--- Log opened Tue Apr 10 00:00:44 2018
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05:21 < kanzure> hmph
05:26 < kanzure> .wik hypercapitalist
05:26 < yoleaux> kanzure: Sorry, that command (.wik) crashed.
05:29 < kanzure> "what synthetic biology will look like in 10 years" what a bleak outlook https://vimeo.com/256440711
05:29 < kanzure> .tw https://twitter.com/antonioregalado/status/983398161699000320
05:29 < yoleaux> Novartis bought a gene therapy company, Avexis, for $8.7 billion after it treated only around 20 kids for a neuron disease. Incredible times for gene therapy. https://www.statnews.com/2018/04/09/novartis-buying-avexis-8-7-billion-strengthen-gene-therapy-capabilities/ (@antonioregalado)
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07:39 < kanzure> why everyone so boring
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08:44 < kanzure> nice to see cadquery is still under development https://github.com/dcowden/cadquery
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09:04 < superkuh> Been doing EM simulation stuff for hobby radio all week. http://superkuh.com/radio-filter-simulations.html http://superkuh.com/dgs-bandpass-filter.html
09:04 < superkuh> Fabbed in china already. Just waiting now.
09:08 < superkuh> End goal will be building a frequency agile notch filter for "cognitive" radio.
09:09 < superkuh> Right now I'm just testing single frequency ones instead of throwing in varactors to tune.
09:56 < archels> neat
09:56 < archels> what's the tunable range, roughly?
10:02 < superkuh> ~40% of center freq.
10:02 < superkuh> Although it degrades a bit at the low end and the bandwidth changes. There's tricky math tricks to balance that and get constant bandwidth but it's over my head.
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10:43 < nmz787> superkuh: very cool. How much did Sonnet cost you?
11:18 < superkuh> I paid the iron price.
11:18 < superkuh> As far as I can tell it's if you have to ask you don't have enough. Or $5000 for the limited version with enough ram allowed to do useful things.
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12:05 < nmz787> superkuh: is that a game of thrones reference?
12:06 < superkuh> Yeah. Sorry. I pirated it.
12:06 < nmz787> well you didn't have to say all that... I was pretty sure I pieced it togehter
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14:47 < fltrz> superkuh, any reason for commercial software? I suspect the open source alternatives are lacking in either functionality or usability? what about http://openems.de/index.php/Tutorial:_CRLH_Parameter_Extraction for example? they plot S parameters in this example
14:49 < CaptHindsight> costs more but works
14:50 < superkuh> At least two. The first was that it was the software suggested for use in the paper that inspired me to try it. The second is that it is incredibly easy to use. It's like drawing in inkscape. Then you just run the sim.
14:50 < CaptHindsight> same for CAD/CAM
14:51 < fltrz> I see, so it is mostly usability
14:51 < superkuh> I don't feel bad about pirating software that I'll never be able to afford and will never use commercially. Nothing about me is commercial in the slightest.
14:51 < CaptHindsight> what is the term used now for non-artificial types of intelligence?
14:51 < fltrz> CaptHindsight, the open source packages seem to work as far as I can tell
14:51 < CaptHindsight> they are getting better
14:52 < fltrz> CaptHindsight, you mean machine learning?
14:52 < CaptHindsight> fltrz: no, non machine
14:52 < CaptHindsight> intelligence intelligence
14:52 < kanzure> cognitive ability, general intelligence, natural intelligence, etc.
14:52 < fltrz> I don't know, perhaps natural intelligence?
14:53 < CaptHindsight> AI is thrown around all the time
14:53 < fltrz> CaptHindsight, could you give an example sentence or context?
14:53 < CaptHindsight> non AI intelligence
14:53 < CaptHindsight> never mind
14:53 < kanzure> neuronal workputing
14:53 < CaptHindsight> NW
14:53 < CaptHindsight> I like that
14:54 < superkuh> Looks like that one requires matlab. And we all know when they say, (or Octave), they mean "Or Octave if you're an expert and can port the little corner cases that will inevitably not work and you'll have to re-implement from scratch".
14:54 < fltrz> why not simply 'intelligence'? 'intellect' is not associated with machine learning
14:55 < CaptHindsight> what frequency is the radio at?
14:55 < fltrz> sure but since its OpenEMS it's primarily for Octave
14:55 < CaptHindsight> superkuh: ^^
14:56 < superkuh> ~80-2000 MHz, frequency hopping.
14:57 < CaptHindsight> I did lots of RF and microwave back n the 70's and 80's
14:59 < CaptHindsight> I looked at some pf the new devices like amps LNA's specifically and everything is >10 times lower noise than what we had to work with
14:59 < fltrz> theres also pyopenems if you prefer python over matlab
15:01 < superkuh> I'm just imagining wasting days trying to go from http://superkuh.com/the-widest-bandstop-but-70db-down-at-460MHz.png to http://superkuh.com/folded-curved-stepped-impedance-bandstop-460MHz.png in python when I can do it in 10 minutes in sonnet.
