--- Log opened Wed Mar 28 00:00:31 2018 00:25 -!- Gurkenglas__ [~Gurkengla@dslb-188-103-223-018.188.103.pools.vodafone-ip.de] has quit [Ping timeout: 256 seconds] 00:29 -!- jtimon [~quassel@142.29.134.37.dynamic.jazztel.es] has joined ##hplusroadmap 00:43 -!- ebowden [~ebowden@128.250.0.194] has joined ##hplusroadmap 01:21 -!- jtimon [~quassel@142.29.134.37.dynamic.jazztel.es] has quit [Ping timeout: 240 seconds] 01:26 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-uwzxikvipwqgjnph] has quit [Quit: Connection closed for inactivity] 01:53 -!- augur_ [~augur@noisebridge130.static.monkeybrains.net] has quit [Remote host closed the connection] 01:53 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has joined ##hplusroadmap 01:59 -!- l_wl [~l_wl@pool-173-66-205-23.washdc.fios.verizon.net] has quit [Remote host closed the connection] 02:05 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has quit [Ping timeout: 264 seconds] 02:13 -!- red-001 [red@gateway/shell/elitebnc/x-vufvifoyxjjximad] has quit [Ping timeout: 268 seconds] 02:37 -!- red-001 [red@gateway/shell/elitebnc/x-imwifqqriiarebld] has joined ##hplusroadmap 03:35 -!- Gurkenglas__ [~Gurkengla@dslb-188-103-223-018.188.103.pools.vodafone-ip.de] has joined ##hplusroadmap 03:36 -!- aeiousomething [~aeiousome@124.123.14.99] has quit [Ping timeout: 264 seconds] 03:48 -!- wrldpc1 [~ben@p539134-ipngn200603kyoto.kyoto.ocn.ne.jp] has joined ##hplusroadmap 04:15 -!- darsie [~username@84-114-73-160.cable.dynamic.surfer.at] has joined ##hplusroadmap 04:21 -!- gabbar1947 [uid205515@gateway/web/irccloud.com/x-iysadgxfeamuarvw] has quit [Quit: Connection closed for inactivity] 04:39 -!- wrldpc1 [~ben@p539134-ipngn200603kyoto.kyoto.ocn.ne.jp] has quit [Quit: wrldpc1] 04:42 -!- wrldpc1 [~ben@p539134-ipngn200603kyoto.kyoto.ocn.ne.jp] has joined ##hplusroadmap 04:46 -!- wrldpc1 [~ben@p539134-ipngn200603kyoto.kyoto.ocn.ne.jp] has quit [Client Quit] 05:45 -!- jtimon [~quassel@142.29.134.37.dynamic.jazztel.es] has joined ##hplusroadmap 06:27 -!- aeiousomething [~aeiousome@124.123.14.99] has joined ##hplusroadmap 07:21 -!- aeiousomething [~aeiousome@124.123.14.99] has quit [Ping timeout: 246 seconds] 07:26 -!- aeiousomething [~aeiousome@124.123.14.99] has joined ##hplusroadmap 07:31 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Quit: Leaving.] 07:45 -!- aeiousomething [~aeiousome@124.123.14.99] has quit [Ping timeout: 246 seconds] 07:49 -!- aeiousomething [~aeiousome@124.123.14.99] has joined ##hplusroadmap 08:07 < kanzure> https://jimshaver.net/2015/02/11/decrypting-tls-browser-traffic-with-wireshark-the-easy-way/ 08:07 * kanzure mumbles about mitmporxy 08:07 < kanzure> .. mitmproxy. 08:07 < kanzure> https://www.wired.com/story/live-forever-synthetic-human-genome/ 08:18 < kanzure> author of this piece seems a little confused (seems to think that storing his dna means he will live forever..?) 08:18 < kanzure> and that long-term dna storage is somehow novel? 08:18 < kanzure> also he doesn't understand the ecoli recoding or multi-virus resistance technical detail (his example is replacing nucleotides but he should have mentioned replacing codons instead) 08:19 < kanzure> also, church seems to offer the idea that recoding only a single human chromosome might provide an observable improvement in multi-virus resistance. i'm not sure how true that could possibly be, since it's really the tRNA synthetases that matter... which are still present because you have the rest of the protein-coding genome to deal with. 08:20 < kanzure> also why hasn't anyone proposed crispr-cas9 bacterial immune system for virus resistance? it's not absolute resistance but you could probably do some fun things. 