--- Log opened Sat Mar 17 00:00:21 2018 00:18 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has quit [Quit: ICE AGE NEAR, SCIENTISTS WARN] 01:09 -!- aeiousomething [aeiousomet@gateway/vpn/privateinternetaccess/aeiousomething] has joined ##hplusroadmap 01:10 -!- aeiousomething [aeiousomet@gateway/vpn/privateinternetaccess/aeiousomething] has quit [Client Quit] 01:10 -!- aeiousomething [aeiousomet@gateway/vpn/privateinternetaccess/aeiousomething] has joined ##hplusroadmap 02:14 -!- ebowden [~ebowden@128.250.0.211] has joined ##hplusroadmap 03:31 -!- CandleGlow [~CandleGlo@unaffiliated/candleglow] has joined ##hplusroadmap 04:00 -!- jtimon [~quassel@142.29.134.37.dynamic.jazztel.es] has joined ##hplusroadmap 04:15 -!- darsie [~username@84-114-73-160.cable.dynamic.surfer.at] has joined ##hplusroadmap 05:25 -!- mrdata is now known as mrdata_ 05:25 -!- mrdata_ is now known as mrdata 05:55 -!- ebowden_ [~ebowden@128.250.0.211] has joined ##hplusroadmap 05:55 -!- ebowden [~ebowden@128.250.0.211] has quit [Read error: Connection reset by peer] 06:06 -!- wrldpc1 [~ben@p539134-ipngn200603kyoto.kyoto.ocn.ne.jp] has joined ##hplusroadmap 06:43 -!- wrldpc1 [~ben@p539134-ipngn200603kyoto.kyoto.ocn.ne.jp] has quit [Quit: wrldpc1] 07:11 < kanzure> http://sphere.diybio.org/projects/diybiosphere/ 07:11 < kanzure> https://diybio.org/local/ 07:13 < kanzure> DARPA biostatis program "Meeting Link (live at 11:45am ET on March 20, 2018): https://connect.darpa.mil/pub-biostasis/ " (proposers day) 07:36 -!- CandleGlow [~CandleGlo@unaffiliated/candleglow] has quit [Quit: ...and all my responses they stay the same.] 08:08 -!- DataPacRat [~dan@dhcp-108-170-158-198.cable.user.start.ca] has quit [Quit: Leaving.] 08:15 -!- DataPacRat [~dan@dhcp-108-170-158-198.cable.user.start.ca] has joined ##hplusroadmap 08:28 -!- DataPacRat [~dan@dhcp-108-170-158-198.cable.user.start.ca] has quit [Quit: Leaving.] 08:38 -!- DataPacRat [~dan@dhcp-108-170-158-198.cable.user.start.ca] has joined ##hplusroadmap 08:38 -!- DataPacRat [~dan@dhcp-108-170-158-198.cable.user.start.ca] has quit [Client Quit] 08:44 -!- DataPacRat [~dan@dhcp-108-170-158-198.cable.user.start.ca] has joined ##hplusroadmap 09:16 -!- Gurkenglas [~Gurkengla@dslb-178-005-162-043.178.005.pools.vodafone-ip.de] has joined ##hplusroadmap 09:39 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has joined ##hplusroadmap 09:45 -!- drewbot [~cinch@54.166.144.121] has quit [Remote host closed the connection] 10:48 -!- srk [sorki@fedora/sorki] has joined ##hplusroadmap 10:48 < srk> o/ 10:48 < maaku> welcome srk 10:49 < srk> thanks :) 10:49 < maaku> srk is interested in open-source CNC machine control interfaces 10:49 < srk> maaku invited me - I'm doing open hardware motion control with haskell for CNCs/3d printers other robots - https://distrap.org/ 10:50 < maaku> if you idle here kanzure might introduce you to some people doing related stuff 10:50 < srk> sure! :) 10:52 < kanzure> there is also #linuxcnc which has linuxcnc people 10:53 < srk> yeah, I'm idling there as well, altough that one is really linuxCNC specific 11:24 -!- DataPacRat [~dan@dhcp-108-170-158-198.cable.user.start.ca] has quit [Quit: Leaving.] 11:32 -!- DataPacRat [~dan@dhcp-108-170-158-198.cable.user.start.ca] has joined ##hplusroadmap 12:36 -!- MrHindsight [~2020@unaffiliated/capthindsight] has joined ##hplusroadmap 12:43 < kanzure> "Successful attenuation of humoral immunity to viral capsid and transgenic protein following AAV-mediated gene transfer with a non-depleting CD4 antibody and cyclosporine" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526978/ 12:44 < kanzure> ".. an anti-AAV8 antibody response was elicited upon rechallenge with AAV8 without immunosuppression" why are you testing this tho 13:35 < kanzure> "Intensive pharmacological immunosuppression allows for repetitive liver gene transfer with recombinant adenovirus in nonhuman primates" https://www.sciencedirect.com/science/article/pii/S1525001616323322 13:35 < kanzure> so... doesn't this solve all the problems? 