--- Log opened Thu Apr 12 00:00:45 2018 01:00 -!- preview [~quassel@203.167.243.242] has joined ##hplusroadmap 01:01 -!- l_wl [~l_wl@pool-173-66-205-23.washdc.fios.verizon.net] has quit [Quit: gone for now but not for good] 01:14 -!- aeiousomething [~aeiousome@124.123.14.99] has joined ##hplusroadmap 01:22 -!- darsie [~username@84-114-73-160.cable.dynamic.surfer.at] has joined ##hplusroadmap 01:24 -!- aeiousomething [~aeiousome@124.123.14.99] has quit [Ping timeout: 240 seconds] 01:32 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has quit [Remote host closed the connection] 02:05 -!- preview [~quassel@203.167.243.242] has quit [Ping timeout: 260 seconds] 02:05 -!- preview_ [~quassel@203.167.243.242] has joined ##hplusroadmap 02:21 -!- red-001 [red@gateway/shell/elitebnc/x-nlnucfgncwevyqcd] has quit [Ping timeout: 265 seconds] 02:42 -!- jtimon [~quassel@142.29.134.37.dynamic.jazztel.es] has joined ##hplusroadmap 02:43 -!- red-001 [red@gateway/shell/elitebnc/x-cpopfsagaevwvslh] has joined ##hplusroadmap 02:49 -!- aeiousomething [~aeiousome@124.123.14.99] has joined ##hplusroadmap 03:07 < kanzure> https://www.technologyreview.com/s/610717/this-company-can-encode-your-favorite-song-in-dnafor-100000/ 03:10 -!- preview [~quassel@203.167.243.242] has joined ##hplusroadmap 03:10 -!- preview_ [~quassel@203.167.243.242] has quit [Ping timeout: 260 seconds] 04:14 -!- preview_ [~quassel@203.167.243.242] has joined ##hplusroadmap 04:14 -!- preview [~quassel@203.167.243.242] has quit [Ping timeout: 260 seconds] 04:26 -!- l_wl [~l_wl@96-88-198-77-static.hfc.comcastbusiness.net] has joined ##hplusroadmap 04:40 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Ping timeout: 276 seconds] 04:55 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 05:18 -!- preview_ [~quassel@203.167.243.242] has quit [Ping timeout: 240 seconds] 05:19 -!- preview [~quassel@203.167.243.242] has joined ##hplusroadmap 05:25 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Remote host closed the connection] 05:52 < CaptHindsight> I'll encode it into a plant genome for $200K and every time it reproduces itself it will violate copyright so that plants can be sued by the RIAA 06:03 < l_wl> I'd like to breed insects with the additional nervous system features such that they can feel pain. This is because I'm trying to mass scale farm insects for food 06:18 < kanzure> i've seen some pain insensitivity mutations but i'm not sure how to increase pain sensitivity 06:22 < TMA> just make the pain a reliable indicator of avoidable death 06:23 -!- preview [~quassel@203.167.243.242] has quit [Ping timeout: 240 seconds] 06:24 -!- preview [~quassel@203.167.243.242] has joined ##hplusroadmap 06:24 < TMA> Azathoth will take care of the rest, if you administer it long enough 06:39 < l_wl> I want to grow the insects in high oxygen environments - so they grow bigger and are more juicy to eat 06:42 < kanzure> you should do directed evolution of insects for size. since they have short generation times you should be able to get some monsters pretty quick. 06:43 < l_wl> That + growing them in high oxygen would be best (mosquitos grow 20% per generation in oxygen % similar to millions of years ago) 06:45 < kanzure> why mosquitos? i thought crickets would be ideal for farming. 06:48 < l_wl> The study was on mosquitos. And for insect farming for food theres probably better insects than crickets to eat 06:52 -!- l_wl [~l_wl@96-88-198-77-static.hfc.comcastbusiness.net] has quit [Quit: gone for now but not for good] 06:53 -!- l_wl [~l_wl@96-88-198-77-static.hfc.comcastbusiness.net] has joined ##hplusroadmap 07:01 -!- drewbot [~cinch@184.73.25.28] has joined ##hplusroadmap 07:14 -!