08:31 < kanzure> "Automated reconstruction of synaptic-resolution neural wiring diagrams" https://www.youtube.com/watch?v=5Wr5ghHF-gk 08:33 < kanzure> "The asteroid terrestrial-impact last alert system" https://www.youtube.com/watch?v=ljA_VyHYKLs 08:34 < kanzure> "A view of the cortex through the thalamus" https://www.youtube.com/watch?v=AJa7JRTnZFI 08:36 < kanzure> thalamocortical system 1 https://www.youtube.com/watch?v=aB2M1gg_1sU and thalamocortical system 2 https://www.youtube.com/watch?v=KBILhSTpzFI 08:37 < kanzure> "High-throughput connectomics" https://www.youtube.com/watch?v=XYkQ_tbdGKI 08:40 < kanzure> there was a recent simons institute talk on zero-knowledge proofs and i can't seem to find it. it was within the last 6 months. where did it go? 08:42 < kanzure> https://github.com/google/neuroglancer "Neuroglancer is a WebGL-based viewer for volumetric data. It is capable of displaying arbitrary (non axis-aligned) cross-sectional views of volumetric data, as well as 3-D meshes and line-segment based models (skeletons)." 08:43 -!- JayDugger [~jwdugger@47.185.249.138] has quit [Quit: Leaving.] 09:18 < kanzure> .title https://www.youtube.com/watch?v=Gb0jYibsW9A 09:18 < yoleaux> Cryonics for uploaders meeting in Second Life, March 25, 2018 - YouTube 09:22 < kanzure> .tw https://twitter.com/kanzure/status/979030583446851584 09:22 < yoleaux> @indbio Human DNA can already be stored. Also, @GP_write is not focused on indefinite storage of DNA. (@kanzure, in reply to tw:978747269083262977) 09:24 -!- aeiousomething [~aeiousome@124.123.14.99] has quit [Ping timeout: 240 seconds] 09:25 -!- aeiousomething [~aeiousome@124.123.14.99] has joined ##hplusroadmap 09:25 -!- WeirdTolkienishF [~Weird@unaffiliated/weirdtolkienishf] has quit [Quit: Leaving] 09:52 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has joined ##hplusroadmap 09:53 < kanzure> we should stalk nuclera more often (jiahao huang et al.) 09:58 < kanzure> .tw https://twitter.com/EmilyLeproust/status/979023559111606273 09:58 < yoleaux> Good question @Fredsie. The first applications would be for rarely accessed but highly valuable cold data, where latency is less of an issue. There is a big opportunity for this incl. medical records, movies / TV media, financial records, clinical trial data, etc. #DNADataStorage https://twitter.com/Fredsie/status/977096745711792133 (@EmilyLeproust) 10:00 < kanzure> "Precise Cas9 targeting enables genomic mutation prevention" http://www.pnas.org/content/early/2018/03/16/1718148115 https://wyss.harvard.edu/keeping-the-genetic-code-clean/ https://twitter.com/mnlimas/status/978632753313927168 10:27 -!- aeiousomething [~aeiousome@124.123.14.99] has quit [Ping timeout: 246 seconds] 10:28 -!- WeirdTolkienishF [~Weird@unaffiliated/weirdtolkienishf] has joined ##hplusroadmap 10:44 -!- yashgaroth [~yashgarot@2606:6000:c308:f700:ce4:e2df:944a:e23c] has joined ##hplusroadmap 10:46 -!- aeiousomething [~aeiousome@124.123.14.99] has joined ##hplusroadmap 10:53 -!- ebowden [~ebowden@128.250.0.194] has quit [Remote host closed the connection] 10:53 -!- ebowden [~ebowden@128.250.0.194] has joined ##hplusroadmap 10:55 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 11:00 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Ping timeout: 248 seconds] 11:01 -!- WeirdTolkienishF [~Weird@unaffiliated/weirdtolkienishf] has quit [Quit: Leaving] 11:03 -!- WizJin [~WizJin@103.93.9.61] has joined ##hplusroadmap 11:15 -!- WizJin [~WizJin@103.93.9.61] has quit [Quit: Leaving] 12:25 < kanzure> https://medium.com/@Numenta/the-thousand-brains-model-of-intelligence-f1a70a6adf9c 12:25 < kanzure> seems like fluff to me (why do people like these guys?) 12:37 -!- Gurkenglas__ [~Gurkengla@dslb-188-103-223-018.188.103.pools.vodafone-ip.de] has quit [Ping timeout: 276 seconds] 13:43 -!