots of data collection
12:31 < kanzure> you can also try out experiments in varying tempreatures and nutrients on a large-scale if you wanted to
12:32 < kanzure> you can also upsell this as a product (even without the artificial womb) where you have 50-100 potential progeny and you simply select the most healthy at the end anyway.
12:32 < kanzure> (e.g. with surrogacy, which doesn't use an artificial womb of course)
12:33 < kanzure> i think that the environmental requirements for each stage of development is going to be pretty simple and discoverable with only 1000 iterations or something
12:33 < kanzure> thing is, nobody has tried because no social desire to do so
12:35 < jrayhawk> emeraldgreen: http://wholehealthsource.blogspot.com/2011/02/polyphenols-hormesis-and-disease-part-i.html http://wholehealthsource.blogspot.com/2011/02/polyphenols-hormesis-and-disease-part.html
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12:56 < jrayhawk> in general the circumin field strikes me as being somewhat bullshitty; little distinction is made between intracellular absorption and paracellular absorption (black pepper increases absorption? Thanks, I'm pretty sure asbestos, cholera, and literally getting shot in the gut would do the same, fuckers), RCTs are done in ludicrously pathogenic circumstances (e.g. no comparisons to exercise,
12:56 < jrayhawk> intermittant fasting, or literally any other polyphenol that would be potentially triggering the same set of hormetic responses)
12:57 < jrayhawk> that said, if you have nothing else in your live upregulating Nrf2, it seems like a perfectly okay choice?
12:57 < jrayhawk> s/live/life/
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13:05 < emeraldgreen> jrayhawk thanks, I'm pretty sceptical myself seeing all the marketing. Personally I think I need something that inhibits inflammation (e.g. propensity of skin to become inflamed), so I'm researching this. I agree that absorption situation is dubious. Also curcumin is known to be a false-lead compound that needs to be discarded in drug design process.
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13:14 < jrayhawk> http://www.google.com/search?q=%28+psoriasis+OR+rosacea+OR+eczema+OR+acne+OR+keratosis+OR+hidradenitis+%29+AND+%28+paleo+OR+primal+OR+gaps+OR+scd+OR+%22specific+carbohydrate%22+OR+wapf+OR+%22weston+price%22+OR+%22raw+food%22+OR+gfcf+OR+%22whole+30%22+%29 other sources of simple intervention ideas
13:15 < kanzure> joey are you having a stroke
13:17 < jrayhawk> if i were, i am not sure i would be the appropriate one to ask
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13:26 < jrayhawk> admittedly i haven't eaten in 30 hours
13:26 < jrayhawk> i should go do that
13:47 < kanzure> nah
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14:16 < TMA> kanzure: While I can easily imagine the utility of artificial wombs for producing test subjects, I have to point out that the world does not need any new means to produce more specimens of homo sapiens sapiens, there are already more than enough traditionally-produced to cause problems.
14:43 < emeraldgreen> TMA I agree with overpopulation sentiment, but world could really use a reproducible process for producing geniuses
14:44 < emeraldgreen> It's a shame we have had only one von Neumann
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17:42 < kanzure> we are nowhere near overpopulation. we can support another 100-200 billion people.
17:59 < kanzure> "Deep learning with coherent nanophotonic circuits" https://www.nature.com/articles/nphoton.2017.93
17:59 < kanzure> cc taek
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18:06 < Taek> fascinating
18:07 < Taek> looks like matrix multiplication is naturally very easy to perform with lenses and interference
18:07 < kanzure> http://diyhpl.us/~bryan/papers2/space/Self-deployed%20extremely%20large%20low%20mass%20space%20structures%20-%202007.pdf
18:17 < kanzure> .title https://news.ycombinator.com/item?id=16555106
18:17 < yoleaux> FCC Accuses Stealthy Startup of Launching Rogue Satellites | Hacker News
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19:25 < kanzure> hmph
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21:38 < nmz787> sup
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23:00 < nmz787> https://hackaday.io/project/62710-taking-digital-xray-shots-for-cheap-300/log/113379-going-realtime
23:00 < nmz787> .title
23:00 < yoleaux> Going realtime | Details | Hackaday.io
23:01 < nmz787> xray scanner
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23:18 < nmz787> http://blogs.sciencemag.org/pipeline/archives/2018/03/09/crystals-via-lasers
23:18 < nmz787> "Several proposals have been made for a mechanism, but this new paper has an interesting one: it appears that the intense laser flux promotes movement of those molecules with a higher refractive index into the beam."
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23:33 < CaptHindsight> https://arstechnica.com/science/2018/03/scary-superbug-can-sneakily-dodge-last-resort-drug-and-we-dont-know-how/
23:33 < CaptHindsight> "researchers also sequenced the genomes of bacteria resisting colistin and those susceptible to it. They were genetically identical.
23:33 < CaptHindsight> Even though they have the same blueprints, they’re activating their genes differently"
23:33 < CaptHindsight> neato!
23:36 < CaptHindsight> http://mbio.asm.org/content/9/2/e02448-17  the actual paper
23:36 < CaptHindsight> Carbapenem-Resistant Klebsiella pneumoniae Exhibiting Clinically Undetected Colistin Heteroresistance Leads to Treatment Failure in a Murine Model of Infection
23:36 < nmz787> yikes
23:37 < nmz787> good reason to work from home and stay away from hospitals as much as possible
23:37 < CaptHindsight> yup!
23:38 < CaptHindsight> looks like it started in China
23:39 < CaptHindsight> then again the first thing they give you there is  Ciprofloxacin
23:40 < CaptHindsight> http://www.thelancet.com/journals/laninf/article/PIIS1473-3099(15)00424-7/abstract
23:40 < CaptHindsight> Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study
23:40 < nmz787> well seems like if anything, individual components of the cell when looking at cell regulation might not mean anything specific, it's all in context of the whole system
23:41 < nmz787> just like the neural network AI stuff
23:41 < nmz787> you can't pinpoint what any single neuron is really doing
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23:41 < nmz787> (AI neuron that is)
--- Log closed Sat Mar 10 00:00:14 2018