- l_wl [~l_wl@96-88-198-77-static.hfc.comcastbusiness.net] has quit [Quit: gone for now but not for good] 07:19 -!- l_wl [~l_wl@96-88-198-77-static.hfc.comcastbusiness.net] has joined ##hplusroadmap 07:29 -!- preview [~quassel@203.167.243.242] has quit [Ping timeout: 256 seconds] 07:29 -!- preview_ [~quassel@203.167.243.242] has joined ##hplusroadmap 07:42 -!- ebowden [~ebowden@128.250.0.209] has quit [Ping timeout: 264 seconds] 07:51 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has joined ##hplusroadmap 08:01 -!- ebowden [~ebowden@128.250.0.209] has joined ##hplusroadmap 08:06 -!- ebowden [~ebowden@128.250.0.209] has quit [Ping timeout: 264 seconds] 08:06 -!- ebowden [~ebowden@128.250.0.209] has joined ##hplusroadmap 08:26 -!- ebowden [~ebowden@128.250.0.209] has quit [Ping timeout: 256 seconds] 08:33 -!- preview [~quassel@203.167.243.242] has joined ##hplusroadmap 08:33 -!- l_wl_ [~l_wl@96-88-198-77-static.hfc.comcastbusiness.net] has joined ##hplusroadmap 08:33 -!- preview_ [~quassel@203.167.243.242] has quit [Ping timeout: 256 seconds] 08:35 -!- ebowden [~ebowden@128.250.0.209] has joined ##hplusroadmap 08:36 -!- l_wl [~l_wl@96-88-198-77-static.hfc.comcastbusiness.net] has quit [Ping timeout: 264 seconds] 08:45 -!- l_wl_ [~l_wl@96-88-198-77-static.hfc.comcastbusiness.net] has quit [Read error: Connection reset by peer] 09:00 -!- preview [~quassel@203.167.243.242] has quit [Quit: No Ping reply in 180 seconds.] 09:01 -!- preview [~quassel@203.167.243.242] has joined ##hplusroadmap 09:42 < kanzure> aren't there some antibiotic drugs that cause protein mistranslation at the ribosomal level, not the level of translation into mRNA? 09:45 -!- yashgaroth [~yashgarot@2606:6000:c308:f700:f5e0:f867:a11d:8d52] has joined ##hplusroadmap 09:53 -!- bluebear_ [~dluhos@80.95.97.194] has joined ##hplusroadmap 10:05 -!- preview [~quassel@203.167.243.242] has quit [Ping timeout: 264 seconds] 10:06 -!- preview [~quassel@203.167.243.242] has joined ##hplusroadmap 10:18 < superkuh> Breakthrough (starshot) conference is live now. Not every talk is about the laser accelerated tiny probe but they're mostly interesting. https://www.youtube.com/watch?v=nFoTyKGHdLc 10:25 -!- Gurkenglas [~Gurkengla@dslb-188-102-077-078.188.102.pools.vodafone-ip.de] has quit [Read error: Connection reset by peer] 11:00 -!- augur [~augur@2600:380:4510:dc42:28f9:a643:afc9:1ff8] has joined ##hplusroadmap 11:10 -!- preview [~quassel@203.167.243.242] has quit [Ping timeout: 264 seconds] 11:10 -!- preview [~quassel@203.167.243.242] has joined ##hplusroadmap 11:28 -!- bluebear_ [~dluhos@80.95.97.194] has quit [Quit: Leaving.] 11:33 -!- augur [~augur@2600:380:4510:dc42:28f9:a643:afc9:1ff8] has quit [Remote host closed the connection] 11:51 -!- redlegion [~x@gateway/tor-sasl/redlegion] has quit [Remote host closed the connection] 11:51 -!- redlegion [~x@gateway/tor-sasl/redlegion] has joined ##hplusroadmap 12:07 -!- drewbot [~cinch@184.73.25.28] has quit [Remote host closed the connection] 12:15 -!- preview_ [~quassel@203.167.243.242] has joined ##hplusroadmap 12:15 -!- preview [~quassel@203.167.243.242] has quit [Ping timeout: 276 seconds] 12:44 < kanzure> juul: do you know any particularly good plasmid visualization tools? ideally things that generate svg and are open-source software. 12:45 < kanzure> i wanna see lots of circles. with annotations. and fancy stuff. 12:50 < juul> kanzure: my notes from last time i looked at that: https://openwetware.org/wiki/Software#Circular_DNA_.28plasmid.29_viewers.2Feditors 12:52 < kanzure> 2016 is relatively recent, great 12:53 < kanzure> cc yashgaroth 12:53 < kanzure> thanks 12:54 < juul> np 12:56 < yashgaroth> oh god github 13:10 -!