15:01 < CaptHindsight> all those patents old are all expired now
15:02 < superkuh> If I can avoid scripting I will.
15:03 < CaptHindsight> superkuh: what do you use for microstrip layout?
15:04 < superkuh> Sonnet. It's all in the write up. I export the gerber to kicad for little things like placing via and all the mask and edge cut stuff required.
15:05 < superkuh> I mean, for the curved thing there I just took the length and then solved for a quarter or half circle radius of the same circumference.
15:05 < CaptHindsight> we used to tune things with razor blades
15:05 < superkuh> I imagine I'll have to do that as well. But I have a VNA now.
15:09 < CaptHindsight> I recall writing a app to layout microstrip and phased arrays using Basic that ran on Dos 2.1
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16:29 < fenn> wetware
16:31 < kanzure> .wik superior ability breeds superior ambition
16:31 < yoleaux> kanzure: Sorry, that command (.wik) crashed.
16:31 < fenn> KAAAAAAAAAAAANezure
16:31 < kanzure> trying to figure out a name
16:42 < Jenda> fltrz: "glycolysis pathway disposes of all the rest as heat?" nope, glycolysis leaves product with lots of unused energy - e.g. lactate, mallate, ethanol. Aerobic metabolism degrades it completely down to CO2
16:44 < Jenda> fltrz: "does the mitochondria express proteins that end up on the outer cell membrane" - I believe not, mitochondria only expresses a handful of genes. Most proteins are imported there from the cell through the TIM/TOM complex
16:44 < Jenda> fltrz: see https://en.wikipedia.org/wiki/TIM/TOM_complex for more
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16:52 < fltrz> Jenda, thanks for your opinion, so really the mitochondrial membrane is more like a prison for the mitochondria
16:59 < fltrz> the products like lactate, mallate, ethanol.. change in energy = work + heat, so either 1) its work the products you describe are useful, or part of their energy content is recycled during their breakdown OR 2) its remaining energy content is lost as heat during breakdown or 3) it is removed from the body in the higher energy state (like urea, because of the nitrogen, we dump it even if its energetic)
17:02 < fltrz> TIM/TOM complex is cool
17:03 < Jenda> 3 is correct
17:04 < Jenda> except that glycolysis without the aerobic step is a domain of singlecellular life (bacteria, facultatively yeasts), where the term "body" is not appropriate
17:06 < fltrz> thanks for clarifying
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19:57 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=3489487e Bryan Bishop: obesity-related SNPs >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
19:58 < kanzure> https://law.stanford.edu/2018/04/05/reproduction-head-transplants/
19:59 < kanzure> https://www.nextbigfuture.com/2018/04/nuclear-fusion-update.html
20:01 < kanzure> "Assessing scientists for hiring, promotion, and tenure" http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2004089 https://twitter.com/goodmanmetrics/status/983825793624170497
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20:04 < kanzure> .tw https://twitter.com/ScienceAlly/status/983726071488036864
20:04 < yoleaux> .@BillGates today strongly endorsed #CRISPR and other gene editing techniques, saying they can help humanity address its “biggest and most persistent challenges” in global health and agriculture. https://bit.ly/2IJxttr https://pbs.twimg.com/media/Dablm7oUwAMnOmK.jpg (@ScienceAlly)
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20:08 < kanzure> https://www.theguardian.com/science/2018/apr/07/gene-therapy-may-help-astronauts-going-to-mars-resist-deadly-radiation
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20:09 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=29b42ba1 Bryan Bishop: more about bitter taste receptors >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
20:23 < kanzure> chronic back pain - rs12310519 in SOX5, rs7833174 between CCDC26 and GSDMC, and rs4384683 in DCC https://www.biorxiv.org/content/early/2018/01/20/244483
20:31 < kanzure> "Structural insight into the assembly of the type II secretion system pilotin–secretin complex from enterotoxigenic Escherichia coli" https://www.nature.com/articles/s41564-018-0148-0
20:31 < kanzure> https://naturemicrobiologycommunity.nature.com/users/98681-meng-yin/posts/32026-never-give-up-your-protein
20:34 < kanzure> insulin physiology review http://jcb.rupress.org/content/early/2018/04/04/jcb.201802095 https://twitter.com/JCellBiol/status/983336735043092480
20:35 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=5b622763 Bryan Bishop: various other gwas study results >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
20:37 < kanzure> "Epilepsy gene therapy using non-integrating lentiviral delivery of an engineered potassium channel gene" https://www.biorxiv.org/content/early/2018/04/10/298588
20:38 < kanzure> "Generation of human vascularized brain organoids" https://insights.ovid.com/pubmed?pmid=29570159
20:40 < kanzure> "Genetic influence on social outcomes during and after the Soviet era in Estonia" https://www.nature.com/articles/s41562-018-0332-5
20:46 < kanzure> http://blogs.plos.org/collections/plos-igem-2017-collection-report/
20:47 < kanzure> some speculation about crispr-cas9 "neuroweapons" https://www.liebertpub.com/doi/abs/10.1089/hs.2016.0120 (paywall)
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22:59 < fenn> this paper on avalanche reactions in picosecond laser initiated proton boron-11 fusion looks promising https://www.nextbigfuture.com/2017/12/billion-times-improvement-with-laser-nuclear-fusion-using-avalanche-reaction-effect.html
23:00 < mrdata> whats the fusion triple product with this method?