- ebowden [~ebowden@128.250.0.194] has quit [Remote host closed the connection] 13:55 -!- ebowden [~ebowden@128.250.0.194] has joined ##hplusroadmap 13:56 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-vzlqfzmwafzmvjfz] has joined ##hplusroadmap 14:03 -!- aeiousom1thing [~aeiousome@27.59.241.86] has joined ##hplusroadmap 14:05 -!- aeiousomething [~aeiousome@124.123.14.99] has quit [Ping timeout: 264 seconds] 14:36 -!- aeiousom1thing [~aeiousome@27.59.241.86] has quit [Ping timeout: 240 seconds] 14:38 -!- aeiousomething [~aeiousome@124.123.14.99] has joined ##hplusroadmap 15:22 < nmz787> https://sites.google.com/site/ulfgri/numerical/gdsii-toolbox 15:22 < nmz787> "The GDSII library, or database, format has become an important industry standard for the description of nano-structure designs that are fabricated with either photo- or electron lithography - despite being poorly documented. GDSII library files are used to define the layout of integrated circuits, MEMS devices, nano-structured optics, and so on. This toolbox of functions for MATLAB or Octave can be 15:22 < nmz787> used to create, read, and modify files in GDSII library format. The toolbox is particularly useful when a layout is the result of numerical modeling as is often the case, e.g., for nano-structured optics, photonic devices, or micro-fluidic devices" 16:01 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-vzlqfzmwafzmvjfz] has quit [Quit: Connection closed for inactivity] 16:02 -!- DataPacRat [~dan@dhcp-108-170-158-198.cable.user.start.ca] has quit [Ping timeout: 260 seconds] 16:03 -!- DataPacRat [~dan@dhcp-108-170-158-198.cable.user.start.ca] has joined ##hplusroadmap 16:08 -!- CandleGlow [~CandleGlo@unaffiliated/candleglow] has joined ##hplusroadmap 16:10 -!- CaptHindsight [~2020@unaffiliated/capthindsight] has quit [Remote host closed the connection] 16:51 -!- aeiousomething [~aeiousome@124.123.14.99] has quit [Ping timeout: 276 seconds] 16:52 -!- aeiousomething [~aeiousome@124.123.14.99] has joined ##hplusroadmap 18:19 -!- mrdata- [~mrdata@unaffiliated/mrdata] has joined ##hplusroadmap 19:00 -!- hehelleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has joined ##hplusroadmap 19:01 -!- hackoon [~hackoon@ec2-54-241-155-80.us-west-1.compute.amazonaws.com] has joined ##hplusroadmap 19:03 < kanzure> hackoon: hi. 19:03 < hackoon> hey 19:03 -!- Guest32875 [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has quit [Ping timeout: 240 seconds] 19:07 < hackoon> was reading up on synthesizing estrogen at home 19:12 -!- drewbot [~cinch@54.92.233.182] has joined ##hplusroadmap 19:13 < kanzure> hackoon: what you got so far? 19:14 < hackoon> http://maggic.ooo/Estrofem-Lab-2016 19:39 -!- mrdata- [~mrdata@unaffiliated/mrdata] has quit [Read error: Connection reset by peer] 20:06 -!- CandleGlow [~CandleGlo@unaffiliated/candleglow] has quit [Read error: Connection reset by peer] 20:09 -!- darsie [~username@84-114-73-160.cable.dynamic.surfer.at] has quit [Ping timeout: 240 seconds] 20:21 < kanzure> .title 20:21 < yoleaux> Estrofem! Lab (2016) - M.A.G.G.I.C. 20:28 -!- Gurkenglas__ [~Gurkengla@dslb-188-103-223-018.188.103.pools.vodafone-ip.de] has joined ##hplusroadmap 20:49 -!- bbrittain [~bbrittain@ec2-34-242-76-124.eu-west-1.compute.amazonaws.com] has quit [Ping timeout: 248 seconds] 20:49 -!- soylentb1mb [~k@unaffiliated/soylentbomb] has quit [Ping timeout: 248 seconds] 20:49 -!- sandeepkr [~sandeepkr@ec2-52-29-251-54.eu-central-1.compute.amazonaws.com] has quit [Ping timeout: 248 seconds] 20:50 -!- soylentbomb [~k@unaffiliated/soylentbomb] has joined ##hplusroadmap 20:51 -!- bbrittain [~bbrittain@ec2-34-242-76-124.eu-west-1.compute.amazonaws.com] has joined ##hplusroadmap 20:51 -!