- jtimon [~quassel@142.29.134.37.dynamic.jazztel.es] has quit [Ping timeout: 265 seconds] 13:19 -!- preview_ [~quassel@203.167.243.242] has quit [Ping timeout: 240 seconds] 13:20 -!- preview [~quassel@203.167.243.242] has joined ##hplusroadmap 13:24 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has joined ##hplusroadmap 13:27 < nmz787> I previously used GENtle and ApE 13:27 < nmz787> that link juul provided doesn't even mention GENtle, only GENtl2 13:28 -!- l_wl [~l_wl@96-88-198-77-static.hfc.comcastbusiness.net] has joined ##hplusroadmap 13:29 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has quit [Ping timeout: 260 seconds] 13:29 < nmz787> dang, last commit 12 years ago https://github.com/magnusmanske/gentle-m 13:30 < nmz787> hmm https://news.open-bio.org/2012/03/02/cross-links-in-genomediagram/ 13:31 < nmz787> https://github.com/biopython/biopython/blob/master/Doc/examples/Proux_et_al_2002_Figure_6.py 13:31 < juul> nmz787: i was focusing on finding a library for use on web. Please do expand and modify that page 13:32 < juul> Oh that one is web. It's been a while 13:33 < nmz787> juul: ah, makes sense 13:34 < nmz787> was this ever mentioned here before? (PyDNA) https://bmcbioinformatics.biomedcentral.com/articles/10.1186/s12859-015-0544-x 13:34 < nmz787> .title 13:34 < yoleaux> Pydna: a simulation and documentation tool for DNA assembly strategies using python | BMC Bioinformatics | Full Text 13:34 < nmz787> grep of logs says no 13:41 -!- jtimon [~quassel@142.29.134.37.dynamic.jazztel.es] has joined ##hplusroadmap 14:05 -!- aeiousomething [~aeiousome@124.123.14.99] has quit [Quit: leaving] 14:05 -!- aeiousomething [~aeiousome@124.123.14.99] has joined ##hplusroadmap 14:07 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has joined ##hplusroadmap 14:11 -!- l_wl [~l_wl@96-88-198-77-static.hfc.comcastbusiness.net] has quit [Quit: gone for now but not for good] 14:24 -!- preview [~quassel@203.167.243.242] has quit [Ping timeout: 240 seconds] 14:24 -!- preview [~quassel@203.167.243.242] has joined ##hplusroadmap 14:26 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has quit [Remote host closed the connection] 14:40 -!- l_wl [~l_wl@96-88-198-77-static.hfc.comcastbusiness.net] has joined ##hplusroadmap 15:28 -!- preview [~quassel@203.167.243.242] has quit [Ping timeout: 240 seconds] 15:29 -!- preview [~quassel@203.167.243.242] has joined ##hplusroadmap 15:40 -!- CandleGlow [~CandleGlo@unaffiliated/candleglow] has joined ##hplusroadmap 15:42 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has joined ##hplusroadmap 16:02 -!- l_wl [~l_wl@96-88-198-77-static.hfc.comcastbusiness.net] has quit [Quit: gone for now but not for good] 16:04 < kanzure> .wik dynamic combinatorial chemistry 16:04 < yoleaux> "Dynamic combinatorial chemistry (DCC; also known as dynamic covalent chemistry) is a method to the generation of new molecules formed by reversible reaction of simple building blocks under thermodynamic control. The library of these reversibly interconverting building blocks is called a dynamic combinatorial library (DCL)." — https://en.wikipedia.org/wiki/Dynamic_combinatorial_chemistry 16:04 < kanzure> https://www.genomeweb.com/business-news/dna-script-dynamic-combinatorial-chemistry-ink-licensing-deal#.WsTFt-jwa3A 16:05 < kanzure> "... initially developed by DCC affiliate Firebird Biomolecular Sciences, they are reversible terminator nucleotides with cleavable protective groups that help in controlling the enzymatic synthesis process" 16:09 -!- l_wl [~l_wl@96-88-198-77-static.hfc.comcastbusiness.net] has joined ##hplusroadmap 16:12 -!- mrdata- [~mrdata@unaffiliated/mrdata] has joined ##hplusroadmap 16:13 -!