23:02 < fenn> i think it's not relevant because this is a chain reaction
23:02 < mrdata> ugh. cant load nextbigfuture right now
23:02 < fenn> https://arxiv.org/abs/1708.09722 actual paper
23:02 < mrdata> ty
23:05 < fenn> am i correct in thinking this could be used to detonate a fusion bomb?
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23:06 < mrdata> if it's a chain reaction, it is a bomb
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23:07 < mrdata> tho perhaps a very small one
23:08 < mrdata> i believe fusion triple product does still apply here
23:09 < fenn> even if the reaction goes to completion?
23:10 < fenn> anyway the numbers aren't provided
23:10 < mrdata> how long does it take to go to completion
23:11 < mrdata> in terms of triple product, the two schemes in the lead right now are JET and dense plasma focus
23:11 < fenn> i think less than a nanosecond
23:12 < mrdata> then the time factor is 10^-9 or so
23:13 < mrdata> the others are density and temperature
23:13 < fenn> i don't even know how to think of the temperature when it's a mix of particles with different energies
23:13 < fenn> see figure 5
23:13 < mrdata> temperature is an average
23:15 < mrdata> but for fusion they use figures in keV
23:17 < fenn> well then i suppose it's (612+2900*3+1040+1860+375+665)/8
23:18 < fenn> 1656keV
23:18 < mrdata> and density is given in particles per m^3
23:20 < mrdata> so presumably this is the starting density of the material because there isnt time for it to escape
23:21 < mrdata> so for proton-boron, that's probably density of decaborane?
23:21 < fenn> density of boron is 2.37 g/ml or 1.3e29 atoms/m^3
23:22 < mrdata> they need both H+B in there
23:22 < fenn> decaborane is 0.94g/ml or 5.1e28
23:23 < fenn> well something like that
23:23 < fenn> 9.4e28
23:24 < mrdata> i'm not sure if we divide by its molecular mass; but okay
23:24 < fenn> you care about moles of atoms, not moles of molecules
23:25 < fenn> i used 2mol/12g
23:25 < mrdata> 9.4e28 / m^3 * 10^-9 s * 1656keV = 1.5e23
23:26 < mrdata> which is fantastic
23:26 < fenn> anyway the laser is only igniting a tiny spot on the side of the fuel pellet, the rest proceeds by chain reaction apparently
23:26 < mrdata> i think 10^26 is needed for break-even?
23:26 < mrdata> or is that only for break-even with D-T
23:26 < mrdata> idk
23:27 < fenn> you're assuming the temperature comes from energy that is input to the system
23:27 < mrdata> no
23:27 < fenn> well, what does "break even" mean then?
23:27 < mrdata> i'm counting only the particles that are ignited
23:27 < mrdata> energy out > energy in
23:27 < fenn> we don't know how many particles are ignited by the laser
23:28 < mrdata> just count the particles that are heated by the laser, then
23:28 < mrdata> the rest of the pellet is heated by the fusion
23:29 < fenn> i don't see why it matters
23:30 < fenn> it's like asking how big was the match you used to start a bonfire
23:31 < fenn> this whole idea of p-B11 being a chain reaction is new to me
23:33 < fenn> the lasers are roughly 2 kJ and the pellet produces 1GJ
23:34 < fenn> oops 11kJ
23:35 < mrdata> which
23:35 < fenn> i'm sure they're horribly inefficient
23:36 < fenn> the confinement laser pulse is 1ns and 1kJ and the ignition laser is 1ps and "more than 10 petawatt" >= 10kJ
23:36 < fenn> the magnetic confinement thingy is a neat trick
23:37 < fenn> 5-10 kilotesla
23:43 < fenn> it's sort of unclear what they actually did
23:44 < fenn> obviously they didn't actually ignite a fusion pellet
23:44 < fenn> i guess it's a simulation result
23:49 < fenn> stand by for triggering... https://www.physics.unsw.edu.au/sites/default/files/LPB%202016%20PoP%20ELIEZER.pdf
23:52 < fenn> here's an image of the actual experiment https://journals.aps.org/prx/abstract/10.1103/PhysRevX.4.031030
--- Log closed Wed Apr 11 00:00:44 2018