- sandeepkr [~sandeepkr@ec2-52-29-251-54.eu-central-1.compute.amazonaws.com] has joined ##hplusroadmap 20:52 -!- streety [~streety@li761-24.members.linode.com] has quit [Ping timeout: 260 seconds] 20:54 -!- streety [~streety@li761-24.members.linode.com] has joined ##hplusroadmap 21:03 -!- aeiousomething [~aeiousome@124.123.14.99] has quit [Ping timeout: 264 seconds] 21:24 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 21:25 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Client Quit] 21:25 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 21:27 -!- justan0theruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 260 seconds] 21:42 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has quit [Quit: this never happened before and it's not happening again] 21:49 < fenn> the only cool thing from that whole page: "binding of estrogen small molecule to RNA aptamer "turns on" ribo-switch, initiates TRANSLATION of GFP reporter protein" 21:49 < fenn> photos of you pissing in a bottle not needed 21:50 < nmz787> yeah apparently we aren't really biohackers 21:50 < fenn> hey i have stickers on my laptop 21:51 < nmz787> sure so do I 21:51 < fenn> they need a bunsen burner to stop contamination of the petri dishes 21:51 < fenn> updraft airflow 21:51 < nmz787> are we bionauts? 21:52 < fenn> i have been watching a lot of garage chemistry videos on youtube 21:52 < fenn> apparently you can do just about everything with a distillation apparatus and buchner funnel 21:53 < fenn> oh and one of those magnetic stir thingies 21:58 < fenn> this could have been cool: https://aylo6061.com/2012/02/24/blyes-bioluminescent-yeast-estrogen-assay/ 21:58 < fenn> but he says in the comments "it didn't go anywhere" 21:58 < fenn> sort of vague. did it not work? they found more compelling things to do instead? 22:00 -!- redlegion [~redlegion@gateway/tor-sasl/redlegion] has quit [Read error: Connection reset by peer] 22:00 < fenn> material transfer agreement problems? 22:00 < fenn> (what, you actually wanted to use our research for something? OHMYGAWD CALL THE COPS) 22:01 -!- redlegion [~redlegion@gateway/tor-sasl/redlegion] has joined ##hplusroadmap 22:01 -!- ebowden [~ebowden@128.250.0.194] has quit [Remote host closed the connection] 22:02 -!- ebowden [~ebowden@128.250.0.194] has joined ##hplusroadmap 22:06 -!- ebowden [~ebowden@128.250.0.194] has quit [Ping timeout: 240 seconds] 22:35 -!- jtimon [~quassel@142.29.134.37.dynamic.jazztel.es] has quit [Ping timeout: 240 seconds] 22:42 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 22:44 -!- maaku [~maaku@173.234.25.100] has quit [Quit: ZNC - http://znc.in] 22:47 -!- maaku [~maaku@173.234.25.100] has joined ##hplusroadmap 23:02 -!- sachy [~sachy@78.108.102.220] has quit [Quit: Leaving.] 23:04 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Ping timeout: 248 seconds] 23:26 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has joined ##hplusroadmap 23:27 -!- Gurkenglas_ [~Gurkengla@dslb-188-103-223-018.188.103.pools.vodafone-ip.de] has joined ##hplusroadmap 23:30 -!- Gurkenglas__ [~Gurkengla@dslb-188-103-223-018.188.103.pools.vodafone-ip.de] has quit [Ping timeout: 240 seconds] 23:31 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has quit [Remote host closed the connection] 23:32 -!- yashgaroth [~yashgarot@2606:6000:c308:f700:ce4:e2df:944a:e23c] has quit [Quit: Leaving] 23:32 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has joined ##hplusroadmap 23:33 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has quit [Remote host closed the connection] 23:34 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has joined ##hplusroadmap --- Log closed Thu Mar 29 00:00:32 2018