- l_wl [~l_wl@96-88-198-77-static.hfc.comcastbusiness.net] has quit [Client Quit] 16:18 < kanzure> zador lab stuff https://www.wired.com/story/new-brain-maps-with-unmatched-detail-may-change-neuroscience/ 16:19 < kanzure> also that article mentions mapseq etc 16:20 < kanzure> for barcoding neuronal connectome tracing scanning things 16:21 < kanzure> "The logic of single-cell projections from visual cortex" https://www.nature.com/articles/nature26159 16:22 -!- l_wl [~l_wl@96-88-198-77-static.hfc.comcastbusiness.net] has joined ##hplusroadmap 16:25 < kanzure> https://www.reddit.com/r/Scholar/comments/7m3uin/meta_if_you_cant_remember_what_domains_scihub_is/ 16:26 < kanzure> https://torrentfreak.com/publisher-gets-carte-blanche-to-seize-new-sci-hub-domains-180410/ 16:27 < kanzure> https://torrentfreak.com/images/acssciamend.pdf 16:27 < kanzure> annnd https://news.ycombinator.com/item?id=16823067 16:30 -!- aeiousomething [~aeiousome@124.123.14.99] has quit [Quit: Lost terminal] 16:34 -!- preview [~quassel@203.167.243.242] has quit [Ping timeout: 260 seconds] 16:34 -!- preview_ [~quassel@203.167.243.242] has joined ##hplusroadmap 16:37 -!- aeiousomething [~aeiousome@124.123.14.99] has joined ##hplusroadmap 16:43 -!- preview_ [~quassel@203.167.243.242] has quit [Quit: No Ping reply in 180 seconds.] 16:44 -!- preview [~quassel@203.167.243.242] has joined ##hplusroadmap 17:08 -!- Guest66665 [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has quit [Read error: Connection reset by peer] 17:19 -!- darsie [~username@84-114-73-160.cable.dynamic.surfer.at] has quit [Ping timeout: 264 seconds] 17:23 -!- helleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has joined ##hplusroadmap 17:33 -!- wrldpc1 [~ben@softbank126225104018.bbtec.net] has joined ##hplusroadmap 17:34 < wrldpc1> Using machine learning to analyze north korean propaganda to see if there are any indicators in their sentiment we can use to help predict missile launch events. I need access to a paper and sci-hub and #icanhazpdf aren’t proving helpful - was wondering if someone here could help me: http://politics.oxfordre.com/view/10.1093/acrefore/9780190228637.001.0001/acrefore-9780190228637-e-418 17:48 -!- preview [~quassel@203.167.243.242] has quit [Ping timeout: 240 seconds] 17:49 -!- preview [~quassel@203.167.243.242] has joined ##hplusroadmap 18:03 -!- wrldpc1 [~ben@softbank126225104018.bbtec.net] has quit [Ping timeout: 263 seconds] 18:03 -!- wrldpc1 [~ben@hcccbcac120.bai.ne.jp] has joined ##hplusroadmap 18:36 -!- l_wl [~l_wl@96-88-198-77-static.hfc.comcastbusiness.net] has quit [Quit: gone for now but not for good] 18:43 -!- aeiousomething [~aeiousome@124.123.14.99] has quit [Ping timeout: 256 seconds] 18:52 -!- preview_ [~quassel@203.167.243.242] has joined ##hplusroadmap 18:52 -!- preview [~quassel@203.167.243.242] has quit [Ping timeout: 240 seconds] 19:50 < kanzure> archels: so did you get the equipment? 19:56 -!- preview_ [~quassel@203.167.243.242] has quit [Ping timeout: 260 seconds] 19:57 -!- preview [~quassel@203.167.243.242] has joined ##hplusroadmap 20:07 -!- l_wl [~l_wl@pool-173-66-205-23.washdc.fios.verizon.net] has joined ##hplusroadmap 20:10 < kanzure> https://whereisscihub.now.sh/ 20:12 < CaptHindsight> .taiwan and .hongkong are usually up 20:18 -!- mrdata- [~mrdata@unaffiliated/mrdata] has quit [Read error: Connection reset by peer] 20:18 -!- mrdata- [~mrdata@unaffiliated/mrdata] has joined ##hplusroadmap 20:20 -!- mrdata- [~mrdata@unaffiliated/mrdata] has quit [Read error: Connection reset by peer] 20:25 -!- CandleGlow [~CandleGlo@unaffiliated/candleglow] has quit [Quit: ...and all my responses they stay the same.] 20:43 -!- Ximensi0ns196 [~drcfwk@2001:bc8:4700:2300::1:d07] has joined ##hplusroadmap 20:45 -!