13:42 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-yplurdxlogdxqtxt] has joined ##hplusroadmap 14:01 < kanzure> not sure what they were looking for in their second study but it may not have worked when they tried a similar experiment? https://translational-medicine.biomedcentral.com/articles/10.1186/1479-5876-10-122 14:18 -!- yashgaroth [~yashgarot@2606:6000:c308:f700:d939:7227:1b66:b88a] has joined ##hplusroadmap 14:37 -!- aeiousomething [aeiousomet@gateway/vpn/privateinternetaccess/aeiousomething] has quit [Ping timeout: 260 seconds] 14:59 < fenn> eww why CAN? why not ethernet? 15:00 < fenn> srk 15:09 < srk> fenn: cost, complexity, realtime properties 15:10 < fenn> it's not very distributed if i need a special purpose bus 15:10 < srk> fenn: we might try etherCAT in teh future but CAN should be enough for now 15:10 < srk> how is CAN more special than ethernet? :) 15:11 < fenn> people have ethernet all over their buildings 15:11 < srk> and CAN all over their cars 15:11 < srk> :) 15:11 < fenn> not me 15:11 < fenn> how is CAN cheaper? 15:13 < srk> easily, cause plain ethernet won't do 15:13 < fenn> have you actually tested that? 15:13 < fenn> i know there are these fancy industrial ethernet endpoints, but in reality it may not be necessary 15:14 < srk> no, I don't even have ethernet driver 15:14 < fenn> i thought most SBCs come with it these days 15:14 < srk> ethernet powerlink might work but as I said, maybe next time :) 15:14 < fenn> are you designing your own boards? 15:15 < srk> yes 15:16 < srk> 1st round of stm32f7 based boards is assembled and working. next banch arrived just today 15:16 < srk> *batch 15:17 < fenn> who is the target demographic? 15:18 < srk> currently DIY robot hackers :) 15:18 < fenn> reprap users have much less to worry about than i.e. industrial robot arm users 15:18 < srk> (CNCs / 3d printers / robot arms) 15:19 < srk> I'm a RepRap user and was quite disappointed by the state of the art 15:19 < fenn> saying "CNCs" marks you as a software person 15:19 < srk> why? 15:19 < fenn> because there's a huge range of CNC equipment and it's all different 15:20 < srk> hence the modular approach 15:26 -!- yashgaroth [~yashgarot@2606:6000:c308:f700:d939:7227:1b66:b88a] has quit [Ping timeout: 276 seconds] 15:27 -!- yashgaroth [~yashgarot@2606:6000:c308:f700:3404:b4bf:c55a:9511] has joined ##hplusroadmap 16:06 < Jenda> .title https://www.youtube.com/watch?v=El6AU3riRI8 16:06 < yoleaux> Richart Sowa's Island Made of Plastic Bottles - COOLEST THING I'VE EVER MADE - EP2 - YouTube 16:40 -!- MrHindsight [~2020@unaffiliated/capthindsight] has quit [Ping timeout: 264 seconds] 16:52 < kanzure> https://www.johnayliff.com/games/seedship/index.html?bmmorbdjlnprt.10.Arcadia.1000.998.6.10.17.1470.1100.6 17:34 -!- drewbot [~cinch@174.129.113.95] has joined ##hplusroadmap 18:01 < fenn> wow 18:07 < fenn> i'd probably name it something better than "Arcadia" 18:18 < kanzure> wasn't my choice 18:19 < fenn> you can click on the name to edit it at some point 18:19 < kanzure> oh damn 18:28 < kanzure> yashgaroth: sounds like adult gene therapy is doable with massive immunosuppression. let's do it? 18:28 < kanzure> i mean, for re-dosing and re-administration and stuff. 18:28 < yashgaroth> alrighty, I'll start shopping for bubbles 18:28 < JayDugger> Seedship is a little different from the Android version. 18:28 < kanzure> do you happen to know their requirements? can it just be a really clean room? 18:29 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 18:29 < kanzure> or is it more like custom acrylic aquarium manufacturing 18:29 < yashgaroth> yeah it ain't hard to sterilize a room, then you blow filtered air in, food through an airlock 18:30 < kanzure> and why aren't we doing this already..? 18:30 < yashgaroth> gotta make them viruses first 18:30 < kanzure> i mean society in general 18:31 < kanzure> society has produced viruses already 18:31 < kanzure> so.. 18:31 < yashgaroth> there's only a subset of diseases that can be cured with gene therapy with no decent alternative 18:32 < kanzure> ah and likelihood of someone needing multiple treatments for different things, unlikely 18:32 < kanzure> plus unlikely that someone is doing the same studies and knows the same people 18:32 < kanzure> s/people/patients 18:32 < yashgaroth> yeah, being super immune to AAV doesn't hurt you otherwise 18:33 < kanzure> the immunosuppression treatment long so it would have to be something with stable integration/expression/something way beyond the duration of the immunosuppression 18:33 < kanzure> *lasts long 18:34 -!- augur [~augur@2600:380:8437:a584:e183:dbd6:9fe1:63ce] has joined ##hplusroadmap 18:35 < yashgaroth> if you're expressing a foreign protein there's still a good chance you'll develop a response to it after the fact, though immune tolerance may develop 18:35 < kanzure> "12 weeks" is longer than some of the lifecycles of certain human cells i think 18:36 < yashgaroth> yeah, depends what tissue you hit - muscle, brain it'll last years whether or not it's integrated 18:36 < yashgaroth> liver, it'll be gone fairly soon unless you integrate into a lot of stem cells, and they're usually pretty isolated from viruses in their lil niche 18:43 < kanzure> what to do about "does this modification have to be present from birth vs will this do a relevant thing in adults" questions? 18:44 < kanzure> for example, KIBRA mutation for +19% working memory (assuming it's fully causative) might only work if present during early life, adolescence, etc. 18:47 < yashgaroth> possible, I don't know brain stuff too well 18:48 < kanzure> should be good enough to test on animals maybe? 18:48 < kanzure> and then look for protein evidence 18:48 < kanzure> in biopsies or w/e 18:48 < kanzure> i guess that doesn't tell you if that protein is going to cause the trait. heh. 18:48 < kanzure> hard problem. hmm. 18:56 < yashgaroth> if you can test working memory in animals, then you can have an inducible promoter and turn it on when they hit adulthood 19:20 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-yplurdxlogdxqtxt] has quit [Quit: Connection closed for inactivity] 20:04 < kanzure> blort 20:05 -!- darsie [~username@84-114-73-160.cable.dynamic.surfer.at] has quit [Ping timeout: 256 seconds] 20:36 -!- augur [~augur@2600:380:8437:a584:e183:dbd6:9fe1:63ce] has quit [Ping timeout: 276 seconds] 20:37 -!- augur [~augur@2600:380:8722:cd8a:5525:2cb5:7c74:b20d] has joined ##hplusroadmap 20:41 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has quit [Quit: SCIENTISTS PREDICT ICE AGE] 21:59 -!- suhdood [~Thaelim@32.208.194.10] has joined ##hplusroadmap 22:03 -!- augur [~augur@2600:380:8722:cd8a:5525:2cb5:7c74:b20d] has quit [Ping timeout: 245 seconds] 22:03 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 240 seconds] 22:16 -!- yashgaroth [~yashgarot@2606:6000:c308:f700:3404:b4bf:c55a:9511] has quit [Quit: Leaving] 22:19 -!- augur [~augur@2600:380:877b:e694:416c:f3f6:7a0b:b7cb] has joined ##hplusroadmap 22:29 -!- aeiousomething [aeiousomet@gateway/vpn/privateinternetaccess/aeiousomething] has joined ##hplusroadmap 22:44 -!- suhdood [~Thaelim@32.208.194.10] has quit [Remote host closed the connection] 22:50 -!- aeiousomething [aeiousomet@gateway/vpn/privateinternetaccess/aeiousomething] has quit [Ping timeout: 260 seconds] 23:44 -!- aeiousomething [aeiousomet@gateway/vpn/privateinternetaccess/aeiousomething] has joined ##hplusroadmap 23:54 -!- augur [~augur@2600:380:877b:e694:416c:f3f6:7a0b:b7cb] has quit [Remote host closed the connection] --- Log closed Sun Mar 18 00:00:22 2018