- Ximensi0ns196 [~drcfwk@2001:bc8:4700:2300::1:d07] has quit [Remote host closed the connection] 21:00 -!- wgfkrr [~jatxmi@189.127.12.250.nipcable.com] has joined ##hplusroadmap 21:01 -!- preview [~quassel@203.167.243.242] has quit [Ping timeout: 264 seconds] 21:01 -!- preview [~quassel@203.167.243.242] has joined ##hplusroadmap 21:04 -!- wgfkrr [~jatxmi@189.127.12.250.nipcable.com] has quit [Remote host closed the connection] 21:15 -!- Qfwfq [Qfwfq@gateway/shell/suchznc/x-xfxvktgewstbabzq] has quit [Remote host closed the connection] 21:18 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has quit [Ping timeout: 264 seconds] 21:18 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has joined ##hplusroadmap 21:39 -!- yashgaroth [~yashgarot@2606:6000:c308:f700:f5e0:f867:a11d:8d52] has quit [Quit: Leaving] 21:49 < CaptHindsight> https://job-openings.monster.com/Molecular-Memory-Scientist-Engineer-Washington-DC-US-Booz-Allen-Hamilton/31/50255190-e291-476c-9180-9c1a326650f6 21:50 < CaptHindsight> "Provide scientific, engineering, and technical assistance (SETA) support to the government program manager (PM) in the science of molecular memory, including the storage of information using molecular species versus conventional media, such as magnetic and solid state." 21:51 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has quit [Quit: ORGANS IN MAINS] 22:05 < CaptHindsight> https://jobs.ourcareerpages.com/job/315381?source=StrategicAnalysisInc&jobFeedCode=StrategicAnalysisInc&returnURL=http://www.sainc.com/ 22:05 < CaptHindsight> Strategic Analysis, Inc. Molecular Memory Scientist 22:05 < CaptHindsight> Strategic Analysis, Inc., (SA) seeks a molecular memory scientist to provide technical support and expertise in the science of molecular memory – the storage of information using molecular species versus conventional media (magnetic, solid state, etc.). 22:06 -!- preview [~quassel@203.167.243.242] has quit [Ping timeout: 240 seconds] 22:06 -!- preview [~quassel@203.167.243.242] has joined ##hplusroadmap 22:22 -!- Qfwfq [Qfwfq@gateway/shell/suchznc/x-gbudgllqasudbfco] has joined ##hplusroadmap 22:22 -!- Qfwfq [Qfwfq@gateway/shell/suchznc/x-gbudgllqasudbfco] has quit [Changing host] 22:22 -!- Qfwfq [Qfwfq@unaffiliated/washirving] has joined ##hplusroadmap 22:22 -!- Qfwfq [Qfwfq@unaffiliated/washirving] has quit [Changing host] 22:22 -!- Qfwfq [Qfwfq@gateway/shell/suchznc/x-gbudgllqasudbfco] has joined ##hplusroadmap 22:28 -!- AgenttiX [agenttix@lakka.kapsi.fi] has quit [Ping timeout: 260 seconds] 22:28 -!- AgenttiX [agenttix@lakka.kapsi.fi] has joined ##hplusroadmap 22:34 -!- l_wl [~l_wl@pool-173-66-205-23.washdc.fios.verizon.net] has quit [Quit: gone for now but not for good] 22:41 -!- mrdata_ [~mrdata@unaffiliated/mrdata] has joined ##hplusroadmap 22:44 -!- mrdata [~mrdata@unaffiliated/mrdata] has quit [Ping timeout: 264 seconds] 22:48 -!- mrdata_ is now known as mrdata 23:09 -!- preview_ [~quassel@203.167.243.242] has joined ##hplusroadmap 23:11 -!- preview [~quassel@203.167.243.242] has quit [Ping timeout: 276 seconds] 23:17 -!- preview_ [~quassel@203.167.243.242] has quit [Ping timeout: 268 seconds] 23:22 -!- preview [~quassel@203.167.243.242] has joined ##hplusroadmap 23:25 -!- augur [~augur@noisebridge130.static.monkeybrains.net] has quit [Remote host closed the connection] 23:29 -!- schindler__ [uid149928@gateway/web/irccloud.com/x-qrsfoxnhjtfifhai] has joined ##hplusroadmap 23:42 -!- preview [~quassel@203.167.243.242] has quit [Quit: No Ping reply in 180 seconds.] 23:44 -!- preview [~quassel@203.167.243.242] has joined ##hplusroadmap 23:56 -!- aeiousomething [~aeiousome@124.123.14.99] has joined ##hplusroadmap --- Log closed Fri Apr 13 00:00:47 2018